(2E,8Z,11Z,14Z)-eicosatetraenoyl-CoA

Three steps

• (7Z)-tetradecenoyl-CoAReach from here →
  1. very-long-chain enoyl-CoA reductase
  2. Dihomo-gamma-linolenoyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase ((7Z)-tetradecenoic acid)

  Catalysed by TECRL, TECR, ACOT7, BAAT and 11 morecytosolOne of 9 routes

• (4Z,7Z,10Z,13Z)-hexadecatetraenoyl-CoAReach from here →
  1. very-long-chain enoyl-CoA reductase
  2. Dihomo-gamma-linolenoyl-CoA hydrolase
  3. Fatty Acid Beta Oxidation (C18:4->C16:4), Mitochondrial

  Catalysed by TECRL, TECR, ACOT7, BAAT and 6 morecytosol, mitochondrial matrixOne of 3 routes

• (2E,5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoAReach from here →
  1. very-long-chain enoyl-CoA reductase
  2. (8Z,11Z,14Z)-eicosatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + O2 = (2E,5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O2

  Catalysed by TECRL, TECR, FADS1, ACOX1cytosol

• (2E,6Z,9Z,12Z)-octadecatetraenoyl-CoAReach from here →
  1. very-long-chain enoyl-CoA reductase
  2. Beta Oxidation of Fatty Acid
  3. (6Z,9Z,12Z)-octadecatrienoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E,6Z,9Z,12Z)-octadecatetraenoyl-CoA + reduced [electron-transfer flavoprotein]

  Catalysed by TECRL, TECR, ACADM, ACADS and 3 morecytosol, mitochondrial matrixOne of 2 routes

• (7Z,10Z)-hexadecadienoyl-CoAReach from here →
  1. very-long-chain enoyl-CoA reductase
  2. Dihomo-gamma-linolenoyl-CoA hydrolase
  3. Fatty Acid Beta Oxidation Trans (C18:2->C16:2), Mitochondrial

  Catalysed by TECRL, TECR, ACOT7, BAAT and 6 morecytosol, mitochondrial matrix

• (4Z,7Z)-decadienoyl-CoAReach from here →
  1. very-long-chain enoyl-CoA reductase
  2. Dihomo-gamma-linolenoyl-CoA hydrolase
  3. Fatty Acid Beta Oxidation (C12:3->C10:2), Mitochondrial

  Catalysed by TECRL, TECR, ACOT7, BAAT and 6 morecytosol, mitochondrial matrixOne of 2 routes

• (5Z)-octenoyl-CoAReach from here →
  1. very-long-chain enoyl-CoA reductase
  2. Dihomo-gamma-linolenoyl-CoA hydrolase
  3. Fatty Acid Beta Oxidation (C10:2->C8:1), Mitochondrial

  Catalysed by TECRL, TECR, ACOT7, BAAT and 6 morecytosol, mitochondrial matrixOne of 2 routes

• CHEBI:27540Reach from here →
  1. very-long-chain enoyl-CoA reductase
  2. Dihomo-gamma-linolenoyl-CoA hydrolase
  3. medium-chain acyl-CoA ligase (hexanoic acid)

  Catalysed by TECRL, TECR, ACOT7, BAAT and 9 morecytosolOne of 6 routes

• elaidic acidReach from here →
  1. very-long-chain enoyl-CoA reductase
  2. Dihomo-gamma-linolenoyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (elaidate)

  Catalysed by TECRL, TECR, ACOT7, BAAT and 11 morecytosolOne of 6 routes

• CHEBI:28701Reach from here →
  1. very-long-chain enoyl-CoA reductase
  2. Dihomo-gamma-linolenoyl-CoA hydrolase
  3. Propanoyl-CoA:acetyl-CoA C-acyltransferase

  Catalysed by TECRL, TECR, ACOT7, BAAT and 6 morecytosol, peroxisomeOne of 7 routes

• an N-acylsphinganineReach from here →
  1. very-long-chain enoyl-CoA reductase
  2. acyl-CoA pool formation and breakdown
  3. sphingosine N-acyltransferase (sphinganine)

  Catalysed by TECRL, TECR, CERS1, CERS6 and 4 morecytosol

• (5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. very-long-chain enoyl-CoA reductase
  2. fatty acyl-CoA desaturase (N-C20:3CoA -> N-C20:4CoA)
  3. Arachidonyl-CoA hydrolase

