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Proteins/UNIPROT:Q86UY6
N-alpha-acetyltransferase that specifically mediates the acetylation of the N-terminal residues of histones H4 and H2A. In contrast to other N-alpha-acetyltransferase, has a very specific selectivity for histones H4 and H2A N-terminus and specifically recognizes the 'Ser-Gly-Arg-Gly sequence'. Acts as a negative regulator of apoptosis. May play a role in hepatic lipid metabolism (By similarity)..
Function from UniProtKB (Q86UY6), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
13 statements
13 statements · 4 reference databases · Subject: NAA40 · Sources: Bgee, Hetionet, Human-GEM, WikiPathways
3 reactions
CHEBI:1146900+proton+MAM02538cCHEBI:15351+CHEBI:15650
Catalysed by LPCAT2 or NAT14 or SH3GLB1 or ZDHHC8 or NAA10 or ZDHHC15 or ZDHHC2 or NAT9 or NAA40 or LPCAT3 or NAA60 or MBOAT7 and 20 more alternatives
7 names
Resolves to: NAA40
Human-GEM MAR01088CC BY 4.0Reference data
N-terminal L-seryl-[histone H4]+acetyl-CoAN-terminal N(alpha)-acetyl-L-seryl-[histone H4]+coenzyme A(4-)+hydron
Catalysed by NAA40
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:50596CC BY 4.0Reference data
N-terminal L-seryl-[histone H2A]+acetyl-CoAN-terminal N(alpha)-acetyl-L-seryl-[histone H2A]+coenzyme A(4-)+hydron
Catalysed by NAA40
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:50600CC BY 4.0Reference data