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Proteins/UNIPROT:O14986
Catalyzes the phosphorylation of phosphatidylinositol 4-phosphate (PtdIns(4)P/PI4P) to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2/PIP2), a lipid second messenger that regulates several cellular processes such as signal transduction, vesicle trafficking, actin cytoskeleton dynamics, cell adhesion, and cell motility (By similarity). PtdIns(4,5)P2 can directly act as a second messenger or can be utilized as a precursor to generate other second messengers: inositol 1,4,5-trisphosphate (IP3), diacylglycerol (DAG) or phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3/PIP3) (By similarity). Mediates RAC1-dependent reorganization of actin filaments. Contributes to the activation of phospholipase PLD2. Together with PIP5K1A, is required, after stimulation by G protein-coupled receptors, for the synthesis of IP3 that will induce stable platelet adhesion (By similarity)..
Function from UniProtKB (O14986), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
47 statements
47 statements · 6 reference databases · Subject: PIP5K1B · Sources: gene ontology, Hetionet, Human-GEM, Reactome, Rhea, WikiPathways
20 reactions
ATP+MAM02735gADP+proton+MAM02734g
Catalysed by PIP5K1B or PIP5K1A or PIP5K1C
Reaction pageLeft to rightBalance undeterminableEC 2.7.1.68Golgi apparatus
Human-GEM MAR02997CC BY 4.0Reference data
a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate)+ATPADP+proton+MAM02735g
Catalysed by
8 names
Resolves to: PIP5K1B
Reaction pageLeft to rightBalance undeterminableEC 2.7.1.68Golgi apparatus
Human-GEM MAR03318CC BY 4.0Reference data
a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)+ATPADP+proton+MAM02736c
Catalysed by PIP5K1B or PIP5K1A or PIP5KL1 or PIP5K1C
Reaction pageLeft to rightBalance undeterminableEC 2.7.1.68cytosol
Human-GEM MAR06551CC BY 4.0Reference data
ATP+1-phosphatidyl-1D-myo-inositola 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate)+ADP+proton
Catalysed by PIP5K1B or PIP5K1A or PIP5KL1 or PIP5K1C
Reaction pageLeft to rightBalance undeterminableEC 2.7.1.68cytosol
Human-GEM MAR06579CC BY 4.0Reference data
ATP+1-phosphatidyl-1D-myo-inositola 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate)+ADP+proton
Catalysed by PIP5K1B or PIP5K1A or PIP5KL1 or PIP5K1C
Reaction pageLeft to rightBalance undeterminableEC 2.7.1.68Golgi apparatus
Human-GEM MAR06580CC BY 4.0Reference data
ATP+1-phosphatidyl-1D-myo-inositola 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate)+ADP+proton
Catalysed by PIP5K1B or PIP5K1A or PIP5KL1 or PIP5K1C
Reaction pageLeft to rightBalance undeterminableEC 2.7.1.68endoplasmic reticulum
Human-GEM MAR06581CC BY 4.0Reference data
MAM00551c+ATPADP+proton+MAM02734c
Catalysed by PIP5K1B or PIP5K1A or PIP5KL1 or PIP5K1C
Reaction pageLeft to rightBalance undeterminableEC 2.7.1.68cytosol
Human-GEM MAR06592CC BY 4.0Reference data
MAM00551n+ATPADP+proton+MAM02734n
Catalysed by PIP5K1B or PIP5K1A or PIP5KL1
Reaction pageLeft to rightBalance undeterminableEC 2.7.1.68nucleus
Human-GEM MAR08811CC BY 4.0Reference data
a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate)+ATPMAM00551c+ADP+proton
Catalysed by PIP5K1B or PIP5K1A or PIP5KL1 or PIP5K1C
Reaction pageLeft to rightBalance undeterminableEC 2.7.1.68cytosol
Human-GEM MAR08813CC BY 4.0Reference data
a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate)+ATPMAM00551n+ADP+proton
Catalysed by PIP5K1B or PIP5K1A or PIP5KL1 or PIP5K1C
Reaction pageLeft to rightBalance undeterminableEC 2.7.1.68nucleus
Human-GEM MAR08814CC BY 4.0Reference data
a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate)+ATPADP+proton+MAM02735c
Catalysed by PIP5K1B or PIP5K1A or PIP5KL1 or PIP5K1C
Reaction pageLeft to rightBalance undeterminableEC 2.7.1.68cytosol
Human-GEM MAR08815CC BY 4.0Reference data
a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)+ATPADP+proton+MAM02736n
Catalysed by PIP5K1B or PIP5K1A or PIP5KL1 or PIP5K1C
Reaction pageLeft to rightBalance undeterminableEC 2.7.1.68nucleus
Human-GEM MAR08821CC BY 4.0Reference data