N-hexadecanoyl-sphinganine-1-phosphocholine

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

167 compounds within 3 steps: 2 in 1, 30 in 2, 135 in 3

Three steps

sn-glycerol 3-phosphocholineReach from here →
1. N-hexadecanoylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = N-hexadecanoyl-sphinganine-1-phosphocholine + a 1,2-diacyl-sn-glycerol
2. a 2-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA
3. 2 a 2-acyl-sn-glycero-3-phosphocholine = sn-glycerol 3-phosphocholine + a 1,2-diacyl-sn-glycero-3-phosphocholine
Catalysed by SGMS1, SGMS2, LPGAT1, ASPGOne of 6 routes
1-acyl-sn-glycerol 3-phosphateReach from here →
1. N-hexadecanoylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = N-hexadecanoyl-sphinganine-1-phosphocholine + a 1,2-diacyl-sn-glycerol
2. a 2-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA
3. acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase
Catalysed by SGMS1, SGMS2, LPGAT1, GPAT3 and 3 moremitochondrial matrix
a cholesterol esterReach from here →
1. N-hexadecanoylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = N-hexadecanoyl-sphinganine-1-phosphocholine + a 1,2-diacyl-sn-glycerol
2. a 2-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA
3. an acyl-CoA + cholesterol = a cholesterol ester + CoA
Catalysed by SGMS1, SGMS2, LPGAT1, SOAT2 and 1 more
all-trans-retinolReach from here →
1. N-hexadecanoylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = N-hexadecanoyl-sphinganine-1-phosphocholine + a 1,2-diacyl-sn-glycerol
2. all-trans-retinol--[retinol-binding protein] + a 1,2-diacyl-sn-glycero-3-phosphocholine = apo--[retinol-binding protein] + an all-trans-retinyl ester + a 2-acyl-sn-glycero-3-phosphocholine
3. carboxylesterase (retinyl-ester)
Catalysed by SGMS1, SGMS2, LRAT, CES2 and 19 morecytosolOne of 2 routes
a 2-acylglycerolReach from here →
1. N-hexadecanoylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = N-hexadecanoyl-sphinganine-1-phosphocholine + a 1,2-diacyl-sn-glycerol
2. a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = phosphocholine + a 1,2-diacyl-sn-glycerol + H(+)
3. a 1,2-diacyl-sn-glycerol + H2O = a 2-acylglycerol + a fatty acid + H(+)
Catalysed by SGMS1, SGMS2, SMPD1, DAGLB and 2 more
a monoacylglycerolReach from here →
1. N-hexadecanoylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = N-hexadecanoyl-sphinganine-1-phosphocholine + a 1,2-diacyl-sn-glycerol
2. a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = phosphocholine + a 1,2-diacyl-sn-glycerol + H(+)
3. 1,2-diacyl-sn-glycerol acylhydrolase
Catalysed by SGMS1, SGMS2, SMPD1, LIPF and 14 moreextracellular spaceOne of 9 routes
1-(alk-1-enyl)-2-acyl-sn-glycero-3-phosphoethanolamineReach from here →
1. N-hexadecanoylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = N-hexadecanoyl-sphinganine-1-phosphocholine + a 1,2-diacyl-sn-glycerol
2. a 2-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA
3. Acyl-CoA:1-alkenylglycerophosphoethanolamine O-acyltransferase
Catalysed by SGMS1, SGMS2, LPGAT1, LPCAT4 and 3 morecytosol
AH2Reach from here →
1. N-hexadecanoylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = N-hexadecanoyl-sphinganine-1-phosphocholine + a 1,2-diacyl-sn-glycerol
2. a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + choline + H(+)
3. choline + A = betaine aldehyde + AH2
Catalysed by SGMS1, SGMS2, PLD2, PLD1 and 2 more
hexadecanalReach from here →
1. N-hexadecanoylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = N-hexadecanoyl-sphinganine-1-phosphocholine + a 1,2-diacyl-sn-glycerol
2. sphinganine + hexadecanoate = N-hexadecanoylsphinganine + H2O
3. hexadecanoate + NADH + 2 H(+) = hexadecanal + NAD(+) + H2O
Catalysed by SGMS1, SGMS2, ASAH2, ALDH3B1 and 2 more
all-trans-retinyl hexadecanoateReach from here →
1. N-hexadecanoylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = N-hexadecanoyl-sphinganine-1-phosphocholine + a 1,2-diacyl-sn-glycerol
2. sphinganine + hexadecanoate = N-hexadecanoylsphinganine + H2O
3. all-trans-retinyl hexadecanoate + H2O = 11-cis-retinol + hexadecanoate + H(+)
