L-aspartate

Three steps

• a cardiolipinReach from here →
  1. acetyl-CoA:L-aspartate N-acetyltransferase
  2. acyl-CoA:sphingosine N-acyltransferase
  3. 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + an acyl-CoA = a cardiolipin + CoA

  Catalysed by NAT8L, ASAH1, ACER2, ACER1 and 2 moremitochondrial matrix, Golgi apparatus

• (2E)-octenoyl-CoAReach from here →
  1. acetyl-CoA:L-aspartate N-acetyltransferase
  2. Octanoyl-CoA:L-carnitine O-octanoyltransferase
  3. trans-oct-2-enoyl-CoA reductase

  Catalysed by NAT8L, CROT, MECRmitochondrial matrixOne of 5 routes

• 3-oxotetradecanoyl-CoAReach from here →
  1. acetyl-CoA:L-aspartate N-acetyltransferase
  2. long-chain-fatty-acid-CoA ligase (lauric acid)
  3. dodecanoyl-CoA + malonyl-CoA + H(+) = 3-oxotetradecanoyl-CoA + CO2 + CoA

  Catalysed by NAT8L, SLC27A2, ACSL4, ACSL3 and 6 moremitochondrial matrix, cytosol

• (3R,5S)-1-pyrroline-3-hydroxy-5-carboxylateReach from here →
  1. Aspartate Intake by System Asct-1 Transporter
  2. prolyl 4-hydroxylase (AKG)
  3. trans-4-Hydroxy-L-proline:NAD+ 5-oxidoreductase

  Catalysed by P4HA2, P4HB, P4HA1, PYCR1 and 2 moreextracellular space, cytosol, endoplasmic reticulumOne of 5 routes

• an all-trans-retinyl esterReach from here →
  1. acetyl-CoA:L-aspartate N-acetyltransferase
  2. acyl-CoA:sphingosine N-acyltransferase
  3. all-trans-retinol + an acyl-CoA = an all-trans-retinyl ester + CoA

  Catalysed by NAT8L, ASAH1, ACER2, ACER1 and 5 moremitochondrial matrix, Golgi apparatusOne of 4 routes

• ubiquinol-10Reach from here →
  1. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  2. sulfite(in) + sulfate(out) = sulfite(out) + sulfate(in)
  3. ubiquinone-10 + hydrogen sulfide + sulfite + 2 H(+) = ubiquinol-10 + thiosulfate

  Catalysed by SLC25A14, SLC25A30, SQORinner side of the membrane, outer side of the membrane

• 1-O-hexadecyl-sn-glycero-3-phosphocholineReach from here →
  1. acetyl-CoA:L-aspartate N-acetyltransferase
  2. acyl-CoA:sphingosine N-acyltransferase
  3. 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + sphing-4-enine = 1-O-hexadecyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine + H(+)

  Catalysed by NAT8L, ASAH1, ACER2, ACER1 and 2 moremitochondrial matrix, Golgi apparatus

• a 1,2-diacyl-sn-glycero-3-phosphoethanolamineReach from here →
  1. acetyl-CoA:L-aspartate N-acetyltransferase
  2. acyl-CoA:sphingosine N-acyltransferase
  3. a 1-acyl-sn-glycero-3-phosphoethanolamine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CoA

  Catalysed by NAT8L, ASAH1, ACER2, ACER1 and 5 moremitochondrial matrix, Golgi apparatus

• a triacyl-sn-glycerolReach from here →
  1. acetyl-CoA:L-aspartate N-acetyltransferase
  2. acyl-CoA:sphingosine N-acyltransferase
  3. an acyl-CoA + a 1,2-diacyl-sn-glycerol = a triacyl-sn-glycerol + CoA

  Catalysed by NAT8L, ASAH1, ACER2, ACER1 and 7 moremitochondrial matrix, Golgi apparatus

• a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)Reach from here →
  1. acetyl-CoA:L-aspartate N-acetyltransferase
  2. acyl-CoA:sphingosine N-acyltransferase
  3. 1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA

  Catalysed by NAT8L, ASAH1, ACER2, ACER1 and 4 moremitochondrial matrix, Golgi apparatus

• 1-octadecanoyl-2-acyl-sn-glycero-3-phospho-1D-myo-inositolReach from here →
  1. acetyl-CoA:L-aspartate N-acetyltransferase
  2. long-chain-fatty-acid-CoA ligase (stearate)
  3. a 2-acyl-sn-glycero-3-phospho-D-myo-inositol + octadecanoyl-CoA = 1-octadecanoyl-2-acyl-sn-glycero-3-phospho-1D-myo-inositol + CoA

