Pathway
NFE2L2 regulating MDR associated enzymes
Subpathway representing multi-drug resistance (MDR) gene regulated by NFE2L2 (NRF2). These MDR-related genes are known to play a role in Drug resistance. For example, ABCF2 have a role in Cisplatin resistance in ovarian cancer. Similarly ABCC1 (MRP1), ABCC3 and ABCG2 also have a role in multiple drug resistance (Cole et al,2014; Zeng et al,1999; Mo et al, 2012).
REACT:R-HSA-9818032Reactome
What the reference databases state
Statements
8 statements
8 statements · 1 reference database · Subject: NFE2L2 regulating MDR associated enzymes · Sources: Reactome
- ABCC1 participates in NFE2L2 regulating MDR associated enzymesProteinReactome R-HSA-9818032Inferred only
- ABCC3 participates in NFE2L2 regulating MDR associated enzymesProteinReactome R-HSA-9818032Inferred only
- ABCF2 participates in NFE2L2 regulating MDR associated enzymesProteinReactome R-HSA-9818032Inferred only
- ABCG2 participates in NFE2L2 regulating MDR associated enzymesProteinReactome R-HSA-9818032Inferred only
- CREBBP participates in NFE2L2 regulating MDR associated enzymesProteinReactome R-HSA-9818032Inferred only
- EP300 participates in NFE2L2 regulating MDR associated enzymesProteinReactome R-HSA-9818032Inferred only
- MAFK participates in NFE2L2 regulating MDR associated enzymesProteinReactome R-HSA-9818032Inferred only
- NFE2L2 participates in NFE2L2 regulating MDR associated enzymesProteinReactome R-HSA-9818032Inferred only