  Catalysed by TECRL, TECR, FADS1, ACOT7 and 4 morecytosolOne of 3 routes

• fatty acidReach from here →
  1. very-long-chain enoyl-CoA reductase
  2. Dihomo-gamma-linolenoyl-CoA hydrolase
  3. (10Z)-heptadecenoic acid formation

  Catalysed by TECRL, TECR, ACOT7, BAAT and 3 morecytosolOne of 4 routes

• a 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholineReach from here →
  1. very-long-chain enoyl-CoA reductase
  2. acyl-CoA pool formation and breakdown
  3. Acyl-CoA:1-alkyl-sn-glycero-3-phosphocholine O-acyltransferase

  Catalysed by TECRL, TECR, LPCAT4, LPCAT3 and 2 morecytosol

• a 1,3-diacylglycerolReach from here →
  1. very-long-chain enoyl-CoA reductase
  2. acyl-CoA pool formation and breakdown
  3. a 1-acylglycerol + an acyl-CoA = a 1,3-diacylglycerol + CoA

  Catalysed by TECRL, TECR, MOGAT2, MOGAT1cytosol

• a 1,2-diacylglycerolReach from here →
  1. very-long-chain enoyl-CoA reductase
  2. acyl-CoA pool formation and breakdown
  3. a 2-acylglycerol + an acyl-CoA = a 1,2-diacylglycerol + CoA

  Catalysed by TECRL, TECR, MOGAT2, MOGAT3 and 3 morecytosolOne of 2 routes

• taurineReach from here →
  1. very-long-chain enoyl-CoA reductase
  2. Dihomo-gamma-linolenoyl-CoA hydrolase
  3. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)

  Catalysed by TECRL, TECR, ACOT7, BAAT and 3 morecytosolOne of 2 routes

• 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholineReach from here →
  1. very-long-chain enoyl-CoA reductase
  2. (8Z,11Z,14Z)-eicosatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
  3. 1-O-hexadecyl-sn-glycero-3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA = 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA

  Catalysed by TECRL, TECR, FADS1, LPCAT4cytosol

• a 1,2-diacyl-sn-glycero-3-phospho-L-serineReach from here →
  1. very-long-chain enoyl-CoA reductase
  2. acyl-CoA pool formation and breakdown
  3. a 1-acyl-sn-glycero-3-phospho-L-serine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phospho-L-serine + CoA

  Catalysed by TECRL, TECR, LPCAT4, LPCAT3 and 1 morecytosol

• glycineReach from here →
  1. very-long-chain enoyl-CoA reductase
  2. Dihomo-gamma-linolenoyl-CoA hydrolase
  3. glycine N-acyltransferase (N-arachidonoylglycine)

  Catalysed by TECRL, TECR, ACOT7, BAAT and 6 morecytosol, mitochondrial matrixOne of 10 routes

• (R)-methylmalonyl-CoAReach from here →
  1. very-long-chain enoyl-CoA reductase
  2. Dihomo-gamma-linolenoyl-CoA hydrolase
  3. aldehyde dehydrogenase (2-methyl-3-oxopropanoate)

  Catalysed by TECRL, TECR, ACOT7, BAAT and 4 morecytosol, mitochondrial matrixOne of 2 routes

• (S)-methylmalonyl-CoAReach from here →
  1. very-long-chain enoyl-CoA reductase
  2. Dihomo-gamma-linolenoyl-CoA hydrolase
  3. (S)-methylmalonyl-CoA hydrolase

  Catalysed by TECRL, TECR, ACOT7, BAAT and 3 morecytosol, mitochondrial matrix

• 3'-dephospho-CoAReach from here →
  1. very-long-chain enoyl-CoA reductase
  2. Dihomo-gamma-linolenoyl-CoA hydrolase
  3. acid phosphatase 2, lysosomal (CoA)

  Catalysed by TECRL, TECR, ACOT7, BAAT and 4 morecytosol, lysosomeOne of 2 routes

• (2E)-dodecenoyl-CoAReach from here →
  1. very-long-chain enoyl-CoA reductase
  2. Dihomo-gamma-linolenoyl-CoA hydrolase
  3. (2E)-dodecenoyl-CoA formation

  Catalysed by TECRL, TECR, ACOT7, BAAT and 3 morecytosol, mitochondrial matrixOne of 3 routes

