Compound
3-oxohexacosanoyl-CoA
A 3-oxo-fatty acyl-CoA(4−) arising from deprotonation of the phosphate and diphosphate functions of 3-oxohexacosanoyl-CoA.
Definition from ChEBI (CHEBI:73980), read 2026-09-23. CC BY 4.0.
Structure
No three-dimensional record for this entry.
- Class
- Organic compound, anion
- Formula
- C47H80N7O18P3S
- Mass
- 1156.177 g/mol
- Charge
- -4
- InChIKey
- VOMUIFOBQMYJPJ-CPIGOPAHSA-J
- SMILES
- CCCCCCCCCCCCCCCCCCCCCCCC(=O)CC(=O)SCCNC(=O)CCNC(=O)[C@H](O)C(C)(C)COP(=O)([O-])OP(=O)([O-])OC[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1OP(=O)([O-])[O-]
- Look it up
- ChEBIBy InChIKey
Identity from ChEBI. Not evidence.
What it touches on the way
Mechanistic reach
3 entities
3 entities reached.
What the reference databases state
Statements
9 statements
9 statements · 2 reference databases · Subject: 3-oxohexacosanoyl-CoA · Sources: Human-GEM, Rhea
- 3-oxohexacosanoyl-CoA is converted to tetracosanoyl-CoACompoundRhea RHEA:78639Inferred only
- tetracosanoyl-CoA is converted to 3-oxohexacosanoyl-CoACompoundRhea RHEA:36515Inferred only
- tetracosanoyl-CoA is converted to 3-oxohexacosanoyl-CoACompoundRhea RHEA:78639Inferred only
- 3-oxohexacosanoyl-CoA is a substrate of ACAA1ProteinHuman-GEM MAR03329Inferred only
- 3-oxohexacosanoyl-CoA is a substrate of ACAA1ProteinHuman-GEM MAR03060Inferred only
- 3-oxohexacosanoyl-CoA is a substrate of HSD17B12ProteinHuman-GEM MAR02217Inferred only
- 3-oxohexacosanoyl-CoA is a substrate of HSD17B12ProteinHuman-GEM MAR02334Inferred only
- 3-oxohexacosanoyl-CoA is a substrate of MYO5BProteinHuman-GEM MAR03060Inferred only
- 3-oxohexacosanoyl-CoA is a substrate of MYO5BProteinHuman-GEM MAR03329Inferred only
Reactions
12 reactions
proton+malonyl-CoA+tetracosanoyl-CoA3-oxohexacosanoyl-CoA+carbon dioxide+CHEBI:1146900
Catalysed by ELOVL5 or ELOVL1 or ELOVL4 or ELOVL3 or ELOVL7 or ELOVL6 or ELOVL2
Reaction pageLeft to rightBalancedEC 2.3.1.199cytosol
Human-GEM MAR02215CC BY 4.0Reference data
3-oxohexacosanoyl-CoA+proton+NADPH(4-)MAM00783c+NADP(3-)
Catalysed by HSD17B12
Reaction pageLeft to rightBalancedEC 1.1.1.330cytosol
Human-GEM MAR02217CC BY 4.0Reference data
(15Z)-tetracosenoyl-CoA+proton+malonyl-CoA3-oxohexacosanoyl-CoA+carbon dioxide+CHEBI:1146900
Catalysed by ELOVL5 or ELOVL1 or ELOVL4 or ELOVL3 or ELOVL7 or ELOVL6 or ELOVL2
Reaction pageLeft to rightBalancedEC 2.3.1.199cytosol
Human-GEM MAR02332CC BY 4.0Reference data
3-oxohexacosanoyl-CoA+proton+NADPH(4-)MAM00715c+NADP(3-)
Catalysed by HSD17B12
Reaction pageLeft to rightBalancedEC 1.1.1.330cytosol
Human-GEM MAR02334CC BY 4.0Reference data
MAM00783x+NAD(+)3-oxohexacosanoyl-CoA+proton+NADH(2-)
Catalysed by ACAA1 & HSD17B4 & EHHADH
Reaction pageLeft to rightBalancedEC 1.1.1.35, 1.1.1.211peroxisome
Human-GEM MAR03059CC BY 4.0Reference data
3-oxohexacosanoyl-CoA+CHEBI:1146900CHEBI:15351+tetracosanoyl-CoA
Reaction pageLeft to rightBalancedEC 2.3.1.16peroxisome
Human-GEM MAR03060CC BY 4.0Reference data
MAM00715x+NAD(+)3-oxohexacosanoyl-CoA+proton+NADH(2-)
Catalysed by ACAA1 & HSD17B4 & EHHADH
Reaction pageLeft to rightBalancedEC 1.1.1.35, 1.1.1.211peroxisome
Human-GEM MAR03328CC BY 4.0Reference data
3-oxohexacosanoyl-CoA+CHEBI:1146900(15Z)-tetracosenoyl-CoA+CHEBI:15351
Reaction pageLeft to rightBalancedEC 2.3.1.16peroxisome
Human-GEM MAR03329CC BY 4.0Reference data
tetracosanoyl-CoA+malonyl-CoA+hydron3-oxohexacosanoyl-CoA+carbon dioxide+coenzyme A(4-)
Reaction pageLeft to rightBalanced
Rhea RHEA:36515CC BY 4.0Reference data
3-oxohexacosanoyl-CoA+NADPH(4-)+hydronCHEBI:76378+NADP(3-)
Reaction pageDirection not assertedBalanced
Rhea RHEA:39207CC BY 4.0Reference data
3-oxohexacosanoyl-CoA+NADH(2-)+hydronCHEBI:76378+NAD(1-)
Catalysed by HSD17B4
Reaction pageRight to leftBalanced
Rhea RHEA:78635CC BY 4.0Reference data
tetracosanoyl-CoA+acetyl-CoA3-oxohexacosanoyl-CoA+coenzyme A(4-)
Reaction pageDirection not assertedBalanced
Rhea RHEA:78639CC BY 4.0Reference data
Other names
11 names
Resolves to: 3-oxohexacosanoyl-CoA
- Also called
- 3-ketocerotoyl-CoA(4-)3-ketocerotoyl-CoA(4−)3-ketohexacosanoyl-CoA(4-)3-ketohexacosanoyl-CoA(4−)3-ketohexacosanoyl-coenzyme A(4-)3-ketohexacosanoyl-coenzyme A(4−)3-oxocerotoyl-CoA(4-)3-oxocerotoyl-CoA(4−)3-oxohexacosanoyl-coenzyme A(4-)3-oxohexacosanoyl-coenzyme A(4−)
- Systematic name
- 3'-phosphonatoadenosine 5'-{3-[(3R)-3-hydroxy-2,2-dimethyl-4-oxo-4-{[3-({2-[(3-oxohexacosanoyl)sulfanyl]ethyl}amino)-3-oxopropyl]amino}butyl] diphosphate}