a ganglioside GT1b (d18:1(4E))

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

105 compounds within 3 steps: 4 in 1, 8 in 2, 93 in 3

Three steps

acetateReach from here →
1. exo-alpha-sialidase (GT1b)
2. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)
3. transport of acetate and pyruvate (cytosol to extracellular)
Catalysed by NEU4, NEU1, NEU3, NEU2 and 6 morecytosol, extracellular spaceOne of 2 routes
formic acidReach from here →
1. exo-alpha-sialidase (GT1b)
2. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)
3. transport of formate and pyruvate (cytosol to extracellular)
Catalysed by NEU4, NEU1, NEU3, NEU2 and 6 morecytosol, extracellular spaceOne of 2 routes
propionic acidReach from here →
1. exo-alpha-sialidase (GT1b)
2. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)
3. transport of propanoate and pyruvate (cytosol to extracellular)
Catalysed by NEU4, NEU1, NEU3, NEU2 and 7 morecytosol, extracellular spaceOne of 2 routes
butyric acidReach from here →
1. exo-alpha-sialidase (GT1b)
2. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)
3. transport of butyrate and pyruvate (cytosol to extracellular)
Catalysed by NEU4, NEU1, NEU3, NEU2 and 7 morecytosol, extracellular spaceOne of 2 routes
3-hydroxypyruvic acidReach from here →
1. exo-alpha-sialidase (GT1b)
2. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)
3. L-Serine:pyruvate aminotransferase
Catalysed by NEU4, NEU1, NEU3, NEU2 and 2 morecytosolOne of 2 routes
3-oxopropanoateReach from here →
1. exo-alpha-sialidase (GT1b)
2. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)
3. 3-oxopropanoate + L-alanine = beta-alanine + pyruvate
Catalysed by NEU4, NEU1, NEU3, NEU2 and 2 morecytosol
D-serineReach from here →
1. exo-alpha-sialidase (GT1b)
2. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)
3. D-serine = pyruvate + NH4(+)
Catalysed by NEU4, NEU1, NEU3, NEU2 and 2 morecytosol
(R)-lactic acidReach from here →
1. exo-alpha-sialidase (GT1b)
2. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)
3. (R)-Lactate:NAD+ oxidoreductase
Catalysed by NEU4, NEU1, NEU3, NEU2 and 2 morecytosol
(S)-lactic acidReach from here →
1. exo-alpha-sialidase (GT1b)
2. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)
3. (S)-Lactate:NAD+ oxidoreductase
Catalysed by NEU4, NEU1, NEU3, NEU2 and 3 morecytosol, mitochondrial matrixOne of 5 routes
2-iminopropanoateReach from here →
1. exo-alpha-sialidase (GT1b)
2. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)
3. 2-iminopropanoate + H2O = pyruvate + NH4(+)
Catalysed by NEU4, NEU1, NEU3, NEU2 and 2 morecytosol
phosphoenolpyruvic acidReach from here →
1. exo-alpha-sialidase (GT1b)
2. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)
3. pyruvate kinase (dTDP)
Catalysed by NEU4, NEU1, NEU3, NEU2 and 3 morecytosol
N-acetyl-D-glucosamineReach from here →
1. exo-alpha-sialidase (GT1b)
2. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)
3. N-acetyl-D-glucosamine 2-epimerase
Catalysed by NEU4, NEU1, NEU3, NEU2 and 2 morecytosol
a 3-acylpyruvateReach from here →
1. exo-alpha-sialidase (GT1b)
2. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)
3. a 3-acylpyruvate + H2O = a carboxylate + pyruvate + H(+)
Catalysed by NEU4, NEU1, NEU3, NEU2 and 2 morecytosol
2-oxo-3-sulfanylpropanoateReach from here →
1. exo-alpha-sialidase (GT1b)
2. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)
3. 2-oxo-3-sulfanylpropanoate + [thioredoxin]-dithiol = [thioredoxin]-disulfide + hydrogen sulfide + pyruvate + H(+)
