Proteins/UNIPROT:Q9Y3C6

PPIL1

ProteinUNIPROT:Q9Y3C6

Involved in pre-mRNA splicing as component of the spliceosome. PPIases accelerate the folding of proteins. Catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Catalyzes prolyl peptide bond isomerization in CDC40/PRP17. Plays an important role in embryonic brain development; this function is independent of its isomerase activity..

Function from UniProtKB (Q9Y3C6), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

1 row

pontocerebellar hypoplasia, type 14 has a germline basis in PPIL1DiseaseGenCC HGNC:9260|MONDO:0030258Inferred only

Statements

30 statements

30 statements · 3 reference databases · Subject: PPIL1 · Sources: Hetionet, Reactome, WikiPathways

Order

PPIL1 covaries with ARHGDIGProteinHetionet hetionet:covaries:398-51645Inferred only
PPIL1 covaries with FAM193BProteinHetionet hetionet:covaries:51645-54540Inferred only
FHL1 covaries with PPIL1ProteinHetionet hetionet:covaries:2273-51645Inferred only
PPIL1 covaries with MYL6ProteinHetionet hetionet:covaries:4637-51645Inferred only
NLRC4 covaries with PPIL1ProteinHetionet hetionet:covaries:51645-58484Inferred only
PPIL1 covaries with SYNGR3ProteinHetionet hetionet:covaries:51645-9143Inferred only
GADD45G interacts with PPIL1ProteinHetionet hetionet:interacts:10912-51645Inferred only
ITGA4 interacts with PPIL1ProteinHetionet hetionet:interacts:3676-51645Inferred only
PCLAF interacts with PPIL1ProteinHetionet hetionet:interacts:51645-9768Inferred only
PPP1R8 interacts with PPIL1ProteinHetionet hetionet:interacts:51645-5511Inferred only
PPIL1 interacts with RBM42ProteinHetionet hetionet:interacts:51645-79171Inferred only
SF3B3 interacts with PPIL1ProteinHetionet hetionet:interacts:23450-51645Inferred only

Show the remaining 18

SNW1 interacts with PPIL1ProteinHetionet hetionet:interacts:22938-51645Inferred only
SRPK1 interacts with PPIL1ProteinHetionet hetionet:interacts:51645-6732Inferred only
SRPK2 interacts with PPIL1ProteinHetionet hetionet:interacts:51645-6733Inferred only
THOC5 interacts with PPIL1ProteinHetionet hetionet:interacts:51645-8563Inferred only
UBC interacts with PPIL1ProteinHetionet hetionet:interacts:51645-7316Inferred only
VCAM1 interacts with PPIL1ProteinHetionet hetionet:interacts:51645-7412Inferred only
PPIL1 interacts with WDR77ProteinHetionet hetionet:interacts:51645-79084Inferred only
PPIL1 interacts with WDR83ProteinHetionet hetionet:interacts:51645-84292Inferred only
PPIL1 participates in 22q11 2 distal CNVPathwayWikiPathways WP5546Inferred only
PPIL1 participates in Dengue Virus InfectionPathwayReactome R-HSA-9839923Inferred only
PPIL1 participates in Dengue Virus-Host InteractionsPathwayReactome R-HSA-9918481Inferred only
PPIL1 participates in DiseasePathwayReactome R-HSA-1643685Inferred only
PPIL1 participates in Infectious diseasePathwayReactome R-HSA-5663205Inferred only
PPIL1 participates in Metabolism of RNAPathwayReactome R-HSA-8953854Inferred only
PPIL1 participates in mRNA SplicingPathwayReactome R-HSA-72172Inferred only
PPIL1 participates in mRNA Splicing - Major PathwayPathwayReactome R-HSA-72163Inferred only
PPIL1 participates in Processing of Capped Intron-Containing Pre-mRNAPathwayReactome R-HSA-72203Inferred only
PPIL1 participates in Viral Infection PathwaysPathwayReactome R-HSA-9824446Inferred only

Reactions

2 reactions

MAM02709cMAM02710c
Catalysed by PPWD1 & PPIL3 & PPIE & PPIL1 or FKBP4 or FKBP6 or FKBP7 or FKBP1A or FKBP5 or PPIL2 or FKBP3 or PIN4 or FKBP8 or FKBP14 or PPIF and 15 more alternatives
Reaction pageReversibleBalance undeterminableEC 5.2.1.8cytosol

Other names

3 names

Resolves to: PPIL1

Also called: CYPL1PPIaseRotamase PPIL1

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