O-octanoyl-(R)-carnitine

Three steps

• CHEBI:16856Reach from here →
  1. solute carrier (L-carnitine)
  2. Utilized Transport
  3. transport of arachidonate and GSH (cytosol to extracellular)

  Catalysed by SLC25A20mitochondrial matrix, cytosol, endoplasmic reticulum, extracellular spaceOne of 2 routes

• CHEBI:16857Reach from here →
  1. solute carrier (L-carnitine)
  2. Carnitine Transport by Atb0
  3. Transport of L-Threonine by Atb0 Transporter

  Catalysed by SLC25A20, SLC6A14mitochondrial matrix, cytosol, extracellular space

• oxalic acidReach from here →
  1. solute carrier (L-carnitine)
  2. Carnitine Transport by Atb0
  3. transport of chloride and oxalate (cytosol to extracellular)

  Catalysed by SLC25A20, SLC6A14, SLC26A6mitochondrial matrix, cytosol, extracellular space

• L-isoleucineReach from here →
  1. solute carrier (L-carnitine)
  2. Carnitine Transport by Atb0
  3. transport of chloride and isoleucine (cytosol to extracellular)

  Catalysed by SLC25A20, SLC6A14mitochondrial matrix, cytosol, extracellular spaceOne of 2 routes

• CHEBI:17203Reach from here →
  1. solute carrier (L-carnitine)
  2. Carnitine Transport by Atb0
  3. Transport of L-Proline by the Apical Imino Amino Acid Transporters

  Catalysed by SLC25A20, SLC6A14, CLTRN, SLC6A20mitochondrial matrix, cytosol, extracellular spaceOne of 2 routes

• itaconateReach from here →
  1. O-octanoyl-(R)-carnitine(in) + (R)-carnitine(out) = O-octanoyl-(R)-carnitine(out) + (R)-carnitine(in)
  2. glutarate(in) + (R)-carnitine(out) = glutarate(out) + (R)-carnitine(in)
  3. itaconate + glutaryl-CoA = itaconyl-CoA + glutarate

  Catalysed by SLC25A20, SLC22A8, SUGCTinner side of the membrane, outer side of the membrane

• anilineReach from here →
  1. solute carrier (L-carnitine)
  2. Carnitine O-Palmitoyltransferase
  3. Acetyl-CoA:arylamine N-acetyltransferase

  Catalysed by SLC25A20, CPT1A, CPT1C, CPT1B and 2 moremitochondrial matrix, cytosol

• CHEBI:17312Reach from here →
  1. solute carrier (L-carnitine)
  2. Carnitine O-Palmitoyltransferase
  3. N1,N12-diacetylspermine to N1-acetylspermine conversion

  Catalysed by SLC25A20, CPT1A, CPT1C, CPT1Bmitochondrial matrix, cytosolOne of 2 routes

• 3-hydroxy-3-methylglutarateReach from here →
  1. O-octanoyl-(R)-carnitine(in) + (R)-carnitine(out) = O-octanoyl-(R)-carnitine(out) + (R)-carnitine(in)
  2. glutarate(in) + (R)-carnitine(out) = glutarate(out) + (R)-carnitine(in)
  3. 3-hydroxy-3-methylglutarate + glutaryl-CoA = (3S)-3-hydroxy-3-methylglutaryl-CoA + glutarate

  Catalysed by SLC25A20, SLC22A8, SUGCTinner side of the membrane, outer side of the membrane

• L-cysteineReach from here →
  1. solute carrier (L-carnitine)
  2. Carnitine O-Palmitoyltransferase
  3. N-acetylglutamate synthase (N-acetyl-L-cysteine)

  Catalysed by SLC25A20, CPT1A, CPT1C, CPT1B and 1 moremitochondrial matrix, cytosolOne of 3 routes

• hexadecanalReach from here →
  1. solute carrier (L-carnitine)
  2. Utilized Transport
  3. 2 H+[c] + NADH[c] + palmitate[c] = H2O[c] + hexadecanal[c] + NAD+[c]

  Catalysed by SLC25A20, ALDH3B1, ALDH3B2, ALDH3A2mitochondrial matrix, cytosol, endoplasmic reticulumOne of 2 routes

• (7Z,10Z,13Z)-hexadecatrienoyl-CoAReach from here →
  1. solute carrier (L-carnitine)
  2. Carnitine O-Palmitoyltransferase
  3. Fatty Acid Beta Oxidation (C18:3->C16:3), Mitochondrial

  Catalysed by SLC25A20, CPT1A, CPT1C, CPT1B and 3 moremitochondrial matrix, cytosol

