Compound

3-oxoeicosanoyl-CoA

A 3-oxoacyl-CoA(4-) arising from deprotonation of the phosphate and diphosphate groups of 3-oxoicosanoyl-CoA: major species at pH 7.3.

Definition from ChEBI (CHEBI:65115), read 2026-09-23. CC BY 4.0.

CHEBI:65115ChEBI

Open in the graph

Structure

2D depiction

No three-dimensional record for this entry.

Class: Organic compound, anion
Formula: C41H68N7O18P3S
Mass: 1072.015 g/mol
Charge: -4
InChIKey: FYBVHNZJDVUVLJ-IBYUJNRCSA-J
SMILES: CCCCCCCCCCCCCCCCCC(=O)CC(=O)SCCNC(=O)CCNC(=O)[C@H](O)C(C)(C)COP(=O)([O-])OP(=O)([O-])OC[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1OP(=O)([O-])[O-]
Look it up: ChEBI By InChIKey

Identity from ChEBI. Not evidence.

What it touches on the way

Mechanistic reach

6 entities

6 entities reached.

0 reported hops6 assembled from the scaffold

What the reference databases state

Statements

9 statements

9 statements · 2 reference databases · Subject: 3-oxoeicosanoyl-CoA · Sources: Human-GEM, Rhea

Order

3-oxoeicosanoyl-CoA is converted to octadecanoyl-CoACompoundRhea RHEA:78599Inferred only
octadecanoyl-CoA is converted to 3-oxoeicosanoyl-CoACompoundRhea RHEA:35319Inferred only
3-oxoeicosanoyl-CoA is a substrate of ACAA1ProteinHuman-GEM MAR03073Inferred only
3-oxoeicosanoyl-CoA is a substrate of ACAA2ProteinHuman-GEM MAR03114Inferred only
3-oxoeicosanoyl-CoA is a substrate of HADHAProteinHuman-GEM MAR03114Inferred only
3-oxoeicosanoyl-CoA is a substrate of HADHBProteinHuman-GEM MAR03114Inferred only
3-oxoeicosanoyl-CoA is a substrate of HADHBProteinRhea RHEA:78599Inferred only
3-oxoeicosanoyl-CoA is a substrate of HSD17B12ProteinHuman-GEM MAR02202Inferred only
3-oxoeicosanoyl-CoA is a substrate of MYO5BProteinHuman-GEM MAR03073Inferred only

Reactions

12 reactions

proton+malonyl-CoA+octadecanoyl-CoA3-oxoeicosanoyl-CoA+carbon dioxide+CHEBI:1146900
Catalysed by ELOVL5 or ELOVL1 or ELOVL4 or ELOVL3 or ELOVL7 or ELOVL6 or ELOVL2
Reaction pageLeft to rightBalancedEC 2.3.1.199cytosol
Human-GEM MAR02201CC BY 4.0Reference data
3-oxoeicosanoyl-CoA+proton+NADPH(4-)MAM00777c+NADP(3-)
Catalysed by HSD17B12
Reaction pageLeft to rightBalancedEC 1.1.1.330cytosol
Human-GEM MAR02202CC BY 4.0Reference data
MAM00777x+NAD(+)3-oxoeicosanoyl-CoA+proton+NADH(2-)
Catalysed by ACAA1 & HSD17B4 & EHHADH
Reaction pageLeft to rightBalancedEC 1.1.1.35, 1.1.1.211peroxisome
Human-GEM MAR03072CC BY 4.0Reference data
3-oxoeicosanoyl-CoA+CHEBI:1146900CHEBI:15351+octadecanoyl-CoA
Catalysed by ACAA1 & MYO5B
Reaction pageLeft to rightBalancedEC 2.3.1.16peroxisome
Human-GEM MAR03073CC BY 4.0Reference data
MAM00777m+NAD(+)3-oxoeicosanoyl-CoA+proton+NADH(2-)
Catalysed by HADHA & HADH & HSD17B10
Reaction pageLeft to rightBalancedEC 1.1.1.35, 1.1.1.211mitochondrial matrix
Human-GEM MAR03113CC BY 4.0Reference data
3-oxoeicosanoyl-CoA+CHEBI:1146900CHEBI:15351+octadecanoyl-CoA
Catalysed by HADHA & ACAA2 & HADHB
Reaction pageLeft to rightBalancedEC 2.3.1.16, 1.1.1.211mitochondrial matrix
Human-GEM MAR03114CC BY 4.0Reference data
octadecanoyl-CoA+malonyl-CoA+hydron3-oxoeicosanoyl-CoA+carbon dioxide+coenzyme A(4-)
Catalysed by ELOVL7 or ELOVL1 or ELOVL3
Reaction pageLeft to rightBalanced
Rhea RHEA:35319CC BY 4.0Reference data
CHEBI:71455+NADP(3-)3-oxoeicosanoyl-CoA+NADPH(4-)+hydron
Reaction pageDirection not assertedBalanced
Rhea RHEA:35339CC BY 4.0Reference data
3-oxoeicosanoyl-CoA+NADPH(4-)+hydronCHEBI:76373+NADP(3-)
Reaction pageDirection not assertedBalanced
Rhea RHEA:39171CC BY 4.0Reference data
CHEBI:76373+NAD(1-)3-oxoeicosanoyl-CoA+NADH(2-)+hydron
Reaction pageDirection not assertedBalanced
Rhea RHEA:78595CC BY 4.0Reference data
octadecanoyl-CoA+acetyl-CoA3-oxoeicosanoyl-CoA+coenzyme A(4-)
Catalysed by HADHB
Reaction pageRight to leftBalanced
Rhea RHEA:78599CC BY 4.0Reference data
CHEBI:87562+NAD(1-)3-oxoeicosanoyl-CoA+NADH(2-)+hydron
Catalysed by HADHA
Reaction pageLeft to rightBalanced
Rhea RHEA:78731CC BY 4.0Reference data

Other names

8 names

Resolves to: 3-oxoeicosanoyl-CoA

Also called: 3-ketoicosanoyl-CoA(4-)3-ketoicosanoyl-CoA(4−)3-ketoicosanoyl-coenzyme A(4-)3-ketoicosanoyl-coenzyme A(4−)3-oxoicosanoyl-coenzyme A(4-)3-oxoicosanoyl-coenzyme A(4−)C20 3-oxoacyl-CoA(4-)C20 3-oxoacyl-CoA(4−)