sn-glycero-3-phospho-1D-myo-inositol

Three steps

• glycineReach from here →
  1. 1-(sn-glycero-3-phospho)-1D-myo-inositol glycerophosphohydrolase
  2. glycerol-3-phosphate 1-O-acyltransferase (lauroyl-CoA)
  3. glycine N-acyltransferase (N-arachidonoylglycine)

  Catalysed by GDE1, GPAT3, GPAT2, GPAT4 and 4 morecytosol, mitochondrial matrixOne of 10 routes

• (R)-methylmalonyl-CoAReach from here →
  1. 1-(sn-glycero-3-phospho)-1D-myo-inositol glycerophosphohydrolase
  2. glycerol-3-phosphate 1-O-acyltransferase (lauroyl-CoA)
  3. aldehyde dehydrogenase (2-methyl-3-oxopropanoate)

  Catalysed by GDE1, GPAT3, GPAT2, GPAT4 and 2 morecytosol, mitochondrial matrixOne of 2 routes

• (S)-methylmalonyl-CoAReach from here →
  1. 1-(sn-glycero-3-phospho)-1D-myo-inositol glycerophosphohydrolase
  2. glycerol-3-phosphate 1-O-acyltransferase (lauroyl-CoA)
  3. (S)-methylmalonyl-CoA hydrolase

  Catalysed by GDE1, GPAT3, GPAT2, GPAT4 and 1 morecytosol, mitochondrial matrix

• 3'-dephospho-CoAReach from here →
  1. 1-(sn-glycero-3-phospho)-1D-myo-inositol glycerophosphohydrolase
  2. glycerol-3-phosphate 1-O-acyltransferase (lauroyl-CoA)
  3. acid phosphatase 2, lysosomal (CoA)

  Catalysed by GDE1, GPAT3, GPAT2, GPAT4 and 2 morecytosol, lysosomeOne of 2 routes

• (2E)-dodecenoyl-CoAReach from here →
  1. 1-(sn-glycero-3-phospho)-1D-myo-inositol glycerophosphohydrolase
  2. glycerol-3-phosphate 1-O-acyltransferase (lauroyl-CoA)
  3. (2E)-dodecenoyl-CoA formation

  Catalysed by GDE1, GPAT3, GPAT2, GPAT4 and 1 morecytosol, mitochondrial matrixOne of 3 routes

• 4,8,12-trimethyltridecanoyl-CoAReach from here →
  1. 1-(sn-glycero-3-phospho)-1D-myo-inositol glycerophosphohydrolase
  2. glycerol-3-phosphate 1-O-acyltransferase (lauroyl-CoA)
  3. propanoyl-CoA C-acyltransferase (3-ketopristanoyl-CoA)

  Catalysed by GDE1, GPAT3, GPAT2, GPAT4 and 3 morecytosol, peroxisomeOne of 2 routes

• (6Z,9Z,12Z)-octadecatrienoyl-CoAReach from here →
  1. 1-(sn-glycero-3-phospho)-1D-myo-inositol glycerophosphohydrolase
  2. glycerol-3-phosphate 1-O-acyltransferase (lauroyl-CoA)
  3. long-chain-fatty-acid-CoA ligase (gamma-linolenate)

  Catalysed by GDE1, GPAT3, GPAT2, GPAT4 and 9 morecytosolOne of 7 routes

• butanoyl-CoAReach from here →
  1. 1-(sn-glycero-3-phospho)-1D-myo-inositol glycerophosphohydrolase
  2. glycerol-3-phosphate 1-O-acyltransferase (lauroyl-CoA)
  3. Butanoate:CoA ligase (AMP-forming)

  Catalysed by GDE1, GPAT3, GPAT2, GPAT4 and 7 morecytosolOne of 9 routes

• dodecanoyl-CoAReach from here →
  1. 1-(sn-glycero-3-phospho)-1D-myo-inositol glycerophosphohydrolase
  2. glycerol-3-phosphate 1-O-acyltransferase (lauroyl-CoA)
  3. long-chain-fatty-acid-CoA ligase (lauric acid)

  Catalysed by GDE1, GPAT3, GPAT2, GPAT4 and 9 morecytosolOne of 9 routes

• glutaryl-CoAReach from here →
  1. 1-(sn-glycero-3-phospho)-1D-myo-inositol glycerophosphohydrolase
  2. glycerol-3-phosphate 1-O-acyltransferase (lauroyl-CoA)
  3. Production of Glutaryl Carnitine

