Proteins/UNIPROT:P32241

VIPR1

ProteinUNIPROT:P32241

G protein-coupled receptor activated by the neuropeptides vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating polypeptide (ADCYAP1/PACAP). Binds VIP and both PACAP27 and PACAP38 bioactive peptides with the following order of ligand affinity VIP = PACAP27 > PACAP38. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. Activates cAMP-dependent pathway..

Function from UniProtKB (P32241), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

67 statements

67 statements · 4 reference databases · Subject: VIPR1 · Sources: gene ontology, Hetionet, Reactome, WikiPathways

Order

ADAMTSL2 covaries with VIPR1ProteinHetionet hetionet:covaries:7433-9719Inferred only
CALM1 interacts with VIPR1ProteinHetionet hetionet:interacts:7433-805Inferred only
CALM1 interacts with VIPR1ProteinHetionet hetionet:interacts:7433-808Inferred only
CALM1 interacts with VIPR1ProteinHetionet hetionet:interacts:7433-801Inferred only
GNAQ interacts with VIPR1ProteinHetionet hetionet:interacts:2776-7433Inferred only
GNAS interacts with VIPR1ProteinHetionet hetionet:interacts:2778-7433Inferred only
VIPR1 interacts with GPRASP1ProteinHetionet hetionet:interacts:7433-9737Inferred only
HLA-B interacts with VIPR1ProteinHetionet hetionet:interacts:3106-7433Inferred only
PTMA interacts with VIPR1ProteinHetionet hetionet:interacts:5757-7433Inferred only
VIPR1 interacts with RAMP1ProteinHetionet hetionet:interacts:10267-7433Inferred only
VIPR1 interacts with RAMP2ProteinHetionet hetionet:interacts:10266-7433Inferred only
VIPR1 interacts with RAMP3ProteinHetionet hetionet:interacts:10268-7433Inferred only

