an acyl-CoA

Two steps

• N-eicosanoylsphinganineReach from here →
  1. acyl-CoA pool formation and breakdown
  2. eicosanoyl-CoA + sphinganine = N-eicosanoylsphinganine + CoA + H(+)

  Catalysed by CERS1, CERS2, CERS4cytosol

• N-(octadecanoyl)-sphinganineReach from here →
  1. acyl-CoA pool formation and breakdown
  2. sphinganine + octadecanoyl-CoA = N-(octadecanoyl)-sphinganine + CoA + H(+)

  Catalysed by CERS1, CERS6, CERS3, CERS5 and 2 morecytosol

• N-hexadecanoylsphinganineReach from here →
  1. a 2-acylglycerol + an acyl-CoA = a 1,2-diacyl-sn-glycerol + CoA
  2. N-hexadecanoylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = N-hexadecanoyl-sphinganine-1-phosphocholine + a 1,2-diacyl-sn-glycerol

  Catalysed by MOGAT2, AWAT2, MOGAT1, SGMS1 and 1 more

• N-(tetradecanoyl)-sphinganineReach from here →
  1. acyl-CoA pool formation and breakdown
  2. sphinganine + tetradecanoyl-CoA = N-(tetradecanoyl)-sphinganine + CoA + H(+)

  Catalysed by CERS6, CERS5cytosol

• an N-acylsphinganine-1-phosphocholineReach from here →
  1. sphingosine N-acyltransferase (sphinganine)
  2. an N-acylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = an N-acylsphinganine-1-phosphocholine + a 1,2-diacyl-sn-glycerol

  Catalysed by CERS1, CERS6, CERS3, CERS5 and 4 morecytosolOne of 2 routes

• 3-oxohexadecasphinganineReach from here →
  1. acyl-CoA pool formation and breakdown
  2. tetradecanoyl-CoA + L-serine + H(+) = 3-oxohexadecasphinganine + CO2 + CoA

  Catalysed by SPTLC1, SPTLC3cytosol

• 3-oxotetradecasphinganineReach from here →
  1. acyl-CoA pool formation and breakdown
  2. dodecanoyl-CoA + L-serine + H(+) = 3-oxotetradecasphinganine + CO2 + CoA

  Catalysed by SPTLC1, SPTLC3cytosol

• 3-oxooctadecanoyl-CoAReach from here →
  1. acyl-CoA pool formation and breakdown
  2. very-long-chain 3-oxoacyl-CoA synthase (malonyl-CoA)

  Catalysed by ELOVL7, ELOVL1, ELOVL4, ELOVL6 and 3 morecytosolOne of 2 routes

• (2E)-octadecenoyl-CoAReach from here →
  1. acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase
  2. Carnitine O-Palmitoyltransferase

  Catalysed by GPAT3, GPAT2, GPAT4, GPAM and 3 moremitochondrial matrix, cytosolOne of 10 routes

• 3-oxodocosanoyl-CoAReach from here →
  1. acyl-CoA pool formation and breakdown
  2. very-long-chain 3-oxoacyl-CoA synthase (eicosanoyl-CoA)

  Catalysed by ELOVL7, ELOVL1, ELOVL4, ELOVL6 and 3 morecytosolOne of 3 routes

• 3-oxo-(8Z,11Z,14Z)-eicosatrienoyl-CoAReach from here →
  1. acyl-CoA pool formation and breakdown
  2. (6Z,9Z,12Z)-octadecatrienoyl-CoA + malonyl-CoA + H(+) = 3-oxo-(8Z,11Z,14Z)-eicosatrienoyl-CoA + CO2 + CoA

  Catalysed by ELOVL7, ELOVL5cytosol

• 3-oxo-(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoAReach from here →
  1. acyl-CoA pool formation and breakdown
  2. (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA + malonyl-CoA + H(+) = 3-oxo-(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + CO2 + CoA