  Catalysed by GDE1, GPAT3, GPAT2, GPAT4 and 4 morecytosolOne of 2 routes

• eicosanoyl-CoAReach from here →
  1. 1-(sn-glycero-3-phospho)-1D-myo-inositol glycerophosphohydrolase
  2. glycerol-3-phosphate 1-O-acyltransferase (lauroyl-CoA)
  3. long-chain-fatty-acid-CoA ligase (eicosanoate)

  Catalysed by GDE1, GPAT3, GPAT2, GPAT4 and 9 morecytosolOne of 12 routes

• itaconyl-CoAReach from here →
  1. 1-(sn-glycero-3-phospho)-1D-myo-inositol glycerophosphohydrolase
  2. glycerol-3-phosphate 1-O-acyltransferase (lauroyl-CoA)
  3. Itaconate:CoA ligase (GDP-forming)

  Catalysed by GDE1, GPAT3, GPAT2, GPAT4 and 4 morecytosol, mitochondrial matrixOne of 2 routes

• (9Z,12Z)-octadecadienoyl-CoAReach from here →
  1. 1-(sn-glycero-3-phospho)-1D-myo-inositol glycerophosphohydrolase
  2. glycerol-3-phosphate 1-O-acyltransferase (lauroyl-CoA)
  3. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)

  Catalysed by GDE1, GPAT3, GPAT2, GPAT4 and 9 morecytosolOne of 13 routes

• tetradecanoyl-CoAReach from here →
  1. 1-(sn-glycero-3-phospho)-1D-myo-inositol glycerophosphohydrolase
  2. glycerol-3-phosphate 1-O-acyltransferase (lauroyl-CoA)
  3. long-chain-fatty-acid-CoA ligase (myristic acid)

  Catalysed by GDE1, GPAT3, GPAT2, GPAT4 and 9 morecytosolOne of 11 routes

• octanoyl-CoAReach from here →
  1. 1-(sn-glycero-3-phospho)-1D-myo-inositol glycerophosphohydrolase
  2. glycerol-3-phosphate 1-O-acyltransferase (lauroyl-CoA)
  3. Octanoyl-CoA:L-carnitine O-octanoyltransferase

  Catalysed by GDE1, GPAT3, GPAT2, GPAT4 and 2 morecytosol, mitochondrial matrixOne of 20 routes

• (9Z)-octadecenoyl-CoAReach from here →
  1. 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = sn-glycero-3-phospho-1D-myo-inositol + (9Z)-octadecenoate + H(+)
  2. 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = sn-glycero-3-phospho-1D-myo-inositol + (9Z)-octadecenoate + H(+)
  3. (9Z)-octadecenoate + ATP + CoA = (9Z)-octadecenoyl-CoA + AMP + diphosphate

  Catalysed by ABHD12, SLC27A2, ACSL3, ACSL1 and 5 more

• phytanoyl-CoAReach from here →
  1. 1-(sn-glycero-3-phospho)-1D-myo-inositol glycerophosphohydrolase
  2. glycerol-3-phosphate 1-O-acyltransferase (lauroyl-CoA)
  3. phytanate-CoA ligase

  Catalysed by GDE1, GPAT3, GPAT2, GPAT4 and 1 morecytosolOne of 5 routes

• octadecanoyl-CoAReach from here →
  1. 1-(sn-glycero-3-phospho)-1D-myo-inositol glycerophosphohydrolase
  2. glycerol-3-phosphate 1-O-acyltransferase (lauroyl-CoA)
  3. long-chain-fatty-acid-CoA ligase (stearate)

  Catalysed by GDE1, GPAT3, GPAT2, GPAT4 and 8 morecytosolOne of 15 routes

• a 1-acylglycerone 3-phosphateReach from here →
  1. sn-glycero-3-phospho-1D-myo-inositol + H2O = myo-inositol + sn-glycerol 3-phosphate + H(+)
  2. sn-glycerol 3-phosphate + NAD(+) = dihydroxyacetone phosphate + NADH + H(+)
  3. dihydroxyacetone phosphate + an acyl-CoA = a 1-acylglycerone 3-phosphate + CoA

  Catalysed by GDE1, GPD1, GPD1L, GNPAT

• sphing-4-enineReach from here →
  1. 1-(sn-glycero-3-phospho)-1D-myo-inositol glycerophosphohydrolase
  2. glycerol-3-phosphate 1-O-acyltransferase (lauroyl-CoA)
  3. acyl-CoA:sphingosine N-acyltransferase

  Catalysed by GDE1, GPAT3, GPAT2, GPAT4 and 5 morecytosol, Golgi apparatusOne of 2 routes