Catalysed by NEU4, NEU1, NEU3, NEU2 and 2 morecytosol
2-methyl-3-oxopropanoateReach from here →
1. exo-alpha-sialidase (GT1b)
2. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)
3. (R)-3-amino-2-methylpropanoate + pyruvate = 2-methyl-3-oxopropanoate + L-alanine
Catalysed by NEU4, NEU1, NEU3, NEU2 and 2 morecytosol
L-methionineReach from here →
1. exo-alpha-sialidase (GT1b)
2. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)
3. N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + L-methionine + CO2 + H2O
Catalysed by NEU4, NEU1, NEU3, NEU2 and 3 morecytosol
L-alanineReach from here →
1. exo-alpha-sialidase (GT1b)
2. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)
3. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
Catalysed by NEU4, NEU1, NEU3, NEU2 and 2 morecytosol, mitochondrial matrixOne of 18 routes
alpha-D-galactose 1-phosphateReach from here →
1. exo-alpha-sialidase (GT1b)
2. Beta-Galactosidase, Lysosomal
3. galactokinase (galactose)
Catalysed by NEU4, NEU1, NEU3, NEU2 and 3 morecytosol, lysosomeOne of 2 routes
aldehydo-N-acetyl-D-mannosamine 6-phosphateReach from here →
1. exo-alpha-sialidase (GT1b)
2. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)
3. ATP:N-acyl-D-mannosamine 6-phosphotransferase
Catalysed by NEU4, NEU1, NEU3, NEU2 and 2 morecytosolOne of 2 routes
a neolactoside IV(3)-alpha-NeuAc-nLc4Cer(d18:1(4E))Reach from here →
1. exo-alpha-sialidase (GT1b)
2. CTP:N-acetylneuraminate cytidylyltransferase
3. ST3 beta-galactoside alpha-2,3-sialyltransferase (CMP-N-acetylneuraminate)
Catalysed by NEU4, NEU1, NEU3, NEU2 and 2 morecytosol, nucleusOne of 3 routes
(3S)-citramalyl-CoAReach from here →
1. exo-alpha-sialidase (GT1b)
2. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)
3. (3S)-citramalyl-CoA = pyruvate + acetyl-CoA
Catalysed by NEU4, NEU1, NEU3, NEU2 and 2 morecytosol
5-amino-2-oxopentanoateReach from here →
1. exo-alpha-sialidase (GT1b)
2. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)
3. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine
Catalysed by NEU4, NEU1, NEU3, NEU2 and 2 morecytosol
a ganglioside GM3 (d18:1(4E))Reach from here →
1. exo-alpha-sialidase (GT1b)
2. CTP:N-acetylneuraminate cytidylyltransferase
3. ST3 beta-galactoside alpha-2,3-sialyltransferase (CMP-N-acetylneuraminate)
Catalysed by NEU4, NEU1, NEU3, NEU2 and 2 morecytosol, nucleusOne of 3 routes
(4R)-4-hydroxy-2-oxoglutarateReach from here →
1. exo-alpha-sialidase (GT1b)
2. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)
3. (4R)-4-hydroxy-2-oxoglutarate = glyoxylate + pyruvate
Catalysed by NEU4, NEU1, NEU3, NEU2 and 2 morecytosol
a ganglioside GM2 (d18:1(4E))Reach from here →
1. exo-alpha-sialidase (GT1b)
2. Beta-Galactosidase, Lysosomal
3. Sialidase, Plasma Membrane (Neu3)
Catalysed by NEU4, NEU1, NEU3, NEU2 and 1 morecytosol, lysosome, extracellular spaceOne of 6 routes
(4S)-4-hydroxy-2-oxoglutarateReach from here →
1. exo-alpha-sialidase (GT1b)
2. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)
3. (4S)-4-hydroxy-2-oxoglutarate = glyoxylate + pyruvate
Catalysed by NEU4, NEU1, NEU3, NEU2 and 2 morecytosol
ganglioside GM1 (d18:1(4E)/18:0)Reach from here →
1. exo-alpha-sialidase (GT1b)
2. CTP:N-acetylneuraminate cytidylyltransferase
3. ganglioside GA1 (d18:1(4E)/18:0) + CMP-N-acetyl-beta-neuraminate = ganglioside GM1 (d18:1(4E)/18:0) + CMP + H(+)
Catalysed by NEU4, NEU1, NEU3, NEU2 and 2 morecytosol, nucleus
