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Proteins/UNIPROT:Q9NUD9
Alpha-1,6-mannosyltransferase that catalyzes the transfer of the second mannose, via an alpha-1,6 bond, from a dolichol-phosphate-mannose (Dol-P-Man) to a 2-acyl-6-(alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl)-1-(1-radyl,2-acyl-sn-glycero-3-phospho)-1D-myo-inositol (also termed H2) intermediate to generate a 2-acyl-6-[alpha-D-mannosyl-(1->6)-alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl]-1-(1-radyl,2-acyl-sn-glycero-3-phospho)-1D-myo-inositol (also termed H3) and participates in the seventh step of the glycosylphosphatidylinositol-anchor biosynthesis (Probable). May also transfer the second mannose on a 2-acyl-6-[2-phosphoethanolamine-alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl]-1-(1-radyl,2-acyl-sn-glycero-3-phospho)-1D-myo-inositol (also termed H5), but less effectively (Probable)..
Function from UniProtKB (Q9NUD9), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
2 rows
51 statements
51 statements · 5 reference databases · Subject: PIGV · Sources: Hetionet, Human-GEM, Reactome, Rhea, WikiPathways
5 reactions
D-glucosyl-N-acylsphingosine+CHEBI:67119proton+a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E))+UDP
Catalysed by GLT8D1 or B4GALT7 or PIGV or B4GALT1 or GALNT7 or B4GALT2 or A4GNT or B4GALT6 or PIGZ or GLT8D2 or B4GALT4 or GCNT7 and 23 more alternatives
4 names
Resolves to: PIGV
Reaction pageLeft to rightBalance undeterminableEC 2.4.1.-endoplasmic reticulum
Human-GEM MAR00765CC BY 4.0Reference data
MAM01734r+MAM02483rMAM01733r+proton+MAM02431r
Catalysed by PIGV
Reaction pageLeft to rightBalance undeterminableEC 2.4.1.-endoplasmic reticulum
Human-GEM MAR08384CC BY 4.0Reference data
MAM01734r+MAM01783rMAM01733r+proton+MAM02463r
Catalysed by PIGV
Reaction pageLeft to rightBalance undeterminableEC 2.4.1.-endoplasmic reticulum
Human-GEM MAR08387CC BY 4.0Reference data
a 2-acyl-6-(alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl)-1-(1-radyl,2-acyl-sn-glycero-3-phospho)-1D-myo-inositol+a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphatea 2-acyl-6-[alpha-D-mannosyl-(1->6)-alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl]-1-(1-radyl,2-acyl-sn-glycero-3-phospho)-1D-myo-inositol+a di-trans,poly-cis-dolichyl phosphate+hydron
Catalysed by PIGV
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:60488CC BY 4.0Reference data
a 2-acyl-6-[2-phosphoethanolamine-alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl]-1-(1-radyl,2-acyl-sn-glycero-3-phospho)-1D-myo-inositol+a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphatea 2-acyl-6-[alpha-D-mannosyl-(1->6)-2-phosphoethanolamine-alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl]-1-(1-radyl,2-acyl-sn-glycero-3-phospho)-1D-myo-inositol+a di-trans,poly-cis-dolichyl phosphate+hydron
Catalysed by PIGV
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:60992CC BY 4.0Reference data