CHEBI:18132

Three steps

• cob(II)alaminReach from here →
  1. Phosphocholine phosphohydrolase
  2. choline + A = betaine aldehyde + AH2
  3. 2 cob(II)alamin + A + 2 H2O + 2 H(+) = 2 aquacob(III)alamin + AH2

  Catalysed by PHOSPHO1, CHDH, MTRRcytosol

• phosphatidic acidReach from here →
  1. CTP:choline-phosphate cytidylyltransferase
  2. diacylglycerol cholinephosphotransferase (1,2-diacylglycerol-LD-PC pool)
  3. phosphatidylcholine phosphatidohydrolase

  Catalysed by PCYT1A, PCYT1B, CHPT1, CEPT1 and 3 morecytosolOne of 4 routes

• iodideReach from here →
  1. Phosphocholine phosphohydrolase
  2. transport of chloride and choline (cytosol to extracellular)
  3. transport of chloride and iodide (cytosol to extracellular)

  Catalysed by PHOSPHO1, SLC5A7, SLC26A4cytosol, extracellular spaceOne of 23 routes

• L-valineReach from here →
  1. Phosphocholine phosphohydrolase
  2. transport of chloride and choline (cytosol to extracellular)
  3. transport of chloride and valine (cytosol to extracellular)

  Catalysed by PHOSPHO1, SLC5A7, SLC6A14cytosol, extracellular spaceOne of 2 routes

• oxaloacetateReach from here →
  1. Phosphocholine phosphohydrolase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. ATP citrate lyase (citrate)

  Catalysed by PHOSPHO1, CHAT, ACLYcytosol

• L-arginineReach from here →
  1. Phosphocholine phosphohydrolase
  2. transport of chloride and choline (cytosol to extracellular)
  3. transport of arginine and chloride (cytosol to extracellular)

  Catalysed by PHOSPHO1, SLC5A7, SLC6A14cytosol, extracellular spaceOne of 2 routes

• nitric oxideReach from here →
  1. Phosphocholine phosphohydrolase
  2. choline + A = betaine aldehyde + AH2
  3. 2 nitrite + AH2 + 2 H(+) = 2 nitric oxide + A + 2 H2O

  Catalysed by PHOSPHO1, CHDH, SUOXcytosol

• 3'-deoxy-3',4'-didehydro-CTPReach from here →
  1. Phosphocholine phosphohydrolase
  2. choline + A = betaine aldehyde + AH2
  3. CTP + AH2 + S-adenosyl-L-methionine = 3'-deoxy-3',4'-didehydro-CTP + 5'-deoxyadenosine + L-methionine + A + H2O + H(+)

  Catalysed by PHOSPHO1, CHDH, RSAD2cytosol

• (S)-2-hydroxyglutarateReach from here →
  1. Phosphocholine phosphohydrolase
  2. choline + A = betaine aldehyde + AH2
  3. (S)-2-hydroxyglutarate + A = 2-oxoglutarate + AH2

  Catalysed by PHOSPHO1, CHDH, L2HGDHcytosol

• CHEBI:16856Reach from here →
  1. Phosphocholine phosphohydrolase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. transport of acetylcholine and GSH (cytosol to extracellular)

  Catalysed by PHOSPHO1, CHAT, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 2 routes

• CHEBI:16857Reach from here →
  1. Phosphocholine phosphohydrolase
  2. transport of chloride and choline (cytosol to extracellular)
  3. Transport of L-Threonine by Atb0 Transporter

  Catalysed by PHOSPHO1, SLC5A7, SLC6A14cytosol, extracellular space

• oxalic acidReach from here →
  1. Phosphocholine phosphohydrolase
  2. transport of chloride and choline (cytosol to extracellular)
  3. transport of chloride and oxalate (cytosol to extracellular)

  Catalysed by PHOSPHO1, SLC5A7, SLC26A6cytosol, extracellular space

• a cholesterol esterReach from here →
  1. CTP:choline-phosphate cytidylyltransferase
  2. diacylglycerol cholinephosphotransferase (1,2-diacylglycerol-LD-PC pool)
  3. Phosphatidylcholine:sterol O-acyltransferase

