2-[(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine

Three steps

• glycolithocholic acidReach from here →
  1. 2-[(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + H2O = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + sn-glycerol 3-phosphocholine + H(+)
  2. Glutathione: 15-HPETE oxidoreductase
  3. transport of glycolithocholate and GSH (cytosol to extracellular)

  Catalysed by PLA2G4A, GPX5, GPX1, GPX2 and 8 morecytosol, extracellular spaceOne of 2 routes

• gamma-Glu-AlaReach from here →
  1. 2-[(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + H2O = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + sn-glycerol 3-phosphocholine + H(+)
  2. Glutathione: 15-HPETE oxidoreductase
  3. gamma-glutamyltransferase (alanine)

  Catalysed by PLA2G4A, GPX5, GPX1, GPX2 and 12 morecytosol, extracellular space

• 3,3',5-triiodo-L-thyronineReach from here →
  1. 2-[(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + H2O = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + sn-glycerol 3-phosphocholine + H(+)
  2. Glutathione: 15-HPETE oxidoreductase
  3. transport of GSH and triiodothyronine (cytosol to extracellular)

  Catalysed by PLA2G4A, GPX5, GPX1, GPX2 and 8 morecytosol, extracellular spaceOne of 2 routes

• prostaglandin E1Reach from here →
  1. 2-[(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + H2O = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + sn-glycerol 3-phosphocholine + H(+)
  2. Glutathione: 15-HPETE oxidoreductase
  3. transport of GSH and prostaglandin E1 (cytosol to extracellular)

  Catalysed by PLA2G4A, GPX5, GPX1, GPX2 and 7 morecytosol, extracellular spaceOne of 2 routes

• prostaglandin I2Reach from here →
  1. 2-[(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + H2O = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + sn-glycerol 3-phosphocholine + H(+)
  2. Glutathione: 15-HPETE oxidoreductase
  3. transport of GSH and prostaglandin I2 (cytosol to extracellular)

  Catalysed by PLA2G4A, GPX5, GPX1, GPX2 and 7 morecytosol, extracellular spaceOne of 2 routes

• prostaglandin F2alphaReach from here →
  1. 2-[(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + H2O = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + sn-glycerol 3-phosphocholine + H(+)
  2. Glutathione: 15-HPETE oxidoreductase
  3. transport of GSH and prostaglandin F2alpha (cytosol to extracellular)

  Catalysed by PLA2G4A, GPX5, GPX1, GPX2 and 7 morecytosol, extracellular spaceOne of 2 routes

• prostaglandin H2Reach from here →
  1. 2-[(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + H2O = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + sn-glycerol 3-phosphocholine + H(+)
  2. Glutathione: 15-HPETE oxidoreductase
  3. transport of GSH and prostaglandin H2 (cytosol to extracellular)

  Catalysed by PLA2G4A, GPX5, GPX1, GPX2 and 7 morecytosol, extracellular spaceOne of 2 routes

• prostaglandin D2Reach from here →
  1. 2-[(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + H2O = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + sn-glycerol 3-phosphocholine + H(+)
  2. Glutathione: 15-HPETE oxidoreductase
  3. transport of GSH and prostaglandin D2 (cytosol to extracellular)

  Catalysed by PLA2G4A, GPX5, GPX1, GPX2 and 7 morecytosol, extracellular spaceOne of 2 routes

• leukotriene A4Reach from here →
  1. 2-[(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + H2O = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + sn-glycerol 3-phosphocholine + H(+)
  2. Glutathione: 15-HPETE oxidoreductase
  3. transport of GSH and leukotriene A4 (cytosol to extracellular)

  Catalysed by PLA2G4A, GPX5, GPX1, GPX2 and 7 morecytosol, extracellular spaceOne of 2 routes

• (R)-S-lactoylglutathioneReach from here →
  1. 2-[(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + H2O = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + sn-glycerol 3-phosphocholine + H(+)
  2. Glutathione: 15-HPETE oxidoreductase
  3. (R)-S-Lactoylglutathione methylglyoxal-lyase (isomerizing)