Show the remaining 55

SCT interacts with VIPR1ProteinHetionet hetionet:interacts:6343-7433Inferred only
VIPR1 interacts with TINF2ProteinHetionet hetionet:interacts:26277-7433Inferred only
VIP interacts with VIPR1ProteinHetionet hetionet:interacts:7432-7433Inferred only
VIPR1 participates in Class B/2 (Secretin family receptors)PathwayReactome R-HSA-373080Inferred only
VIPR1 participates in G alpha (s) signalling eventsPathwayReactome R-HSA-418555Inferred only
VIPR1 participates in Glucagon-type ligand receptorsPathwayReactome R-HSA-420092Inferred only
VIPR1 participates in GPCR downstream signallingPathwayReactome R-HSA-388396Inferred only
VIPR1 participates in GPCR ligand bindingPathwayReactome R-HSA-500792Inferred only
VIPR1 participates in GPCRs class B secretin likePathwayWikiPathways WP334Inferred only
VIPR1 participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
VIPR1 participates in Signaling by GPCRPathwayReactome R-HSA-372790Inferred only
VIPR1 participates in Sudden infant death syndrome SIDS susceptibility pathwaysPathwayWikiPathways WP706Inferred only
VIPR1 regulates positive regulation of cell population proliferationBiological processgene ontology P32241|GO:0008284Inferred only
VIPR1 increases the expression of ABCC5ProteinHetionet hetionet:regulates:7433-10057Inferred only
VIPR1 decreases the expression of ANXA2ProteinHetionet hetionet:regulates:7433-302Inferred only
VIPR1 decreases the expression of BNIP3LProteinHetionet hetionet:regulates:7433-665Inferred only
VIPR1 decreases the expression of CASC3ProteinHetionet hetionet:regulates:7433-22794Inferred only
VIPR1 decreases the expression of CEBPBProteinHetionet hetionet:regulates:7433-1051Inferred only
VIPR1 decreases the expression of CEMIP2ProteinHetionet hetionet:regulates:7433-23670Inferred only
VIPR1 increases the expression of CES1ProteinHetionet hetionet:regulates:7433-1066Inferred only
VIPR1 increases the expression of CNPY3ProteinHetionet hetionet:regulates:7433-10695Inferred only
VIPR1 increases the expression of COL11A1ProteinHetionet hetionet:regulates:7433-1301Inferred only
VIPR1 decreases the expression of DDX47ProteinHetionet hetionet:regulates:7433-51202Inferred only
VIPR1 decreases the expression of DPYSL2ProteinHetionet hetionet:regulates:7433-1808Inferred only
VIPR1 decreases the expression of FABP5ProteinHetionet hetionet:regulates:7433-2171Inferred only
VIPR1 decreases the expression of G3BP1ProteinHetionet hetionet:regulates:7433-10146Inferred only
VIPR1 increases the expression of HPProteinHetionet hetionet:regulates:7433-3240Inferred only
VIPR1 increases the expression of IKBKEProteinHetionet hetionet:regulates:7433-9641Inferred only
VIPR1 increases the expression of INPP4BProteinHetionet hetionet:regulates:7433-8821Inferred only
VIPR1 decreases the expression of LDHBProteinHetionet hetionet:regulates:7433-3945Inferred only
VIPR1 decreases the expression of LGALS1ProteinHetionet hetionet:regulates:7433-3956Inferred only
VIPR1 increases the expression of MALProteinHetionet hetionet:regulates:7433-4118Inferred only
VIPR1 increases the expression of ME2ProteinHetionet hetionet:regulates:7433-4200Inferred only
VIPR1 decreases the expression of MSNProteinHetionet hetionet:regulates:7433-4478Inferred only
VIPR1 decreases the expression of NDUFA9ProteinHetionet hetionet:regulates:7433-4704Inferred only
VIPR1 decreases the expression of NT5DC2ProteinHetionet hetionet:regulates:7433-64943Inferred only
VIPR1 decreases the expression of PDHXProteinHetionet hetionet:regulates:7433-8050Inferred only
VIPR1 decreases the expression of PWP1ProteinHetionet hetionet:regulates:7433-11137Inferred only
VIPR1 increases the expression of RBKSProteinHetionet hetionet:regulates:7433-64080Inferred only
VIPR1 increases the expression of RBP4ProteinHetionet hetionet:regulates:7433-5950Inferred only
VIPR1 decreases the expression of RNH1ProteinHetionet hetionet:regulates:7433-6050Inferred only
VIPR1 decreases the expression of RPIAProteinHetionet hetionet:regulates:7433-22934Inferred only
VIPR1 decreases the expression of RPS4Y1ProteinHetionet hetionet:regulates:7433-6192Inferred only
VIPR1 decreases the expression of S100A6ProteinHetionet hetionet:regulates:7433-6277Inferred only
VIPR1 decreases the expression of SPAG7ProteinHetionet hetionet:regulates:7433-9552Inferred only
VIPR1 increases the expression of SUV39H1ProteinHetionet hetionet:regulates:7433-6839Inferred only
VIPR1 decreases the expression of TEX10ProteinHetionet hetionet:regulates:7433-54881Inferred only
VIPR1 decreases the expression of TKTProteinHetionet hetionet:regulates:7433-7086Inferred only
VIPR1 decreases the expression of TLCD3AProteinHetionet hetionet:regulates:7433-79850Inferred only
VIPR1 decreases the expression of TMEM109ProteinHetionet hetionet:regulates:7433-79073Inferred only
VIPR1 decreases the expression of TNFRSF21ProteinHetionet hetionet:regulates:7433-27242Inferred only
VIPR1 decreases the expression of UBE2SProteinHetionet hetionet:regulates:7433-27338Inferred only
VIPR1 decreases the expression of VAT1ProteinHetionet hetionet:regulates:7433-10493Inferred only
VIPR1 increases the expression of WIF1ProteinHetionet hetionet:regulates:7433-11197Inferred only
VIPR1 decreases the expression of YBX3ProteinHetionet hetionet:regulates:7433-8531Inferred only

Other names

7 names

Resolves to: VIPR1

Also called: PACAP type II receptorPACAP-R-2PACAP-R2Pituitary adenylate cyclase-activating polypeptide type II receptorVIP-R-1VPAC1 receptorVPAC1R

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