  Catalysed by ELOVL5cytosol

• (8Z,11Z,14Z)-eicosatrienoateReach from here →
  1. acyl-CoA pool formation and breakdown
  2. Dihomo-gamma-linolenoyl-CoA hydrolase

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 1 morecytosol

• 1-dodecanoyl-sn-glycerol 3-phosphateReach from here →
  1. acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase
  2. 1-acylglycerol-3-phosphate pool formation and breakdown

  Catalysed by GPAT3, GPAT2, GPAT4, GPAMmitochondrial matrix, cytosolOne of 3 routes

• 1-tetradecanoyl-sn-glycerol 3-phosphateReach from here →
  1. acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase
  2. 1-acylglycerol-3-phosphate pool formation and breakdown

  Catalysed by GPAT3, GPAT2, GPAT4, GPAMmitochondrial matrix, cytosolOne of 2 routes

• 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol)Reach from here →
  1. acyl-CoA pool formation and breakdown
  2. 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + octadecanoyl-CoA = 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA

  Catalysed by LCLAT1cytosol

• 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-(1D-myo-inositol)Reach from here →
  1. acyl-CoA pool formation and breakdown
  2. 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + (9Z,12Z)-octadecadienoyl-CoA = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA

  Catalysed by LCLAT1cytosol

• 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)Reach from here →
  1. acyl-CoA pool formation and breakdown
  2. 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + octadecanoyl-CoA = 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA

  Catalysed by LCLAT1, LPGAT1cytosol

• 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-(1'-sn-glycerol)Reach from here →
  1. acyl-CoA pool formation and breakdown
  2. 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + (9Z,12Z)-octadecadienoyl-CoA = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA

  Catalysed by LCLAT1cytosol

• 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphateReach from here →
  1. acyl-CoA pool formation and breakdown
  2. 1-hexadecanoyl-sn-glycero-3-phosphate + octadecanoyl-CoA = 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphate + CoA

  Catalysed by AGPAT2cytosol

• 1-hexadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphateReach from here →
  1. acyl-CoA pool formation and breakdown
  2. 1-hexadecanoyl-sn-glycero-3-phosphate + tetradecanoyl-CoA = 1-hexadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphate + CoA

  Catalysed by AGPAT2cytosol

• N-octadecanoylsphing-4-enineReach from here →
  1. acyl-CoA pool formation and breakdown
  2. sphing-4-enine + octadecanoyl-CoA = N-octadecanoylsphing-4-enine + CoA + H(+)

  Catalysed by CERS1, TLCD3B, CERS2, CERS4cytosol

• N-eicosanoyl-sphing-4-enineReach from here →
  1. acyl-CoA pool formation and breakdown
  2. eicosanoyl-CoA + sphing-4-enine = N-eicosanoyl-sphing-4-enine + CoA + H(+)

  Catalysed by TLCD3B, CERS2cytosol

• N-tetracosanoyl-sphing-4-enineReach from here →
  1. acyl-CoA pool formation and breakdown
  2. tetracosanoyl-CoA + sphing-4-enine = N-tetracosanoyl-sphing-4-enine + CoA + H(+)

  Catalysed by CERS2cytosol

• 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholineReach from here →
  1. acyl-CoA pool formation and breakdown
  2. octadecanoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + CoA

  Catalysed by LPCAT3cytosol

• 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholineReach from here →
  1. acyl-CoA pool formation and breakdown
  2. (9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + CoA

  Catalysed by LPCAT3, MBOAT2, LPCAT1cytosol

• an N-acylsphing-4-enine 1-phosphoethanolamineReach from here →
  1. a 1-acyl-sn-glycero-3-phosphoethanolamine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CoA
  2. an N-acylsphing-4-enine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine = an N-acylsphing-4-enine 1-phosphoethanolamine + a 1,2-diacyl-sn-glycerol