  Catalysed by PLA2G4A, GPX5, GPX1, GPX2 and 8 morecytosolOne of 2 routes

• 1-hexadecanoyl-sn-glycero-3-phosphateReach from here →
  1. 2-[(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + H2O = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + sn-glycerol 3-phosphocholine + H(+)
  2. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  3. glycerol-3-phosphate 1-O-acyltransferase (palmitoyl-CoA)

  Catalysed by PLA2G4A, GPCPD1, GPAT3, GPAT2 and 2 morecytosolOne of 2 routes

• dihydroxyacetone phosphateReach from here →
  1. 2-[(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + H2O = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + sn-glycerol 3-phosphocholine + H(+)
  2. sn-glycerol 3-phosphocholine + H2O = sn-glycerol 3-phosphate + choline + H(+)
  3. sn-glycerol 3-phosphate + NAD(+) = dihydroxyacetone phosphate + NADH + H(+)

  Catalysed by PLA2G4A, GDPD5, GPCPD1, GPD1 and 1 moreOne of 2 routes

• sn-glycerol 1-phosphateReach from here →
  1. 2-[(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + H2O = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + sn-glycerol 3-phosphocholine + H(+)
  2. sn-glycerol 3-phosphocholine + H2O = phosphocholine + glycerol + H(+)
  3. sn-glycerol 1-phosphate + H2O = glycerol + phosphate

  Catalysed by PLA2G4A, ENPP6, PGP

• S-formylglutathioneReach from here →
  1. 2-[(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + H2O = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + sn-glycerol 3-phosphocholine + H(+)
  2. Glutathione: 15-HPETE oxidoreductase
  3. alcohol dehydrogenase (formaldehyde)

  Catalysed by PLA2G4A, GPX5, GPX1, GPX2 and 12 morecytosol

• a 1-acyl-sn-glycero-3-phosphateReach from here →
  1. 2-[(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + H2O = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + sn-glycerol 3-phosphocholine + H(+)
  2. sn-glycerol 3-phosphocholine + H2O = sn-glycerol 3-phosphate + choline + H(+)
  3. sn-glycerol 3-phosphate + an acyl-CoA = a 1-acyl-sn-glycero-3-phosphate + CoA

  Catalysed by PLA2G4A, GDPD5, GPCPD1, GPAT3 and 3 more

• leukotriene C4Reach from here →
  1. 2-[(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + H2O = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + sn-glycerol 3-phosphocholine + H(+)
  2. Glutathione: 15-HPETE oxidoreductase
  3. leukotriene C4 synthase (GSH)

  Catalysed by PLA2G4A, GPX5, GPX1, GPX2 and 7 morecytosolOne of 4 routes

• glutathione disulfideReach from here →
  1. 2-[(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + H2O = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + sn-glycerol 3-phosphocholine + H(+)
  2. Glutathione: 15-HPETE oxidoreductase
  3. Glutathione: 15-HPETE oxidoreductase

  Catalysed by PLA2G4A, GPX5, GPX1, GPX2 and 6 morecytosolOne of 14 routes

• taurolithocholate 3-sulfateReach from here →
  1. 2-[(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + H2O = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + sn-glycerol 3-phosphocholine + H(+)
  2. Glutathione: 15-HPETE oxidoreductase
  3. transport of GSH and sulfotaurolithocholate (cytosol to extracellular)

  Catalysed by PLA2G4A, GPX5, GPX1, GPX2 and 8 morecytosol, extracellular spaceOne of 2 routes

• CDP-glycerolReach from here →
  1. 2-[(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + H2O = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + sn-glycerol 3-phosphocholine + H(+)
  2. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  3. CDPglycerol phosphoglycerohydrolase

  Catalysed by PLA2G4A, GPCPD1, ADPRMcytosolOne of 2 routes

• histamineReach from here →
  1. 2-[(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + H2O = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + sn-glycerol 3-phosphocholine + H(+)
  2. Glutathione: 15-HPETE oxidoreductase
  3. transport of GSH and histamine (cytosol to extracellular)

  Catalysed by PLA2G4A, GPX5, GPX1, GPX2 and 8 morecytosol, extracellular spaceOne of 2 routes