• a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate)Reach from here →
  1. 1-(sn-glycero-3-phospho)-1D-myo-inositol glycerophosphohydrolase
  2. CDP-diacylglycerol:myo-inositol 3-phosphatidyltransferase
  3. 1-phosphatidylinositol-4-phosphate 5-kinase (PI pool)

  Catalysed by GDE1, CDIPT, PIP5K1B, PIP5K1C and 2 morecytosolOne of 5 routes

• spermidineReach from here →
  1. 1-(sn-glycero-3-phospho)-1D-myo-inositol glycerophosphohydrolase
  2. glycerol-3-phosphate 1-O-acyltransferase (lauroyl-CoA)
  3. diamine N-acetyltransferase (N1-acetylspermidine)

  Catalysed by GDE1, GPAT3, GPAT2, GPAT4 and 3 morecytosolOne of 3 routes

• L-methionineReach from here →
  1. 1-(sn-glycero-3-phospho)-1D-myo-inositol glycerophosphohydrolase
  2. glycerol-3-phosphate 1-O-acyltransferase (lauroyl-CoA)
  3. N-acetylglutamate synthase (N-acetylmethionine)

  Catalysed by GDE1, GPAT3, GPAT2, GPAT4 and 2 morecytosol, mitochondrial matrix

• 6-phospho-D-glucono-1,5-lactoneReach from here →
  1. sn-Glycero-3-phospho-1-inositol inositolphosphohydrolase
  2. inositol-3-phosphate synthase (inositol-1-phosphate)
  3. D-glucose-6-phosphate:NADP+ 1-oxidoreductase

  Catalysed by ANXA3, GDPD2, ISYNA1, G6PDcytosol, endoplasmic reticulumOne of 3 routes

• L-alanineReach from here →
  1. 1-(sn-glycero-3-phospho)-1D-myo-inositol glycerophosphohydrolase
  2. glycerol-3-phosphate 1-O-acyltransferase (lauroyl-CoA)
  3. amino-acid N-acetyltransferase (N-acetyl-L-alanine)

  Catalysed by GDE1, GPAT3, GPAT2, GPAT4 and 1 morecytosol, mitochondrial matrix

• L-asparagineReach from here →
  1. 1-(sn-glycero-3-phospho)-1D-myo-inositol glycerophosphohydrolase
  2. glycerol-3-phosphate 1-O-acyltransferase (lauroyl-CoA)
  3. N-acetylglutamate synthase (N-acetyl-L-asparagine)

  Catalysed by GDE1, GPAT3, GPAT2, GPAT4 and 2 morecytosol, mitochondrial matrix

• a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate)Reach from here →
  1. 1-(sn-glycero-3-phospho)-1D-myo-inositol glycerophosphohydrolase
  2. CDP-diacylglycerol:myo-inositol 3-phosphatidyltransferase
  3. ATP:1-phosphatidyl-1D-myo-inositol 3-phosphotransferase

  Catalysed by GDE1, CDIPT, PIK3C3cytosolOne of 4 routes

• L,L-cystathionineReach from here →
  1. 1-(sn-glycero-3-phospho)-1D-myo-inositol glycerophosphohydrolase
  2. glycerol-3-phosphate 1-O-acyltransferase (lauroyl-CoA)
  3. N-acetylglutamate synthase (N-acetyl-L-cystathionine)

  Catalysed by GDE1, GPAT3, GPAT2, GPAT4 and 2 morecytosol, mitochondrial matrix

• a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)Reach from here →
  1. 1-(sn-glycero-3-phospho)-1D-myo-inositol glycerophosphohydrolase
  2. CDP-diacylglycerol:myo-inositol 3-phosphatidyltransferase
  3. ATP:1-Phosphatidyl-1D-myo-inositol 4-phosphotransferase

  Catalysed by GDE1, CDIPT, PI4KA, PI4K2B and 2 morecytosolOne of 3 routes

• 1-hexadecanoylglycerone 3-phosphateReach from here →
  1. 1-(sn-glycero-3-phospho)-1D-myo-inositol glycerophosphohydrolase
  2. sn-Glycerol-3-phosphate:(acceptor) 2-oxidoreductase
  3. glyceronephosphate O-acyltransferase (DHAP)

  Catalysed by GDE1, GPD2, GNPATcytosol, mitochondrial matrix, peroxisomeOne of 3 routes

• a CDP-1,2-diacyl-sn-glycerolReach from here →
  1. 1-(sn-glycero-3-phospho)-1D-myo-inositol glycerophosphohydrolase
  2. a CDP-1,2-diacyl-sn-glycerol + myo-inositol = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + CMP + H(+)
  3. a CDP-1,2-diacyl-sn-glycerol + myo-inositol = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + CMP + H(+)