• 4,8,12-trimethyltridecanoyl-CoAReach from here →
  1. very-long-chain enoyl-CoA reductase
  2. Dihomo-gamma-linolenoyl-CoA hydrolase
  3. propanoyl-CoA C-acyltransferase (3-ketopristanoyl-CoA)

  Catalysed by TECRL, TECR, ACOT7, BAAT and 5 morecytosol, peroxisomeOne of 2 routes

• butanoyl-CoAReach from here →
  1. very-long-chain enoyl-CoA reductase
  2. Dihomo-gamma-linolenoyl-CoA hydrolase
  3. Butanoate:CoA ligase (AMP-forming)

  Catalysed by TECRL, TECR, ACOT7, BAAT and 9 morecytosolOne of 9 routes

• dodecanoyl-CoAReach from here →
  1. very-long-chain enoyl-CoA reductase
  2. Dihomo-gamma-linolenoyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (lauric acid)

  Catalysed by TECRL, TECR, ACOT7, BAAT and 11 morecytosolOne of 10 routes

• glutaryl-CoAReach from here →
  1. very-long-chain enoyl-CoA reductase
  2. Dihomo-gamma-linolenoyl-CoA hydrolase
  3. Production of Glutaryl Carnitine

  Catalysed by TECRL, TECR, ACOT7, BAAT and 6 morecytosolOne of 2 routes

• eicosanoyl-CoAReach from here →
  1. very-long-chain enoyl-CoA reductase
  2. Dihomo-gamma-linolenoyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (eicosanoate)

  Catalysed by TECRL, TECR, ACOT7, BAAT and 11 morecytosolOne of 13 routes

• itaconyl-CoAReach from here →
  1. very-long-chain enoyl-CoA reductase
  2. Dihomo-gamma-linolenoyl-CoA hydrolase
  3. Itaconate:CoA ligase (GDP-forming)

  Catalysed by TECRL, TECR, ACOT7, BAAT and 6 morecytosol, mitochondrial matrixOne of 2 routes

• (9Z,12Z)-octadecadienoyl-CoAReach from here →
  1. very-long-chain enoyl-CoA reductase
  2. Dihomo-gamma-linolenoyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)

  Catalysed by TECRL, TECR, ACOT7, BAAT and 11 morecytosolOne of 14 routes

• tetradecanoyl-CoAReach from here →
  1. very-long-chain enoyl-CoA reductase
  2. Dihomo-gamma-linolenoyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (myristic acid)

  Catalysed by TECRL, TECR, ACOT7, BAAT and 11 morecytosolOne of 12 routes

• octanoyl-CoAReach from here →
  1. very-long-chain enoyl-CoA reductase
  2. Dihomo-gamma-linolenoyl-CoA hydrolase
  3. Octanoyl-CoA:L-carnitine O-octanoyltransferase

  Catalysed by TECRL, TECR, ACOT7, BAAT and 4 morecytosol, mitochondrial matrixOne of 22 routes

• phytanoyl-CoAReach from here →
  1. very-long-chain enoyl-CoA reductase
  2. Dihomo-gamma-linolenoyl-CoA hydrolase
  3. phytanate-CoA ligase

  Catalysed by TECRL, TECR, ACOT7, BAAT and 3 morecytosolOne of 5 routes

• octadecanoyl-CoAReach from here →
  1. very-long-chain enoyl-CoA reductase
  2. Dihomo-gamma-linolenoyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (stearate)

  Catalysed by TECRL, TECR, ACOT7, BAAT and 10 morecytosolOne of 16 routes

• a 1-acylglycerone 3-phosphateReach from here →
  1. very-long-chain enoyl-CoA reductase
  2. acyl-CoA pool formation and breakdown
  3. dihydroxyacetone phosphate + an acyl-CoA = a 1-acylglycerone 3-phosphate + CoA

  Catalysed by TECRL, TECR, GNPATcytosol

• a 1,2-diacyl-sn-glycero-3-phosphocholineReach from here →
  1. very-long-chain enoyl-CoA reductase
  2. acyl-CoA pool formation and breakdown
  3. a 2-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA

  Catalysed by TECRL, TECR, LPGAT1cytosolOne of 2 routes

• an N-acylglycineReach from here →
  1. very-long-chain enoyl-CoA reductase
  2. acyl-CoA pool formation and breakdown
  3. an acyl-CoA + glycine = an N-acylglycine + CoA + H(+)