a ganglioside GD3 (d18:1(4E))Reach from here →
1. exo-alpha-sialidase (GT1b)
2. Beta-Galactosidase, Lysosomal
3. Hexosaminidase A, Lysosomal
Catalysed by NEU4, NEU1, NEU3, NEU2 and 3 morecytosol, lysosomeOne of 5 routes
a ganglioside GT3 (d18:1(4E))Reach from here →
1. exo-alpha-sialidase (GT1b)
2. CTP:N-acetylneuraminate cytidylyltransferase
3. alpha-N-acetylneuraminate alpha-2,8-sialyltransferase (CMP-N-acetylneuraminate)
Catalysed by NEU4, NEU1, NEU3, NEU2 and 3 morecytosol, nucleusOne of 3 routes
a ganglioside GD1a (d18:1(4E))Reach from here →
1. exo-alpha-sialidase (GT1b)
2. Sialidase, Cytosol (Neu2)
3. beta-galactoside alpha-2,3-sialyltransferase (CMP-N-acetylneuraminate)
Catalysed by NEU4, NEU1, NEU3, NEU2 and 3 morecytosolOne of 7 routes
a ganglioside GT1a (d18:1(4E))Reach from here →
1. exo-alpha-sialidase (GT1b)
2. CTP:N-acetylneuraminate cytidylyltransferase
3. ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase (CMP-N-acetylneuraminate)
Catalysed by NEU4, NEU1, NEU3, NEU2 and 2 morecytosol, nucleusOne of 3 routes
a ganglioside GM4 (d18:1(4E))Reach from here →
1. exo-alpha-sialidase (GT1b)
2. CTP:N-acetylneuraminate cytidylyltransferase
3. a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + CMP-N-acetyl-beta-neuraminate = a ganglioside GM4 (d18:1(4E)) + CMP + H(+)
Catalysed by NEU4, NEU1, NEU3, NEU2 and 2 morecytosol, nucleus
ganglioside GM2 (d18:1(4E)/18:0)Reach from here →
1. exo-alpha-sialidase (GT1b)
2. CTP:N-acetylneuraminate cytidylyltransferase
3. ganglioside GA2 (d18:1(4E)/18:0) + CMP-N-acetyl-beta-neuraminate = ganglioside GM2 (d18:1(4E)/18:0) + CMP + H(+)
Catalysed by NEU4, NEU1, NEU3, NEU2 and 2 morecytosol, nucleus
a ganglioside GM1b (d18:1(4E))Reach from here →
1. exo-alpha-sialidase (GT1b)
2. CTP:N-acetylneuraminate cytidylyltransferase
3. a ganglioside GA1 (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = a ganglioside GM1b (d18:1(4E)) + CMP + H(+)
Catalysed by NEU4, NEU1, NEU3, NEU2 and 4 morecytosol, nucleus
a ganglioside GD1alpha (d18:1(4E))Reach from here →
1. exo-alpha-sialidase (GT1b)
2. CTP:N-acetylneuraminate cytidylyltransferase
3. a ganglioside GM1b (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = a ganglioside GD1alpha (d18:1(4E)) + CMP + H(+)
Catalysed by NEU4, NEU1, NEU3, NEU2 and 5 morecytosol, nucleus
a ganglioside GT1aalpha (d18:1(4E))Reach from here →
1. exo-alpha-sialidase (GT1b)
2. CTP:N-acetylneuraminate cytidylyltransferase
3. a ganglioside GD1a (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = a ganglioside GT1aalpha (d18:1(4E)) + CMP + H(+)
Catalysed by NEU4, NEU1, NEU3, NEU2 and 2 morecytosol, nucleus
a ganglioside Fuc-GM1 (d18:1(4E))Reach from here →
1. exo-alpha-sialidase (GT1b)
2. Sialidase, Cytosol (Neu2)
3. a ganglioside GM1 (d18:1(4E)) + GDP-beta-L-fucose = a ganglioside Fuc-GM1 (d18:1(4E)) + GDP + H(+)
Catalysed by NEU4, NEU1, NEU3, NEU2 and 1 morecytosol
a ganglioside GD3Reach from here →
1. exo-alpha-sialidase (GT1b)
2. CTP:N-acetylneuraminate cytidylyltransferase
3. a ganglioside GM3 + CMP-N-acetyl-beta-neuraminate = a ganglioside GD3 + CMP + H(+)
Catalysed by NEU4, NEU1, NEU3, NEU2 and 3 morecytosol, nucleus
a ganglioside GT3Reach from here →
1. exo-alpha-sialidase (GT1b)
2. CTP:N-acetylneuraminate cytidylyltransferase
3. a ganglioside GD3 + CMP-N-acetyl-beta-neuraminate = a ganglioside GT3 + CMP + H(+)
Catalysed by NEU4, NEU1, NEU3, NEU2 and 2 morecytosol, nucleus
a ganglioside GD1aReach from here →
1. exo-alpha-sialidase (GT1b)
