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CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
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Chemistry

ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
ProcessesWhat proteins are annotated as doing
AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
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MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

Compounds
Outcomes
Proteins
Interactions
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Articles

Chemistry

Reactions
Reach

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Pathways
Processes
Anatomy
Cell types
Organisms
Materials
Assessments
Diseases

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Pathway

Cholestasis

Genetic causes of cholestasis. The pathway describes the enzymes involved in the bile acid (Ba) uptake and metabolism.

Description from WikiPathways (WP5238), read 2026-09-23.

WP:5238

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What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

Statements

19 statements

19 statements · 1 reference database · Subject: Cholestasis · Sources: WikiPathways

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ABCB11 participates in CholestasisProteinWikiPathways WP5238Inferred only
ABCB4 participates in CholestasisProteinWikiPathways WP5238Inferred only
ABCC2 participates in CholestasisProteinWikiPathways WP5238Inferred only
ABCC3 participates in CholestasisProteinWikiPathways WP5238Inferred only
ABCC4 participates in CholestasisProteinWikiPathways WP5238Inferred only
ABCG5 participates in CholestasisProteinWikiPathways WP5238Inferred only
ABCG8 participates in CholestasisProteinWikiPathways WP5238Inferred only
ATP8B1 participates in CholestasisProteinWikiPathways WP5238Inferred only
EPHX1 participates in CholestasisProteinWikiPathways WP5238Inferred only
HMGCR participates in CholestasisProteinWikiPathways WP5238Inferred only
LDLR participates in CholestasisProteinWikiPathways WP5238Inferred only
NR1H4 participates in CholestasisProteinWikiPathways WP5238Inferred only

Show the remaining 7

NR1I3 participates in CholestasisProteinWikiPathways WP5238Inferred only
RXRA participates in CholestasisProteinWikiPathways WP5238Inferred only
SCARB1 participates in CholestasisProteinWikiPathways WP5238Inferred only
SLC10A1 participates in CholestasisProteinWikiPathways WP5238Inferred only
SLC22A1 participates in CholestasisProteinWikiPathways WP5238Inferred only
SLCO1A2 participates in CholestasisProteinWikiPathways WP5238Inferred only
TJP2 participates in CholestasisProteinWikiPathways WP5238Inferred only