• CHEBI:17724Reach from here →
  1. O-octanoyl-(R)-carnitine(in) + (R)-carnitine(out) = O-octanoyl-(R)-carnitine(out) + (R)-carnitine(in)
  2. glycine betaine(out) + (R)-carnitine(in) = glycine betaine(in) + (R)-carnitine(out)
  3. Trimethylaminoacetate:L-homosysteine S-methyltransferase

  Catalysed by SLC25A20, SLC22A5, BHMT, BHMT2inner side of the membrane, outer side of the membrane, cytosol

• urateReach from here →
  1. O-octanoyl-(R)-carnitine(in) + (R)-carnitine(out) = O-octanoyl-(R)-carnitine(out) + (R)-carnitine(in)
  2. glutarate(in) + (R)-carnitine(out) = glutarate(out) + (R)-carnitine(in)
  3. urate(in) + glutarate(out) = urate(out) + glutarate(in)

  Catalysed by SLC25A20, SLC22A8inner side of the membrane, outer side of the membraneOne of 2 routes

• CHEBI:17895Reach from here →
  1. solute carrier (L-carnitine)
  2. Carnitine Transport by Atb0
  3. Transport of L-Tyrosine by Atb0 Transporter

  Catalysed by SLC25A20, SLC6A14mitochondrial matrix, cytosol, extracellular spaceOne of 2 routes

• CHEBI:17927Reach from here →
  1. solute carrier (L-carnitine)
  2. Carnitine O-Palmitoyltransferase
  3. N1,N8-diacetylspermidine to N1-acetylspermidine conversion

  Catalysed by SLC25A20, CPT1A, CPT1C, CPT1Bmitochondrial matrix, cytosol

• butanoateReach from here →
  1. solute carrier (L-carnitine)
  2. transport of butyryl-CoA and L-carnitine (cytosol to mitochondria)
  3. butanoyl-CoA + H2O = butanoate + CoA + H(+)

  Catalysed by SLC25A20, SLC33A1, ESCO2, OXSM and 6 moremitochondrial matrix, cytosol

• CHEBI:18019Reach from here →
  1. solute carrier (L-carnitine)
  2. Carnitine Transport by Atb0
  3. transport of chloride and lysine (cytosol to extracellular)

  Catalysed by SLC25A20, SLC6A14mitochondrial matrix, cytosol, extracellular space

• L-glutamineReach from here →
  1. solute carrier (L-carnitine)
  2. Carnitine Transport by Atb0
  3. Transport of L-Glutamine by Atb0 Transporter

  Catalysed by SLC25A20, SLC6A14mitochondrial matrix, cytosol, extracellular space

• CHEBI:18095Reach from here →
  1. solute carrier (L-carnitine)
  2. Carnitine Transport by Atb0
  3. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)

  Catalysed by SLC25A20, SLC6A14, CLTRN, SLC6A20mitochondrial matrix, cytosol, extracellular space

• N-carbamoyl-beta-alanineReach from here →
  1. solute carrier (L-carnitine)
  2. Carnitine Transport by Atb0
  3. Transport of 3-Ureidopropionate

  Catalysed by SLC25A20, SLC6A14mitochondrial matrix, cytosol, extracellular spaceOne of 2 routes

• 5alpha-androstane-3alpha,17beta-diol 3-O-(beta-D-glucuronate)Reach from here →
  1. O-octanoyl-(R)-carnitine(in) + (R)-carnitine(out) = O-octanoyl-(R)-carnitine(out) + (R)-carnitine(in)
  2. glutarate(in) + (R)-carnitine(out) = glutarate(out) + (R)-carnitine(in)
  3. 5alpha-androstane-3alpha,17beta-diol 3-O-(beta-D-glucuronate)(out) + glutarate(in) = 5alpha-androstane-3alpha,17beta-diol 3-O-(beta-D-glucuronate)(in) + glutarate(out)

  Catalysed by SLC25A20, SLC22A8, SLC22A24inner side of the membrane, outer side of the membraneOne of 2 routes

• 1-butanoyl-2-(9Z-octadecenoyl)-glycerolReach from here →
  1. solute carrier (L-carnitine)
  2. transport of butyryl-CoA and L-carnitine (cytosol to mitochondria)
  3. 2-(9Z-octadecenoyl)-glycerol + butanoyl-CoA = 1-butanoyl-2-(9Z-octadecenoyl)-glycerol + CoA

  Catalysed by SLC25A20, SLC33A1, ESCO2, OXSM and 2 moremitochondrial matrix, cytosol

• (5Z)-dodecenoyl-CoAReach from here →
  1. solute carrier (L-carnitine)
  2. Carnitine O-Palmitoyltransferase
  3. acetyl-CoA C-acyltransferase (3-oxomyrist-7-enoyl-CoA)

  Catalysed by SLC25A20, CPT1A, CPT1C, CPT1B and 3 moremitochondrial matrix, cytosolOne of 2 routes