  Catalysed by NAT8L, SLC27A2, ACSL4, ACSL3 and 5 moremitochondrial matrix, cytosol

• 3-oxoeicosasphinganineReach from here →
  1. acetyl-CoA:L-aspartate N-acetyltransferase
  2. long-chain-fatty-acid-CoA ligase (stearate)
  3. octadecanoyl-CoA + L-serine + H(+) = 3-oxoeicosasphinganine + CO2 + CoA

  Catalysed by NAT8L, SLC27A2, ACSL4, ACSL3 and 7 moremitochondrial matrix, cytosol

• a 2,3-saturated acyl-CoAReach from here →
  1. L-aspartate(in) + L-methionine(out) = L-aspartate(out) + L-methionine(in)
  2. N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-SH + AH2 + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-H + 5'-deoxyadenosine + L-methionine + A + S-adenosyl-L-homocysteine + 2 H(+)
  3. a 2,3-saturated acyl-CoA + A = a 2,3-dehydroacyl-CoA + AH2

  Catalysed by SLC7A13, CDKAL1, ACAD10inner side of the membrane, outer side of the membrane

• 3-oxoeicosanoyl-CoAReach from here →
  1. acetyl-CoA:L-aspartate N-acetyltransferase
  2. long-chain-fatty-acid-CoA ligase (stearate)
  3. very-long-chain 3-oxoacyl-CoA synthase (malonyl-CoA)

  Catalysed by NAT8L, SLC27A2, ACSL4, ACSL3 and 11 moremitochondrial matrix, cytosolOne of 2 routes

• N-docosanoylsphinganineReach from here →
  1. acetyl-CoA:L-aspartate N-acetyltransferase
  2. long-chain-fatty-acid-CoA ligase (behenic acid)
  3. docosanoyl-CoA + sphinganine = N-docosanoylsphinganine + CoA + H(+)

  Catalysed by NAT8L, SLC27A2, ACSL4, ACSL3 and 8 moremitochondrial matrix, cytosol

• N-eicosanoylsphinganineReach from here →
  1. acetyl-CoA:L-aspartate N-acetyltransferase
  2. long-chain-fatty-acid-CoA ligase (eicosanoate)
  3. eicosanoyl-CoA + sphinganine = N-eicosanoylsphinganine + CoA + H(+)

  Catalysed by NAT8L, SLC27A2, ACSL4, ACSL3 and 8 moremitochondrial matrix, cytosol

• N-(octadecanoyl)-sphinganineReach from here →
  1. acetyl-CoA:L-aspartate N-acetyltransferase
  2. long-chain-fatty-acid-CoA ligase (stearate)
  3. sphinganine + octadecanoyl-CoA = N-(octadecanoyl)-sphinganine + CoA + H(+)

  Catalysed by NAT8L, SLC27A2, ACSL4, ACSL3 and 10 moremitochondrial matrix, cytosol

• N-(tetradecanoyl)-sphinganineReach from here →
  1. acetyl-CoA:L-aspartate N-acetyltransferase
  2. long-chain-fatty-acid-CoA ligase (myristic acid)
  3. sphinganine + tetradecanoyl-CoA = N-(tetradecanoyl)-sphinganine + CoA + H(+)

  Catalysed by NAT8L, SLC27A2, ACSL4, ACSL3 and 7 moremitochondrial matrix, cytosol

• 3-oxohexadecasphinganineReach from here →
  1. acetyl-CoA:L-aspartate N-acetyltransferase
  2. long-chain-fatty-acid-CoA ligase (myristic acid)
  3. tetradecanoyl-CoA + L-serine + H(+) = 3-oxohexadecasphinganine + CO2 + CoA

  Catalysed by NAT8L, SLC27A2, ACSL4, ACSL3 and 7 moremitochondrial matrix, cytosol

• 3-oxotetradecasphinganineReach from here →
  1. acetyl-CoA:L-aspartate N-acetyltransferase
  2. long-chain-fatty-acid-CoA ligase (lauric acid)
  3. dodecanoyl-CoA + L-serine + H(+) = 3-oxotetradecasphinganine + CO2 + CoA

  Catalysed by NAT8L, SLC27A2, ACSL4, ACSL3 and 7 moremitochondrial matrix, cytosol

