Catalyst

Reference

Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
ArticlesReadings of the evidence

Chemistry

ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
ProcessesWhat proteins are annotated as doing
AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

Atlas Graph Twin Access

Search the graph

Search ?

Reference

Evidence

Compounds
Outcomes
Proteins
Interactions
Papers
Articles

Chemistry

Reactions
Reach

Reference layer

Pathways
Processes
Anatomy
Cell types
Organisms
Materials
Assessments
Diseases

Atlas Graph Twin Access

Loading the page.

Catalyst

Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

The graph

Compounds
Outcomes
Proteins
Atlas
Interactions
Papers
Articles
Graph
Search

Reference layer

Pathways
Processes
Anatomy
Cell types
Organisms
Materials
Assessments
Diseases
Reactions
Reach

How it works

Mission
Method
Twin
How to read the evidence
Sources and licences

Build on it

Access
In your assistant
For agents
Query the graph
Bulk export

A reference for what the literature reports. Not medical advice.

Reach

N-tetradecanoylglycine

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

Inferred

Every route here is a hypothesis drawn from reference reactions (Rhea and Human-GEM), not a finding. Currency species such as water, ATP and NAD(H) never form a step. Evidence key

528 compounds within 3 steps: 4 in 1, 102 in 2, 422 in 3

Does it reach a compound?

Two steps

glycodeoxycholateReach from here →
1. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
2. Glycodeoxycholate amidohydrolase
Catalysed by GLYATL2cytosolOne of 2 routes
O-tetradecanoyl-(R)-carnitineReach from here →
1. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
2. tetradecanoyl-CoA + (R)-carnitine = O-tetradecanoyl-(R)-carnitine + CoA
Catalysed by GLYATL2, CPT2
(5Z)-tetradecenoyl-CoAReach from here →
1. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
2. stearoyl-CoA 9-desaturase (myristoyl-CoA)
Catalysed by GLYATL2, SCD, SCD5cytosol
N-eicosanoylglycinateReach from here →
1. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
2. eicosanoyl-CoA + glycine = N-eicosanoylglycinate + CoA + H(+)
Catalysed by GLYATL2, BAAT
N-docosanoylglycineReach from here →
1. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
2. docosanoyl-CoA + glycine = N-docosanoylglycine + CoA + H(+)
Catalysed by GLYATL2, BAAT
N-hexacosanoylglycineReach from here →
1. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
2. hexacosanoyl-CoA + glycine = N-hexacosanoylglycine + CoA + H(+)
Catalysed by GLYATL2, BAAT

Three steps

beta-carbolineReach from here →
Catalysed by GLYATL2, SLC7A5extracellular space, cytosol
(S)-carnitineReach from here →
Catalysed by GLYATL2, BAAT and 1 more

Page 3 of 11

, CPT1A

, CPT1C

peroxisome, cytosol

One of 245 routes

3-methyl-2-oxobutanoateReach from here →

tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
transport of glycine and valine (cytosol to extracellular)
L-Valine:2-oxoglutarate aminotransferase

Catalysed by GLYATL2, SLC7A5, BCAT2extracellular space, cytosol, mitochondrial matrixOne of 3 routes

2-phenylpropan-2-olReach from here →

tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
cumene hydroperoxide + 2 glutathione = 2-phenylpropan-2-ol + glutathione disulfide + H2O

Catalysed by GLYATL2, GSS, CLIC2, GPX1 and 2 more

a hydroxy polyunsaturated fatty acidReach from here →

tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
a hydroperoxy polyunsaturated fatty acid + 2 glutathione = a hydroxy polyunsaturated fatty acid + glutathione disulfide + H2O

Catalysed by GLYATL2, GSS, GPX1, GPX2 and 1 more

AReach from here →

tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
transport of cysteine and glycine (cytosol to extracellular)
Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O

Catalysed by GLYATL2, SLC3A2, SLC7A5, SLC7A8 and 1 moreextracellular space, cytosol

S-dodecanoyl-4'-phosphopantetheineReach from here →

tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
Fatty Acid Beta Oxidation (C14->C12), Mitochondrial
dodecanoyl-CoA + H2O = S-dodecanoyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)

Catalysed by GLYATL2, HADHA, ACADVL, HADHB and 2 moremitochondrial matrix

an acyl-4'-phosphopantetheineReach from here →

tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
acyl-CoA pool formation and breakdown
an acyl-CoA + H2O = an acyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)

Catalysed by GLYATL2, NUDT19, FITM2, NUDT8cytosol

tauroursodeoxycholateReach from here →

tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)
transport of GSH and tauroursodeoxycholate (cytosol to extracellular)

Catalysed by GLYATL2, GSS, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 3 routes

13-hydroxytetradecanoateReach from here →

tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
Myristoyl-CoA hydrolase
myristic acid[r] + O2[r] + FMNH2[r] = FMN[r] + H2O[r] + 13-hydroxytetradecanoate[r]

Catalysed by GLYATL2, ACOT7, BAAT, THEM4 and 3 morecytosol, endoplasmic reticulumOne of 3 routes

N-(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-glycineReach from here →

tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + glycine = N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + CoA + H(+)
N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + O2 = N-(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-glycine

Catalysed by GLYATL2, ALOX15, ALOX12

N-(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-glycineReach from here →

tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + glycine = N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + CoA + H(+)
N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + O2 = N-(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-glycine

