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Proteins/UNIPROT:Q02928
A cytochrome P450 monooxygenase involved in the metabolism of fatty acids and their oxygenated derivatives (oxylipins). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes predominantly the oxidation of the terminal carbon (omega-oxidation) of saturated and unsaturated fatty acids, the catalytic efficiency decreasing in the following order: dodecanoic > tetradecanoic > (9Z)-octadecenoic > (9Z,12Z)-octadecadienoic > hexadecanoic acid. Acts as a major omega-hydroxylase for dodecanoic (lauric) acid in liver. Participates in omega-hydroxylation of (5Z,8Z,11Z,14Z)-eicosatetraenoic acid (arachidonate) to 20-hydroxyeicosatetraenoic acid (20-HETE), a signaling molecule acting both as vasoconstrictive and natriuretic with overall effect on arterial blood pressure. Can also catalyze the oxidation of the penultimate carbon (omega-1 oxidation) of fatty acids with lower efficiency. May contribute to the degradation of saturated very long-chain fatty acids (VLCFAs) such as docosanoic acid, by catalyzing successive omega-oxidations to the corresponding dicarboxylic acid, thereby initiating chain shortening. Omega-hydroxylates (9R,10S)-epoxy-octadecanoate stereoisomer. Plays a minor role in omega-oxidation of long-chain 3-hydroxy fatty acids. Has little activity toward prostaglandins A1 and E1..
Function from UniProtKB (Q02928), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
46 statements
46 statements · 8 reference databases · Subject: CYP4A11 · Sources: Bgee, gene ontology, Hetionet, Human-GEM, Reactome, Rhea, UniProt, WikiPathways
15 reactions
10 names
Resolves to: CYP4A11
Reaction pageLeft to rightBalancedEC 1.14.14.1, 1.14.15.3cytosol
Human-GEM MAR00934CC BY 4.0Reference data
proton+dodecanoate+NADPH(4-)+dioxygen12-hydroxydodecanoate+water+NADP(3-)
Catalysed by CYP4A22 or CYP4A11
Reaction pageLeft to rightBalancedEC 1.14.15.3cytosol
Human-GEM MAR08036CC BY 4.0Reference data
proton+tetradecanoate+NADPH(4-)+dioxygen14-hydroxytetradecanoate+water+NADP(3-)
Catalysed by CYP4A22 or CYP4A11
Reaction pageLeft to rightBalancedEC 1.14.15.3cytosol
Human-GEM MAR08037CC BY 4.0Reference data
proton+NADPH(4-)+dioxygen+hexadecanoic acid16-hydroxyhexadecanoate+water+NADP(3-)
Catalysed by CYP4A22 or CYP4A11
Reaction pageLeft to rightBalancedEC 1.14.15.3cytosol
Human-GEM MAR08038CC BY 4.0Reference data
an organic molecule+reduced [NADPH--hemoprotein reductase]+dioxygenan alcohol+oxidized [NADPH--hemoprotein reductase]+water+hydron
Catalysed by CYP2D7 or CYP1A1 or CYP1A2 or CYP2E1 or CYP3A4 or CYP2C8 or CYP2C9 or CYP4B1 or CYP3A5 or CYP2A7 or CYP3A7 or CYP2F1 and 13 more alternatives
Reaction pageReversibleBalance undeterminable
Rhea RHEA:17149CC BY 4.0Reference data
dodecanoate+reduced [NADPH--hemoprotein reductase]+dioxygen12-hydroxydodecanoate+oxidized [NADPH--hemoprotein reductase]+water+hydron
Catalysed by CYP4B1 or CYP4A11 or CYP4V2 or CYP4F11
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:38947CC BY 4.0Reference data
CHEBI:76298+reduced [NADPH--hemoprotein reductase]+dioxygendocosanedioate+oxidized [NADPH--hemoprotein reductase]+water+2hydron
Catalysed by CYP4F2 or CYP4A11 or CYP4F3
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:39043CC BY 4.0Reference data
CHEBI:76304+reduced [NADPH--hemoprotein reductase]+dioxygenCHEBI:76298+oxidized [NADPH--hemoprotein reductase]+2water+hydron
Catalysed by CYP4F2 or CYP4A11 or CYP4F3
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:39055CC BY 4.0Reference data
CHEBI:76613+reduced [NADPH--hemoprotein reductase]+dioxygenCHEBI:63904+oxidized [NADPH--hemoprotein reductase]+water+hydron
Catalysed by CYP4F2 or CYP4A11 or CYP4F3 or CYP4F11
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:39731CC BY 4.0Reference data
(5Z,8Z,11Z,14Z)-eicosatetraenoate+reduced [NADPH--hemoprotein reductase]+dioxygen20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate+oxidized [NADPH--hemoprotein reductase]+water+hydron
Catalysed by CYP4F2 or CYP4A11 or CYP4F3 or CYP2U1 or CYP4F11
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:39755CC BY 4.0Reference data
hexadecanoate+reduced [NADPH--hemoprotein reductase]+dioxygen16-hydroxyhexadecanoate+oxidized [NADPH--hemoprotein reductase]+water+hydron
Catalysed by CYP4A11 or CYP4V2 or CYP4F11
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:40199CC BY 4.0Reference data
tetradecanoate+reduced [NADPH--hemoprotein reductase]+dioxygen14-hydroxytetradecanoate+oxidized [NADPH--hemoprotein reductase]+water+hydron
Catalysed by CYP4A11 or CYP4V2
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:40203CC BY 4.0Reference data