Proteins/UNIPROT:Q96CC6

RHBDF1

ProteinUNIPROT:Q96CC6

Regulates ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, thereby plays a role in sleep, cell survival, proliferation, migration and inflammation. Does not exhibit any protease activity on its own. Regulator of proteosomal assembly by promoting formation of the proteosome assembly chaperone PSMG1-PSMG2 heterodimer, positively regulating proteosome activity..

Function from UniProtKB (Q96CC6), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

1 row

dilated cardiomyopathy has a germline basis in RHBDF1DiseaseGenCC HGNC:20561|MONDO:0005021Inferred only

Statements

20 statements

20 statements · 2 reference databases · Subject: RHBDF1 · Sources: gene ontology, Hetionet

Order

RHBDF1 covaries with MXRA8ProteinHetionet hetionet:covaries:54587-64285Inferred only
PAQR9 covaries with RHBDF1ProteinHetionet hetionet:covaries:344838-64285Inferred only
TGFA interacts with RHBDF1ProteinHetionet hetionet:interacts:64285-7039Inferred only
UBC interacts with RHBDF1ProteinHetionet hetionet:interacts:64285-7316Inferred only
RHBDF1 regulates negative regulation of protein secretionBiological processgene ontology Q96CC6|GO:0050709Inferred only
RHBDF1 regulates regulation of epidermal growth factor receptor signaling pathwayBiological processgene ontology Q96CC6|GO:0042058Inferred only
RHBDF1 regulates regulation of proteasomal protein catabolic processBiological processgene ontology Q96CC6|GO:0061136Inferred only
RHBDF1 regulates regulation of protein secretionBiological processgene ontology Q96CC6|GO:0050708Inferred only
AKT1 increases the expression of RHBDF1ProteinHetionet hetionet:regulates:207-64285Inferred only
B4GALT1 increases the expression of RHBDF1ProteinHetionet hetionet:regulates:2683-64285Inferred only
CBS increases the expression of RHBDF1ProteinHetionet hetionet:regulates:875-64285Inferred only
CDKN1B increases the expression of RHBDF1ProteinHetionet hetionet:regulates:1027-64285Inferred only

Show the remaining 8

EGFR increases the expression of RHBDF1ProteinHetionet hetionet:regulates:1956-64285Inferred only
MTF2 increases the expression of RHBDF1ProteinHetionet hetionet:regulates:22823-64285Inferred only
PDPK1 increases the expression of RHBDF1ProteinHetionet hetionet:regulates:5170-64285Inferred only
RPS6 increases the expression of RHBDF1ProteinHetionet hetionet:regulates:6194-64285Inferred only
RUVBL1 increases the expression of RHBDF1ProteinHetionet hetionet:regulates:8607-64285Inferred only
TNFRSF21 increases the expression of RHBDF1ProteinHetionet hetionet:regulates:27242-64285Inferred only
TUBB3 increases the expression of RHBDF1ProteinHetionet hetionet:regulates:10381-64285Inferred only
USP7 increases the expression of RHBDF1ProteinHetionet hetionet:regulates:7874-64285Inferred only

Other names

7 names

Resolves to: RHBDF1

Also called: C16orf8DIST1Epidermal growth factor receptor-related proteinIRHOM1p100hRhoRhomboid 5 homolog 1Rhomboid family member 1

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