succinyl-CoA

Three steps

• 1,2-diacyl-sn-glycero-3-phosphocholine(1+)Reach from here →
  1. a 3-oxo acid + succinyl-CoA = a 3-oxoacyl-CoA + succinate
  2. an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA
  3. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase

  Catalysed by OXCT1, OXCT2, ACAA1, SCP2 and 6 morecytosol

• 11-cis-retinolReach from here →
  1. itaconate + succinyl-CoA = itaconyl-CoA + succinate
  2. Itaconate:CoA ligase (GDP-forming)
  3. Palmitoyl-CoA:retinol O-acyltransferase

  Catalysed by SUGCT, SUCLG1, SUCLG2, SUCLA2 and 5 moremitochondrial matrix, cytosol

• phosphatidic acidReach from here →
  1. a 3-oxo acid + succinyl-CoA = a 3-oxoacyl-CoA + succinate
  2. an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA
  3. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase

  Catalysed by OXCT1, OXCT2, ACAA1, SCP2 and 11 moremitochondrial matrixOne of 7 routes

• (R)-carnitineReach from here →
  1. glutarate + succinyl-CoA = glutaryl-CoA + succinate
  2. glutaryl-CoA + H2O = glutarate + CoA + H(+)
  3. glutarate(in) + (R)-carnitine(out) = glutarate(out) + (R)-carnitine(in)

  Catalysed by SUGCT, ACOT8, ACOT4, SLC22A8inner side of the membrane, outer side of the membraneOne of 2 routes

• oxaloacetateReach from here →
  1. itaconate + succinyl-CoA = itaconyl-CoA + succinate
  2. Itaconate:CoA ligase (GDP-forming)
  3. ATP citrate lyase (citrate)

  Catalysed by SUGCT, SUCLG1, SUCLG2, SUCLA2 and 1 moremitochondrial matrix, cytosol

• 1-acyl-sn-glycerol 3-phosphateReach from here →
  1. a 3-oxo acid + succinyl-CoA = a 3-oxoacyl-CoA + succinate
  2. an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA
  3. acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase

  Catalysed by OXCT1, OXCT2, ACAA1, SCP2 and 6 moremitochondrial matrix

• a cholesterol esterReach from here →
  1. a 3-oxo acid + succinyl-CoA = a 3-oxoacyl-CoA + succinate
  2. an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA
  3. an acyl-CoA + cholesterol = a cholesterol ester + CoA

  Catalysed by OXCT1, OXCT2, ACAA1, SCP2 and 4 more

• (R)-3-hydroxybutyric acidReach from here →
  1. 3-hydroxy-3-methylglutarate + succinyl-CoA = (3S)-3-hydroxy-3-methylglutaryl-CoA + succinate
  2. (3S)-3-hydroxy-3-methylglutaryl-CoA = acetoacetate + acetyl-CoA
  3. (R)-3-Hydroxybutanoate:NAD+ oxidoreductase

  Catalysed by SUGCT, HMGCL, HMGCLL1, BDH1 and 1 moremitochondrial matrixOne of 4 routes

• anilineReach from here →
  1. itaconate + succinyl-CoA = itaconyl-CoA + succinate
  2. Itaconate:CoA ligase (GDP-forming)
  3. Acetyl-CoA:arylamine N-acetyltransferase

  Catalysed by SUGCT, SUCLG1, SUCLG2, SUCLA2 and 2 moremitochondrial matrix, cytosol

• CHEBI:17312Reach from here →
  1. itaconate + succinyl-CoA = itaconyl-CoA + succinate
  2. Itaconate:CoA ligase (GDP-forming)
  3. N1,N12-diacetylspermine to N1-acetylspermine conversion

  Catalysed by SUGCT, SUCLG1, SUCLG2, SUCLA2mitochondrial matrix, cytosolOne of 2 routes

• 1-(alk-1-enyl)-2-acyl-sn-glycero-3-phosphoethanolamineReach from here →
  1. a 3-oxo acid + succinyl-CoA = a 3-oxoacyl-CoA + succinate
  2. an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA
  3. Acyl-CoA:1-alkenylglycerophosphoethanolamine O-acyltransferase

