tetra-mu3-sulfido-tetrairon(2+)

Three steps

• 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidineReach from here →
  1. lipoyl synthase
  2. transport of glutamine and methionine (cytosol to extracellular)
  3. N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide + L-glutamine + ATP + H2O = 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + L-glutamate + ADP + phosphate + H(+)

  Catalysed by LIAS, FDX1, FDXR, GCSH and 5 moremitochondrial matrix, extracellular space, cytosol

• kinetensinReach from here →
  1. lipoyl synthase
  2. transport of methionine and phenylalanine (cytosol to extracellular)
  3. Chymase

  Catalysed by LIAS, FDX1, FDXR, GCSH and 5 moremitochondrial matrix, extracellular space, cytosolOne of 3 routes

• an N-(fatty acyl)-glycineReach from here →
  1. lipoyl synthase
  2. transport of glycine and methionine (cytosol to extracellular)
  3. a fatty acyl-CoA + glycine = an N-(fatty acyl)-glycine + CoA + H(+)

  Catalysed by LIAS, FDX1, FDXR, GCSH and 5 moremitochondrial matrix, extracellular space, cytosol

• N-(9Z,12Z-octadecadienoyl)-glycineReach from here →
  1. lipoyl synthase
  2. transport of glycine and methionine (cytosol to extracellular)
  3. (9Z,12Z)-octadecadienoyl-CoA + glycine = N-(9Z,12Z-octadecadienoyl)-glycine + CoA + H(+)

  Catalysed by LIAS, FDX1, FDXR, GCSH and 5 moremitochondrial matrix, extracellular space, cytosol

• (7Z)-octadecenoyl-CoAReach from here →
  1. lipoyl synthase
  2. N-acetylglutamate synthase (N-acetylmethionine)
  3. carnitine O-palmitoyltransferase ((7Z)-octadecenoyl-CoA)

  Catalysed by LIAS, FDX1, FDXR, GCSH and 7 moremitochondrial matrix, cytosolOne of 3 routes

• acetaldehydeReach from here →
  1. lipoyl synthase
  2. transport of methionine and threonine (cytosol to extracellular)
  3. L-threonine acetaldehyde-lyase (glycine-forming)

  Catalysed by LIAS, FDX1, FDXR, GCSH and 4 moremitochondrial matrix, extracellular space, cytosol

• CHEBI:15345Reach from here →
  1. lipoyl synthase
  2. N-acetylglutamate synthase (N-acetylmethionine)
  3. Acetoacetate:CoA ligase (AMP-forming)

  Catalysed by LIAS, FDX1, FDXR, GCSH and 5 moremitochondrial matrix, cytosolOne of 2 routes

• cholineReach from here →
  1. lipoyl synthase
  2. N-acetylglutamate synthase (N-acetylmethionine)
  3. Acetyl-CoA:choline O-acetyltransferase

  Catalysed by LIAS, FDX1, FDXR, GCSH and 5 moremitochondrial matrix, nucleusOne of 2 routes

• pyruvateReach from here →
  1. lipoyl synthase
  2. De novo synthesis of 2Fe2S
  3. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase

  Catalysed by LIAS, FDX1, FDXR, GCSH and 10 moremitochondrial matrixOne of 20 routes

• 4a-hydroxytetrahydrobiopterinReach from here →
  1. lipoyl synthase
  2. transport of methionine and tryptophan (cytosol to extracellular)
  3. L-tryptophan,tetrahydrobiopterin:oxygen oxidoreductase(5-hydroxylating)

  Catalysed by LIAS, FDX1, FDXR, GCSH and 6 moremitochondrial matrix, extracellular space, cytosolOne of 3 routes

• CHEBI:15380Reach from here →
  1. lipoyl synthase
  2. N-acetylglutamate synthase (N-acetylmethionine)
  3. 5-aminolevulinate synthase (2-amino-3-oxoadipate)

  Catalysed by LIAS, FDX1, FDXR, GCSH and 6 moremitochondrial matrixOne of 8 routes

• CHEBI:15477Reach from here →
  1. lipoyl synthase
  2. N-acetylglutamate synthase (N-acetylmethionine)
  3. glycine N-acyltransferase (2-methylbutyryl-CoA)

  Catalysed by LIAS, FDX1, FDXR, GCSH and 7 moremitochondrial matrixOne of 2 routes