• O-[(5Z),(8Z),(11Z),(14Z)-eicosatetraenoyl]-beta-D-glucuronateReach from here →
  1. solute carrier (L-carnitine)
  2. Utilized Transport
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + UDP-alpha-D-glucuronate = O-[(5Z),(8Z),(11Z),(14Z)-eicosatetraenoyl]-beta-D-glucuronate + UDP

  Catalysed by SLC25A20, UGT1A9, UGT2B7, UGT1A6 and 3 moremitochondrial matrix, cytosol, endoplasmic reticulum

• (11Z)-docosenoyl-CoA(4-)Reach from here →
  1. solute carrier (L-carnitine)
  2. Carnitine O-Palmitoyltransferase
  3. long-chain-fatty-acid-CoA ligase (cis-cetoleic acid)

  Catalysed by SLC25A20, CPT1A, CPT1C, CPT1B and 8 moremitochondrial matrix, cytosolOne of 5 routes

• (7Z)-tetradecenoyl-CoAReach from here →
  1. solute carrier (L-carnitine)
  2. Carnitine O-Palmitoyltransferase
  3. long-chain-fatty-acid-CoA ligase ((7Z)-tetradecenoic acid)

  Catalysed by SLC25A20, CPT1A, CPT1C, CPT1B and 8 moremitochondrial matrix, cytosolOne of 8 routes

• (4Z,7Z,10Z,13Z)-hexadecatetraenoyl-CoAReach from here →
  1. solute carrier (L-carnitine)
  2. Carnitine O-Palmitoyltransferase
  3. Fatty Acid Beta Oxidation (C18:4->C16:4), Mitochondrial

  Catalysed by SLC25A20, CPT1A, CPT1C, CPT1B and 3 moremitochondrial matrix, cytosolOne of 3 routes

• (7Z,10Z)-hexadecadienoyl-CoAReach from here →
  1. solute carrier (L-carnitine)
  2. Carnitine O-Palmitoyltransferase
  3. Fatty Acid Beta Oxidation Trans (C18:2->C16:2), Mitochondrial

  Catalysed by SLC25A20, CPT1A, CPT1C, CPT1B and 3 moremitochondrial matrix, cytosol

• (4Z,7Z)-decadienoyl-CoAReach from here →
  1. solute carrier (L-carnitine)
  2. Carnitine O-Palmitoyltransferase
  3. Fatty Acid Beta Oxidation (C12:3->C10:2), Mitochondrial

  Catalysed by SLC25A20, CPT1A, CPT1C, CPT1B and 3 moremitochondrial matrix, cytosolOne of 2 routes

• (5Z)-octenoyl-CoAReach from here →
  1. solute carrier (L-carnitine)
  2. Carnitine O-Palmitoyltransferase
  3. Fatty Acid Beta Oxidation (C10:2->C8:1), Mitochondrial

  Catalysed by SLC25A20, CPT1A, CPT1C, CPT1B and 3 moremitochondrial matrix, cytosolOne of 2 routes

• CHEBI:240943Reach from here →
  1. solute carrier (L-carnitine)
  2. Carnitine Transport by Atb0
  3. 2-Methylbutyrylglycine Transport, Extracellular

  Catalysed by SLC25A20, SLC6A14, SLC6A5mitochondrial matrix, cytosol, extracellular spaceOne of 2 routes

• hypochlorous acidReach from here →
  1. solute carrier (L-carnitine)
  2. Carnitine Transport by Atb0
  3. Peroxidase

  Catalysed by SLC25A20, SLC6A14, LPOmitochondrial matrix, cytosol, extracellular spaceOne of 4 routes

• octadecanoateReach from here →
  1. solute carrier (L-carnitine)
  2. Utilized Transport
  3. Fas180

  Catalysed by SLC25A20mitochondrial matrix, cytosol, endoplasmic reticulum

• potassium atomReach from here →
  1. solute carrier (L-carnitine)
  2. Carnitine Transport by Atb0
  3. transport of chloride (cytosol to extracellular)

  Catalysed by SLC25A20, SLC6A14, SLC12A2, SLC12A1mitochondrial matrix, cytosol, extracellular spaceOne of 2 routes

• N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamineReach from here →
  1. solute carrier (L-carnitine)
  2. Utilized Transport
  3. fatty acylamide amidohydrolase

  Catalysed by SLC25A20, FAAHmitochondrial matrix, cytosol, endoplasmic reticulum

• decanoateReach from here →
  1. Octanoyl-CoA:L-carnitine O-octanoyltransferase
  2. fatty acyl-CoA synthase (N-C10:0CoA)
  3. Decanoyl-CoA hydrolase