  Catalysed by OXCT1, OXCT2, ACAA1, SCP2 and 6 morecytosol

• L-cysteineReach from here →
  1. itaconate + succinyl-CoA = itaconyl-CoA + succinate
  2. Itaconate:CoA ligase (GDP-forming)
  3. N-acetylglutamate synthase (N-acetyl-L-cysteine)

  Catalysed by SUGCT, SUCLG1, SUCLG2, SUCLA2 and 1 moremitochondrial matrix

• (7Z,10Z,13Z)-hexadecatrienoyl-CoAReach from here →
  1. itaconate + succinyl-CoA = itaconyl-CoA + succinate
  2. Itaconate:CoA ligase (GDP-forming)
  3. Fatty Acid Beta Oxidation (C18:3->C16:3), Mitochondrial

  Catalysed by SUGCT, SUCLG1, SUCLG2, SUCLA2 and 3 moremitochondrial matrix

• urateReach from here →
  1. glutarate + succinyl-CoA = glutaryl-CoA + succinate
  2. glutaryl-CoA + H2O = glutarate + CoA + H(+)
  3. urate(in) + glutarate(out) = urate(out) + glutarate(in)

  Catalysed by SUGCT, ACOT8, ACOT4, SLC22A8inner side of the membrane, outer side of the membraneOne of 2 routes

• a 1,2-diacyl-sn-glycerolReach from here →
  1. a 3-oxo acid + succinyl-CoA = a 3-oxoacyl-CoA + succinate
  2. an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA
  3. a 2-acylglycerol + an acyl-CoA = a 1,2-diacyl-sn-glycerol + CoA

  Catalysed by OXCT1, OXCT2, ACAA1, SCP2 and 5 more

• a triacylglycerolReach from here →
  1. a 3-oxo acid + succinyl-CoA = a 3-oxoacyl-CoA + succinate
  2. an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA
  3. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase

  Catalysed by OXCT1, OXCT2, ACAA1, SCP2 and 7 morecytosol

• CHEBI:17927Reach from here →
  1. itaconate + succinyl-CoA = itaconyl-CoA + succinate
  2. Itaconate:CoA ligase (GDP-forming)
  3. N1,N8-diacetylspermidine to N1-acetylspermidine conversion

  Catalysed by SUGCT, SUCLG1, SUCLG2, SUCLA2mitochondrial matrix, cytosol

• 4-fumarylacetoacetateReach from here →
  1. 3-hydroxy-3-methylglutarate + succinyl-CoA = (3S)-3-hydroxy-3-methylglutaryl-CoA + succinate
  2. (3S)-3-hydroxy-3-methylglutaryl-CoA = acetoacetate + acetyl-CoA
  3. 4-fumarylacetoacetate + H2O = acetoacetate + fumarate + H(+)

  Catalysed by SUGCT, HMGCL, HMGCLL1, FAH

• 5alpha-androstane-3alpha,17beta-diol 3-O-(beta-D-glucuronate)Reach from here →
  1. glutarate + succinyl-CoA = glutaryl-CoA + succinate
  2. glutaryl-CoA + H2O = glutarate + CoA + H(+)
  3. 5alpha-androstane-3alpha,17beta-diol 3-O-(beta-D-glucuronate)(out) + glutarate(in) = 5alpha-androstane-3alpha,17beta-diol 3-O-(beta-D-glucuronate)(in) + glutarate(out)

  Catalysed by SUGCT, ACOT8, ACOT4, SLC22A24inner side of the membrane, outer side of the membraneOne of 2 routes

• (5Z)-dodecenoyl-CoAReach from here →
  1. itaconate + succinyl-CoA = itaconyl-CoA + succinate
  2. Itaconate:CoA ligase (GDP-forming)
  3. acetyl-CoA C-acyltransferase (3-oxomyrist-7-enoyl-CoA)

  Catalysed by SUGCT, SUCLG1, SUCLG2, SUCLA2 and 3 moremitochondrial matrixOne of 2 routes

