Pathway
Synthesis of PIPs at the plasma membrane
At the plasma membrane, subsequent phosphorylation of phosphatidylinositol 4-phosphate (PI4P) produces phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) and phosphatidylinositol 3,4,5-trisphosphate (PI(3,4,5)P3) while the actions of various other kinases and phosphatases produces phosphatidylinositol 3-phosphate (PI3P), phosphatidylinositol 5-phosphate (PI5P), phosphatidylinositol 3,4-bisphosphate (PI(3,4)P2), and phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2). Many of the phosphatidylinositol phosphatases that act at the plasma membrane belong to the myotubularin family. Enzymatically inactive myotubularin family members can heterodimerize with catalytically active mytotubularins to regulate their stability, activity and/or substrate specificity.
REACT:R-HSA-1660499Reactome
What the reference databases state
Statements
52 statements
52 statements · 1 reference database · Subject: Synthesis of PIPs at the plasma membrane · Sources: Reactome
- ARF1 participates in Synthesis of PIPs at the plasma membraneProteinReactome R-HSA-1660499Inferred only
- BMX participates in Synthesis of PIPs at the plasma membraneProteinReactome R-HSA-1660499Inferred only
- INPP4A participates in Synthesis of PIPs at the plasma membraneProteinReactome R-HSA-1660499Inferred only
- INPP4B participates in Synthesis of PIPs at the plasma membraneProteinReactome R-HSA-1660499Inferred only
- INPP5D participates in Synthesis of PIPs at the plasma membraneProteinReactome R-HSA-1660499Inferred only
- INPP5J participates in Synthesis of PIPs at the plasma membraneProteinReactome R-HSA-1660499Inferred only
- INPP5K participates in Synthesis of PIPs at the plasma membraneProteinReactome R-HSA-1660499Inferred only
- INPPL1 participates in Synthesis of PIPs at the plasma membraneProteinReactome R-HSA-1660499Inferred only
- MTM1 participates in Synthesis of PIPs at the plasma membraneProteinReactome R-HSA-1660499Inferred only
- MTMR1 participates in Synthesis of PIPs at the plasma membraneProteinReactome R-HSA-1660499Inferred only
- MTMR14 participates in Synthesis of PIPs at the plasma membraneProteinReactome R-HSA-1660499Inferred only
- MTMR2 participates in Synthesis of PIPs at the plasma membraneProteinReactome R-HSA-1660499Inferred only
Show the remaining 40
- MTMR3 participates in Synthesis of PIPs at the plasma membraneProteinReactome R-HSA-1660499Inferred only
- MTMR6 participates in Synthesis of PIPs at the plasma membraneProteinReactome R-HSA-1660499Inferred only
- MTMR8 participates in Synthesis of PIPs at the plasma membraneProteinReactome R-HSA-1660499Inferred only
- MTMR9 participates in Synthesis of PIPs at the plasma membraneProteinReactome R-HSA-1660499Inferred only
- OCRL participates in Synthesis of PIPs at the plasma membraneProteinReactome R-HSA-1660499Inferred only
- PI4K2A participates in Synthesis of PIPs at the plasma membraneProteinReactome R-HSA-1660499Inferred only
- PI4K2B participates in Synthesis of PIPs at the plasma membraneProteinReactome R-HSA-1660499Inferred only
- PIK3C2A participates in Synthesis of PIPs at the plasma membraneProteinReactome R-HSA-1660499Inferred only
- PIK3C2B participates in Synthesis of PIPs at the plasma membraneProteinReactome R-HSA-1660499Inferred only
- PIK3C2G participates in Synthesis of PIPs at the plasma membraneProteinReactome R-HSA-1660499Inferred only
- PIK3CA participates in Synthesis of PIPs at the plasma membraneProteinReactome R-HSA-1660499Inferred only
- PIK3CB participates in Synthesis of PIPs at the plasma membraneProteinReactome R-HSA-1660499Inferred only
- PIK3CD participates in Synthesis of PIPs at the plasma membraneProteinReactome R-HSA-1660499Inferred only
- PIK3CG participates in Synthesis of PIPs at the plasma membraneProteinReactome R-HSA-1660499Inferred only
- PIK3R1 participates in Synthesis of PIPs at the plasma membraneProteinReactome R-HSA-1660499Inferred only
- PIK3R2 participates in Synthesis of PIPs at the plasma membraneProteinReactome R-HSA-1660499Inferred only
- PIK3R3 participates in Synthesis of PIPs at the plasma membraneProteinReactome R-HSA-1660499Inferred only
- PIK3R5 participates in Synthesis of PIPs at the plasma membraneProteinReactome R-HSA-1660499Inferred only
- PIK3R6 participates in Synthesis of PIPs at the plasma membraneProteinReactome R-HSA-1660499Inferred only
- PIP4K2A participates in Synthesis of PIPs at the plasma membraneProteinReactome R-HSA-1660499Inferred only
- PIP4K2B participates in Synthesis of PIPs at the plasma membraneProteinReactome R-HSA-1660499Inferred only
- PIP4K2C participates in Synthesis of PIPs at the plasma membraneProteinReactome R-HSA-1660499Inferred only
- PIP5K1A participates in Synthesis of PIPs at the plasma membraneProteinReactome R-HSA-1660499Inferred only
- PIP5K1B participates in Synthesis of PIPs at the plasma membraneProteinReactome R-HSA-1660499Inferred only
- PIP5K1C participates in Synthesis of PIPs at the plasma membraneProteinReactome R-HSA-1660499Inferred only
- PLEKHA1 participates in Synthesis of PIPs at the plasma membraneProteinReactome R-HSA-1660499Inferred only
- PLEKHA2 participates in Synthesis of PIPs at the plasma membraneProteinReactome R-HSA-1660499Inferred only
- PLEKHA4 participates in Synthesis of PIPs at the plasma membraneProteinReactome R-HSA-1660499Inferred only
- PLEKHA5 participates in Synthesis of PIPs at the plasma membraneProteinReactome R-HSA-1660499Inferred only
- PLEKHA6 participates in Synthesis of PIPs at the plasma membraneProteinReactome R-HSA-1660499Inferred only
- PLEKHA8 participates in Synthesis of PIPs at the plasma membraneProteinReactome R-HSA-1660499Inferred only
- PTEN participates in Synthesis of PIPs at the plasma membraneProteinReactome R-HSA-1660499Inferred only
- PTPN13 participates in Synthesis of PIPs at the plasma membraneProteinReactome R-HSA-1660499Inferred only
- RAB14 participates in Synthesis of PIPs at the plasma membraneProteinReactome R-HSA-1660499Inferred only
- RAB4A participates in Synthesis of PIPs at the plasma membraneProteinReactome R-HSA-1660499Inferred only
- RAB5A participates in Synthesis of PIPs at the plasma membraneProteinReactome R-HSA-1660499Inferred only
- RUFY1 participates in Synthesis of PIPs at the plasma membraneProteinReactome R-HSA-1660499Inferred only
- SBF2 participates in Synthesis of PIPs at the plasma membraneProteinReactome R-HSA-1660499Inferred only
- SYNJ1 participates in Synthesis of PIPs at the plasma membraneProteinReactome R-HSA-1660499Inferred only
- SYNJ2 participates in Synthesis of PIPs at the plasma membraneProteinReactome R-HSA-1660499Inferred only