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Proteins/UNIPROT:P25874
Mitochondrial protein responsible for thermogenic respiration, a specialized capacity of brown adipose tissue and beige fat that participates in non-shivering adaptive thermogenesis to temperature and diet variations and more generally to the regulation of energy balance (By similarity). Functions as a long-chain fatty acid/LCFA and proton symporter, simultaneously transporting one LCFA and one proton through the inner mitochondrial membrane. However, LCFAs remaining associated with the transporter via their hydrophobic tails, it results in an apparent transport of protons activated by LCFAs. Thereby, dissipates the mitochondrial proton gradient and converts the energy of substrate oxydation into heat instead of ATP. Regulates the production of reactive oxygen species/ROS by mitochondria (By similarity)..
Function from UniProtKB (P25874), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
25 statements
25 statements · 6 reference databases · Subject: UCP1 · Sources: gene ontology, Hetionet, Human-GEM, Reactome, Rhea, WikiPathways
7 reactions
Transported by SLC25A14 or UCP1 or SLC25A27 or UCP3 or UCP2
Reaction pageLeft to rightBalancedcytosol, mitochondrial matrix
Human-GEM MAR07638CC BY 4.0Reference data
proton+MAM03981mproton+MAM03981c
Transported by UCP1
Reaction pageLeft to rightBalancedmitochondrial intermembrane space, mitochondrial matrix, cytosol
5 names
Resolves to: UCP1
Human-GEM MAR11737CC BY 4.0Reference data
proton+MAM03657mproton+MAM03657c
Transported by UCP1
Reaction pageLeft to rightBalancedmitochondrial intermembrane space, mitochondrial matrix, cytosol
Human-GEM MAR11741CC BY 4.0Reference data
proton+MAM03682mproton+MAM03682c
Transported by UCP1
Reaction pageLeft to rightBalancedmitochondrial intermembrane space, mitochondrial matrix, cytosol
Human-GEM MAR11746CC BY 4.0Reference data
proton+MAM03283mproton+MAM03283c
Transported by UCP1
Reaction pageLeft to rightBalancedmitochondrial intermembrane space, mitochondrial matrix, cytosol
Human-GEM MAR11753CC BY 4.0Reference data
Transported by SLC25A14 or UCP1 or SLC25A27 or UCP3 or UCP2
Reaction pageLeft to rightBalancedmitochondrial intermembrane space, mitochondrial matrix
Human-GEM MAR13080CC BY 4.0Reference data