• (11Z)-docosenoyl-CoA(4-)Reach from here →
  1. a 3-oxo acid + succinyl-CoA = a 3-oxoacyl-CoA + succinate
  2. an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA
  3. acyl-CoA pool formation and breakdown

  Catalysed by OXCT1, OXCT2, ACAA1, SCP2 and 2 morecytosolOne of 6 routes

• (7Z)-tetradecenoyl-CoAReach from here →
  1. a 3-oxo acid + succinyl-CoA = a 3-oxoacyl-CoA + succinate
  2. an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA
  3. acyl-CoA pool formation and breakdown

  Catalysed by OXCT1, OXCT2, ACAA1, SCP2 and 2 morecytosolOne of 9 routes

• (4Z,7Z,10Z,13Z)-hexadecatetraenoyl-CoAReach from here →
  1. itaconate + succinyl-CoA = itaconyl-CoA + succinate
  2. Itaconate:CoA ligase (GDP-forming)
  3. Fatty Acid Beta Oxidation (C18:4->C16:4), Mitochondrial

  Catalysed by SUGCT, SUCLG1, SUCLG2, SUCLA2 and 3 moremitochondrial matrixOne of 3 routes

• (7Z,10Z)-hexadecadienoyl-CoAReach from here →
  1. itaconate + succinyl-CoA = itaconyl-CoA + succinate
  2. Itaconate:CoA ligase (GDP-forming)
  3. Fatty Acid Beta Oxidation Trans (C18:2->C16:2), Mitochondrial

  Catalysed by SUGCT, SUCLG1, SUCLG2, SUCLA2 and 3 moremitochondrial matrix

• (4Z,7Z)-decadienoyl-CoAReach from here →
  1. itaconate + succinyl-CoA = itaconyl-CoA + succinate
  2. Itaconate:CoA ligase (GDP-forming)
  3. Fatty Acid Beta Oxidation (C12:3->C10:2), Mitochondrial

  Catalysed by SUGCT, SUCLG1, SUCLG2, SUCLA2 and 3 moremitochondrial matrixOne of 2 routes

• (5Z)-octenoyl-CoAReach from here →
  1. itaconate + succinyl-CoA = itaconyl-CoA + succinate
  2. Itaconate:CoA ligase (GDP-forming)
  3. Fatty Acid Beta Oxidation (C10:2->C8:1), Mitochondrial

  Catalysed by SUGCT, SUCLG1, SUCLG2, SUCLA2 and 3 moremitochondrial matrixOne of 2 routes

• CHEBI:27540Reach from here →
  1. itaconate + succinyl-CoA = itaconyl-CoA + succinate
  2. Itaconate:CoA ligase (GDP-forming)
  3. medium-chain acyl-CoA ligase (hexanoic acid)

  Catalysed by SUGCT, SUCLG1, SUCLG2, SUCLA2 and 6 moremitochondrial matrix, cytosolOne of 6 routes

• elaidic acidReach from here →
  1. a 3-oxo acid + succinyl-CoA = a 3-oxoacyl-CoA + succinate
  2. an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA
  3. acyl-CoA pool formation and breakdown

  Catalysed by OXCT1, OXCT2, ACAA1, SCP2 and 2 morecytosolOne of 6 routes

• CHEBI:28701Reach from here →
  1. itaconate + succinyl-CoA = itaconyl-CoA + succinate
  2. Itaconate:CoA ligase (GDP-forming)
  3. Propanoyl-CoA:acetyl-CoA C-acyltransferase

  Catalysed by SUGCT, SUCLG1, SUCLG2, SUCLA2 and 3 moremitochondrial matrix, peroxisomeOne of 7 routes

• glycocholateReach from here →
  1. glutarate + succinyl-CoA = glutaryl-CoA + succinate
  2. glutaryl-CoA + H2O = glutarate + CoA + H(+)
  3. glycocholate(out) + glutarate(in) = glycocholate(in) + glutarate(out)

  Catalysed by SUGCT, ACOT8, ACOT4, SLC22A24inner side of the membrane, outer side of the membraneOne of 2 routes