  Catalysed by LPCAT4, LPCAT3, MBOAT1, MBOAT2 and 3 more

• a 1-O-alkylglycerone 3-phosphateReach from here →
  1. Acyl-CoA:glycerone-phosphate O-acyltransferase
  2. alkylglycerone phosphate synthase (acylglycerone-phosphate)

  Catalysed by GNPAT, AGPScytosol, peroxisomeOne of 2 routes

• (9Z,12Z)-octadecadien-1-olReach from here →
  1. acyl-CoA pool formation and breakdown
  2. (9Z,12Z)-octadecadienoyl-CoA + 2 NADPH + 2 H(+) = (9Z,12Z)-octadecadien-1-ol + 2 NADP(+) + CoA

  Catalysed by FAR1cytosol

• 3-oxo-(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoAReach from here →
  1. acyl-CoA pool formation and breakdown
  2. (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + malonyl-CoA + H(+) = 3-oxo-(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + CO2 + CoA

  Catalysed by ELOVL2, ELOVL5cytosol

• (9Z,12Z,15Z,18Z,21Z)-3-oxotetracosapentaenoyl-CoAReach from here →
  1. acyl-CoA pool formation and breakdown
  2. (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + malonyl-CoA + H(+) = (9Z,12Z,15Z,18Z,21Z)-3-oxotetracosapentaenoyl-CoA + CO2 + CoA

  Catalysed by ELOVL2cytosol

• 3-oxooctacosanyol-CoAReach from here →
  1. acyl-CoA pool formation and breakdown
  2. hexacosanoyl-CoA + malonyl-CoA + H(+) = 3-oxooctacosanyol-CoA + CO2 + CoA

  Catalysed by ELOVL1, ELOVL4cytosol

• 3-oxotetracosanoyl-CoAReach from here →
  1. acyl-CoA pool formation and breakdown
  2. very-long-chain 3-oxoacyl-CoA synthase (docosanoyl-CoA)

  Catalysed by ELOVL7, ELOVL1, ELOVL4, ELOVL6 and 3 morecytosolOne of 3 routes

• 3-oxohexacosanoyl-CoAReach from here →
  1. acyl-CoA pool formation and breakdown
  2. very-long-chain 3-oxoacyl-CoA synthase ((15Z)-tetracosenoyl-CoA)

  Catalysed by ELOVL7, ELOVL1, ELOVL4, ELOVL6 and 3 morecytosolOne of 3 routes

• 1-hexadecanoyl-2-[(9Z)-hexadec-9-enoyl]-sn-glycero-3-phosphateReach from here →
  1. acyl-CoA pool formation and breakdown
  2. 1-hexadecanoyl-sn-glycero-3-phosphate + (9Z)-hexadecenoyl-CoA = 1-hexadecanoyl-2-[(9Z)-hexadec-9-enoyl]-sn-glycero-3-phosphate + CoA

  Catalysed by MBOAT2cytosol

• 1-hexadecanoyl-2-(9Z)-hexadecenoyl-sn-glycero-3-phosphoethanolamineReach from here →
  1. acyl-CoA pool formation and breakdown
  2. 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + (9Z)-hexadecenoyl-CoA = 1-hexadecanoyl-2-(9Z)-hexadecenoyl-sn-glycero-3-phosphoethanolamine + CoA

  Catalysed by MBOAT2cytosol

• 1-hexadecanoyl-2-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholineReach from here →
  1. acyl-CoA pool formation and breakdown
  2. (9Z)-hexadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine + CoA

  Catalysed by LPCAT3, MBOAT2cytosol

• (11Z,14Z)-3-oxoicosa-11,14-dienoyl-CoAReach from here →
  1. acyl-CoA pool formation and breakdown
  2. (9Z,12Z)-octadecadienoyl-CoA + malonyl-CoA + H(+) = (11Z,14Z)-3-oxoicosa-11,14-dienoyl-CoA + CO2 + CoA

