(5S)-hydroperoxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

108 compounds within 3 steps: 3 in 1, 7 in 2, 98 in 3

One step

(5S)-hydroxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoateReach from here →
1. (5S)-hydroperoxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate + 2 glutathione = (5S)-hydroxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate + glutathione disulfide + H2O
Catalysed by GPX1, GPX4
leukotriene A5Reach from here →
1. (5S)-hydroperoxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate = leukotriene A5 + H2O
Catalysed by ALOX5
glutathione disulfideReach from here →
1. (5S)-hydroperoxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate + 2 glutathione = (5S)-hydroxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate + glutathione disulfide + H2O
Catalysed by GPX1, GPX4

Two steps

leukotriene B5Reach from here →
1. (5S)-hydroperoxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate = leukotriene A5 + H2O
2. leukotriene A4 hydrolase (leukotriene A5)
Catalysed by ALOX5, LTA4HcytosolOne of 2 routes
15(S)-HPETEReach from here →
1. (5S)-hydroperoxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate + 2 glutathione = (5S)-hydroxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate + glutathione disulfide + H2O
2. Glutathione: 15-HPETE oxidoreductase
Catalysed by GPX1, GPX4, GPX5, GPX2 and 5 morecytosol

Three steps

L-cystine

Reach from here →

Catalysed by GPX1, GPX4cytosol

CHEBI:16856Reach from here →

Catalysed by GPX1, GPX4, GPX5, GPX2 and 5 morecytosolOne of 7 routes

methylarsonateReach from here →

Catalysed by GPX1, GPX4, GSTO1, GSTO2

thiosulfateReach from here →

Catalysed by GPX1, GPX4, TSTD1

glutathioneReach from here →

Catalysed by GPX1, GPX4, GSROne of 4 routes

Catalysed by GPX1, GPX4, GSR, GPX2

tauroursodeoxycholateReach from here →

Catalysed by GPX1, GPX4, GPX5, GPX2 and 7 morecytosol, extracellular spaceOne of 3 routes

glycoursodeoxycholateReach from here →

Catalysed by GPX1, GPX4, GPX5, GPX2 and 7 morecytosol, extracellular spaceOne of 3 routes

(15S)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoateReach from here →

Catalysed by GPX1, GPX4, GPX5, GPX2 and 5 morecytosolOne of 2 routes

(11S,15S)-dihydroxy-14(R)-S-glutathionyl-(5Z,8Z,12E)-eicosatrienoateReach from here →

Catalysed by GPX1, GPX4, GPX5, GPX2 and 26 morecytosolOne of 5 routes

prostaglandin E3Reach from here →

Catalysed by GPX1, GPX4, GPX5, GPX2 and 6 morecytosol, extracellular spaceOne of 2 routes

prostaglandin A2Reach from here →

Catalysed by GPX1, GPX4, GPX5, GPX2 and 6 morecytosol, extracellular spaceOne of 2 routes

prostaglandin B1Reach from here →

Catalysed by GPX1, GPX4, GPX5, GPX2 and 6 morecytosol, extracellular spaceOne of 2 routes

leukotriene F4Reach from here →

Catalysed by GPX1, GPX4, GPX5, GPX2 and 5 morecytosol, extracellular spaceOne of 2 routes

prostaglandin A2-S-(R)-glutathioneReach from here →

Catalysed by GPX1, GPX4, GSR, GSTA1 and 1 more

prostaglandin A2-S-(S)-glutathioneReach from here →

Catalysed by GPX1, GPX4, GSR, GSTP1 and 1 more

prostaglandin J2-S-(R)-glutathioneReach from here →

Catalysed by GPX1, GPX4, GSR, GSTA1 and 2 more

prostaglandin J2-S-(S)-glutathioneReach from here →

Catalysed by GPX1, GPX4, GSR, GSTP1 and 1 more

2,4-dinitrophenyl-S-glutathioneReach from here →

Catalysed by GPX1, GPX4, GSR, PTGES and 3 more

(13R)-S-glutathionyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoateReach from here →

Catalysed by GPX1, GPX4, GSR, GSTM4 and 1 more

S-methyl glutathioneReach from here →

Catalysed by GPX1, GPX4, GSR, MMACHC

L-cystine-bis-glycineReach from here →

Catalysed by GPX1, GPX4, DPEP1, DPEP2cytosol

S-adenosylglutathioneReach from here →

Catalysed by GPX1, GPX4, GSR, MMACHC

acetylcholineReach from here →

Catalysed by GPX1, GPX4, GPX5, GPX2 and 7 morecytosol, extracellular spaceOne of 2 routes

pyruvateReach from here →

Catalysed by GPX1, GPX4, CTHcytosol

(S)-malateReach from here →

Catalysed by GPX1, GPX4, TSTD1, SLC25A10mitochondrial matrix, cytosolOne of 2 routes

L-leucineReach from here →

Catalysed by GPX1, GPX4, SLC7A9, SLC3A1cytosol, extracellular space

CHEBI:15650Reach from here →

Catalysed by GPX1, GPX4, GPX5, GPX2 and 6 morecytosol, extracellular spaceOne of 2 routes

bromideReach from here →

Catalysed by GPX1, GPX4, GPX5, GPX2 and 22 morecytosolOne of 2 routes

a halide anionReach from here →

Catalysed by GPX1, GPX4, GSR, GSTT4 and 22 more

sulfateReach from here →

Catalysed by GPX1, GPX4, TSTD1cytosolOne of 3 routes

lithocholic acidReach from here →

Catalysed by GPX1, GPX4, GPX5, GPX2 and 7 morecytosol, extracellular spaceOne of 2 routes

L-arginineReach from here →

Catalysed by GPX1, GPX4, SLC7A9cytosol, inner side of the membrane, outer side of the membrane

bilirubin IXalphaReach from here →

Catalysed by GPX1, GPX4, GPX5, GPX2 and 7 morecytosol, extracellular spaceOne of 2 routes

taurolithocholateReach from here →

Catalysed by GPX1, GPX4, GPX5, GPX2 and 7 morecytosol, extracellular spaceOne of 2 routes

CHEBI:17208Reach from here →

Catalysed by GPX1, GPX4, GPX5, GPX2 and 5 morecytosol

homocysteineReach from here →

Catalysed by GPX1, GPX4, GPX5, GPX2 and 5 morecytosol

sulfiteReach from here →

Catalysed by GPX1, GPX4, GSR, TSTD1One of 6 routes

L-cysteineReach from here →

Catalysed by GPX1, GPX4, GPX5, GPX2 and 5 morecytosolOne of 4 routes

urateReach from here →

Catalysed by GPX1, GPX4, GSR, SLC22A13inner side of the membrane, outer side of the membrane

methylarsonous acidReach from here →

Catalysed by GPX1, GPX4, GSR, GSTO1 and 1 moreOne of 2 routes

fumaric acidReach from here →

Catalysed by GPX1, GPX4, TSTD1, SLC25A10mitochondrial matrix, cytosolOne of 2 routes

thiocyanateReach from here →

Catalysed by GPX1, GPX4, TSTD1, MPST and 1 moremitochondrial matrixOne of 2 routes

arsenic triglutathioneReach from here →

Catalysed by GPX1, GPX4, GSR, AS3MTOne of 3 routes