Loading the page.
Proteins/UNIPROT:Q9P0L2
Serine/threonine-protein kinase. Involved in cell polarity and microtubule dynamics regulation. Phosphorylates DCX, MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU. Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3)..
Function from UniProtKB (Q9P0L2), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
42 statements
42 statements · 4 reference databases · Subject: MARK1 · Sources: gene ontology, Hetionet, UniProt, WikiPathways
4 reactions
6 names
Resolves to: MARK1
Catalysed by SGK1 or CDC7 or PLK4 or STK25 or CIT or RIOK3 or MAP2K7 or CHEK1 or BCKDK or IKBKB or CASK or AURKA and 347 more alternatives
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:17989CC BY 4.0Reference data