Catalysed by SGMS1, SGMS2, ASAH2, RPE65
glycerolReach from here →
1. N-hexadecanoylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = N-hexadecanoyl-sphinganine-1-phosphocholine + a 1,2-diacyl-sn-glycerol
2. a 3-acyl-sn-glycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine = a 1,3-diacylglycerol + a 1-acyl-sn-glycero-3-phosphocholine
3. a 1-acylglycerol + a 1,3-diacylglycerol = a triacylglycerol + glycerol
Catalysed by SGMS1, SGMS2, PLA2G15, PNPLA4 and 2 moreOne of 2 routes
a diacylglycerolReach from here →
1. N-hexadecanoylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = N-hexadecanoyl-sphinganine-1-phosphocholine + a 1,2-diacyl-sn-glycerol
2. a 1,2-diacylglycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine = a triacylglycerol + a 1-acyl-sn-glycero-3-phosphocholine
3. a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+)
Catalysed by SGMS1, SGMS2, TMEM68, DDHD2 and 18 moreOne of 2 routes
CHEBI:18132Reach from here →
1. N-hexadecanoylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = N-hexadecanoyl-sphinganine-1-phosphocholine + a 1,2-diacyl-sn-glycerol
2. a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + choline + H(+)
3. ATP:choline phosphotransferase
Catalysed by SGMS1, SGMS2, PLD2, PLD1 and 3 morecytosolOne of 5 routes
(11Z)-docosenoyl-CoA(4-)Reach from here →
1. N-hexadecanoylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = N-hexadecanoyl-sphinganine-1-phosphocholine + a 1,2-diacyl-sn-glycerol
2. a 2-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA
3. acyl-CoA pool formation and breakdown
Catalysed by SGMS1, SGMS2, LPGAT1cytosol
(7Z)-tetradecenoyl-CoAReach from here →
1. N-hexadecanoylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = N-hexadecanoyl-sphinganine-1-phosphocholine + a 1,2-diacyl-sn-glycerol
2. a 2-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA
3. acyl-CoA pool formation and breakdown
Catalysed by SGMS1, SGMS2, LPGAT1cytosol
S-hexadecanoyl-N-acetylcysteamineReach from here →
1. N-hexadecanoylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = N-hexadecanoyl-sphinganine-1-phosphocholine + a 1,2-diacyl-sn-glycerol
2. sphinganine + hexadecanoate = N-hexadecanoylsphinganine + H2O
3. S-hexadecanoyl-N-acetylcysteamine + H2O = N-acetylcysteamine + hexadecanoate + H(+)
Catalysed by SGMS1, SGMS2, ASAH2, PPT1 and 1 more
S-hexadecanoyl-N-acetylcysteine methyl esterReach from here →
1. N-hexadecanoylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = N-hexadecanoyl-sphinganine-1-phosphocholine + a 1,2-diacyl-sn-glycerol
2. sphinganine + hexadecanoate = N-hexadecanoylsphinganine + H2O
3. S-hexadecanoyl-N-acetylcysteine methyl ester + H2O = N-acetylcysteine methyl ester + hexadecanoate + H(+)
Catalysed by SGMS1, SGMS2, ASAH2, PPT1
elaidic acidReach from here →
1. N-hexadecanoylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = N-hexadecanoyl-sphinganine-1-phosphocholine + a 1,2-diacyl-sn-glycerol
2. a 2-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA
3. acyl-CoA pool formation and breakdown
Catalysed by SGMS1, SGMS2, LPGAT1cytosol
chlorine(.)Reach from here →
1. N-hexadecanoylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = N-hexadecanoyl-sphinganine-1-phosphocholine + a 1,2-diacyl-sn-glycerol
2. a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + choline + H(+)
3. transport of chloride and choline (cytosol to extracellular)
Catalysed by SGMS1, SGMS2, PLD2, PLD1 and 2 moreextracellular space, cytosol
a 1-O-alkyl-sn-glycero-3-phosphocholineReach from here →
1. N-hexadecanoylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = N-hexadecanoyl-sphinganine-1-phosphocholine + a 1,2-diacyl-sn-glycerol
2. a 2-acylglycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine = a 1,2-diacylglycerol + a 1-acyl-sn-glycero-3-phosphocholine
3. a 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + a 1,2-diacylglycerol = a 1-O-alkyl-sn-glycero-3-phosphocholine + a triacylglycerol
Catalysed by SGMS1, SGMS2, PLA2G15, TMEM68