• 2-methylcrotonoyl-CoAReach from here →
  1. lipoyl synthase
  2. N-acetylglutamate synthase (N-acetylmethionine)
  3. Production of Tiglylcarnitine

  Catalysed by LIAS, FDX1, FDXR, GCSH and 6 moremitochondrial matrix, cytosolOne of 2 routes

• isobutyryl-CoAReach from here →
  1. lipoyl synthase
  2. N-acetylglutamate synthase (N-acetylmethionine)
  3. acetyl-CoA C-acyltransferase (3-oxo-4-methyl-pentanoyl-CoA)

  Catalysed by LIAS, FDX1, FDXR, GCSH and 7 moremitochondrial matrixOne of 3 routes

• 3-methylbut-2-enoyl-CoAReach from here →
  1. lipoyl synthase
  2. N-acetylglutamate synthase (N-acetylmethionine)
  3. glycine-N-acyltransferase (3-methylcrotonoylglycine)

  Catalysed by LIAS, FDX1, FDXR, GCSH and 5 moremitochondrial matrix

• isovaleryl-CoAReach from here →
  1. lipoyl synthase
  2. N-acetylglutamate synthase (N-acetylmethionine)
  3. glycine N-acyltransferase (isovalerylglycine)

  Catalysed by LIAS, FDX1, FDXR, GCSH and 7 moremitochondrial matrixOne of 3 routes

• arachidonoyl-CoAReach from here →
  1. lipoyl synthase
  2. N-acetylglutamate synthase (N-acetylmethionine)
  3. Arachidonate:CoA ligase (AMP-forming)

  Catalysed by LIAS, FDX1, FDXR, GCSH and 12 moremitochondrial matrix, cytosolOne of 11 routes

• CHEBI:15519Reach from here →
  1. lipoyl synthase
  2. N-acetylglutamate synthase (N-acetylmethionine)
  3. propanoyl-CoA C-acyltransferase

  Catalysed by LIAS, FDX1, FDXR, GCSH and 7 moremitochondrial matrix, peroxisomeOne of 2 routes

• palmitoyl-CoAReach from here →
  1. lipoyl synthase
  2. N-acetylglutamate synthase (N-acetylmethionine)
  3. Palmitate:CoA ligase (AMP-forming)

  Catalysed by LIAS, FDX1, FDXR, GCSH and 12 moremitochondrial matrix, cytosolOne of 11 routes

• oleoyl-CoAReach from here →
  1. lipoyl synthase
  2. N-acetylglutamate synthase (N-acetylmethionine)
  3. Transport of octadecenoyl-CoA into Mitochondrial Matrix

  Catalysed by LIAS, FDX1, FDXR, GCSH and 7 moremitochondrial matrix, cytosolOne of 11 routes

• phenylacetyl-CoAReach from here →
  1. lipoyl synthase
  2. N-acetylglutamate synthase (N-acetylmethionine)
  3. Phenylacetate:CoA ligase

  Catalysed by LIAS, FDX1, FDXR, GCSH and 4 moremitochondrial matrix, cytosolOne of 3 routes

• propionyl-CoAReach from here →
  1. lipoyl synthase
  2. N-acetylglutamate synthase (N-acetylmethionine)
  3. Propanoate:CoA ligase (AMP-forming)

  Catalysed by LIAS, FDX1, FDXR, GCSH and 7 moremitochondrial matrix, cytosolOne of 43 routes

• CHEBI:15570Reach from here →
  1. lipoyl synthase
  2. De novo synthesis of 2Fe2S
  3. alanine racemase

  Catalysed by LIAS, FDX1, FDXR, GCSH and 9 moremitochondrial matrix, cytosolOne of 5 routes

• (S)-malateReach from here →
  1. lipoyl synthase
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. transport of malate and thiosulfate (cytosol to mitochondria)

  Catalysed by LIAS, FDX1, FDXR, GCSH and 5 moremitochondrial matrix, cytosolOne of 6 routes

• CHEBI:15611Reach from here →
  1. lipoyl synthase
  2. transport of glycine and methionine (cytosol to extracellular)
  3. S-Adenosyl-L-methionine:glycine N-methyltransferase

  Catalysed by LIAS, FDX1, FDXR, GCSH and 5 moremitochondrial matrix, extracellular space, cytosol

