1,2-diacyl-sn-glycero-3-phosphocholine(1+)

Three steps

• cholesteryl 3-beta-D-glucosideReach from here →
  1. Phosphatidylcholine:sterol O-acyltransferase
  2. a cholesterol ester + H2O = cholesterol + a fatty acid + H(+)
  3. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + an N-acylsphing-4-enine

  Catalysed by LCAT, CES1, LIPN, NCEH1 and 3 morecytosolOne of 7 routes

• 7alpha-hydroxycholesterolReach from here →
  1. Phosphatidylcholine:sterol O-acyltransferase
  2. a cholesterol ester + H2O = cholesterol + a fatty acid + H(+)
  3. cholesterol + reduced [NADPH--hemoprotein reductase] + O2 = 7alpha-hydroxycholesterol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

  Catalysed by LCAT, CES1, LIPN, NCEH1 and 2 morecytosol

• L-cysteineReach from here →
  1. phosphatidylcholine 2-acylhydrolase
  2. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  3. N-acetylglutamate synthase (N-acetyl-L-cysteine)

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 19 moreendoplasmic reticulum, cytosol, mitochondrial matrixOne of 3 routes

• hexadecanalReach from here →
  1. phosphatidylcholine 2-acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. 2 H+[c] + NADH[c] + palmitate[c] = H2O[c] + hexadecanal[c] + NAD+[c]

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 17 moreendoplasmic reticulum, extracellular space, cytosolOne of 2 routes

• all-trans-retinyl hexadecanoateReach from here →
  1. ceramide:phosphatidylcholine cholinephosphotransferase
  2. 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + an N-acylsphing-4-enine = 1,2-dihexadecanoyl-sn-glycerol + a sphingomyelin
  3. all-trans-retinol + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine = all-trans-retinyl hexadecanoate + 2-hexadecanoyl-sn-glycero-3-phosphocholine

  Catalysed by SGMS1, SGMS2, LRATGolgi apparatusOne of 5 routes

• 3,3',5'-triiodo-L-thyronine sulfateReach from here →
  1. phosphatidylserine synthase (PC-LD pool)
  2. choline + A = betaine aldehyde + AH2
  3. 3,3',5'-triiodo-L-thyronine sulfate + iodide + A + H(+) = L-thyroxine sulfate + AH2

  Catalysed by PTDSS1, CHDH, DIO1cytosol

• 3,3'-diiodo-L-thyronineReach from here →
  1. phosphatidylserine synthase (PC-LD pool)
  2. choline + A = betaine aldehyde + AH2
  3. 3,3'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5-triiodo-L-thyronine + AH2

  Catalysed by PTDSS1, CHDH, DIO1, DIO3cytosolOne of 2 routes

• 3,3'-diiodo-L-thyronine sulfateReach from here →
  1. phosphatidylserine synthase (PC-LD pool)
  2. choline + A = betaine aldehyde + AH2
  3. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5-triiodo-L-thyronine sulfate + AH2

  Catalysed by PTDSS1, CHDH, DIO1cytosolOne of 2 routes

• 26-hydroxycholesterolReach from here →
  1. Phosphatidylcholine:sterol O-acyltransferase
  2. a cholesterol ester + H2O = cholesterol + a fatty acid + H(+)
  3. cholesterol + reduced [NADPH--hemoprotein reductase] + O2 = 26-hydroxycholesterol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

  Catalysed by LCAT, CES1, LIPN, NCEH1 and 2 morecytosol

• (7Z,10Z,13Z)-hexadecatrienoyl-CoAReach from here →
  1. phosphatidylcholine 2-acylhydrolase
  2. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  3. Fatty Acid Beta Oxidation (C18:3->C16:3), Mitochondrial

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 21 moreendoplasmic reticulum, cytosol, mitochondrial matrix

• glycine betaineReach from here →
  1. phosphatidylserine synthase (PC-LD pool)
  2. choline dehydrogenase (choline)
  3. p-cumic alcohol:NAD+ oxidoreductase

  Catalysed by PTDSS1, CHDH, ALDH7A1cytosolOne of 7 routes

• glycerolReach from here →
  1. phosphatidylcholine 2-acylhydrolase
  2. 1-Acyl-sn-glycero-3-phosphocholine acylhydrolase
  3. sn-glycerol 3-phosphocholine + H2O = phosphocholine + glycerol + H(+)

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 23 moreendoplasmic reticulum, cytosolOne of 3 routes

