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Proteins/UNIPROT:Q8TE54
Acts as an anion channel mediating the transport of chloride, sulfate and oxalate ions. Mediates the transport of bromide, iodide, nitrate, gluconate, thiocyanate and bicarbonate ions (By similarity). Its permeability towards bicarbonate is weak and increases when pH is above 7 (By similarity). Mediates thiocyanate transport in retinal pigment epithelium cells (By similarity). Mediates iodide transport in the thyroid gland, playing an important role in the synthesis of thyroid hormones and the maintenance of thyroid function. Although it is an anion channel, according to PubMed:12736153 and PubMed:32119864 it has been shown to exhibit chloride-bicarbonate exchanger activity..
Function from UniProtKB (Q8TE54), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 1 · transported by
1 compound
1 compound.
0 reported routes1 assembled route
1 row
25 statements
25 statements · 5 reference databases · Subject: SLC26A7 · Sources: Bgee, Hetionet, Human-GEM, Reactome, Rhea
13 reactions
2hydrogencarbonate+sulfate2hydrogencarbonate+sulfate
Transported by SLC26A8 or SLC26A1 or SLC26A7 or SLC26A2 or SLC26A9 or SLC26A11
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR04946CC BY 4.0Reference data
Transported by
3 names
Resolves to: SLC26A7
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR06058CC BY 4.0Reference data
chlorine(.)+2hydrogencarbonatechlorine(.)+2hydrogencarbonate
Transported by SLC26A8 or SLC26A7 or SLC26A2 or SLC26A9
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR06534CC BY 4.0Reference data
hydrogencarbonatehydrogencarbonate
Transported by BEST1 or CFTR or CLDN17 or BEST4 or BEST2 or SLC26A7
Reaction pageRight to leftBalanced
Rhea RHEA:28695CC BY 4.0Reference data
Transported by GABRR3 or GPHRA or KCNK1 or CLIC1 or GABRP or CLDN4 or GABRD or CLIC2 or SLC26A4 or GLRA3 or BEST1 or KCNK2 and 69 more alternatives
Reaction pageRight to leftBalanced
Rhea RHEA:29823CC BY 4.0Reference data
Transported by CLIC1 or CLCN1 or SLC1A4 or CLCN2 or CLCNKA or CLCNKB or CLDN17 or CLDN10 or AQP6 or SLC1A5 or SLC5A8 or SLC26A7 and 3 more alternatives
Reaction pageDirection not assertedBalanced
Rhea RHEA:34923CC BY 4.0Reference data
Transported by SLC25A14 or SLC25A30 or SLC26A7
Reaction pageDirection not assertedBalanced
Rhea RHEA:34983CC BY 4.0Reference data
Transported by GPHRA or CLIC1 or CLDN4 or SLC26A4 or GPHRB or CLCN1 or SLC1A4 or CLCN2 or CLCNKA or CLCNKB or CLDN8 or CLDN17 and 14 more alternatives
Reaction pageReversibleBalanced
Rhea RHEA:66324CC BY 4.0Reference data
hydrogencarbonate+chloridehydrogencarbonate+chloride
Transported by SLC26A4 or SLC4A1 or SLC4A2 or SLC4A3 or SLC26A9 or SLC26A11 or SLC26A7
Reaction pageDirection not assertedBalanced
Rhea RHEA:72363CC BY 4.0Reference data
Transported by CLIC1 or CLCN1 or SLC1A4 or CLCN2 or CLDN17 or SLC1A5 or SLC26A7 or CLIC4
Reaction pageDirection not assertedBalanced
Rhea RHEA:75347CC BY 4.0Reference data
Transported by GPHRA or CLIC1 or CLDN4 or GPHRB or CLCN1 or CLCN2 or CLCNKA or CLCNKB or CLDN8 or CLDN17 or AQP6 or SLC5A8 and 3 more alternatives
Reaction pageDirection not assertedBalanced
Rhea RHEA:75383CC BY 4.0Reference data
Transported by SLC26A7 or PANX2 or PANX1
Reaction pageDirection not assertedBalanced
Rhea RHEA:76139CC BY 4.0Reference data