2. CTP:N-acetylneuraminate cytidylyltransferase
3. a ganglioside GM1 + CMP-N-acetyl-beta-neuraminate = a ganglioside GD1a + CMP + H(+)
Catalysed by NEU4, NEU1, NEU3, NEU2 and 3 morecytosol, nucleus
N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1<->1')-ceramideReach from here →
1. exo-alpha-sialidase (GT1b)
2. CTP:N-acetylneuraminate cytidylyltransferase
3. a beta-D-Gal-(1<->1')-ceramide + CMP-N-acetyl-beta-neuraminate = N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1<->1')-ceramide + CMP + H(+)
Catalysed by NEU4, NEU1, NEU3, NEU2 and 2 morecytosol, nucleus
a ganglioside GT1bReach from here →
1. exo-alpha-sialidase (GT1b)
2. CTP:N-acetylneuraminate cytidylyltransferase
3. a ganglioside GD1b + CMP-N-acetyl-beta-neuraminate = a ganglioside GT1b + CMP + H(+)
Catalysed by NEU4, NEU1, NEU3, NEU2 and 3 morecytosol, nucleus
a ganglioside GD1c (d18:1(4E))Reach from here →
1. exo-alpha-sialidase (GT1b)
2. CTP:N-acetylneuraminate cytidylyltransferase
3. a ganglioside GM1b (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = a ganglioside GD1c (d18:1(4E)) + CMP + H(+)
Catalysed by NEU4, NEU1, NEU3, NEU2 and 4 morecytosol, nucleus
a ganglioside GQ1c (d18:1(4E))Reach from here →
1. exo-alpha-sialidase (GT1b)
2. CTP:N-acetylneuraminate cytidylyltransferase
3. a ganglioside GT1c (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = a ganglioside GQ1c (d18:1(4E)) + CMP + H(+)
Catalysed by NEU4, NEU1, NEU3, NEU2 and 2 morecytosol, nucleus
a ganglioside GP1c (d18:1(4E))Reach from here →
1. exo-alpha-sialidase (GT1b)
2. CTP:N-acetylneuraminate cytidylyltransferase
3. a ganglioside GQ1c (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = a ganglioside GP1c (d18:1(4E)) + CMP + H(+)
Catalysed by NEU4, NEU1, NEU3, NEU2 and 2 morecytosol, nucleus
N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminosyl-(2->6)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enineReach from here →
1. exo-alpha-sialidase (GT1b)
2. CTP:N-acetylneuraminate cytidylyltransferase
3. N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine + CMP-N-acetyl-beta-neuraminate = N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminosyl-(2->6)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine + CMP + H(+)
Catalysed by NEU4, NEU1, NEU3, NEU2 and 3 morecytosol, nucleus
a ganglioside GM1bReach from here →
1. exo-alpha-sialidase (GT1b)
2. CTP:N-acetylneuraminate cytidylyltransferase
3. a ganglioside GA1 + CMP-N-acetyl-beta-neuraminate = a ganglioside GM1b + CMP + H(+)
Catalysed by NEU4, NEU1, NEU3, NEU2 and 3 morecytosol, nucleus
ganglioside GD1a (18:1(4E)/18:0)Reach from here →
1. exo-alpha-sialidase (GT1b)
2. CTP:N-acetylneuraminate cytidylyltransferase
3. ganglioside GM1 (d18:1(4E)/18:0) + CMP-N-acetyl-beta-neuraminate = ganglioside GD1a (18:1(4E)/18:0) + CMP + H(+)
Catalysed by NEU4, NEU1, NEU3, NEU2 and 3 morecytosol, nucleus
a neolactoside IV(3)-alpha-NeuAc-nLc4CerReach from here →
1. exo-alpha-sialidase (GT1b)
2. CTP:N-acetylneuraminate cytidylyltransferase
3. a neolactoside nLc4Cer + CMP-N-acetyl-beta-neuraminate = a neolactoside IV(3)-alpha-NeuAc-nLc4Cer + CMP + H(+)
Catalysed by NEU4, NEU1, NEU3, NEU2 and 2 morecytosol, nucleus
a ganglioside GT1aReach from here →
1. exo-alpha-sialidase (GT1b)
2. CTP:N-acetylneuraminate cytidylyltransferase
3. a ganglioside GD1a + CMP-N-acetyl-beta-neuraminate = a ganglioside GT1a + CMP + H(+)
Catalysed by NEU4, NEU1, NEU3, NEU2 and 2 morecytosol, nucleus