an N-acylsphinganineReach from here →
1. N-hexadecanoylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = N-hexadecanoyl-sphinganine-1-phosphocholine + a 1,2-diacyl-sn-glycerol
2. a 2-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA
3. sphingosine N-acyltransferase (sphinganine)
Catalysed by SGMS1, SGMS2, LPGAT1, CERS1 and 5 morecytosolOne of 4 routes
an N-acyl-(4R)-4-hydroxysphinganineReach from here →
1. N-hexadecanoylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = N-hexadecanoyl-sphinganine-1-phosphocholine + a 1,2-diacyl-sn-glycerol
2. a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = phosphocholine + a 1,2-diacyl-sn-glycerol + H(+)
3. an N-acyl-(4R)-4-hydroxysphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = an N-acyl-(4R)-4-hydroxysphinganine-phosphocholine + a 1,2-diacyl-sn-glycerol
Catalysed by SGMS1, SGMS2, SMPD1One of 2 routes
an acylcholineReach from here →
1. N-hexadecanoylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = N-hexadecanoyl-sphinganine-1-phosphocholine + a 1,2-diacyl-sn-glycerol
2. a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + choline + H(+)
3. an acylcholine + H2O = a carboxylate + choline + H(+)
Catalysed by SGMS1, SGMS2, PLD2, PLD1 and 2 more
fatty acidReach from here →
1. N-hexadecanoylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = N-hexadecanoyl-sphinganine-1-phosphocholine + a 1,2-diacyl-sn-glycerol
2. a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = phosphocholine + a 1,2-diacyl-sn-glycerol + H(+)
3. 1,2-diacyl-sn-glycerol acylhydrolase
Catalysed by SGMS1, SGMS2, SMPD1, LPLextracellular spaceOne of 12 routes
a fatty aldehydeReach from here →
1. N-hexadecanoylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = N-hexadecanoyl-sphinganine-1-phosphocholine + a 1,2-diacyl-sn-glycerol
2. a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)
3. a fatty aldehyde + NAD(+) + H2O = a fatty acid + NADH + 2 H(+)
Catalysed by SGMS1, SGMS2, PLA2G10, PLA2G6 and 29 more
a 1-acylglycerolReach from here →
1. N-hexadecanoylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = N-hexadecanoyl-sphinganine-1-phosphocholine + a 1,2-diacyl-sn-glycerol
2. a 3-acyl-sn-glycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine = a 1,3-diacylglycerol + a 1-acyl-sn-glycero-3-phosphocholine
3. a 1,3-diacylglycerol + H2O = a 1-acylglycerol + a fatty acid + H(+)
Catalysed by SGMS1, SGMS2, PLA2G15, DDHD2 and 1 moreOne of 2 routes
a 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholineReach from here →
1. N-hexadecanoylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = N-hexadecanoyl-sphinganine-1-phosphocholine + a 1,2-diacyl-sn-glycerol
2. a 2-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA
3. Acyl-CoA:1-alkyl-sn-glycero-3-phosphocholine O-acyltransferase
Catalysed by SGMS1, SGMS2, LPGAT1, LPCAT4 and 3 morecytosol
N-(2-hydroxytetracosanoyl)-sphinganineReach from here →
1. N-hexadecanoylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = N-hexadecanoyl-sphinganine-1-phosphocholine + a 1,2-diacyl-sn-glycerol
2. sphinganine + hexadecanoate = N-hexadecanoylsphinganine + H2O
3. 2-hydroxytetracosanoyl-CoA + sphinganine = N-(2-hydroxytetracosanoyl)-sphinganine + CoA + H(+)
Catalysed by SGMS1, SGMS2, ASAH2, CERS3 and 1 more
an N-acylsphing-4-enineReach from here →
1. N-hexadecanoylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = N-hexadecanoyl-sphinganine-1-phosphocholine + a 1,2-diacyl-sn-glycerol
2. a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = phosphocholine + a 1,2-diacyl-sn-glycerol + H(+)
3. an N-acylsphing-4-enine + a 1,2-diacyl-sn-glycero-3-phosphocholine = a sphingomyelin + a 1,2-diacyl-sn-glycerol
Catalysed by SGMS1, SGMS2, SMPD1One of 10 routes
an N-acylethanolamineReach from here →
1. N-hexadecanoylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = N-hexadecanoyl-sphinganine-1-phosphocholine + a 1,2-diacyl-sn-glycerol
2. a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + a 1,2-diacyl-sn-glycero-3-phosphocholine = an N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine + a 2-acyl-sn-glycero-3-phosphocholine + H(+)
