L-leucine

1. Acetylation of Leucine
2. long-chain-fatty-acid-CoA ligase (nonadecylic acid)

Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 4 moremitochondrial matrix, cytosolOne of 6 routes

1. Acetylation of Leucine
2. Transport of 11-Octadecenoyl Carnitine into the Mitochondrial Matrix

Catalysed by CPT1A, CPT1C, CPT1Bmitochondrial matrix, cytosolOne of 3 routes

1. Acetylation of Leucine
2. Activation of dodecanedioic acid

No catalyst recordedmitochondrial matrix, cytosolOne of 4 routes

1. Acetylation of Leucine
2. Production of Sebacoylcarnitine

Catalysed by CPT1A, CPT1C, CPT1Bmitochondrial matrix, cytosolOne of 4 routes

1. Acetylation of Leucine
2. Production of Suberylcarnitine

Catalysed by CPT1A, CPT1C, CPT1Bmitochondrial matrix, cytosolOne of 4 routes

1. Acetylation of Leucine
2. Activation of adipic acid for Formation of Adipoyl Carnitine

No catalyst recordedmitochondrial matrix, cytosolOne of 4 routes

1. Acetylation of Leucine
2. long-chain-fatty-acid-CoA ligase ((4Z,7Z,10Z,13Z,16Z)-DPA)

Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 4 moremitochondrial matrix, cytosolOne of 7 routes

1. Acetylation of Leucine
2. long-chain-fatty-acid-CoA ligase ((11Z,14Z)-eicosadienoic acid)

Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 4 moremitochondrial matrix, cytosolOne of 5 routes

1. Acetylation of Leucine
2. Production of 3-Hydroxyoctadecenoylcarnitinec

Catalysed by CPT1A, CPT1C, CPT1Bmitochondrial matrix, cytosol

1. Acetylation of Leucine
2. long-chain-fatty-acid-CoA ligase ((13Z)-eicosenoic acid)

Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 4 moremitochondrial matrix, cytosolOne of 5 routes

1. Acetylation of Leucine
2. Carnitine Dimethyl Nonanoyl Transferase, Revsible, Peroxisomal

Catalysed by CRAT, CROTmitochondrial matrix, peroxisomeOne of 3 routes

1. Acetylation of Leucine
2. Fatty Acid Beta Oxidation (C16Dc->C14Dc), Peroxisomal

Catalysed by ACAA1, HSD17B4, EHHADH, ACOX1mitochondrial matrix, peroxisome

1. Acetylation of Leucine
2. Production of Hexadecanedioylcarnitine

Catalysed by CPT1A, CPT1C, CPT1Bmitochondrial matrix, cytosolOne of 2 routes

1. Acetylation of Leucine
2. fatty-acid-CoA ligase

Catalysed by SLC27A2mitochondrial matrix, cytosolOne of 2 routes

1. Acetylation of Leucine
2. medium-chain acyl-CoA ligase (undecylic acid)

Catalysed by ACSM4, ACSM1, ACSM2A, ACSM3 and 2 moremitochondrial matrix, cytosolOne of 3 routes

1. transport of cysteine and leucine (cytosol to extracellular)
2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O

Catalysed by SLC7A9, SLC3A1, MOCOSextracellular space, cytosol

1. transport of glycine and leucine (cytosol to extracellular)
2. Glycodeoxycholate amidohydrolase

Catalysed by SLC7A5extracellular space, cytosolOne of 2 routes

1. Acetylation of Leucine
2. long-chain-fatty-acid-CoA ligase (physeteric acid)

Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 4 moremitochondrial matrix, cytosolOne of 8 routes

1. Acetylation of Leucine
2. Fatty Acid Beta Oxidation (C12:1->C10:1), Mitochondrial

Catalysed by ACADM, ECHS1, ACAA2, HADHmitochondrial matrix

1. transport of glycine and leucine (cytosol to extracellular)
2. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)

Catalysed by SLC7A5, GLYATL2extracellular space, cytosol

1. Acetylation of Leucine
2. acetyl-CoA C-acyltransferase (3-oxo-4(R),8-dimethyl-nonanoyl-CoA)

Catalysed by HADHA, ACAA2, HADHBmitochondrial matrix

1. transport of glycine and leucine (cytosol to extracellular)
2. eicosanoyl-CoA + glycine = N-eicosanoylglycinate + CoA + H(+)

Catalysed by SLC7A5, BAATextracellular space, cytosol

1. transport of glycine and leucine (cytosol to extracellular)
2. docosanoyl-CoA + glycine = N-docosanoylglycine + CoA + H(+)

Catalysed by SLC7A5, BAATextracellular space, cytosol

1. transport of glycine and leucine (cytosol to extracellular)
2. hexacosanoyl-CoA + glycine = N-hexacosanoylglycine + CoA + H(+)

Catalysed by SLC7A5, BAATextracellular space, cytosol

1. transport of glutamine and leucine (cytosol to extracellular)
2. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)

Catalysed by SLC7A5, GLYATL1B, GLYATL1extracellular space, cytosol

1. Acetylation of Leucine
2. long-chain-fatty-acid-CoA ligase (7-palmitoleic acid)

Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 4 moremitochondrial matrix, cytosolOne of 8 routes

1. Acetylation of Leucine
2. long-chain-fatty-acid-CoA ligase (tricosanoic acid)

Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 4 moremitochondrial matrix, cytosolOne of 4 routes

1. transport of leucine and tyrosine (cytosol to extracellular)
2. L-tyrosine:2-oxoglutarate aminotransferase
3. (2R)-2-hydroxy-3-(4-hydroxyphenyl)propanoate + NAD(+) = 3-(4-hydroxyphenyl)pyruvate + NADH + H(+)

Catalysed by SLC7A5, GOT2, GOT1, TAT and 1 moreextracellular space, cytosol

1. transport of alanine and leucine (cytosol to extracellular)
2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
3. transport of 2-hydroxybutyrate and pyruvate (cytosol to extracellular)