3-oxohexacosanoyl-CoA

Three steps

• CHEBI:17927Reach from here →
  1. acetyl-CoA C-acyltransferase (3-oxohexacosanoyl-CoA)
  2. Tetracosenoyl-CoA hydrolase
  3. N1,N8-diacetylspermidine to N1-acetylspermidine conversion

  Catalysed by ACAA1, MYO5B, BAAT, THEM4peroxisome, cytosol

• 1-eicosanoyl-2-(9Z-octadecenoyl)-glycerolReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxohexacosanoyl-CoA)
  2. Beta Oxidation of Long Chain Fatty Acid
  3. eicosanoyl-CoA + 2-(9Z-octadecenoyl)-glycerol = 1-eicosanoyl-2-(9Z-octadecenoyl)-glycerol + CoA

  Catalysed by ACAA1, MYO5B, HSD17B4, EHHADH and 3 moreperoxisome

• (5Z)-dodecenoyl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxohexacosanoyl-CoA)
  2. Tetracosenoyl-CoA hydrolase
  3. acetyl-CoA C-acyltransferase (3-oxomyrist-7-enoyl-CoA)

  Catalysed by ACAA1, MYO5B, BAAT, THEM4 and 3 moreperoxisome, cytosol, mitochondrial matrixOne of 2 routes

• (11Z)-docosenoyl-CoA(4-)Reach from here →
  1. acetyl-CoA C-acyltransferase (3-oxohexacosanoyl-CoA)
  2. Tetracosenoyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (cis-cetoleic acid)

  Catalysed by ACAA1, MYO5B, BAAT, THEM4 and 8 moreperoxisome, cytosolOne of 6 routes

• (7Z)-tetradecenoyl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxohexacosanoyl-CoA)
  2. Tetracosenoyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase ((7Z)-tetradecenoic acid)

  Catalysed by ACAA1, MYO5B, BAAT, THEM4 and 8 moreperoxisome, cytosolOne of 9 routes

• (4Z,7Z,10Z,13Z)-hexadecatetraenoyl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxohexacosanoyl-CoA)
  2. Tetracosenoyl-CoA hydrolase
  3. Fatty Acid Beta Oxidation (C18:4->C16:4), Mitochondrial

  Catalysed by ACAA1, MYO5B, BAAT, THEM4 and 3 moreperoxisome, cytosol, mitochondrial matrixOne of 3 routes

• (7Z,10Z)-hexadecadienoyl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxohexacosanoyl-CoA)
  2. Tetracosenoyl-CoA hydrolase
  3. Fatty Acid Beta Oxidation Trans (C18:2->C16:2), Mitochondrial

  Catalysed by ACAA1, MYO5B, BAAT, THEM4 and 3 moreperoxisome, cytosol, mitochondrial matrix

• (4Z,7Z)-decadienoyl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxohexacosanoyl-CoA)
  2. Tetracosenoyl-CoA hydrolase
  3. Fatty Acid Beta Oxidation (C12:3->C10:2), Mitochondrial

  Catalysed by ACAA1, MYO5B, BAAT, THEM4 and 3 moreperoxisome, cytosol, mitochondrial matrixOne of 2 routes

• (5Z)-octenoyl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxohexacosanoyl-CoA)
  2. Tetracosenoyl-CoA hydrolase
  3. Fatty Acid Beta Oxidation (C10:2->C8:1), Mitochondrial

  Catalysed by ACAA1, MYO5B, BAAT, THEM4 and 3 moreperoxisome, cytosol, mitochondrial matrixOne of 2 routes

• docosanoateReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxohexacosanoyl-CoA)
  2. Fatty Acid Beta Oxidation (C24->C22), Peroxisomal
  3. Docosanoyl-CoA hydrolase

  Catalysed by ACAA1, MYO5B, HSD17B4, EHHADH and 3 moreperoxisome, cytosolOne of 4 routes

• CHEBI:27540Reach from here →
  1. acetyl-CoA C-acyltransferase (3-oxohexacosanoyl-CoA)
  2. Tetracosenoyl-CoA hydrolase
  3. medium-chain acyl-CoA ligase (hexanoic acid)

  Catalysed by ACAA1, MYO5B, BAAT, THEM4 and 6 moreperoxisome, cytosolOne of 6 routes

• elaidic acidReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxohexacosanoyl-CoA)
  2. Tetracosenoyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (elaidate)

  Catalysed by ACAA1, MYO5B, BAAT, THEM4 and 8 moreperoxisome, cytosolOne of 6 routes