• CHEBI:17895Reach from here →
  1. phosphatidylserine synthase (PC-LD pool)
  2. transport of chloride and choline (cytosol to extracellular)
  3. Transport of L-Tyrosine by Atb0 Transporter

  Catalysed by PTDSS1, SLC5A7, SLC6A14cytosol, extracellular spaceOne of 2 routes

• all-trans-retinalReach from here →
  1. Lecithin Retinol Acyltransferase
  2. carboxylesterase (retinyl-ester)
  3. retinol: NADP+ oxidoreductase

  Catalysed by LRAT, CES2, RBP4, LIPF and 23 morecytosolOne of 6 routes

• CHEBI:17927Reach from here →
  1. phosphatidylcholine 2-acylhydrolase
  2. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  3. N1,N8-diacetylspermidine to N1-acetylspermidine conversion

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 18 moreendoplasmic reticulum, cytosol

• 4-methylpentanalReach from here →
  1. Phosphatidylcholine:sterol O-acyltransferase
  2. a cholesterol ester + H2O = cholesterol + a fatty acid + H(+)
  3. 6 reduced [adrenodoxin] + cholesterol + 3 O2 + 6 H(+) = 4-methylpentanal + pregnenolone + 6 oxidized [adrenodoxin] + 4 H2O

  Catalysed by LCAT, CES1, LIPN, NCEH1 and 2 morecytosol

• CHEBI:18019Reach from here →
  1. phosphatidylserine synthase (PC-LD pool)
  2. transport of chloride and choline (cytosol to extracellular)
  3. transport of chloride and lysine (cytosol to extracellular)

  Catalysed by PTDSS1, SLC5A7, SLC6A14cytosol, extracellular space

• a diacylglycerolReach from here →
  1. ceramide:phosphatidylcholine cholinephosphotransferase
  2. acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
  3. a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+)

  Catalysed by SGMS1, SGMS2, DGAT1, MOGAT2 and 22 moreGolgi apparatus, cytosolOne of 3 routes

• L-glutamineReach from here →
  1. phosphatidylserine synthase (PC-LD pool)
  2. transport of chloride and choline (cytosol to extracellular)
  3. Transport of L-Glutamine by Atb0 Transporter

  Catalysed by PTDSS1, SLC5A7, SLC6A14cytosol, extracellular space

• CHEBI:18095Reach from here →
  1. phosphatidylserine synthase (PC-LD pool)
  2. transport of chloride and choline (cytosol to extracellular)
  3. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)

  Catalysed by PTDSS1, SLC5A7, CLTRN, SLC6A20cytosol, extracellular space

• N-carbamoyl-beta-alanineReach from here →
  1. phosphatidylserine synthase (PC-LD pool)
  2. transport of chloride and choline (cytosol to extracellular)
  3. Transport of 3-Ureidopropionate

  Catalysed by PTDSS1, SLC5A7cytosol, extracellular spaceOne of 2 routes

• D-glucosyl-N-acylsphingosineReach from here →
  1. ceramide:phosphatidylcholine cholinephosphotransferase
  2. an N-acylsphing-4-enine + a 1,2-diacyl-sn-glycero-3-phosphocholine = a sphingomyelin + a 1,2-diacyl-sn-glycerol
  3. UDP-glucose:N-acylsphingosine D-glucosyltransferase

  Catalysed by SGMS1, SGMS2, UGCGGolgi apparatus, cytosolOne of 2 routes

• a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enineReach from here →
  1. ceramide:phosphatidylcholine cholinephosphotransferase
  2. an N-acylsphing-4-enine + a 1,2-diacyl-sn-glycero-3-phosphocholine = a sphingomyelin + a 1,2-diacyl-sn-glycerol
  3. an N-acylsphing-4-enine + UDP-alpha-D-galactose = a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + UDP + H(+)

  Catalysed by SGMS1, SGMS2, UGT8Golgi apparatusOne of 2 routes

• cholesteryl 3-beta-D-galactosideReach from here →
  1. Phosphatidylcholine:sterol O-acyltransferase
  2. a cholesterol ester + H2O = cholesterol + a fatty acid + H(+)
  3. a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-galactoside + an N-acylsphing-4-enine

  Catalysed by LCAT, CES1, LIPN, NCEH1 and 3 morecytosolOne of 2 routes

• cholesteryl 3-beta-D-xylosideReach from here →
  1. Phosphatidylcholine:sterol O-acyltransferase
  2. a cholesterol ester + H2O = cholesterol + a fatty acid + H(+)
  3. a beta-D-xylosyl-(1<->1')-N-acylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-xyloside + an N-acylsphing-4-enine