  Catalysed by PCYT1A, PCYT1B, CHPT1, CEPT1 and 1 morecytosolOne of 2 routes

• L-isoleucineReach from here →
  1. Phosphocholine phosphohydrolase
  2. transport of chloride and choline (cytosol to extracellular)
  3. transport of chloride and isoleucine (cytosol to extracellular)

  Catalysed by PHOSPHO1, SLC5A7, SLC6A14cytosol, extracellular spaceOne of 2 routes

• CHEBI:17203Reach from here →
  1. Phosphocholine phosphohydrolase
  2. transport of chloride and choline (cytosol to extracellular)
  3. Transport of L-Proline by the Apical Imino Amino Acid Transporters

  Catalysed by PHOSPHO1, SLC5A7, CLTRN, SLC6A20cytosol, extracellular spaceOne of 2 routes

• anilineReach from here →
  1. Phosphocholine phosphohydrolase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. Acetyl-CoA:arylamine N-acetyltransferase

  Catalysed by PHOSPHO1, CHAT, NAT2, NAT1cytosol

• CHEBI:17312Reach from here →
  1. Phosphocholine phosphohydrolase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. N1,N12-diacetylspermine to N1-acetylspermine conversion

  Catalysed by PHOSPHO1, CHATcytosolOne of 2 routes

• 5'-deoxyadenosineReach from here →
  1. Phosphocholine phosphohydrolase
  2. choline + A = betaine aldehyde + AH2
  3. N(6)-dimethylallyladenosine(37) in tRNA + (sulfur carrier)-SH + AH2 + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-dimethylallyladenosine(37) in tRNA + (sulfur carrier)-H + 5'-deoxyadenosine + L-methionine + A + S-adenosyl-L-homocysteine + 2 H(+)

  Catalysed by PHOSPHO1, CHDH, CDK5RAP1cytosolOne of 4 routes

• 1-O-acyl-sn-glycero-3-phosphocholine(1+)Reach from here →
  1. CTP:choline-phosphate cytidylyltransferase
  2. diacylglycerol cholinephosphotransferase (1,2-diacylglycerol-LD-PC pool)
  3. phosphatidylcholine 2-acylhydrolase

  Catalysed by PCYT1A, PCYT1B, CHPT1, CEPT1 and 18 morecytosol, endoplasmic reticulumOne of 8 routes

• L-cysteineReach from here →
  1. Phosphocholine phosphohydrolase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. N-acetylglutamate synthase (N-acetyl-L-cysteine)

  Catalysed by PHOSPHO1, CHAT, NAGScytosol, mitochondrial matrixOne of 3 routes

• 3,3',5'-triiodo-L-thyronine sulfateReach from here →
  1. Phosphocholine phosphohydrolase
  2. choline + A = betaine aldehyde + AH2
  3. 3,3',5'-triiodo-L-thyronine sulfate + iodide + A + H(+) = L-thyroxine sulfate + AH2

  Catalysed by PHOSPHO1, CHDH, DIO1cytosol

• 3,3'-diiodo-L-thyronineReach from here →
  1. Phosphocholine phosphohydrolase
  2. choline + A = betaine aldehyde + AH2
  3. 3,3'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5-triiodo-L-thyronine + AH2

  Catalysed by PHOSPHO1, CHDH, DIO1, DIO3cytosolOne of 2 routes

• 3,3'-diiodo-L-thyronine sulfateReach from here →
  1. Phosphocholine phosphohydrolase
  2. choline + A = betaine aldehyde + AH2
  3. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5-triiodo-L-thyronine sulfate + AH2

  Catalysed by PHOSPHO1, CHDH, DIO1cytosolOne of 2 routes

• (7Z,10Z,13Z)-hexadecatrienoyl-CoAReach from here →
  1. Phosphocholine phosphohydrolase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. Fatty Acid Beta Oxidation (C18:3->C16:3), Mitochondrial

  Catalysed by PHOSPHO1, CHAT, HADHA, ACADVL and 1 morecytosol, mitochondrial matrix

• glycine betaineReach from here →
  1. Phosphocholine phosphohydrolase
  2. choline dehydrogenase (choline)
  3. p-cumic alcohol:NAD+ oxidoreductase

  Catalysed by PHOSPHO1, CHDH, ALDH7A1cytosolOne of 7 routes

• a 1,2-diacyl-sn-glycerolReach from here →
  1. CTP:choline-phosphate cytidylyltransferase
  2. diacylglycerol cholinephosphotransferase (1,2-diacylglycerol-LD-PC pool)
  3. ceramide:phosphatidylcholine cholinephosphotransferase