• CHEBI:28701Reach from here →
  1. acetyl-CoA C-acyltransferase (3-oxohexacosanoyl-CoA)
  2. Tetracosenoyl-CoA hydrolase
  3. Propanoyl-CoA:acetyl-CoA C-acyltransferase

  Catalysed by ACAA1, MYO5B, BAAT, THEM4 and 1 moreperoxisome, cytosolOne of 7 routes

• (9Z)-octadecenoateReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxo-hexacosenoyl-CoA)
  2. Beta Oxidation of Long Chain Fatty Acid
  3. Oleoyl-CoA hydrolase

  Catalysed by ACAA1, MYO5B, HSD17B4, EHHADH and 6 moreperoxisome, cytosol

• docosan-1-olReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxohexacosanoyl-CoA)
  2. Fatty Acid Beta Oxidation (C24->C22), Peroxisomal
  3. docosanoyl-CoA + 2 NADPH + 2 H(+) = docosan-1-ol + 2 NADP(+) + CoA

  Catalysed by ACAA1, MYO5B, HSD17B4, EHHADH and 2 moreperoxisome

• an N-acylsphinganineReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxohexacosanoyl-CoA)
  2. acyl-CoA pool formation and breakdown
  3. sphingosine N-acyltransferase (sphinganine)

  Catalysed by ACAA1, MYO5B, CERS1, CERS6 and 4 moreperoxisome, cytosol

• eicosanoateReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxohexacosanoyl-CoA)
  2. Beta Oxidation of Long Chain Fatty Acid
  3. Eicosanoyl-CoA hydrolase

  Catalysed by ACAA1, MYO5B, HSD17B4, EHHADH and 4 moreperoxisome, cytosolOne of 4 routes

• fatty acidReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxohexacosanoyl-CoA)
  2. Tetracosenoyl-CoA hydrolase
  3. (10Z)-heptadecenoic acid formation

  Catalysed by ACAA1, MYO5B, BAAT, THEM4peroxisome, cytosolOne of 8 routes

• a 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholineReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxohexacosanoyl-CoA)
  2. acyl-CoA pool formation and breakdown
  3. Acyl-CoA:1-alkyl-sn-glycero-3-phosphocholine O-acyltransferase

  Catalysed by ACAA1, MYO5B, LPCAT4, LPCAT3 and 2 moreperoxisome, cytosol

• cholesteryl (9Z-octadecenoate)Reach from here →
  1. acetyl-CoA C-acyltransferase (3-oxo-hexacosenoyl-CoA)
  2. Beta Oxidation of Long Chain Fatty Acid
  3. Acyl-CoA:cholesterol O-acyltransferase

  Catalysed by ACAA1, MYO5B, HSD17B4, EHHADH and 3 moreperoxisome, endoplasmic reticulum

• a 1,3-diacylglycerolReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxohexacosanoyl-CoA)
  2. acyl-CoA pool formation and breakdown
  3. a 1-acylglycerol + an acyl-CoA = a 1,3-diacylglycerol + CoA

  Catalysed by ACAA1, MYO5B, MOGAT2, MOGAT1peroxisome, cytosol

• a 1,2-diacylglycerolReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxohexacosanoyl-CoA)
  2. acyl-CoA pool formation and breakdown
  3. a 2-acylglycerol + an acyl-CoA = a 1,2-diacylglycerol + CoA

  Catalysed by ACAA1, MYO5B, MOGAT2, MOGAT3 and 3 moreperoxisome, cytosolOne of 2 routes

• taurineReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxohexacosanoyl-CoA)
  2. Tetracosenoyl-CoA hydrolase
  3. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)

  Catalysed by ACAA1, MYO5B, BAAT, THEM4peroxisome, cytosolOne of 2 routes

• a 1,2-diacyl-sn-glycero-3-phospho-L-serineReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxohexacosanoyl-CoA)
  2. acyl-CoA pool formation and breakdown
  3. a 1-acyl-sn-glycero-3-phospho-L-serine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phospho-L-serine + CoA

  Catalysed by ACAA1, MYO5B, LPCAT4, LPCAT3 and 1 moreperoxisome, cytosol

• glycineReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxohexacosanoyl-CoA)
  2. Tetracosenoyl-CoA hydrolase
  3. glycine N-acyltransferase (N-arachidonoylglycine)

  Catalysed by ACAA1, MYO5B, BAAT, THEM4 and 3 moreperoxisome, cytosol, mitochondrial matrixOne of 10 routes

• (R)-methylmalonyl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxohexacosanoyl-CoA)
  2. Tetracosenoyl-CoA hydrolase
  3. aldehyde dehydrogenase (2-methyl-3-oxopropanoate)