• acetateReach from here →
  1. 3-hydroxy-3-methylglutarate + succinyl-CoA = (3S)-3-hydroxy-3-methylglutaryl-CoA + succinate
  2. (3S)-3-hydroxy-3-methylglutaryl-CoA = acetoacetate + acetyl-CoA
  3. transport of acetate and acetoacetate (cytosol to extracellular)

  Catalysed by SUGCT, HMGCL, HMGCLL1, SLC16A4 and 4 moreextracellular space, cytosolOne of 2 routes

• formic acidReach from here →
  1. 3-hydroxy-3-methylglutarate + succinyl-CoA = (3S)-3-hydroxy-3-methylglutaryl-CoA + succinate
  2. (3S)-3-hydroxy-3-methylglutaryl-CoA = acetoacetate + acetyl-CoA
  3. transport of acetoacetate and formate (cytosol to extracellular)

  Catalysed by SUGCT, HMGCL, HMGCLL1, SLC16A4 and 1 moreextracellular space, cytosolOne of 2 routes

• propionic acidReach from here →
  1. 3-hydroxy-3-methylglutarate + succinyl-CoA = (3S)-3-hydroxy-3-methylglutaryl-CoA + succinate
  2. (3S)-3-hydroxy-3-methylglutaryl-CoA = acetoacetate + acetyl-CoA
  3. transport of acetoacetate and propanoate (cytosol to extracellular)

  Catalysed by SUGCT, HMGCL, HMGCLL1, SLC16A4 and 4 moreextracellular space, cytosolOne of 2 routes

• butyric acidReach from here →
  1. 3-hydroxy-3-methylglutarate + succinyl-CoA = (3S)-3-hydroxy-3-methylglutaryl-CoA + succinate
  2. (3S)-3-hydroxy-3-methylglutaryl-CoA = acetoacetate + acetyl-CoA
  3. transport of acetoacetate and butyrate (cytosol to extracellular)

  Catalysed by SUGCT, HMGCL, HMGCLL1, SLC16A4 and 4 moreextracellular space, cytosolOne of 2 routes

• adipic acidReach from here →
  1. glutarate + succinyl-CoA = glutaryl-CoA + succinate
  2. glutaryl-CoA + H2O = glutarate + CoA + H(+)
  3. hexanedioate + glutaryl-CoA = hexanedioyl-CoA + glutarate

  Catalysed by SUGCT, ACOT8, ACOT4One of 4 routes

• an N-acylsphinganineReach from here →
  1. a 3-oxo acid + succinyl-CoA = a 3-oxoacyl-CoA + succinate
  2. an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA
  3. sphingosine N-acyltransferase (sphinganine)

  Catalysed by OXCT1, OXCT2, ACAA1, SCP2 and 8 morecytosol

• taurocholateReach from here →
  1. glutarate + succinyl-CoA = glutaryl-CoA + succinate
  2. glutaryl-CoA + H2O = glutarate + CoA + H(+)
  3. taurocholate(out) + glutarate(in) = taurocholate(in) + glutarate(out)

  Catalysed by SUGCT, ACOT8, ACOT4, SLC22A24 and 1 moreinner side of the membrane, outer side of the membraneOne of 2 routes

• a 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholineReach from here →
  1. a 3-oxo acid + succinyl-CoA = a 3-oxoacyl-CoA + succinate
  2. an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA
  3. Acyl-CoA:1-alkyl-sn-glycero-3-phosphocholine O-acyltransferase

  Catalysed by OXCT1, OXCT2, ACAA1, SCP2 and 6 morecytosol

• (S)-lactic acidReach from here →
  1. 3-hydroxy-3-methylglutarate + succinyl-CoA = (3S)-3-hydroxy-3-methylglutaryl-CoA + succinate
  2. (3S)-3-hydroxy-3-methylglutaryl-CoA = acetoacetate + acetyl-CoA
  3. transport of acetoacetate and L-lactate (cytosol to extracellular)

  Catalysed by SUGCT, HMGCL, HMGCLL1, SLC16A4 and 4 moreextracellular space, cytosolOne of 2 routes

• a 1,3-diacylglycerolReach from here →
  1. a 3-oxo acid + succinyl-CoA = a 3-oxoacyl-CoA + succinate
  2. an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA
  3. a 1-acylglycerol + an acyl-CoA = a 1,3-diacylglycerol + CoA