  Catalysed by TECRL, TECR, GLYATL3, GLYAT and 1 morecytosol

• sphing-4-enineReach from here →
  1. very-long-chain enoyl-CoA reductase
  2. Dihomo-gamma-linolenoyl-CoA hydrolase
  3. acyl-CoA:sphingosine N-acyltransferase

  Catalysed by TECRL, TECR, ACOT7, BAAT and 7 morecytosol, Golgi apparatusOne of 2 routes

• spermidineReach from here →
  1. very-long-chain enoyl-CoA reductase
  2. Dihomo-gamma-linolenoyl-CoA hydrolase
  3. diamine N-acetyltransferase (N1-acetylspermidine)

  Catalysed by TECRL, TECR, ACOT7, BAAT and 5 morecytosolOne of 3 routes

• L-methionineReach from here →
  1. very-long-chain enoyl-CoA reductase
  2. Dihomo-gamma-linolenoyl-CoA hydrolase
  3. N-acetylglutamate synthase (N-acetylmethionine)

  Catalysed by TECRL, TECR, ACOT7, BAAT and 4 morecytosol, mitochondrial matrix

• a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)Reach from here →
  1. very-long-chain enoyl-CoA reductase
  2. acyl-CoA pool formation and breakdown
  3. a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA

  Catalysed by TECRL, TECR, LCLAT1, MBOAT7cytosol

• a 1-acyl-sn-glycero-3-phosphateReach from here →
  1. very-long-chain enoyl-CoA reductase
  2. acyl-CoA pool formation and breakdown
  3. sn-glycerol 3-phosphate + an acyl-CoA = a 1-acyl-sn-glycero-3-phosphate + CoA

  Catalysed by TECRL, TECR, GPAT3, GPAT2 and 2 morecytosol

• L-alanineReach from here →
  1. very-long-chain enoyl-CoA reductase
  2. Dihomo-gamma-linolenoyl-CoA hydrolase
  3. amino-acid N-acetyltransferase (N-acetyl-L-alanine)

  Catalysed by TECRL, TECR, ACOT7, BAAT and 3 morecytosol, mitochondrial matrix

• L-asparagineReach from here →
  1. very-long-chain enoyl-CoA reductase
  2. Dihomo-gamma-linolenoyl-CoA hydrolase
  3. N-acetylglutamate synthase (N-acetyl-L-asparagine)

  Catalysed by TECRL, TECR, ACOT7, BAAT and 4 morecytosol, mitochondrial matrix

• L,L-cystathionineReach from here →
  1. very-long-chain enoyl-CoA reductase
  2. Dihomo-gamma-linolenoyl-CoA hydrolase
  3. N-acetylglutamate synthase (N-acetyl-L-cystathionine)

  Catalysed by TECRL, TECR, ACOT7, BAAT and 4 morecytosol, mitochondrial matrix

• (3Z)-dodecenoyl-CoAReach from here →
  1. very-long-chain enoyl-CoA reductase
  2. Dihomo-gamma-linolenoyl-CoA hydrolase
  3. acetyl-CoA C-acyltransferase (3-oxomyrist-5-enoyl-CoA)

  Catalysed by TECRL, TECR, ACOT7, BAAT and 6 morecytosol, mitochondrial matrixOne of 3 routes

• a 1,2-diacyl-sn-glycero-3-phosphateReach from here →
  1. very-long-chain enoyl-CoA reductase
  2. acyl-CoA pool formation and breakdown
  3. a 1-acyl-sn-glycero-3-phosphate + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphate + CoA

  Catalysed by TECRL, TECR, AGPAT2, GPAT3 and 11 morecytosol

• (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoAReach from here →
  1. very-long-chain enoyl-CoA reductase
  2. Dihomo-gamma-linolenoyl-CoA hydrolase
  3. 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate:CoA ligase (AMP-forming)

  Catalysed by TECRL, TECR, ACOT7, BAAT and 5 morecytosol, endoplasmic reticulumOne of 3 routes

• deoxycholoyl-CoAReach from here →
  1. very-long-chain enoyl-CoA reductase
  2. Dihomo-gamma-linolenoyl-CoA hydrolase
  3. cholate-CoA ligase (3alpha,12alpha-dihydroxy-5beta-cholanate)

  Catalysed by TECRL, TECR, ACOT7, BAAT and 5 morecytosolOne of 4 routes