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Proteins/UNIPROT:Q9UBB5
Binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binds hemimethylated DNA as well. Recruits histone deacetylases and DNA methyltransferases to chromatin. Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin. Acts as a transcriptional repressor and plays a role in gene silencing. Functions as a scaffold protein, targeting GATAD2A and GATAD2B to chromatin to promote repression. May enhance the activation of some unmethylated cAMP-responsive promoters..
Function from UniProtKB (Q9UBB5), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
44 statements
44 statements · 4 reference databases · Subject: MBD2 · Sources: gene ontology, Hetionet, Reactome, WikiPathways
3 names
Resolves to: MBD2