• N(5)-[(Z)-amino(hydroxyimino)methyl]ornithineReach from here →
  1. L-Citrulline:L-aspartate ligase (AMP-forming)
  2. 2-(Nomega-L-arginino)succinate arginine-lyase (fumarate-forming)
  3. L-arginine,NADPH:oxygen oxidoreductase (N-(omega)-hydroxyarginine-forming)

  Catalysed by ASS1, ASL, NOS3, NOS1 and 1 morecytosol

• xanthurenateReach from here →
  1. L-tryptophan(out) + L-aspartate(in) = L-tryptophan(in) + L-aspartate(out)
  2. Transport of 3-Hydroxy-L-Kynurenine
  3. Kynurenine-Oxoglutarate Transaminase

  Catalysed by SLC7A13, SLC7A5, AADATinner side of the membrane, outer side of the membrane, extracellular space, cytosol, mitochondrial matrixOne of 3 routes

• 3-oxooctadecanoyl-CoAReach from here →
  1. acetyl-CoA:L-aspartate N-acetyltransferase
  2. Palmitate:CoA ligase (AMP-forming)
  3. very-long-chain 3-oxoacyl-CoA synthase (malonyl-CoA)

  Catalysed by NAT8L, SLC27A2, ACSL4, ACSL3 and 12 moremitochondrial matrix, cytosolOne of 2 routes

• 3-oxodocosanoyl-CoAReach from here →
  1. acetyl-CoA:L-aspartate N-acetyltransferase
  2. long-chain-fatty-acid-CoA ligase (eicosanoate)
  3. very-long-chain 3-oxoacyl-CoA synthase (eicosanoyl-CoA)

  Catalysed by NAT8L, SLC27A2, ACSL4, ACSL3 and 12 moremitochondrial matrix, cytosolOne of 3 routes

• 3-oxo-(8Z,11Z,14Z)-eicosatrienoyl-CoAReach from here →
  1. acetyl-CoA:L-aspartate N-acetyltransferase
  2. long-chain-fatty-acid-CoA ligase (gamma-linolenate)
  3. (6Z,9Z,12Z)-octadecatrienoyl-CoA + malonyl-CoA + H(+) = 3-oxo-(8Z,11Z,14Z)-eicosatrienoyl-CoA + CO2 + CoA

  Catalysed by NAT8L, SLC27A2, ACSL4, ACSL3 and 7 moremitochondrial matrix, cytosol

• 3-oxo-(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoAReach from here →
  1. acetyl-CoA:L-aspartate N-acetyltransferase
  2. long-chain-fatty-acid-CoA ligase (stearidonic acid)
  3. (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA + malonyl-CoA + H(+) = 3-oxo-(8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + CO2 + CoA

  Catalysed by NAT8L, SLC27A2, ACSL4, ACSL3 and 6 moremitochondrial matrix, cytosol

• 3',3'-cGAMPReach from here →
  1. 1-(5-Phosphoribosyl)-5-amino-4-carboxyimidazole:L-aspartate ligase (ADP-forming)
  2. 1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole AMP-lyase
  3. 3',3'-cGAMP(out) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(in) = 3',3'-cGAMP(in) + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(out)

  Catalysed by PAICS, ADSL, SLC19A1cytosol, inner side of the membrane, outer side of the membrane

• (8Z,11Z,14Z)-eicosatrienoateReach from here →
  1. acetyl-CoA:L-aspartate N-acetyltransferase
  2. Carnitine O-Palmitoyltransferase
  3. Utilized Transport

  Catalysed by NAT8L, CPT1A, CPT1C, CPT1Bmitochondrial matrix, cytosol, endoplasmic reticulumOne of 2 routes

• (4S)-4-hydroxy-2-oxoglutarateReach from here →
  1. L-Aspartate:2-oxoglutarate aminotransferase
  2. Oxaloacetate Decarboxylase
  3. (4S)-4-hydroxy-2-oxoglutarate = glyoxylate + pyruvate

  Catalysed by GOT2, FAHD1, HOGA1mitochondrial matrix, cytosol

• 1-dodecanoyl-sn-glycerol 3-phosphateReach from here →
  1. acetyl-CoA:L-aspartate N-acetyltransferase
  2. long-chain-fatty-acid-CoA ligase (lauric acid)
  3. glycerol-3-phosphate 1-O-acyltransferase (lauroyl-CoA)