  Catalysed by LCAT, CES1, LIPN, NCEH1 and 3 morecytosolOne of 2 routes

• a beta-D-xylosyl-(1<->1')-N-acylsphing-4-enineReach from here →
  1. ceramide:phosphatidylcholine cholinephosphotransferase
  2. an N-acylsphing-4-enine + a 1,2-diacyl-sn-glycero-3-phosphocholine = a sphingomyelin + a 1,2-diacyl-sn-glycerol
  3. a beta-D-xylosyl-(1<->1')-N-acylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-xyloside + an N-acylsphing-4-enine

  Catalysed by SGMS1, SGMS2, GBA1, GBA3Golgi apparatusOne of 2 routes

• 11-cis-retinyl esterReach from here →
  1. Lecithin Retinol Acyltransferase
  2. all-trans-retinyl ester acylhydrolase, 11-cis-retinol forming
  3. 11-cis-retinol + a fatty acyl-CoA = 11-cis-retinyl ester + CoA

  Catalysed by LRAT, RPE65, AWAT2cytosol

• (5S)-hydroperoxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoateReach from here →
  1. phosphatidylcholine 2-acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 = (5S)-hydroperoxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 15 moreendoplasmic reticulum, extracellular space

• 3',5'-diiodo-L-thyronineReach from here →
  1. phosphatidylserine synthase (PC-LD pool)
  2. choline + A = betaine aldehyde + AH2
  3. 3',5'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine + AH2

  Catalysed by PTDSS1, CHDH, DIO3cytosol

• a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enineReach from here →
  1. ceramide:phosphatidylcholine cholinephosphotransferase
  2. an N-acylsphing-4-enine + a 1,2-diacyl-sn-glycero-3-phosphocholine = a sphingomyelin + a 1,2-diacyl-sn-glycerol
  3. an N-acylsphing-4-enine + UDP-alpha-D-glucose = a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + UDP + H(+)

  Catalysed by SGMS1, SGMS2, UGCGGolgi apparatusOne of 2 routes

• (5Z)-dodecenoyl-CoAReach from here →
  1. phosphatidylcholine 2-acylhydrolase
  2. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  3. acetyl-CoA C-acyltransferase (3-oxomyrist-7-enoyl-CoA)

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 21 moreendoplasmic reticulum, cytosol, mitochondrial matrixOne of 2 routes

• O-[(5Z),(8Z),(11Z),(14Z)-eicosatetraenoyl]-beta-D-glucuronateReach from here →
  1. phosphatidylcholine 2-acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + UDP-alpha-D-glucuronate = O-[(5Z),(8Z),(11Z),(14Z)-eicosatetraenoyl]-beta-D-glucuronate + UDP

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 20 moreendoplasmic reticulum, extracellular space

• 3-iodothyronamineReach from here →
  1. phosphatidylserine synthase (PC-LD pool)
  2. choline + A = betaine aldehyde + AH2
  3. 3-iodothyronamine + iodide + A + H(+) = 3,5-diiodothyronamine + AH2

  Catalysed by PTDSS1, CHDH, DIO1, DIO3cytosolOne of 2 routes

• (11Z)-docosenoyl-CoA(4-)Reach from here →
  1. phosphatidylcholine 2-acylhydrolase
  2. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  3. long-chain-fatty-acid-CoA ligase (cis-cetoleic acid)

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 26 moreendoplasmic reticulum, cytosolOne of 5 routes

• 3-iodo-L-thyronineReach from here →
  1. phosphatidylserine synthase (PC-LD pool)
  2. choline + A = betaine aldehyde + AH2
  3. 3-iodo-L-thyronine + iodide + A + H(+) = 3,5-diiodo-L-thyronine + AH2

  Catalysed by PTDSS1, CHDH, DIO1, DIO3cytosolOne of 2 routes

• (7Z)-tetradecenoyl-CoAReach from here →
  1. phosphatidylcholine 2-acylhydrolase
  2. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  3. long-chain-fatty-acid-CoA ligase ((7Z)-tetradecenoic acid)

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 26 moreendoplasmic reticulum, cytosolOne of 8 routes

• 3'-iodo-L-thyronineReach from here →
  1. phosphatidylserine synthase (PC-LD pool)
  2. choline + A = betaine aldehyde + AH2
  3. 3'-iodo-L-thyronine + iodide + A + H(+) = 3',5'-diiodo-L-thyronine + AH2