• L-thyroxineReach from here →
  1. 2-[(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + H2O = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + sn-glycerol 3-phosphocholine + H(+)
  2. Glutathione: 15-HPETE oxidoreductase
  3. transport of GSH and thyroxine (cytosol to extracellular)

  Catalysed by PLA2G4A, GPX5, GPX1, GPX2 and 8 morecytosol, extracellular spaceOne of 2 routes

• CDP-cholineReach from here →
  1. 2-[(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + H2O = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + sn-glycerol 3-phosphocholine + H(+)
  2. sn-glycerol 3-phosphocholine + H2O = phosphocholine + glycerol + H(+)
  3. phosphocholine + CTP + H(+) = CDP-choline + diphosphate

  Catalysed by PLA2G4A, ENPP6, PCYT1A, PCYT1BOne of 2 routes

• S-sulfanylglutathioneReach from here →
  1. 2-[(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + H2O = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + sn-glycerol 3-phosphocholine + H(+)
  2. Glutathione: 15-HPETE oxidoreductase
  3. Sulfide:glutathione,quinone oxidoreductase

  Catalysed by PLA2G4A, GPX5, GPX1, GPX2 and 7 morecytosol, mitochondrial matrix

• dopamineReach from here →
  1. 2-[(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + H2O = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + sn-glycerol 3-phosphocholine + H(+)
  2. Glutathione: 15-HPETE oxidoreductase
  3. transport of dopamine and GSH (cytosol to extracellular)

  Catalysed by PLA2G4A, GPX5, GPX1, GPX2 and 8 morecytosol, extracellular spaceOne of 2 routes

• glycolithocholate 3-sulfateReach from here →
  1. 2-[(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + H2O = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + sn-glycerol 3-phosphocholine + H(+)
  2. Glutathione: 15-HPETE oxidoreductase
  3. transport of GSH and sulfoglycolithocholate (cytosol to extracellular)

  Catalysed by PLA2G4A, GPX5, GPX1, GPX2 and 8 morecytosol, extracellular spaceOne of 2 routes

• a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate)Reach from here →
  1. 2-[(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + H2O = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + sn-glycerol 3-phosphocholine + H(+)
  2. sn-glycerol 3-phosphocholine + H2O = sn-glycerol 3-phosphate + choline + H(+)
  3. a CDP-1,2-diacyl-sn-glycerol + sn-glycerol 3-phosphate = a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + CMP + H(+)

  Catalysed by PLA2G4A, GDPD5, GPCPD1, PGS1

• prostaglandin E2Reach from here →
  1. 2-[(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + H2O = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + sn-glycerol 3-phosphocholine + H(+)
  2. Glutathione: 15-HPETE oxidoreductase
  3. transport of GSH and prostaglandin E2 (cytosol to extracellular)

  Catalysed by PLA2G4A, GPX5, GPX1, GPX2 and 8 morecytosol, extracellular spaceOne of 2 routes

• L-cysteinylglycineReach from here →
  1. 2-[(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + H2O = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + sn-glycerol 3-phosphocholine + H(+)
  2. Glutathione: 15-HPETE oxidoreductase
  3. glutathione gamma-glutamylaminopeptidase

  Catalysed by PLA2G4A, GPX5, GPX1, GPX2 and 12 morecytosolOne of 4 routes

• (R)-noradrenalineReach from here →
  1. 2-[(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + H2O = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + sn-glycerol 3-phosphocholine + H(+)
  2. Glutathione: 15-HPETE oxidoreductase
  3. transport of GSH and noradrenaline (cytosol to extracellular)

  Catalysed by PLA2G4A, GPX5, GPX1, GPX2 and 8 morecytosol, extracellular spaceOne of 2 routes

• 1-dodecanoyl-sn-glycerol 3-phosphateReach from here →
  1. 2-[(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + H2O = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + sn-glycerol 3-phosphocholine + H(+)
  2. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  3. glycerol-3-phosphate 1-O-acyltransferase (lauroyl-CoA)

