CHEBI:15650

Three steps

• (2E)-butenoyl-CoAReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. Butanoate:CoA ligase (AMP-forming)
  3. butanoyl-CoA:electron-transfer flavoprotein 2,3-oxidoreductase

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 36 morecytosol, mitochondrial matrixOne of 4 routes

• 3-methyl-(2E)-glutaconyl-CoAReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. glycine-N-acyltransferase (3-methylcrotonoylglycine)
  3. 3-Methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 31 morecytosol, mitochondrial matrixOne of 2 routes

• 3-oxohexadecanoyl-CoAReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. long-chain-fatty-acid-CoA ligase (myristic acid)
  3. tetradecanoyl-CoA + malonyl-CoA + H(+) = 3-oxohexadecanoyl-CoA + CO2 + CoA

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 38 morecytosol

• (2E)-glutaconyl-CoAReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. Production of Glutaryl Carnitine
  3. glutaryl-CoA + O2 = (2E)-glutaconyl-CoA + H2O2

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 32 morecytosol

• acryloyl-CoAReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. Propanoate:CoA ligase (AMP-forming)
  3. medium-chain acyl-CoA dehydrogenase (propanoyl-CoA)

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 33 morecytosol, mitochondrial matrix

• (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoAReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. long-chain-fatty-acid-CoA ligase (dihomo-gamma-linolenate)
  3. (8Z,11Z,14Z)-eicosatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 37 morecytosolOne of 2 routes

• choloyl-CoAReach from here →
  1. transport of GSH and leukotriene E4 (cytosol to extracellular)
  2. solute carrier organic anion transporter (cholate)
  3. cholate + ATP + CoA = choloyl-CoA + AMP + diphosphate

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, SLC27A5extracellular space, cytosol

• hexadecanoyl-CoAReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. Carnitine O-Palmitoyltransferase
  3. (2E)-hexadecenoyl-CoA + NADPH + H(+) = hexadecanoyl-CoA + NADP(+)

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 32 morecytosolOne of 2 routes

• (9Z)-octadecenoyl-CoAReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. long-chain-fatty-acid-CoA ligase (stearate)
  3. octadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 37 morecytosol

• propanoyl-CoAReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. (S)-methylmalonyl-CoA hydrolase
  3. (S)-methylmalonyl-CoA + H(+) = propanoyl-CoA + CO2

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 29 morecytosol, mitochondrial matrix

• 15-oxoprostaglandin E2Reach from here →
  1. transport of GSH and leukotriene E4 (cytosol to extracellular)
  2. transport of GSH and prostaglandin E2 (cytosol to extracellular)
  3. prostaglandin E2 + NAD(+) = 15-oxoprostaglandin E2 + NADH + H(+)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, HPGDextracellular space, cytosolOne of 2 routes

• 15-oxoprostaglandin E1Reach from here →
  1. transport of GSH and leukotriene E4 (cytosol to extracellular)
  2. transport of GSH and prostaglandin E1 (cytosol to extracellular)
  3. (13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-13-enoate:NADP+ 15-oxidoreductase

  Catalysed by SLCO1B1, SLCO2A1, CBR3, CBR1 and 1 moreextracellular space, cytosolOne of 3 routes

• 15-oxoprostaglandin D2Reach from here →
  1. transport of GSH and leukotriene E4 (cytosol to extracellular)
  2. transport of GSH and prostaglandin D2 (cytosol to extracellular)
  3. 15-dehydro-prostaglandin D2 reduction

  Catalysed by SLCO1B1, SLCO2A1extracellular space, cytosolOne of 2 routes

• 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoateReach from here →
  1. transport of GSH and leukotriene E4 (cytosol to extracellular)
  2. Glutathione: 15-HPETE oxidoreductase
  3. (15S)-15-Hydroxy-5,8,11-cis-13-trans-icosatetraenoate:NADP+ 15-oxidoreductase

  Catalysed by SLCO1B1, GPX5, GPX1, GPX2 and 6 moreextracellular space, cytosolOne of 3 routes