  Catalysed by PCYT1A, PCYT1B, CHPT1, CEPT1 and 2 morecytosol, Golgi apparatusOne of 4 routes

• a triacylglycerolReach from here →
  1. CTP:choline-phosphate cytidylyltransferase
  2. diacylglycerol cholinephosphotransferase (1-alkyl-2-acylglycerol)
  3. a 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + a 1,2-diacylglycerol = a 1-O-alkyl-sn-glycero-3-phosphocholine + a triacylglycerol

  Catalysed by PCYT1A, PCYT1B, CHPT1, CEPT1 and 1 morecytosol

• CHEBI:17895Reach from here →
  1. Phosphocholine phosphohydrolase
  2. transport of chloride and choline (cytosol to extracellular)
  3. Transport of L-Tyrosine by Atb0 Transporter

  Catalysed by PHOSPHO1, SLC5A7, SLC6A14cytosol, extracellular spaceOne of 2 routes

• CHEBI:17927Reach from here →
  1. Phosphocholine phosphohydrolase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. N1,N8-diacetylspermidine to N1-acetylspermidine conversion

  Catalysed by PHOSPHO1, CHATcytosol

• CHEBI:18019Reach from here →
  1. Phosphocholine phosphohydrolase
  2. transport of chloride and choline (cytosol to extracellular)
  3. transport of chloride and lysine (cytosol to extracellular)

  Catalysed by PHOSPHO1, SLC5A7, SLC6A14cytosol, extracellular space

• L-glutamineReach from here →
  1. Phosphocholine phosphohydrolase
  2. transport of chloride and choline (cytosol to extracellular)
  3. Transport of L-Glutamine by Atb0 Transporter

  Catalysed by PHOSPHO1, SLC5A7, SLC6A14cytosol, extracellular space

• CHEBI:18095Reach from here →
  1. Phosphocholine phosphohydrolase
  2. transport of chloride and choline (cytosol to extracellular)
  3. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)

  Catalysed by PHOSPHO1, SLC5A7, CLTRN, SLC6A20cytosol, extracellular space

• N-carbamoyl-beta-alanineReach from here →
  1. Phosphocholine phosphohydrolase
  2. transport of chloride and choline (cytosol to extracellular)
  3. Transport of 3-Ureidopropionate

  Catalysed by PHOSPHO1, SLC5A7cytosol, extracellular spaceOne of 2 routes

• phosphatidyl-L-serineReach from here →
  1. CTP:choline-phosphate cytidylyltransferase
  2. diacylglycerol cholinephosphotransferase (1,2-diacylglycerol-LD-PC pool)
  3. phosphatidylserine synthase (PC-LD pool)

  Catalysed by PCYT1A, PCYT1B, CHPT1, CEPT1 and 1 morecytosol

• 3',5'-diiodo-L-thyronineReach from here →
  1. Phosphocholine phosphohydrolase
  2. choline + A = betaine aldehyde + AH2
  3. 3',5'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine + AH2

  Catalysed by PHOSPHO1, CHDH, DIO3cytosol

• (5Z)-dodecenoyl-CoAReach from here →
  1. Phosphocholine phosphohydrolase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. acetyl-CoA C-acyltransferase (3-oxomyrist-7-enoyl-CoA)

  Catalysed by PHOSPHO1, CHAT, HADHA, ACAA2 and 1 morecytosol, mitochondrial matrixOne of 2 routes

• 3-iodothyronamineReach from here →
  1. Phosphocholine phosphohydrolase
  2. choline + A = betaine aldehyde + AH2
  3. 3-iodothyronamine + iodide + A + H(+) = 3,5-diiodothyronamine + AH2

  Catalysed by PHOSPHO1, CHDH, DIO1, DIO3cytosolOne of 2 routes

• (11Z)-docosenoyl-CoA(4-)Reach from here →
  1. Phosphocholine phosphohydrolase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (cis-cetoleic acid)