  Catalysed by PLA2G4A, GPCPD1, GPAT3, GPAT2 and 2 morecytosolOne of 2 routes

• 1-tetradecanoyl-sn-glycerol 3-phosphateReach from here →
  1. 2-[(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + H2O = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + sn-glycerol 3-phosphocholine + H(+)
  2. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  3. glycerol-3-phosphate 1-O-acyltransferase (myristoyl-CoA)

  Catalysed by PLA2G4A, GPCPD1, GPAT3, GPAT2 and 2 morecytosol

• a 2,3-saturated aldehydeReach from here →
  1. 2-[(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + H2O = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + sn-glycerol 3-phosphocholine + H(+)
  2. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + H2O = a 2,3-saturated aldehyde + sn-glycerol 3-phosphocholine
  3. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + H2O = a 2,3-saturated aldehyde + sn-glycerol 3-phosphocholine

  Catalysed by PLA2G4A, TMEM86A, TMEM86B

• 1-octadecanoyl-sn-glycero-3-phosphocholineReach from here →
  1. 2-[(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + H2O = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + sn-glycerol 3-phosphocholine + H(+)
  2. sn-glycerol 3-phosphocholine + H2O = phosphocholine + glycerol + H(+)
  3. 1-octadecanoyl-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + glycerol = 1-(9Z,12Z,15Z-octadecatrienoyl)-glycerol + 1-octadecanoyl-sn-glycero-3-phosphocholine

  Catalysed by PLA2G4A, ENPP6One of 2 routes

• 1-(9Z-octadecenoyl)-sn-glycero-3-phosphateReach from here →
  1. 2-[(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + H2O = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + sn-glycerol 3-phosphocholine + H(+)
  2. sn-glycerol 3-phosphocholine + H2O = sn-glycerol 3-phosphate + choline + H(+)
  3. sn-glycerol 3-phosphate + (9Z)-octadecenoyl-CoA = 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA

  Catalysed by PLA2G4A, GDPD5, GPCPD1, GPAT3 and 2 more

• 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphateReach from here →
  1. 2-[(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + H2O = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + sn-glycerol 3-phosphocholine + H(+)
  2. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  3. glycerol-3-phosphate 1-O-acyltransferase (linoleoyl-CoA)

  Catalysed by PLA2G4A, GPCPD1, GPAT3, GPAT2 and 2 morecytosolOne of 2 routes

• 1-octadecanoyl-sn-glycero-3-phosphateReach from here →
  1. 2-[(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + H2O = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + sn-glycerol 3-phosphocholine + H(+)
  2. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  3. glycerol-3-phosphate 1-O-acyltransferase (sn-glycerol-3-phosphate)

  Catalysed by PLA2G4A, GPCPD1, GPAT3, GPAT2 and 2 morecytosolOne of 2 routes

• 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphateReach from here →
  1. 2-[(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + H2O = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + sn-glycerol 3-phosphocholine + H(+)
  2. sn-Glycero-3-phosphocholine glycerophosphohydrolase
  3. glycerol-3-phosphate 1-O-acyltransferase (arachidonyl-CoA)

  Catalysed by PLA2G4A, GPCPD1, GPAT3, GPAT2 and 2 morecytosolOne of 2 routes

• 1-(9Z,12Z,15Z-octadecatrienoyl)-glycerolReach from here →
  1. 2-[(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + H2O = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + sn-glycerol 3-phosphocholine + H(+)
  2. sn-glycerol 3-phosphocholine + H2O = phosphocholine + glycerol + H(+)
  3. 1-octadecanoyl-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + glycerol = 1-(9Z,12Z,15Z-octadecatrienoyl)-glycerol + 1-octadecanoyl-sn-glycero-3-phosphocholine

  Catalysed by PLA2G4A, ENPP6

• 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerolReach from here →
  1. 2-[(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + H2O = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + sn-glycerol 3-phosphocholine + H(+)
  2. sn-glycerol 3-phosphocholine + H2O = phosphocholine + glycerol + H(+)
  3. 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + glycerol = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + 1-octadecanoyl-sn-glycero-3-phosphocholine

  Catalysed by PLA2G4A, ENPP6

• 20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. 2-[(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + H2O = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + sn-glycerol 3-phosphocholine + H(+)
  2. Glutathione: 15-HPETE oxidoreductase
  3. Resistance-Nodulation-Cell Division (Rnd) Tcdb:2.A.60.1.2

