Proteins/UNIPROT:Q15847

ADIRF

ProteinUNIPROT:Q15847

Plays a role in fat cell development; promotes adipogenic differentiation and stimulates transcription initiation of master adipogenesis factors like PPARG and CEBPA at early stages of preadipocyte differentiation. Its overexpression confers resistance to the anticancer chemotherapeutic drug cisplatin..

Function from UniProtKB (Q15847), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

14 statements

14 statements · 4 reference databases · Subject: ADIRF · Sources: gene ontology, Hetionet, Reactome, WikiPathways

Order

GSK3B interacts with ADIRFProteinHetionet hetionet:interacts:10974-2932Inferred only
ADIRF interacts with RPS6KA6ProteinHetionet hetionet:interacts:10974-27330Inferred only
UBC interacts with ADIRFProteinHetionet hetionet:interacts:10974-7316Inferred only
ADIRF participates in 10q22q23 copy number variationPathwayWikiPathways WP5402Inferred only
ADIRF participates in AdipogenesisPathwayReactome R-HSA-9843745Inferred only
ADIRF participates in Developmental BiologyPathwayReactome R-HSA-1266738Inferred only
ADIRF participates in Transcriptional regulation of white adipocyte differentiationPathwayReactome R-HSA-381340Inferred only
ADIRF regulates positive regulation of fat cell differentiationBiological processgene ontology Q15847|GO:0045600Inferred only
ADIRF regulates positive regulation of transcription by RNA polymerase IIBiological processgene ontology Q15847|GO:0045944Inferred only
AGL increases the expression of ADIRFProteinHetionet hetionet:regulates:178-10974Inferred only
RAD9A increases the expression of ADIRFProteinHetionet hetionet:regulates:5883-10974Inferred only
SLC25A14 increases the expression of ADIRFProteinHetionet hetionet:regulates:9016-10974Inferred only

Show the remaining 2

TGFBR1 increases the expression of ADIRFProteinHetionet hetionet:regulates:7046-10974Inferred only
YES1 increases the expression of ADIRFProteinHetionet hetionet:regulates:7525-10974Inferred only

Other names

7 names

Resolves to: ADIRF

Also called: Adipogenesis factor rich in obesityAdipose most abundant gene transcript 2 proteinAdipose-specific protein 2AFROapM-2APM2C10orf116

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