Proteins/UNIPROT:P07093

SERPINE2

ProteinUNIPROT:P07093

Serine protease inhibitor with activity toward thrombin, trypsin, and urokinase. Promotes neurite extension by inhibiting thrombin. Binds heparin.

Function from UniProtKB (P07093), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

35 statements

35 statements · 4 reference databases · Subject: SERPINE2 · Sources: gene ontology, Hetionet, Reactome, WikiPathways

Order

H3C15; H3C14; H3C13 covaries with SERPINE2ProteinHetionet hetionet:covaries:5270-653604Inferred only
COL4A1 interacts with SERPINE2ProteinHetionet hetionet:interacts:1282-5270Inferred only
COL4A2 interacts with SERPINE2ProteinHetionet hetionet:interacts:1284-5270Inferred only
COL4A4 interacts with SERPINE2ProteinHetionet hetionet:interacts:1286-5270Inferred only
COL4A5 interacts with SERPINE2ProteinHetionet hetionet:interacts:1287-5270Inferred only
COL4A6 interacts with SERPINE2ProteinHetionet hetionet:interacts:1288-5270Inferred only
SERPINE2 interacts with PLAUProteinHetionet hetionet:interacts:5270-5328Inferred only
SERPINE2 participates in Amplification and propagation of coagulation cascadePathwayReactome R-HSA-9769743Inferred only
SERPINE2 participates in Coagulation pathwayPathwayReactome R-HSA-9769740Inferred only
SERPINE2 participates in Dissolution of Fibrin ClotPathwayReactome R-HSA-75205Inferred only
SERPINE2 participates in Fibrin formationPathwayReactome R-HSA-9769733Inferred only
SERPINE2 participates in HemostasisPathwayReactome R-HSA-109582Inferred only

Show the remaining 23

SERPINE2 participates in miR targeted genes in leukocytesPathwayWikiPathways WP2003Inferred only
SERPINE2 participates in miR targeted genes in lymphocytesPathwayWikiPathways WP2004Inferred only
SERPINE2 participates in Regulation of clotting cascadePathwayReactome R-HSA-9769739Inferred only
SERPINE2 regulates negative regulation of blood coagulationBiological processgene ontology P07093|GO:0030195Inferred only
SERPINE2 regulates negative regulation of plasminogen activationBiological processgene ontology P07093|GO:0010757Inferred only
SERPINE2 regulates negative regulation of platelet aggregationBiological processgene ontology P07093|GO:0090331Inferred only
SERPINE2 regulates negative regulation of protein processingBiological processgene ontology P07093|GO:0010955Inferred only
SERPINE2 regulates negative regulation of proteolysisBiological processgene ontology P07093|GO:0045861Inferred only
SERPINE2 regulates positive regulation of astrocyte differentiationBiological processgene ontology P07093|GO:0048711Inferred only
SERPINE2 regulates regulation of cell migrationBiological processgene ontology P07093|GO:0030334Inferred only
AK3 decreases the expression of SERPINE2ProteinHetionet hetionet:regulates:50808-5270Inferred only
AKAP8L decreases the expression of SERPINE2ProteinHetionet hetionet:regulates:26993-5270Inferred only
APOE increases the expression of SERPINE2ProteinHetionet hetionet:regulates:348-5270Inferred only
CFLAR increases the expression of SERPINE2ProteinHetionet hetionet:regulates:8837-5270Inferred only
COPS2 decreases the expression of SERPINE2ProteinHetionet hetionet:regulates:9318-5270Inferred only
HDAC6 decreases the expression of SERPINE2ProteinHetionet hetionet:regulates:10013-5270Inferred only
HOXC11 decreases the expression of SERPINE2ProteinHetionet hetionet:regulates:3227-5270Inferred only
OVOL2 decreases the expression of SERPINE2ProteinHetionet hetionet:regulates:58495-5270Inferred only
PPIE decreases the expression of SERPINE2ProteinHetionet hetionet:regulates:10450-5270Inferred only
RAF1 decreases the expression of SERPINE2ProteinHetionet hetionet:regulates:5894-5270Inferred only
SYT1 increases the expression of SERPINE2ProteinHetionet hetionet:regulates:6857-5270Inferred only
TRIO decreases the expression of SERPINE2ProteinHetionet hetionet:regulates:7204-5270Inferred only
ZNF596 decreases the expression of SERPINE2ProteinHetionet hetionet:regulates:169270-5270Inferred only

Other names

9 names

Resolves to: SERPINE2

Also called: GDNPeptidase inhibitor 7PI-7PI7PN-1PN1Protease nexin 1Protease nexin ISerpin E2

← Every protein Find it in the graph →