  Catalysed by PLA2G4A, GPX5, GPX1, GPX2 and 7 morecytosol, extracellular spaceOne of 2 routes

• a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphateReach from here →
  1. 2-[(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + H2O = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + sn-glycerol 3-phosphocholine + H(+)
  2. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + H2O = a 2,3-saturated aldehyde + sn-glycerol 3-phosphocholine
  3. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + H2O = a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphate + choline + H(+)

  Catalysed by PLA2G4A, TMEM86A, TMEM86B, ENPP2

• a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholineReach from here →
  1. 2-[(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + H2O = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + sn-glycerol 3-phosphocholine + H(+)
  2. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + H2O = a 2,3-saturated aldehyde + sn-glycerol 3-phosphocholine
  3. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + an acyl-CoA = a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + CoA

  Catalysed by PLA2G4A, TMEM86A, TMEM86B, LPCAT2 and 1 more

• 1-O-(1Z)-alkenyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholineReach from here →
  1. 2-[(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + H2O = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + sn-glycerol 3-phosphocholine + H(+)
  2. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + H2O = a 2,3-saturated aldehyde + sn-glycerol 3-phosphocholine
  3. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + (9Z)-octadecenoyl-CoA = 1-O-(1Z)-alkenyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + CoA

  Catalysed by PLA2G4A, TMEM86A, TMEM86B, MBOAT2

• 1-O-(1Z)-alkenyl-2-hexadecanoyl-sn-glycero-3-phosphocholineReach from here →
  1. 2-[(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + H2O = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + sn-glycerol 3-phosphocholine + H(+)
  2. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + H2O = a 2,3-saturated aldehyde + sn-glycerol 3-phosphocholine
  3. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1-O-(1Z)-alkenyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA

  Catalysed by PLA2G4A, TMEM86A, TMEM86B, LPCAT1

• 1-O-(1Z)-alkenyl-2-acetyl-sn-glycero-3-phosphocholineReach from here →
  1. 2-[(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + H2O = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + sn-glycerol 3-phosphocholine + H(+)
  2. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + H2O = a 2,3-saturated aldehyde + sn-glycerol 3-phosphocholine
  3. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + acetyl-CoA = 1-O-(1Z)-alkenyl-2-acetyl-sn-glycero-3-phosphocholine + CoA

  Catalysed by PLA2G4A, TMEM86A, TMEM86B, LPCAT2

• ursodeoxycholateReach from here →
  1. 2-[(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + H2O = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + sn-glycerol 3-phosphocholine + H(+)
  2. Glutathione: 15-HPETE oxidoreductase
  3. transport of GSH and ursodeoxycholate (cytosol to extracellular)

  Catalysed by PLA2G4A, GPX5, GPX1, GPX2 and 8 morecytosol, extracellular spaceOne of 2 routes

• prostaglandin G2Reach from here →
  1. 2-[(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + H2O = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + sn-glycerol 3-phosphocholine + H(+)
  2. Glutathione: 15-HPETE oxidoreductase
  3. transport of GSH and prostaglandin G2 (cytosol to extracellular)

  Catalysed by PLA2G4A, GPX5, GPX1, GPX2 and 7 morecytosol, extracellular spaceOne of 2 routes

• thromboxane B2Reach from here →
  1. 2-[(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + H2O = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + sn-glycerol 3-phosphocholine + H(+)
  2. Glutathione: 15-HPETE oxidoreductase
  3. transport of GSH and thromboxane B2 (cytosol to extracellular)

  Catalysed by PLA2G4A, GPX5, GPX1, GPX2 and 7 morecytosol, extracellular spaceOne of 2 routes

• taurochenodeoxycholateReach from here →
  1. 2-[(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + H2O = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + sn-glycerol 3-phosphocholine + H(+)
  2. Glutathione: 15-HPETE oxidoreductase
  3. solute carrier organic anion transporter (GSH)

  Catalysed by PLA2G4A, GPX5, GPX1, GPX2 and 9 morecytosol, extracellular spaceOne of 2 routes