3. an N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine + H2O = an N-acylethanolamine + a 1,2-diacyl-sn-glycero-3-phosphate + H(+)
Catalysed by SGMS1, SGMS2, PLA2G4E, PLAAT5 and 2 more
N-tetracosanoylsphinganineReach from here →
1. N-hexadecanoylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = N-hexadecanoyl-sphinganine-1-phosphocholine + a 1,2-diacyl-sn-glycerol
2. sphinganine + hexadecanoate = N-hexadecanoylsphinganine + H2O
3. tetracosanoyl-CoA + sphinganine = N-tetracosanoylsphinganine + CoA + H(+)
Catalysed by SGMS1, SGMS2, ASAH2, CERS3 and 2 more
N-hexacosanoylsphinganineReach from here →
1. N-hexadecanoylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = N-hexadecanoyl-sphinganine-1-phosphocholine + a 1,2-diacyl-sn-glycerol
2. sphinganine + hexadecanoate = N-hexadecanoylsphinganine + H2O
3. hexacosanoyl-CoA + sphinganine = N-hexacosanoylsphinganine + CoA + H(+)
Catalysed by SGMS1, SGMS2, ASAH2, CERS3 and 2 more
16-hydroxyhexadecanoateReach from here →
1. N-hexadecanoylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = N-hexadecanoyl-sphinganine-1-phosphocholine + a 1,2-diacyl-sn-glycerol
2. sphinganine + hexadecanoate = N-hexadecanoylsphinganine + H2O
3. hexadecanoate + reduced [NADPH--hemoprotein reductase] + O2 = 16-hydroxyhexadecanoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)
Catalysed by SGMS1, SGMS2, ASAH2, CYP4A11 and 2 more
(6Z,9Z,12Z)-octadecatrienoyl-CoAReach from here →
1. N-hexadecanoylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = N-hexadecanoyl-sphinganine-1-phosphocholine + a 1,2-diacyl-sn-glycerol
2. a 2-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA
3. acyl-CoA pool formation and breakdown
Catalysed by SGMS1, SGMS2, LPGAT1cytosol
dodecanoyl-CoAReach from here →
1. N-hexadecanoylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = N-hexadecanoyl-sphinganine-1-phosphocholine + a 1,2-diacyl-sn-glycerol
2. a 2-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA
3. acyl-CoA pool formation and breakdown
Catalysed by SGMS1, SGMS2, LPGAT1cytosol
hexadecanoyl-CoAReach from here →
1. N-hexadecanoylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = N-hexadecanoyl-sphinganine-1-phosphocholine + a 1,2-diacyl-sn-glycerol
2. sphinganine + hexadecanoate = N-hexadecanoylsphinganine + H2O
3. hexadecanoate + ATP + CoA = hexadecanoyl-CoA + AMP + diphosphate
Catalysed by SGMS1, SGMS2, ASAH2, SLC27A2 and 10 more
eicosanoyl-CoAReach from here →
1. N-hexadecanoylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = N-hexadecanoyl-sphinganine-1-phosphocholine + a 1,2-diacyl-sn-glycerol
2. a 2-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA
3. acyl-CoA pool formation and breakdown
Catalysed by SGMS1, SGMS2, LPGAT1cytosol
(9Z,12Z)-octadecadienoyl-CoAReach from here →
1. N-hexadecanoylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = N-hexadecanoyl-sphinganine-1-phosphocholine + a 1,2-diacyl-sn-glycerol
2. a 2-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA
3. acyl-CoA pool formation and breakdown
Catalysed by SGMS1, SGMS2, LPGAT1cytosol
tetradecanoyl-CoAReach from here →
1. N-hexadecanoylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = N-hexadecanoyl-sphinganine-1-phosphocholine + a 1,2-diacyl-sn-glycerol
2. a 2-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA
3. acyl-CoA pool formation and breakdown
Catalysed by SGMS1, SGMS2, LPGAT1cytosol
octadecanoyl-CoAReach from here →
1. N-hexadecanoylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = N-hexadecanoyl-sphinganine-1-phosphocholine + a 1,2-diacyl-sn-glycerol
2. a 2-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA
3. acyl-CoA pool formation and breakdown
Catalysed by SGMS1, SGMS2, LPGAT1cytosol
a 1-acylglycerone 3-phosphateReach from here →
1. N-hexadecanoylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = N-hexadecanoyl-sphinganine-1-phosphocholine + a 1,2-diacyl-sn-glycerol
2. a 2-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA
3. dihydroxyacetone phosphate + an acyl-CoA = a 1-acylglycerone 3-phosphate + CoA
Catalysed by SGMS1, SGMS2, LPGAT1, GNPAT
an N-acylglycineReach from here →
1. N-hexadecanoylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = N-hexadecanoyl-sphinganine-1-phosphocholine + a 1,2-diacyl-sn-glycerol
2. a 2-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA
3. an acyl-CoA + glycine = an N-acylglycine + CoA + H(+)
Catalysed by SGMS1, SGMS2, LPGAT1, GLYATL3 and 2 more
a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)Reach from here →
1. N-hexadecanoylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = N-hexadecanoyl-sphinganine-1-phosphocholine + a 1,2-diacyl-sn-glycerol
2. a 2-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA
3. a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA
Catalysed by SGMS1, SGMS2, LPGAT1, LCLAT1 and 1 moreOne of 5 routes
sphinganine 1-phosphateReach from here →
1. N-hexadecanoylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = N-hexadecanoyl-sphinganine-1-phosphocholine + a 1,2-diacyl-sn-glycerol
2. sphinganine + hexadecanoate = N-hexadecanoylsphinganine + H2O
3. sphinganine + ATP = sphinganine 1-phosphate + ADP + H(+)
Catalysed by SGMS1, SGMS2, ASAH2, SPHK2 and 1 more
a 1-acyl-sn-glycero-3-phosphateReach from here →
1. N-hexadecanoylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = N-hexadecanoyl-sphinganine-1-phosphocholine + a 1,2-diacyl-sn-glycerol
2. a 2-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA
3. sn-glycerol 3-phosphate + an acyl-CoA = a 1-acyl-sn-glycero-3-phosphate + CoA
Catalysed by SGMS1, SGMS2, LPGAT1, GPAT3 and 3 moreOne of 3 routes
a 1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholineReach from here →
1. N-hexadecanoylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = N-hexadecanoyl-sphinganine-1-phosphocholine + a 1,2-diacyl-sn-glycerol
2. a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)
3. a 1-acyl-sn-glycero-3-phosphocholine + (9Z)-octadecenoyl-CoA = a 1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + CoA
Catalysed by SGMS1, SGMS2, PLA2G10, PLA2G6 and 29 more
a CDP-1,2-diacyl-sn-glycerolReach from here →
1. N-hexadecanoylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = N-hexadecanoyl-sphinganine-1-phosphocholine + a 1,2-diacyl-sn-glycerol
2. a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + choline + H(+)
3. a 1,2-diacyl-sn-glycero-3-phosphate + CTP + H(+) = a CDP-1,2-diacyl-sn-glycerol + diphosphate
Catalysed by SGMS1, SGMS2, PLD2, PLD1 and 4 moreOne of 2 routes
a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate)Reach from here →
1. N-hexadecanoylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = N-hexadecanoyl-sphinganine-1-phosphocholine + a 1,2-diacyl-sn-glycerol
2. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)(out) + a 1,2-diacyl-sn-glycero-3-phosphocholine(in) = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)(in) + a 1,2-diacyl-sn-glycero-3-phosphocholine(out)
3. a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+)
Catalysed by SGMS1, SGMS2, OSBPL3, PIP5K1B and 2 moreinner side of the membrane, outer side of the membrane
CDP-cholineReach from here →
1. N-hexadecanoylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = N-hexadecanoyl-sphinganine-1-phosphocholine + a 1,2-diacyl-sn-glycerol
2. a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = phosphocholine + a 1,2-diacyl-sn-glycerol + H(+)
3. phosphocholine + CTP + H(+) = CDP-choline + diphosphate
Catalysed by SGMS1, SGMS2, SMPD1, PCYT1A and 1 moreOne of 2 routes
1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholineReach from here →
1. N-hexadecanoylsphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = N-hexadecanoyl-sphinganine-1-phosphocholine + a 1,2-diacyl-sn-glycerol
2. a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)
3. (9Z,12Z)-octadecadienoyl-CoA + a 1-acyl-sn-glycero-3-phosphocholine = 1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + CoA
Catalysed by SGMS1, SGMS2, PLA2G10, PLA2G6 and 29 more