  Catalysed by PHOSPHO1, CHAT, SLC27A2, ACSL4 and 6 morecytosolOne of 5 routes

• 3-iodo-L-thyronineReach from here →
  1. Phosphocholine phosphohydrolase
  2. choline + A = betaine aldehyde + AH2
  3. 3-iodo-L-thyronine + iodide + A + H(+) = 3,5-diiodo-L-thyronine + AH2

  Catalysed by PHOSPHO1, CHDH, DIO1, DIO3cytosolOne of 2 routes

• (7Z)-tetradecenoyl-CoAReach from here →
  1. Phosphocholine phosphohydrolase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase ((7Z)-tetradecenoic acid)

  Catalysed by PHOSPHO1, CHAT, SLC27A2, ACSL4 and 6 morecytosolOne of 8 routes

• 3'-iodo-L-thyronineReach from here →
  1. Phosphocholine phosphohydrolase
  2. choline + A = betaine aldehyde + AH2
  3. 3'-iodo-L-thyronine + iodide + A + H(+) = 3',5'-diiodo-L-thyronine + AH2

  Catalysed by PHOSPHO1, CHDH, DIO1, DIO2cytosolOne of 2 routes

• L-thyronineReach from here →
  1. Phosphocholine phosphohydrolase
  2. choline + A = betaine aldehyde + AH2
  3. L-thyronine + iodide + A + H(+) = 3-iodo-L-thyronine + AH2

  Catalysed by PHOSPHO1, CHDH, DIO3cytosol

• thyronamineReach from here →
  1. Phosphocholine phosphohydrolase
  2. choline + A = betaine aldehyde + AH2
  3. thyronamine + iodide + A + H(+) = 3-iodothyronamine + AH2

  Catalysed by PHOSPHO1, CHDH, DIO3cytosol

• 3'-iodothyronamineReach from here →
  1. Phosphocholine phosphohydrolase
  2. choline + A = betaine aldehyde + AH2
  3. 3'-iodothyronamine + iodide + A + H(+) = 3',5'-diiodothyronamine + AH2

  Catalysed by PHOSPHO1, CHDH, DIO1, DIO2cytosolOne of 2 routes

• 3,3'-diiodothyronamineReach from here →
  1. Phosphocholine phosphohydrolase
  2. choline + A = betaine aldehyde + AH2
  3. 3,3'-diiodothyronamine + iodide + A + H(+) = 3,3',5'-triiodothyronamine + AH2

  Catalysed by PHOSPHO1, CHDH, DIO1, DIO2cytosolOne of 2 routes

• 3',5'-diiodothyronamineReach from here →
  1. Phosphocholine phosphohydrolase
  2. choline + A = betaine aldehyde + AH2
  3. 3',5'-diiodothyronamine + iodide + A + H(+) = 3,3',5'-triiodothyronamine + AH2

  Catalysed by PHOSPHO1, CHDH, DIO3cytosol

• 3,3',5'-triiodothyronamineReach from here →
  1. Phosphocholine phosphohydrolase
  2. choline + A = betaine aldehyde + AH2
  3. 3,3',5'-triiodothyronamine + iodide + A + H(+) = 3,3',5,5'-tetraiodothyronamine + AH2

  Catalysed by PHOSPHO1, CHDH, DIO3cytosol

• (4Z,7Z,10Z,13Z)-hexadecatetraenoyl-CoAReach from here →
  1. Phosphocholine phosphohydrolase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. Fatty Acid Beta Oxidation (C18:4->C16:4), Mitochondrial

  Catalysed by PHOSPHO1, CHAT, HADHA, ACADVL and 1 morecytosol, mitochondrial matrixOne of 3 routes

• (7Z,10Z)-hexadecadienoyl-CoAReach from here →
  1. Phosphocholine phosphohydrolase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. Fatty Acid Beta Oxidation Trans (C18:2->C16:2), Mitochondrial

  Catalysed by PHOSPHO1, CHAT, HADHA, ACADVL and 1 morecytosol, mitochondrial matrix

• (4Z,7Z)-decadienoyl-CoAReach from here →
  1. Phosphocholine phosphohydrolase
  2. Acetyl-CoA:choline O-acetyltransferase
  3. Fatty Acid Beta Oxidation (C12:3->C10:2), Mitochondrial

  Catalysed by PHOSPHO1, CHAT, ECHS1, ACAA2 and 1 morecytosol, mitochondrial matrixOne of 2 routes