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Proteins/UNIPROT:Q13733
Sperm-specific catalytic alpha subunit of the Na(+)/K(+)-ATPase responsible for ATP-dependent Na(+)/K(+) exchange across the plasma membrane. Transports 3 Na(+) ions out of the cell and 2 K(+) ions into the cell for each ATP hydrolyze. Plays an essential for sperm motility, capacitation, and male fertility by maintaining ionic gradients required for flagellar function and signaling (By similarity)..
Function from UniProtKB (Q13733), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 1 · transported by
1 compound
1 compound.
0 reported routes1 assembled route
23 statements
23 statements · 7 reference databases · Subject: ATP1A4 · Sources: gene ontology, Hetionet, Human-GEM, Reactome, Rhea, UniProt, WikiPathways
2 reactions
ATP+water+2potassium atom+3sodium(1+)ADP+proton+2potassium atom+3sodium(1+)+phosphate(3-)
Transported by ATP1A1 & FXYD2 & ATP1B4 or ATP1B2 & ATP1A2 & FXYD2 or ATP1A2 & ATP1B3 &
3 names
Resolves to: ATP1A4
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR05429CC BY 4.0Reference data
2K(+)+3sodium(1+)+ATP(4-)+water2K(+)+3sodium(1+)+ADP(3-)+hydrogenphosphate+hydron
Transported by ATP1A1 or ATP1A3 or ATP1A2 or ATP12A or ATP1A4
Reaction pageLeft to rightBalanced
Rhea RHEA:18353CC BY 4.0Reference data