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Proteins/UNIPROT:Q96PE3
Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2). Also catalyzes inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate (By similarity). Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival (By similarity). May protect neurons from excitotoxic cell death by regulating the synaptic localization of cell surface N-methyl-D-aspartate-type glutamate receptors (NMDARs) and NMDAR-mediated excitatory postsynaptic current (By similarity)..
[Isoform 4]: Displays no 4-phosphatase activity for PtdIns(3,4)P2, Ins(3,4)P2, or Ins(1,3,4)P3..
Function from UniProtKB (Q96PE3), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
2 rows
16 statements
16 statements · 3 reference databases · Subject: INPP4A · Sources: Hetionet, Reactome, WikiPathways
6 reactions
MAM00551c+watera 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate)+phosphate(3-)
Reaction pageLeft to rightBalance undeterminableEC 3.1.3.66cytosol
Human-GEM MAR06549CC BY 4.0Reference data
2 names
Resolves to: INPP4A
Human-GEM MAR06570CC BY 4.0Reference data
MAM00551n+watera 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate)+phosphate(3-)
Reaction pageLeft to rightBalance undeterminableEC 3.1.3.66nucleus
Human-GEM MAR08810CC BY 4.0Reference data
CHEBI:57658+watera 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate)+hydrogenphosphate
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:17193CC BY 4.0Reference data
CHEBI:83241+water1D-myo-inositol 3-phosphate+hydrogenphosphate
Reaction pageLeft to rightBalanced
Rhea RHEA:43388CC BY 4.0Reference data
CHEBI:58414+waterCHEBI:83242+hydrogenphosphate
Reaction pageLeft to rightBalanced
Rhea RHEA:43392CC BY 4.0Reference data