• D-alanineReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. D-alanine(out) + L-alanine(in) = D-alanine(in) + L-alanine(out)

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 29 morecytosol, mitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 2 routes

• sarcosineReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. sarcosine + O2 + H2O = formaldehyde + glycine + H2O2

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 32 morecytosol, mitochondrial matrixOne of 2 routes

• S-adenosyl 3-(methylsulfanyl)propylamineReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. diamine N-acetyltransferase (N1-acetylspermidine)
  3. S-adenosyl 3-(methylsulfanyl)propylamine + putrescine = S-methyl-5'-thioadenosine + spermidine + H(+)

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 31 morecytosol

• (12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoateReach from here →
  1. transport of GSH and leukotriene E4 (cytosol to extracellular)
  2. transport of arachidonate and GSH (cytosol to extracellular)
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate

  Catalysed by SLCO1B1, ALOX5, ALOX15, ALOX12extracellular space, cytosol

• thromboxane A2Reach from here →
  1. transport of GSH and leukotriene E4 (cytosol to extracellular)
  2. transport of GSH and thromboxane B2 (cytosol to extracellular)
  3. thromboxane A2 hydrolysis

  Catalysed by SLCO1B1extracellular space, cytosol, endoplasmic reticulumOne of 4 routes

• (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoateReach from here →
  1. transport of GSH and leukotriene E4 (cytosol to extracellular)
  2. transport of arachidonate and GSH (cytosol to extracellular)
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate

  Catalysed by SLCO1B1, ALOX15B, ALOX15, ALOX12extracellular space, cytosol

• (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. transport of GSH and leukotriene E4 (cytosol to extracellular)
  2. transport of arachidonate and GSH (cytosol to extracellular)
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate

  Catalysed by SLCO1B1, ALOX5extracellular space, cytosol

• 7,8-dihydrofolateReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)
  3. uridine(34) in tRNA + 5,10-methylenetetrahydrofolate + taurine + GTP + A + H2O = 5-taurinomethyluridine(34) in tRNA + 7,8-dihydrofolate + GDP + AH2 + phosphate + H(+)

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 30 morecytosol

• (6S)-5,6,7,8-tetrahydrofolateReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 33 morecytosol, mitochondrial matrix

• propane-1,3-diamineReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. diamine N-acetyltransferase (N1-acetylspermidine)
  3. [eIF5A protein]-L-lysine + spermidine = [eIF5A protein]-deoxyhypusine + propane-1,3-diamine

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 31 morecytosol

• L-dopaReach from here →
  1. transport of GSH and leukotriene E4 (cytosol to extracellular)
  2. transport of dopamine and GSH (cytosol to extracellular)
  3. L-dopa + H(+) = dopamine + CO2

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, DDCextracellular space, cytosol

• 1-hexadecanoyl-sn-glycero-3-phosphateReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. Palmitate:CoA ligase (AMP-forming)
  3. glycerol-3-phosphate 1-O-acyltransferase (palmitoyl-CoA)

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 40 morecytosol

• a 1-acylglycerone 3-phosphateReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. acyl-CoA:sphingosine N-acyltransferase
  3. dihydroxyacetone phosphate + an acyl-CoA = a 1-acylglycerone 3-phosphate + CoA

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 33 morecytosol, Golgi apparatus

• O-acetyl-(R)-carnitineReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. Carnitine O-Palmitoyltransferase
  3. Acetyl-CoA:carnitine O-acetyltransferase

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 31 morecytosolOne of 9 routes

• L-histidineReach from here →
  1. transport of GSH and leukotriene E4 (cytosol to extracellular)
  2. transport of GSH and histamine (cytosol to extracellular)
  3. L-histidine + H(+) = histamine + CO2

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, HDCextracellular space, cytosol

• a 1,2-diacyl-sn-glycero-3-phosphocholineReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. acyl-CoA:sphingosine N-acyltransferase
  3. a 2-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 33 morecytosol, Golgi apparatusOne of 2 routes