  Catalysed by PTDSS1, CHDH, DIO1, DIO2cytosolOne of 2 routes

• L-thyronineReach from here →
  1. phosphatidylserine synthase (PC-LD pool)
  2. choline + A = betaine aldehyde + AH2
  3. L-thyronine + iodide + A + H(+) = 3-iodo-L-thyronine + AH2

  Catalysed by PTDSS1, CHDH, DIO3cytosol

• thyronamineReach from here →
  1. phosphatidylserine synthase (PC-LD pool)
  2. choline + A = betaine aldehyde + AH2
  3. thyronamine + iodide + A + H(+) = 3-iodothyronamine + AH2

  Catalysed by PTDSS1, CHDH, DIO3cytosol

• 3'-iodothyronamineReach from here →
  1. phosphatidylserine synthase (PC-LD pool)
  2. choline + A = betaine aldehyde + AH2
  3. 3'-iodothyronamine + iodide + A + H(+) = 3',5'-diiodothyronamine + AH2

  Catalysed by PTDSS1, CHDH, DIO1, DIO2cytosolOne of 2 routes

• 3,3'-diiodothyronamineReach from here →
  1. phosphatidylserine synthase (PC-LD pool)
  2. choline + A = betaine aldehyde + AH2
  3. 3,3'-diiodothyronamine + iodide + A + H(+) = 3,3',5'-triiodothyronamine + AH2

  Catalysed by PTDSS1, CHDH, DIO1, DIO2cytosolOne of 2 routes

• 3',5'-diiodothyronamineReach from here →
  1. phosphatidylserine synthase (PC-LD pool)
  2. choline + A = betaine aldehyde + AH2
  3. 3',5'-diiodothyronamine + iodide + A + H(+) = 3,3',5'-triiodothyronamine + AH2

  Catalysed by PTDSS1, CHDH, DIO3cytosol

• 3,3',5'-triiodothyronamineReach from here →
  1. phosphatidylserine synthase (PC-LD pool)
  2. choline + A = betaine aldehyde + AH2
  3. 3,3',5'-triiodothyronamine + iodide + A + H(+) = 3,3',5,5'-tetraiodothyronamine + AH2

  Catalysed by PTDSS1, CHDH, DIO3cytosol

• (4Z,7Z,10Z,13Z)-hexadecatetraenoyl-CoAReach from here →
  1. phosphatidylcholine 2-acylhydrolase
  2. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  3. Fatty Acid Beta Oxidation (C18:4->C16:4), Mitochondrial

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 21 moreendoplasmic reticulum, cytosol, mitochondrial matrixOne of 3 routes

• (7Z,10Z)-hexadecadienoyl-CoAReach from here →
  1. phosphatidylcholine 2-acylhydrolase
  2. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  3. Fatty Acid Beta Oxidation Trans (C18:2->C16:2), Mitochondrial

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 21 moreendoplasmic reticulum, cytosol, mitochondrial matrix

• (4Z,7Z)-decadienoyl-CoAReach from here →
  1. phosphatidylcholine 2-acylhydrolase
  2. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  3. Fatty Acid Beta Oxidation (C12:3->C10:2), Mitochondrial

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 21 moreendoplasmic reticulum, cytosol, mitochondrial matrixOne of 2 routes

• (5Z)-octenoyl-CoAReach from here →
  1. phosphatidylcholine 2-acylhydrolase
  2. Acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
  3. Fatty Acid Beta Oxidation (C10:2->C8:1), Mitochondrial

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 21 moreendoplasmic reticulum, cytosol, mitochondrial matrixOne of 2 routes

• CHEBI:240943Reach from here →
  1. phosphatidylserine synthase (PC-LD pool)
  2. transport of chloride and choline (cytosol to extracellular)
  3. 2-Methylbutyrylglycine Transport, Extracellular

  Catalysed by PTDSS1, SLC5A7, SLC6A5cytosol, extracellular spaceOne of 2 routes

• hypochlorous acidReach from here →
  1. phosphatidylserine synthase (PC-LD pool)
  2. transport of chloride and choline (cytosol to extracellular)
  3. Peroxidase

  Catalysed by PTDSS1, SLC5A7, LPOcytosol, extracellular spaceOne of 4 routes

• potassium atomReach from here →
  1. phosphatidylserine synthase (PC-LD pool)
  2. transport of chloride and choline (cytosol to extracellular)
  3. transport of chloride (cytosol to extracellular)

  Catalysed by PTDSS1, SLC5A7, SLC12A2, SLC12A1cytosol, extracellular spaceOne of 2 routes