• (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterinReach from here →
  1. lipoyl synthase
  2. transport of methionine and tryptophan (cytosol to extracellular)
  3. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tryptophan + O2 = 5-hydroxy-L-tryptophan + (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin

  Catalysed by LIAS, FDX1, FDXR, GCSH and 6 moremitochondrial matrix, extracellular space, cytosolOne of 2 routes

• CHEBI:15650Reach from here →
  1. lipoyl synthase
  2. N-acetylglutamate synthase (N-acetylmethionine)
  3. N-acetyl-LTE4 to leukotriene E4 conversion

  Catalysed by LIAS, FDX1, FDXR, GCSH and 36 moremitochondrial matrix, cytosolOne of 2 routes

• trimethylenediamineReach from here →
  1. lipoyl synthase
  2. transport of lysine and methionine (cytosol to extracellular)
  3. deoxyhypusine synthase (1,3-diaminopropane)

  Catalysed by LIAS, FDX1, FDXR, GCSH and 5 moremitochondrial matrix, extracellular space, cytosol

• CHEBI:15727Reach from here →
  1. lipoyl synthase
  2. N-acetylglutamate synthase (N-acetylmethionine)
  3. N-alpha-acetyltransferase 10, NatA catalytic subunit (acetylcarnosine)

  Catalysed by LIAS, FDX1, FDXR, GCSH and 5 moremitochondrial matrix, cytosolOne of 2 routes

• CHEBI:15746Reach from here →
  1. lipoyl synthase
  2. N-acetylglutamate synthase (N-acetylmethionine)
  3. diamine N-acetyltransferase (N1-acetylspermine)

  Catalysed by LIAS, FDX1, FDXR, GCSH and 6 moremitochondrial matrix, cytosolOne of 2 routes

• CHEBI:15765Reach from here →
  1. lipoyl synthase
  2. transport of methionine and tyrosine (cytosol to extracellular)
  3. L-Tyrosine,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating)

  Catalysed by LIAS, FDX1, FDXR, GCSH and 5 moremitochondrial matrix, extracellular space, cytosolOne of 5 routes

• malonateReach from here →
  1. lipoyl synthase
  2. hydrogen sulfide + 2 O2 = sulfate + H(+)
  3. malonate(in) + sulfate(out) = malonate(out) + sulfate(in)

  Catalysed by LIAS, FDX1, FDXR, GCSH and 7 moremitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 2 routes

• N-carbamoyl-L-aspartic acidReach from here →
  1. lipoyl synthase
  2. L-aspartate(in) + L-methionine(out) = L-aspartate(out) + L-methionine(in)
  3. carbamoyl-phosphate:L-aspartate carbamoyltransferase

  Catalysed by LIAS, FDX1, FDXR, GCSH and 5 moremitochondrial matrix, inner side of the membrane, outer side of the membrane, cytosol

• alpha-D-glucosamine 6-phosphateReach from here →
  1. lipoyl synthase
  2. transport of glutamine and methionine (cytosol to extracellular)
  3. L-glutamine:D-fructose-6-phosphate isomerase (deaminating)

  Catalysed by LIAS, FDX1, FDXR, GCSH and 6 moremitochondrial matrix, extracellular space, cytosol

• thioredoxin dithiolReach from here →
  1. lipoyl synthase
  2. L-Methionine:tRNAMet ligase (AMP-forming)
  3. glycyl-tRNA(gly) phosphorylation

  Catalysed by LIAS, FDX1, FDXR, GCSH and 4 moremitochondrial matrix, cytosolOne of 2 routes

• a halide anionReach from here →
  1. lipoyl synthase
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. RX + glutathione = an S-substituted glutathione + a halide anion + H(+)

  Catalysed by LIAS, FDX1, FDXR, GCSH and 27 moremitochondrial matrix

• ureaReach from here →
  1. lipoyl synthase
  2. transport of arginine and methionine (cytosol to extracellular)
  3. L-Arginine amidinohydrolase

  Catalysed by LIAS, FDX1, FDXR, GCSH and 5 moremitochondrial matrix, extracellular space, cytosolOne of 3 routes

• L-cystineReach from here →
  1. lipoyl synthase
  2. De novo synthesis of 2Fe2S
  3. Transport of L-Cystine (L-Alanine antiport) by B0, +At Transporter

  Catalysed by LIAS, FDX1, FDXR, GCSH and 11 moremitochondrial matrix, extracellular space, cytosolOne of 9 routes