  Catalysed by CROT, ACOT7mitochondrial matrix, cytosolOne of 2 routes

• elaidic acidReach from here →
  1. solute carrier (L-carnitine)
  2. Carnitine O-Palmitoyltransferase
  3. long-chain-fatty-acid-CoA ligase (elaidate)

  Catalysed by SLC25A20, CPT1A, CPT1C, CPT1B and 8 moremitochondrial matrix, cytosolOne of 5 routes

• CHEBI:28701Reach from here →
  1. solute carrier (L-carnitine)
  2. Carnitine O-Palmitoyltransferase
  3. Propanoyl-CoA:acetyl-CoA C-acyltransferase

  Catalysed by SLC25A20, CPT1A, CPT1C, CPT1B and 3 moremitochondrial matrix, cytosol, peroxisomeOne of 7 routes

• glycocholateReach from here →
  1. O-octanoyl-(R)-carnitine(in) + (R)-carnitine(out) = O-octanoyl-(R)-carnitine(out) + (R)-carnitine(in)
  2. glutarate(in) + (R)-carnitine(out) = glutarate(out) + (R)-carnitine(in)
  3. glycocholate(out) + glutarate(in) = glycocholate(in) + glutarate(out)

  Catalysed by SLC25A20, SLC22A8, SLC22A24inner side of the membrane, outer side of the membraneOne of 2 routes

• formic acidReach from here →
  1. solute carrier (L-carnitine)
  2. Carnitine Transport by Atb0
  3. transport of chloride and formate (cytosol to extracellular)

  Catalysed by SLC25A20, SLC6A14, SLC26A4mitochondrial matrix, cytosol, extracellular spaceOne of 2 routes

• propionic acidReach from here →
  1. solute carrier (L-carnitine)
  2. Active Transport
  3. Propanoyl-CoA hydrolase

  Catalysed by SLC25A20, ACOT7mitochondrial matrix, cytosolOne of 3 routes

• butyric acidReach from here →
  1. solute carrier (L-carnitine)
  2. transport of butyryl-CoA and L-carnitine (cytosol to mitochondria)
  3. Butyryl-CoA hydrolase

  Catalysed by SLC25A20, SLC33A1, ESCO2, OXSM and 1 moremitochondrial matrix, cytosol

• malonic acidReach from here →
  1. solute carrier (L-carnitine)
  2. Carnitine Transport by Atb0
  3. Malonate Transport, Antiport with Chloride

  Catalysed by SLC25A20, SLC6A14mitochondrial matrix, cytosol, extracellular spaceOne of 2 routes

• adipic acidReach from here →
  1. O-octanoyl-(R)-carnitine(in) + (R)-carnitine(out) = O-octanoyl-(R)-carnitine(out) + (R)-carnitine(in)
  2. glutarate(in) + (R)-carnitine(out) = glutarate(out) + (R)-carnitine(in)
  3. hexanedioate + glutaryl-CoA = hexanedioyl-CoA + glutarate

  Catalysed by SLC25A20, SLC22A8, SUGCTinner side of the membrane, outer side of the membrane

• fatty acidReach from here →
  1. solute carrier (L-carnitine)
  2. Utilized Transport
  3. (10Z)-heptadecenoic acid formation

  Catalysed by SLC25A20mitochondrial matrix, cytosol, endoplasmic reticulumOne of 28 routes

• taurocholateReach from here →
  1. O-octanoyl-(R)-carnitine(in) + (R)-carnitine(out) = O-octanoyl-(R)-carnitine(out) + (R)-carnitine(in)
  2. glutarate(in) + (R)-carnitine(out) = glutarate(out) + (R)-carnitine(in)
  3. taurocholate(out) + glutarate(in) = taurocholate(in) + glutarate(out)

  Catalysed by SLC25A20, SLC22A8, SLC22A24inner side of the membrane, outer side of the membraneOne of 2 routes

• taurineReach from here →
  1. solute carrier (L-carnitine)
  2. Carnitine O-Palmitoyltransferase
  3. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)

  Catalysed by SLC25A20, CPT1A, CPT1C, CPT1B and 1 moremitochondrial matrix, cytosolOne of 4 routes

• 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerolReach from here →
  1. solute carrier (L-carnitine)
  2. Utilized Transport
  3. fatty acid amide hydrolase (2-arachidonoylglycerol)

  Catalysed by SLC25A20, FAAHmitochondrial matrix, cytosol, endoplasmic reticulum

• 1,2,3-tri-(9Z-octadecenoyl)-glycerolReach from here →
  1. solute carrier (L-carnitine)
  2. Utilized Transport
  3. 1,2-di-(9Z-octadecenoyl)-glycerol + (9Z)-octadecenoate + H(+) = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O

  Catalysed by SLC25A20, DGAT1, LIPA, PNPLA4 and 2 moremitochondrial matrix, cytosol, endoplasmic reticulum