  Catalysed by NAT8L, SLC27A2, ACSL4, ACSL3 and 9 moremitochondrial matrix, cytosolOne of 2 routes

• 1-tetradecanoyl-sn-glycerol 3-phosphateReach from here →
  1. acetyl-CoA:L-aspartate N-acetyltransferase
  2. long-chain-fatty-acid-CoA ligase (myristic acid)
  3. glycerol-3-phosphate 1-O-acyltransferase (myristoyl-CoA)

  Catalysed by NAT8L, SLC27A2, ACSL4, ACSL3 and 9 moremitochondrial matrix, cytosol

• 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol)Reach from here →
  1. acetyl-CoA:L-aspartate N-acetyltransferase
  2. long-chain-fatty-acid-CoA ligase (stearate)
  3. 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + octadecanoyl-CoA = 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA

  Catalysed by NAT8L, SLC27A2, ACSL4, ACSL3 and 5 moremitochondrial matrix, cytosol

• 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-(1D-myo-inositol)Reach from here →
  1. acetyl-CoA:L-aspartate N-acetyltransferase
  2. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)
  3. 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + (9Z,12Z)-octadecadienoyl-CoA = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA

  Catalysed by NAT8L, SLC27A2, ACSL4, ACSL3 and 6 moremitochondrial matrix, cytosol

• 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)Reach from here →
  1. acetyl-CoA:L-aspartate N-acetyltransferase
  2. long-chain-fatty-acid-CoA ligase (stearate)
  3. 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + octadecanoyl-CoA = 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA

  Catalysed by NAT8L, SLC27A2, ACSL4, ACSL3 and 6 moremitochondrial matrix, cytosol

• 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-(1'-sn-glycerol)Reach from here →
  1. acetyl-CoA:L-aspartate N-acetyltransferase
  2. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)
  3. 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + (9Z,12Z)-octadecadienoyl-CoA = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA

  Catalysed by NAT8L, SLC27A2, ACSL4, ACSL3 and 6 moremitochondrial matrix, cytosol

• 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphateReach from here →
  1. acetyl-CoA:L-aspartate N-acetyltransferase
  2. long-chain-fatty-acid-CoA ligase (stearate)
  3. 1-hexadecanoyl-sn-glycero-3-phosphate + octadecanoyl-CoA = 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphate + CoA

  Catalysed by NAT8L, SLC27A2, ACSL4, ACSL3 and 5 moremitochondrial matrix, cytosol

• 1-hexadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphateReach from here →
  1. acetyl-CoA:L-aspartate N-acetyltransferase
  2. long-chain-fatty-acid-CoA ligase (myristic acid)
  3. 1-hexadecanoyl-sn-glycero-3-phosphate + tetradecanoyl-CoA = 1-hexadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphate + CoA

  Catalysed by NAT8L, SLC27A2, ACSL4, ACSL3 and 6 moremitochondrial matrix, cytosol

• N-dodecanoylsphing-4-enineReach from here →
  1. acetyl-CoA:L-aspartate N-acetyltransferase
  2. acyl-CoA:sphingosine N-acyltransferase
  3. N-dodecanoylsphing-4-enine + H2O = dodecanoate + sphing-4-enine

  Catalysed by NAT8L, ASAH1, ACER2, ACER1 and 2 moremitochondrial matrix, Golgi apparatus

• N-tetradecanoylsphing-4-enineReach from here →
  1. acetyl-CoA:L-aspartate N-acetyltransferase
  2. acyl-CoA:sphingosine N-acyltransferase
  3. N-tetradecanoylsphing-4-enine + H2O = sphing-4-enine + tetradecanoate

  Catalysed by NAT8L, ASAH1, ACER2, ACER1 and 1 moremitochondrial matrix, Golgi apparatus

• N-hexadecanoylsphing-4-enineReach from here →
  1. acetyl-CoA:L-aspartate N-acetyltransferase
  2. acyl-CoA:sphingosine N-acyltransferase
  3. sphing-4-enine + hexadecanoyl-CoA = N-hexadecanoylsphing-4-enine + CoA + H(+)

  Catalysed by NAT8L, ASAH1, ACER2, ACER1 and 5 moremitochondrial matrix, Golgi apparatusOne of 2 routes

• N-octadecanoylsphing-4-enineReach from here →
  1. acetyl-CoA:L-aspartate N-acetyltransferase
  2. long-chain-fatty-acid-CoA ligase (stearate)
  3. sphing-4-enine + octadecanoyl-CoA = N-octadecanoylsphing-4-enine + CoA + H(+)