• an N-acylglycineReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. acyl-CoA:sphingosine N-acyltransferase
  3. an acyl-CoA + glycine = an N-acylglycine + CoA + H(+)

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 35 morecytosol, Golgi apparatusOne of 2 routes

• 2-oxo-3-sulfanylpropanoateReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. N-acetylglutamate synthase (N-acetyl-L-cysteine)
  3. L-Cysteine:2-oxoglutarate aminotransferase

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 31 morecytosol, mitochondrial matrixOne of 3 routes

• guanidinoacetateReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. L-Arginine:glycine amidinotransferase

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 32 morecytosol, mitochondrial matrixOne of 2 routes

• D-threonineReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. D-threonine(out) + L-alanine(in) = D-threonine(in) + L-alanine(out)

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 29 morecytosol, mitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 2 routes

• a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)Reach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. acyl-CoA:sphingosine N-acyltransferase
  3. a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 32 morecytosol, Golgi apparatus

• L-tryptophanReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. transport of glycine and tryptophan (cytosol to extracellular)

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 32 morecytosol, mitochondrial matrix, extracellular spaceOne of 20 routes

• glutathioneReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 32 morecytosol, mitochondrial matrixOne of 17 routes

• L-threonineReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. L-threonine(out) + L-alanine(in) = L-threonine(in) + L-alanine(out)

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 29 morecytosol, mitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 4 routes

• L-kynurenineReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. L-kynurenine + H2O = anthranilate + L-alanine + H(+)

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 29 morecytosol, mitochondrial matrix

• beta-alanineReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. beta-alanine(out) + L-alanine(in) = beta-alanine(in) + L-alanine(out)

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 29 morecytosol, mitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 3 routes

• a 1-acyl-sn-glycero-3-phosphateReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. acyl-CoA:sphingosine N-acyltransferase
  3. sn-glycerol 3-phosphate + an acyl-CoA = a 1-acyl-sn-glycero-3-phosphate + CoA

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 36 morecytosol, Golgi apparatus

• taurocyamineReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)
  3. taurine + L-arginine = taurocyamine + L-ornithine

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 30 morecytosol

• L-cysteateReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)
  3. L-cysteate + H(+) = taurine + CO2

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 31 morecytosol

• L-phenylalanineReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. glycine N-acyltransferase (N-arachidonoylglycine)
  3. transport of glycine and phenylalanine (cytosol to extracellular)

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 32 morecytosol, mitochondrial matrix, extracellular spaceOne of 28 routes

• N(1)-acetylspermineReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. diamine N-acetyltransferase (N1-acetylspermidine)
  3. N(1)-acetylspermine + O2 + H2O = 3-acetamidopropanal + spermidine + H2O2

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 31 morecytosol

• 3-hydroxy-L-kynurenineReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
  3. 3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 29 morecytosol, mitochondrial matrix

• gamma-L-glutamyl-L-cysteineReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. N-acetylglutamate synthase (N-acetyl-L-cysteine)
  3. L-glutamate:L-cysteine gamma-ligase (ADP-forming)

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 31 morecytosol, mitochondrial matrixOne of 2 routes

• L-homocysteineReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. N-acetylglutamate synthase (N-acetyl-L-cystathionine)
  3. L-homocysteine + L-serine = L,L-cystathionine + H2O

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 30 morecytosol, mitochondrial matrixOne of 2 routes

• S-methyl-L-methionineReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. N-acetylglutamate synthase (N-acetylmethionine)
  3. S-methyl-L-methionine + L-homocysteine = 2 L-methionine + H(+)

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 30 morecytosol, mitochondrial matrix

• 3-oxosphinganineReach from here →
  1. N-acetyl-LTE4 to leukotriene E4 conversion
  2. Palmitate:CoA ligase (AMP-forming)
  3. Palmitoyl-CoA:L-serine C-palmitoyltransferase (decarboxylating)

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 39 morecytosol