• 11-cis-retinolReach from here →
  1. lipoyl synthase
  2. N-acetylglutamate synthase (N-acetylmethionine)
  3. Palmitoyl-CoA:retinol O-acyltransferase

  Catalysed by LIAS, FDX1, FDXR, GCSH and 9 moremitochondrial matrix, cytosol

• cob(II)alaminReach from here →
  1. lipoyl synthase
  2. N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-SH + AH2 + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-H + 5'-deoxyadenosine + L-methionine + A + S-adenosyl-L-homocysteine + 2 H(+)
  3. 2 cob(II)alamin + A + 2 H2O + 2 H(+) = 2 aquacob(III)alamin + AH2

  Catalysed by LIAS, FDX1, FDXR, GCSH and 5 moremitochondrial matrix

• (R)-3-aminoisobutyric acidReach from here →
  1. lipoyl synthase
  2. De novo synthesis of 2Fe2S
  3. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase

  Catalysed by LIAS, FDX1, FDXR, GCSH and 10 moremitochondrial matrix

• iodideReach from here →
  1. lipoyl synthase
  2. transport of methionine and tyrosine (cytosol to extracellular)
  3. thyroid peroxidase (iodine)

  Catalysed by LIAS, FDX1, FDXR, GCSH and 5 moremitochondrial matrix, extracellular space, cytosolOne of 25 routes

• oxaloacetateReach from here →
  1. lipoyl synthase
  2. N-acetylglutamate synthase (N-acetylmethionine)
  3. ATP citrate lyase (citrate)

  Catalysed by LIAS, FDX1, FDXR, GCSH and 5 moremitochondrial matrix, cytosolOne of 6 routes

• nitric oxideReach from here →
  1. lipoyl synthase
  2. transport of arginine and methionine (cytosol to extracellular)
  3. L-Arginine, NADPH:Oxygen Oxidoreductase (Nitric-Oxide-Forming)

  Catalysed by LIAS, FDX1, FDXR, GCSH and 7 moremitochondrial matrix, extracellular space, cytosolOne of 3 routes

• CHEBI:16523Reach from here →
  1. lipoyl synthase
  2. transport of glycine and methionine (cytosol to extracellular)
  3. transport of D-serine and glycine (cytosol to extracellular)

  Catalysed by LIAS, FDX1, FDXR, GCSH and 6 moremitochondrial matrix, extracellular space, cytosolOne of 4 routes

• N(2)-acetyl-L-ornithineReach from here →
  1. lipoyl synthase
  2. transport of methionine and ornithine (cytosol to extracellular)
  3. N2-Acetyl-L-ornithine amidohydrolase

  Catalysed by LIAS, FDX1, FDXR, GCSH and 5 moremitochondrial matrix, extracellular space, cytosol

• 2-phenylacetamideReach from here →
  1. lipoyl synthase
  2. transport of methionine and phenylalanine (cytosol to extracellular)
  3. L-phenylalanine:oxygen 2-oxidoreductase (decarboxylating)

  Catalysed by LIAS, FDX1, FDXR, GCSH and 5 moremitochondrial matrix, extracellular space, cytosol

• CHEBI:16633Reach from here →
  1. lipoyl synthase
  2. De novo synthesis of 2Fe2S
  3. L-selenocysteine selenide-lyase (L-alanine-forming)

  Catalysed by LIAS, FDX1, FDXR, GCSH and 10 moremitochondrial matrix, cytosol

• quinolinic acidReach from here →
  1. lipoyl synthase
  2. hydrogen sulfide + 2 O2 = sulfate + H(+)
  3. Transport of Quinolinic Acid

  Catalysed by LIAS, FDX1, FDXR, GCSH and 5 moremitochondrial matrix, extracellular space, cytosolOne of 2 routes

• 3'-deoxy-3',4'-didehydro-CTPReach from here →
  1. lipoyl synthase
  2. N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-SH + AH2 + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-H + 5'-deoxyadenosine + L-methionine + A + S-adenosyl-L-homocysteine + 2 H(+)
  3. CTP + AH2 + S-adenosyl-L-methionine = 3'-deoxy-3',4'-didehydro-CTP + 5'-deoxyadenosine + L-methionine + A + H2O + H(+)

  Catalysed by LIAS, FDX1, FDXR, GCSH and 5 moremitochondrial matrix