  Catalysed by NAT8L, SLC27A2, ACSL4, ACSL3 and 8 moremitochondrial matrix, cytosolOne of 3 routes

• N-eicosanoyl-sphing-4-enineReach from here →
  1. acetyl-CoA:L-aspartate N-acetyltransferase
  2. long-chain-fatty-acid-CoA ligase (eicosanoate)
  3. eicosanoyl-CoA + sphing-4-enine = N-eicosanoyl-sphing-4-enine + CoA + H(+)

  Catalysed by NAT8L, SLC27A2, ACSL4, ACSL3 and 7 moremitochondrial matrix, cytosolOne of 2 routes

• N-tetracosanoyl-sphing-4-enineReach from here →
  1. acetyl-CoA:L-aspartate N-acetyltransferase
  2. long-chain-fatty-acid-CoA ligase (lignocerate)
  3. tetracosanoyl-CoA + sphing-4-enine = N-tetracosanoyl-sphing-4-enine + CoA + H(+)

  Catalysed by NAT8L, SLC27A2, ACSL4, ACSL3 and 6 moremitochondrial matrix, cytosolOne of 2 routes

• 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholineReach from here →
  1. acetyl-CoA:L-aspartate N-acetyltransferase
  2. long-chain-fatty-acid-CoA ligase (stearate)
  3. octadecanoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + CoA

  Catalysed by NAT8L, SLC27A2, ACSL4, ACSL3 and 5 moremitochondrial matrix, cytosol

• 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholineReach from here →
  1. acetyl-CoA:L-aspartate N-acetyltransferase
  2. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)
  3. (9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + CoA

  Catalysed by NAT8L, SLC27A2, ACSL4, ACSL3 and 8 moremitochondrial matrix, cytosol

• a 1-(1-hydroxyalkyl)-sn-glycerolReach from here →
  1. L-tyrosine(out) + L-aspartate(in) = L-tyrosine(in) + L-aspartate(out)
  2. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine
  3. 1-O-(1,2-saturated-alkyl)-sn-glycerol + (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 = a 1-(1-hydroxyalkyl)-sn-glycerol + (6R)-L-erythro-6,7-dihydrobiopterin + H2O

  Catalysed by SLC7A13, PAH, AGMOinner side of the membrane, outer side of the membrane

• (9Z,12Z)-octadecadien-1-olReach from here →
  1. acetyl-CoA:L-aspartate N-acetyltransferase
  2. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)
  3. (9Z,12Z)-octadecadienoyl-CoA + 2 NADPH + 2 H(+) = (9Z,12Z)-octadecadien-1-ol + 2 NADP(+) + CoA

  Catalysed by NAT8L, SLC27A2, ACSL4, ACSL3 and 6 moremitochondrial matrix, cytosol

• L-threonylcarbamoyladenylateReach from here →
  1. L-aspartate(in) + L-glutamine(out) = L-aspartate(out) + L-glutamine(in)
  2. L-threonine(in) + L-glutamine(out) + Na(+)(out) = L-threonine(out) + L-glutamine(in) + Na(+)(in)
  3. L-threonine + hydrogencarbonate + ATP = L-threonylcarbamoyladenylate + diphosphate + H2O

  Catalysed by SLC7A13, SLC1A5, YRDCinner side of the membrane, outer side of the membrane

• 3-oxo-(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoAReach from here →
  1. acetyl-CoA:L-aspartate N-acetyltransferase
  2. long-chain-fatty-acid-CoA ligase (EPA)
  3. (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + malonyl-CoA + H(+) = 3-oxo-(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + CO2 + CoA

  Catalysed by NAT8L, SLC27A2, ACSL4, ACSL3 and 7 moremitochondrial matrix, cytosol

• (9Z,12Z,15Z,18Z,21Z)-3-oxotetracosapentaenoyl-CoAReach from here →
  1. acetyl-CoA:L-aspartate N-acetyltransferase
  2. long-chain-fatty-acid-CoA ligase (DPA)
  3. (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + malonyl-CoA + H(+) = (9Z,12Z,15Z,18Z,21Z)-3-oxotetracosapentaenoyl-CoA + CO2 + CoA

  Catalysed by NAT8L, SLC27A2, ACSL4, ACSL3 and 6 moremitochondrial matrix, cytosol