  Catalysed by GDE1, CDIPTcytosolOne of 2 routes

• an acyl-CoAReach from here →
  1. 1-(sn-glycero-3-phospho)-1D-myo-inositol glycerophosphohydrolase
  2. glycerol-3-phosphate 1-O-acyltransferase (lauroyl-CoA)
  3. acyl-CoA:sphingosine N-acyltransferase

  Catalysed by GDE1, GPAT3, GPAT2, GPAT4 and 5 morecytosol, Golgi apparatusOne of 2 routes

• trans-4-hydroxy-L-prolineReach from here →
  1. sn-glycero-3-phospho-1D-myo-inositol + H2O = myo-inositol + sn-glycerol 3-phosphate + H(+)
  2. a quinone + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + a quinol
  3. trans-4-hydroxy-L-proline + a quinone = (3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate + a quinol + H(+)

  Catalysed by GDE1, GPD2, PRODH2

• 1D-myo-inositol 3-phosphateReach from here →
  1. sn-Glycero-3-phospho-1-inositol inositolphosphohydrolase
  2. inositol-3-phosphate synthase (inositol-1-phosphate)
  3. 1D-myo-inositol-3-phosphate lyase (isomerizing)

  Catalysed by ANXA3, GDPD2, ISYNA1cytosol

• (3Z)-dodecenoyl-CoAReach from here →
  1. 1-(sn-glycero-3-phospho)-1D-myo-inositol glycerophosphohydrolase
  2. glycerol-3-phosphate 1-O-acyltransferase (lauroyl-CoA)
  3. acetyl-CoA C-acyltransferase (3-oxomyrist-5-enoyl-CoA)

  Catalysed by GDE1, GPAT3, GPAT2, GPAT4 and 4 morecytosol, mitochondrial matrixOne of 3 routes

• a 1,2-diacyl-sn-glycero-3-phosphateReach from here →
  1. 1-(sn-glycero-3-phospho)-1D-myo-inositol glycerophosphohydrolase
  2. a CDP-1,2-diacyl-sn-glycerol + myo-inositol = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + CMP + H(+)
  3. a 1,2-diacyl-sn-glycero-3-phosphate(out) + a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)(in) = a 1,2-diacyl-sn-glycero-3-phosphate(in) + a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)(out)

  Catalysed by GDE1, CDIPT, PITPNM1cytosol, inner side of the membrane, outer side of the membraneOne of 4 routes

• (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoAReach from here →
  1. 1-(sn-glycero-3-phospho)-1D-myo-inositol glycerophosphohydrolase
  2. glycerol-3-phosphate 1-O-acyltransferase (lauroyl-CoA)
  3. 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate:CoA ligase (AMP-forming)

  Catalysed by GDE1, GPAT3, GPAT2, GPAT4 and 3 morecytosol, endoplasmic reticulumOne of 3 routes

• deoxycholoyl-CoAReach from here →
  1. 1-(sn-glycero-3-phospho)-1D-myo-inositol glycerophosphohydrolase
  2. glycerol-3-phosphate 1-O-acyltransferase (lauroyl-CoA)
  3. cholate-CoA ligase (3alpha,12alpha-dihydroxy-5beta-cholanate)

  Catalysed by GDE1, GPAT3, GPAT2, GPAT4 and 3 morecytosolOne of 4 routes

• D-glyceraldehyde 3-phosphateReach from here →
  1. sn-glycero-3-phospho-1D-myo-inositol + H2O = 1D-myo-inositol 1-phosphate + glycerol + H(+)
  2. glycerol + NADP(+) = D-glyceraldehyde + NADPH + H(+)
  3. D-glyceraldehyde + ATP = D-glyceraldehyde 3-phosphate + ADP + H(+)

  Catalysed by GDPD2, AKR1A1, AKR1B1, TKFCOne of 2 routes

• L-prolineReach from here →
  1. sn-glycero-3-phospho-1D-myo-inositol + H2O = myo-inositol + sn-glycerol 3-phosphate + H(+)
  2. a quinone + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + a quinol
  3. L-proline + a quinone = (S)-1-pyrroline-5-carboxylate + a quinol + H(+)

  Catalysed by GDE1, GPD2, PRODH, PRODH2

• decanoyl-CoAReach from here →
  1. 1-(sn-glycero-3-phospho)-1D-myo-inositol glycerophosphohydrolase
  2. glycerol-3-phosphate 1-O-acyltransferase (lauroyl-CoA)
  3. medium-chain acyl-CoA ligase (decanoic acid)