  Catalysed by ELOVL7, ELOVL6, ELOVL3, ELOVL5cytosol

• (11Z,14Z,17Z)-3-oxoeicosatrienoyl-CoAReach from here →
  1. acyl-CoA pool formation and breakdown
  2. (9Z,12Z,15Z)-octadecatrienoyl-CoA + malonyl-CoA + H(+) = (11Z,14Z,17Z)-3-oxoeicosatrienoyl-CoA + CO2 + CoA

  Catalysed by ELOVL7, ELOVL6, ELOVL3, ELOVL5cytosol

• 3-oxo-(13Z)-docosenoyl-CoAReach from here →
  1. acyl-CoA pool formation and breakdown
  2. (11Z)-eicosenoyl-CoA + malonyl-CoA + H(+) = 3-oxo-(13Z)-docosenoyl-CoA + CO2 + CoA

  Catalysed by ELOVL1cytosol

• 3-oxo-(15Z)-tetracosenoyl-CoAReach from here →
  1. acyl-CoA pool formation and breakdown
  2. (13Z)-docosenoyl-CoA + malonyl-CoA + H(+) = 3-oxo-(15Z)-tetracosenoyl-CoA + CO2 + CoA

  Catalysed by ELOVL1cytosol

• 2-hydroxyoctadecanoyl-CoAReach from here →
  1. acyl-CoA pool formation and breakdown
  2. octadecanoyl-CoA + 2-oxoglutarate + O2 = 2-hydroxyoctadecanoyl-CoA + succinate + CO2

  Catalysed by PHYHcytosol

• N-(15Z-tetracosenoyl)-sphinganineReach from here →
  1. acyl-CoA pool formation and breakdown
  2. (15Z)-tetracosenoyl-CoA + sphinganine = N-(15Z-tetracosenoyl)-sphinganine + CoA + H(+)

  Catalysed by CERS2cytosol

• N-tetracosanoyl-heptadecasphing-4-enineReach from here →
  1. acyl-CoA pool formation and breakdown
  2. heptadecasphing-4-enine + tetracosanoyl-CoA = N-tetracosanoyl-heptadecasphing-4-enine + CoA + H(+)

  Catalysed by CERS2cytosol

• (2E)-hexacosenoyl-CoAReach from here →
  1. acyl-CoA pool formation and breakdown
  2. acyl-CoA oxidase (hexacosanoyl-CoA)

  Catalysed by ACOX3, ACOX1cytosol, peroxisomeOne of 2 routes

• 3-oxo-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoAReach from here →
  1. acyl-CoA pool formation and breakdown
  2. (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + malonyl-CoA + H(+) = 3-oxo-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + CO2 + CoA

  Catalysed by ELOVL4cytosol

• 3-oxo-(8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoAReach from here →
  1. acyl-CoA pool formation and breakdown
  2. (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + malonyl-CoA + H(+) = 3-oxo-(8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + CO2 + CoA

  Catalysed by ELOVL4cytosol

• 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphateReach from here →
  1. acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase
  2. 1-acylglycerol-3-phosphate pool formation and breakdown

  Catalysed by GPAT3, GPAT2, GPAT4, GPAMmitochondrial matrix, cytosolOne of 3 routes

• 1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycero-3-phosphateReach from here →
  1. acyl-CoA pool formation and breakdown
  2. 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + octadecanoyl-CoA = 1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycero-3-phosphate + CoA

  Catalysed by GPAT3, LCLAT1, ABHD5, AGPAT1 and 2 morecytosol

• 1-(9Z)-octadecenoyl-2-heptadecanoyl-sn-glycero-3-phosphateReach from here →
  1. acyl-CoA pool formation and breakdown
  2. heptadecanoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate = 1-(9Z)-octadecenoyl-2-heptadecanoyl-sn-glycero-3-phosphate + CoA

  Catalysed by AGPAT2, LPCAT2, AGPAT1, AGPAT3 and 1 morecytosol