Catalysed by GLYATL2, ALOX15B, ALOX15, ALOX12

(15S)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoateReach from here →

tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
(15S)-hydroperoxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + 2 glutathione = (15S)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + glutathione disulfide + H2O

Catalysed by GLYATL2, GSS, GPX1, GPX4

(11S,15S)-dihydroxy-14(R)-S-glutathionyl-(5Z,8Z,12E)-eicosatrienoateReach from here →

tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)
glutathione transferase (GSH)

Catalysed by GLYATL2, GSS, PTGES, MGST3 and 19 morecytosolOne of 5 routes

prostaglandin E3Reach from here →

tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)
transport of GSH and prostaglandin E3 (cytosol to extracellular)

Catalysed by GLYATL2, GSS, SLCO2A1cytosol, extracellular spaceOne of 2 routes

prostaglandin A2Reach from here →

tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)
transport of GSH and prostaglandin A2 (cytosol to extracellular)

Catalysed by GLYATL2, GSS, SLCO2A1cytosol, extracellular spaceOne of 2 routes

prostaglandin B1Reach from here →

tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)
transport of GSH and prostaglandin B1 (cytosol to extracellular)

Catalysed by GLYATL2, GSS, SLCO2A1cytosol, extracellular spaceOne of 2 routes

leukotriene F4Reach from here →

tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)
transport of GSH and leukotriene F4 (cytosol to extracellular)

Catalysed by GLYATL2, GSScytosol, extracellular spaceOne of 4 routes

prostaglandin A2-S-(R)-glutathioneReach from here →

tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
prostaglandin A2 + glutathione = prostaglandin A2-S-(R)-glutathione

Catalysed by GLYATL2, GSS, GSTA1, GSTM1

prostaglandin A2-S-(S)-glutathioneReach from here →

tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
prostaglandin A2 + glutathione = prostaglandin A2-S-(S)-glutathione

Catalysed by GLYATL2, GSS, GSTP1, GSTM1

prostaglandin J2-S-(R)-glutathioneReach from here →

tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
prostaglandin J2 + glutathione = prostaglandin J2-S-(R)-glutathione

Catalysed by GLYATL2, GSS, GSTA1, GSTP1 and 1 more

prostaglandin J2-S-(S)-glutathioneReach from here →

tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
prostaglandin J2 + glutathione = prostaglandin J2-S-(S)-glutathione

Catalysed by GLYATL2, GSS, GSTP1, GSTM1

2,4-dinitrophenyl-S-glutathioneReach from here →

tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
bile acid-CoA: amino acid N-acyltransferase
solute carrier organic anion transporter (glycocholate)

Catalysed by GLYATL2, BAAT, SLCO1A2, SLCO1B3peroxisome, extracellular space, cytosolOne of 11 routes

N-(9Z-octadecenoyl)-L-phenylalanineReach from here →

tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
transport of glycine and phenylalanine (cytosol to extracellular)
L-phenylalanine + (9Z)-octadecenoate = N-(9Z-octadecenoyl)-L-phenylalanine + H2O

Catalysed by GLYATL2, SLC7A5, PM20D1extracellular space, cytosol

N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-phenylalanineReach from here →

tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
transport of glycine and phenylalanine (cytosol to extracellular)
(5Z,8Z,11Z,14Z)-eicosatetraenoate + L-phenylalanine = N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-phenylalanine + H2O

Catalysed by GLYATL2, SLC7A5, PM20D1extracellular space, cytosol

N-(9Z-octadecenoyl)-L-leucineReach from here →

tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
transport of glycine and leucine (cytosol to extracellular)
N-(9Z-octadecenoyl)-L-leucine + H2O = L-leucine + (9Z)-octadecenoate

Catalysed by GLYATL2, SLC7A5, PM20D1extracellular space, cytosol

(13R)-S-glutathionyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoateReach from here →

tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
(13S,14S)-epoxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + glutathione = (13R)-S-glutathionyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate

Catalysed by GLYATL2, GSS, GSTM4, LTC4S

2-hydroxydodecanoyl-CoAReach from here →

tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
Fatty Acid Beta Oxidation (C14->C12), Mitochondrial
dodecanoyl-CoA + 2-oxoglutarate + O2 = 2-hydroxydodecanoyl-CoA + succinate + CO2

Catalysed by GLYATL2, HADHA, ACADVL, HADHB and 1 moremitochondrial matrix

S-methyl glutathioneReach from here →

tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
apo-[alkylcobalamin reductase] + methylcob(III)alamin + glutathione = S-methyl glutathione + cob(I)alamin-[alkylcobalamin reductase] + H(+)

Catalysed by GLYATL2, GSS, MMACHC

N-octanoyl-(2S)-hydroxyglycineReach from here →

N-tetradecanoylglycine + 2 L-ascorbate + O2 = N-tetradecanoyl-(2S)-hydroxyglycine + 2 monodehydro-L-ascorbate radical + H2O
N-tetradecanoylglycine + 2 L-ascorbate + O2 = N-tetradecanoyl-(2S)-hydroxyglycine + 2 monodehydro-L-ascorbate radical + H2O
N-octanoylglycine + 2 L-ascorbate + O2 = N-octanoyl-(2S)-hydroxyglycine + 2 monodehydro-L-ascorbate radical + H2O