  Catalysed by GDE1, GPAT3, GPAT2, GPAT4 and 7 morecytosolOne of 7 routes

• (2E)-hexadecenoyl-CoAReach from here →
  1. 1-(sn-glycero-3-phospho)-1D-myo-inositol glycerophosphohydrolase
  2. glycerol-3-phosphate 1-O-acyltransferase (lauroyl-CoA)
  3. Carnitine O-Palmitoyltransferase

  Catalysed by GDE1, GPAT3, GPAT2, GPAT4 and 4 morecytosolOne of 4 routes

• (9Z)-hexadecenoyl-CoAReach from here →
  1. 1-(sn-glycero-3-phospho)-1D-myo-inositol glycerophosphohydrolase
  2. glycerol-3-phosphate 1-O-acyltransferase (lauroyl-CoA)
  3. long-chain-fatty-acid-CoA ligase (palmitolate)

  Catalysed by GDE1, GPAT3, GPAT2, GPAT4 and 9 morecytosolOne of 11 routes

• 3-hydroxyisovaleryl-CoAReach from here →
  1. 1-(sn-glycero-3-phospho)-1D-myo-inositol glycerophosphohydrolase
  2. glycerol-3-phosphate 1-O-acyltransferase (lauroyl-CoA)
  3. (3-Hydroxyisovalerylcoa->3-Hydroxyisovalerylcarnitine)

  Catalysed by GDE1, GPAT3, GPAT2, GPAT4 and 3 morecytosol

• CHEBI:63544Reach from here →
  1. 1-(sn-glycero-3-phospho)-1D-myo-inositol glycerophosphohydrolase
  2. glycerol-3-phosphate 1-O-acyltransferase (lauroyl-CoA)
  3. long-chain-fatty-acid-CoA ligase (adrenic acid)

  Catalysed by GDE1, GPAT3, GPAT2, GPAT4 and 9 morecytosolOne of 7 routes

• a 1-acyl-sn-glycerolReach from here →
  1. sn-glycero-3-phospho-1D-myo-inositol + H2O = myo-inositol + sn-glycerol 3-phosphate + H(+)
  2. sn-glycerol 3-phosphate + an acyl-CoA = a 1-acyl-sn-glycero-3-phosphate + CoA
  3. a 1-acyl-sn-glycero-3-phosphate + H2O = a 1-acyl-sn-glycerol + phosphate

  Catalysed by GDE1, GPAT3, GPAT2, GPAT4 and 3 more

• a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)Reach from here →
  1. sn-glycero-3-phospho-1D-myo-inositol + H2O = myo-inositol + sn-glycerol 3-phosphate + H(+)
  2. a CDP-1,2-diacyl-sn-glycerol + sn-glycerol 3-phosphate = a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + CMP + H(+)
  3. a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + phosphate

  Catalysed by GDE1, PGS1, PTPMT1

• 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphateReach from here →
  1. 1-(sn-glycero-3-phospho)-1D-myo-inositol glycerophosphohydrolase
  2. glycerol-3-phosphate 1-O-acyltransferase (palmitoyl-CoA)
  3. 1-hexadecanoyl-sn-glycero-3-phosphate + (9Z)-octadecenoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA

  Catalysed by GDE1, GPAT3, GPAT2, GPAT4 and 9 morecytosolOne of 2 routes

• 1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol)Reach from here →
  1. sn-glycero-3-phospho-1D-myo-inositol + H2O = myo-inositol + sn-glycerol 3-phosphate + H(+)
  2. sn-glycerol 3-phosphate + an acyl-CoA = a 1-acyl-sn-glycero-3-phosphate + CoA
  3. a 1-acyl-sn-glycero-3-phosphate + a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) = 1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a 1,2-diacyl-sn-glycero-3-phosphate

  Catalysed by GDE1, GPAT3, GPAT2, GPAT4 and 2 more

• 1-acyl-2-hexadecanoyl-sn-glycero-3-phosphateReach from here →
  1. sn-glycero-3-phospho-1D-myo-inositol + H2O = myo-inositol + sn-glycerol 3-phosphate + H(+)
  2. sn-glycerol 3-phosphate + an acyl-CoA = a 1-acyl-sn-glycero-3-phosphate + CoA
  3. a 1-acyl-sn-glycero-3-phosphate + hexadecanoyl-CoA = 1-acyl-2-hexadecanoyl-sn-glycero-3-phosphate + CoA

  Catalysed by GDE1, GPAT3, GPAT2, GPAT4 and 2 more