Compound
3-oxo-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA
A 3-oxo-fatty acyl-CoA(4−) arising from deprotonation of the phosphate and diphosphate functions of (6Z,9Z,12Z,15Z,18Z,21Z)-3-oxotetracosahexaenoyl-CoA.
Definition from ChEBI (CHEBI:74304), read 2026-09-23. CC BY 4.0.
Structure
No three-dimensional record for this entry.
- Class
- Organic compound, anion
- Formula
- C45H64N7O18P3S
- Mass
- 1116.027 g/mol
- Charge
- -4
- InChIKey
- DNHDPAXPQGYGIJ-KWFBMMABSA-J
- SMILES
- CC/C=CC/C=CC/C=CC/C=CC/C=CC/C=CCCC(=O)CC(=O)SCCNC(=O)CCNC(=O)[C@H](O)C(C)(C)COP(=O)([O-])OP(=O)([O-])OC[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1OP(=O)([O-])[O-]
- Look it up
- ChEBIBy InChIKey
Identity from ChEBI. Not evidence.
What it touches on the way
Mechanistic reach
2 entities
2 entities reached.
0 reported hops2 assembled from the scaffold
What the reference databases state
Statements
6 statements
6 statements · 2 reference databases · Subject: 3-oxo-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA · Sources: Human-GEM, Rhea
- (3R)-hydroxy-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA is converted to 3-oxo-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoACompoundRhea RHEA:79191Inferred only
- 3-oxo-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA is converted to (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoACompoundRhea RHEA:39131Inferred only
- (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA is converted to 3-oxo-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoACompoundRhea RHEA:36943Inferred only
- 3-oxo-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA is a substrate of ACAA1ProteinHuman-GEM MAR02513Inferred only
- 3-oxo-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA is a substrate of ACAA1ProteinRhea RHEA:39131Inferred only
- 3-oxo-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA is a substrate of MYO5BProteinHuman-GEM MAR02513Inferred only
Reactions
6 reactions
MAM00801x+NAD(+)3-oxo-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA+proton+NADH(2-)
Catalysed by ACAA1 & HSD17B4 & EHHADH
Reaction pageLeft to rightBalancedEC 1.1.1.35, 1.1.1.211peroxisome
Human-GEM MAR02512CC BY 4.0Reference data
3-oxo-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA+CHEBI:1146900(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA+CHEBI:15351
Reaction pageLeft to rightBalancedEC 2.3.1.16peroxisome
Human-GEM MAR02513CC BY 4.0Reference data
(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA+malonyl-CoA+hydron3-oxo-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA+carbon dioxide+coenzyme A(4-)
Catalysed by ELOVL4
Reaction pageLeft to rightBalanced
Rhea RHEA:36943CC BY 4.0Reference data
CHEBI:76356+NAD(1-)3-oxo-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA+NADH(2-)+hydron
Reaction pageDirection not assertedBalanced
Rhea RHEA:39127CC BY 4.0Reference data
3-oxo-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA+coenzyme A(4-)(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA+acetyl-CoA
Catalysed by ACAA1
Reaction pageLeft to rightBalanced
Rhea RHEA:39131CC BY 4.0Reference data
(3R)-hydroxy-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA+NAD(1-)3-oxo-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA+NADH(2-)+hydron
Catalysed by HSD17B4
Reaction pageLeft to rightBalanced
Rhea RHEA:79191CC BY 4.0Reference data
Other names
15 names
Resolves to: 3-oxo-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA
- Also called
- (6Z,9Z,12Z,15Z,18Z,21Z)-3-ketotetracosahexaenoyl-CoA(4-)(6Z,9Z,12Z,15Z,18Z,21Z)-3-ketotetracosahexaenoyl-CoA(4−)(6Z,9Z,12Z,15Z,18Z,21Z)-3-ketotetracosahexaenoyl-coenzyme A(4-)(6Z,9Z,12Z,15Z,18Z,21Z)-3-ketotetracosahexaenoyl-coenzyme A(4−)(6Z,9Z,12Z,15Z,18Z,21Z)-3-oxotetracosahexaenoyl-coenzyme A(4-)(6Z,9Z,12Z,15Z,18Z,21Z)-3-oxotetracosahexaenoyl-coenzyme A(4−)3-keto-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexanoyl-CoA(4-)3-keto-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexanoyl-CoA(4−)3-oxo-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexanoyl-CoA(4-)3-oxo-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexanoyl-CoA(4−)3-oxo-all-cis-(omega-3)-tetracosahexanoyl-CoA(4-)3-oxo-all-cis-(ω-3)-tetracosahexanoyl-CoA(4−)3-oxo-C24:6(omega-3)-CoA(4-)3-oxo-C24:6(ω-3)-CoA(4−)
- Systematic name
- 3'-phosphonatoadenosine 5'-{3-[(3R)-3-hydroxy-2,2-dimethyl-4-({3-[(2-{[(6Z,9Z,12Z,15Z,18Z,21Z)-3-oxotetracosacosa-6,9,12,15,18,21-hexaenoyl]sulfanyl}ethyl)amino]-3-oxopropyl}amino)-4-oxobutyl] diphosphate}