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Proteins/UNIPROT:O95847
Facilitates proton transport across the inner mitochondrial membrane and may dissipate excessive proton gradient associated with oxidative and metabolic stress at neuronal synapses. Regulates glutamate-induced proton conductance in astrocytes, shifting the energy metabolism toward aerobic glycolysis and lactate transfer to neurons for ATP synthesis. Can transport chloride ions with lower efficiency. The transport mechanism remains to be elucidated..
Function from UniProtKB (O95847), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
70 statements
70 statements · 7 reference databases · Subject: SLC25A27 · Sources: Bgee, gene ontology, Hetionet, Human-GEM, Reactome, Rhea, WikiPathways
4 reactions
3 names
Resolves to: SLC25A27
Reaction pageLeft to rightBalancedmitochondrial intermembrane space, mitochondrial matrix
Human-GEM MAR13080CC BY 4.0Reference data
Transported by GABRR3 or GPHRA or KCNK1 or CLIC1 or GABRP or CLDN4 or GABRD or CLIC2 or SLC26A4 or GLRA3 or BEST1 or KCNK2 and 69 more alternatives
Reaction pageRight to leftBalanced
Rhea RHEA:29823CC BY 4.0Reference data