  Catalysed by OXCT1, OXCT2, ACAA1, SCP2 and 4 more

• a 1,2-diacylglycerolReach from here →
  1. a 3-oxo acid + succinyl-CoA = a 3-oxoacyl-CoA + succinate
  2. an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA
  3. a 2-acylglycerol + an acyl-CoA = a 1,2-diacylglycerol + CoA

  Catalysed by OXCT1, OXCT2, ACAA1, SCP2 and 7 moreOne of 2 routes

• taurineReach from here →
  1. itaconate + succinyl-CoA = itaconyl-CoA + succinate
  2. Itaconate:CoA ligase (GDP-forming)
  3. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)

  Catalysed by SUGCT, SUCLG1, SUCLG2, SUCLA2 and 1 moremitochondrial matrix, cytosolOne of 2 routes

• a 1,2-diacyl-sn-glycero-3-phospho-L-serineReach from here →
  1. a 3-oxo acid + succinyl-CoA = a 3-oxoacyl-CoA + succinate
  2. an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA
  3. a 1-acyl-sn-glycero-3-phospho-L-serine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phospho-L-serine + CoA

  Catalysed by OXCT1, OXCT2, ACAA1, SCP2 and 5 more

• glycineReach from here →
  1. itaconate + succinyl-CoA = itaconyl-CoA + succinate
  2. Itaconate:CoA ligase (GDP-forming)
  3. glycine N-acyltransferase (N-arachidonoylglycine)

  Catalysed by SUGCT, SUCLG1, SUCLG2, SUCLA2 and 3 moremitochondrial matrixOne of 10 routes

• (R)-methylmalonyl-CoAReach from here →
  1. itaconate + succinyl-CoA = itaconyl-CoA + succinate
  2. Itaconate:CoA ligase (GDP-forming)
  3. aldehyde dehydrogenase (2-methyl-3-oxopropanoate)

  Catalysed by SUGCT, SUCLG1, SUCLG2, SUCLA2 and 1 moremitochondrial matrixOne of 2 routes

• (S)-methylmalonyl-CoAReach from here →
  1. itaconate + succinyl-CoA = itaconyl-CoA + succinate
  2. Itaconate:CoA ligase (GDP-forming)
  3. (S)-methylmalonyl-CoA hydrolase

  Catalysed by SUGCT, SUCLG1, SUCLG2, SUCLA2mitochondrial matrix

• 3'-dephospho-CoAReach from here →
  1. itaconate + succinyl-CoA = itaconyl-CoA + succinate
  2. Itaconate:CoA ligase (GDP-forming)
  3. acid phosphatase 2, lysosomal (CoA)

  Catalysed by SUGCT, SUCLG1, SUCLG2, SUCLA2 and 1 moremitochondrial matrix, lysosomeOne of 2 routes

• (2E)-dodecenoyl-CoAReach from here →
  1. itaconate + succinyl-CoA = itaconyl-CoA + succinate
  2. Itaconate:CoA ligase (GDP-forming)
  3. (2E)-dodecenoyl-CoA formation

  Catalysed by SUGCT, SUCLG1, SUCLG2, SUCLA2mitochondrial matrixOne of 3 routes

• 4,8,12-trimethyltridecanoyl-CoAReach from here →
  1. itaconate + succinyl-CoA = itaconyl-CoA + succinate
  2. Itaconate:CoA ligase (GDP-forming)
  3. propanoyl-CoA C-acyltransferase (3-ketopristanoyl-CoA)

  Catalysed by SUGCT, SUCLG1, SUCLG2, SUCLA2 and 2 moremitochondrial matrix, peroxisomeOne of 2 routes

• (6Z,9Z,12Z)-octadecatrienoyl-CoAReach from here →
  1. a 3-oxo acid + succinyl-CoA = a 3-oxoacyl-CoA + succinate
  2. an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA
  3. acyl-CoA pool formation and breakdown

  Catalysed by OXCT1, OXCT2, ACAA1, SCP2 and 2 morecytosolOne of 8 routes