  Catalysed by ACAA1, MYO5B, BAAT, THEM4 and 1 moreperoxisome, cytosol, mitochondrial matrixOne of 2 routes

• (S)-methylmalonyl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxohexacosanoyl-CoA)
  2. Tetracosenoyl-CoA hydrolase
  3. (S)-methylmalonyl-CoA hydrolase

  Catalysed by ACAA1, MYO5B, BAAT, THEM4peroxisome, cytosol, mitochondrial matrix

• 3'-dephospho-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxohexacosanoyl-CoA)
  2. Tetracosenoyl-CoA hydrolase
  3. acid phosphatase 2, lysosomal (CoA)

  Catalysed by ACAA1, MYO5B, BAAT, THEM4 and 1 moreperoxisome, cytosol, lysosomeOne of 2 routes

• (2E)-dodecenoyl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxohexacosanoyl-CoA)
  2. Tetracosenoyl-CoA hydrolase
  3. (2E)-dodecenoyl-CoA formation

  Catalysed by ACAA1, MYO5B, BAAT, THEM4peroxisome, cytosol, mitochondrial matrixOne of 3 routes

• 4,8,12-trimethyltridecanoyl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxohexacosanoyl-CoA)
  2. Tetracosenoyl-CoA hydrolase
  3. propanoyl-CoA C-acyltransferase (3-ketopristanoyl-CoA)

  Catalysed by ACAA1, MYO5B, BAAT, THEM4peroxisome, cytosolOne of 2 routes

• (6Z,9Z,12Z)-octadecatrienoyl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxohexacosanoyl-CoA)
  2. Tetracosenoyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (gamma-linolenate)

  Catalysed by ACAA1, MYO5B, BAAT, THEM4 and 8 moreperoxisome, cytosolOne of 8 routes

• butanoyl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxohexacosanoyl-CoA)
  2. Tetracosenoyl-CoA hydrolase
  3. Butanoate:CoA ligase (AMP-forming)

  Catalysed by ACAA1, MYO5B, BAAT, THEM4 and 6 moreperoxisome, cytosolOne of 9 routes

• dodecanoyl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxohexacosanoyl-CoA)
  2. Tetracosenoyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (lauric acid)

  Catalysed by ACAA1, MYO5B, BAAT, THEM4 and 8 moreperoxisome, cytosolOne of 10 routes

• glutaryl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxohexacosanoyl-CoA)
  2. Tetracosenoyl-CoA hydrolase
  3. Production of Glutaryl Carnitine

  Catalysed by ACAA1, MYO5B, BAAT, THEM4 and 3 moreperoxisome, cytosolOne of 2 routes

• itaconyl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxohexacosanoyl-CoA)
  2. Tetracosenoyl-CoA hydrolase
  3. Itaconate:CoA ligase (GDP-forming)

  Catalysed by ACAA1, MYO5B, BAAT, THEM4 and 3 moreperoxisome, cytosol, mitochondrial matrixOne of 2 routes

• (9Z,12Z)-octadecadienoyl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxohexacosanoyl-CoA)
  2. Tetracosenoyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)

  Catalysed by ACAA1, MYO5B, BAAT, THEM4 and 8 moreperoxisome, cytosolOne of 16 routes

• tetradecanoyl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxohexacosanoyl-CoA)
  2. Tetracosenoyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (myristic acid)

  Catalysed by ACAA1, MYO5B, BAAT, THEM4 and 8 moreperoxisome, cytosolOne of 12 routes

• octanoyl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxohexacosanoyl-CoA)
  2. Tetracosenoyl-CoA hydrolase
  3. Octanoyl-CoA:L-carnitine O-octanoyltransferase

  Catalysed by ACAA1, MYO5B, BAAT, THEM4 and 1 moreperoxisome, cytosol, mitochondrial matrixOne of 21 routes

• phytanoyl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxohexacosanoyl-CoA)
  2. Tetracosenoyl-CoA hydrolase
  3. phytanate-CoA ligase

  Catalysed by ACAA1, MYO5B, BAAT, THEM4peroxisome, cytosolOne of 5 routes

• octadecanoyl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxohexacosanoyl-CoA)
  2. Tetracosenoyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (stearate)

  Catalysed by ACAA1, MYO5B, BAAT, THEM4 and 7 moreperoxisome, cytosolOne of 18 routes

• a 1-acylglycerone 3-phosphateReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxohexacosanoyl-CoA)
  2. acyl-CoA pool formation and breakdown
  3. dihydroxyacetone phosphate + an acyl-CoA = a 1-acylglycerone 3-phosphate + CoA

  Catalysed by ACAA1, MYO5B, GNPATperoxisome, cytosol

• a 1,2-diacyl-sn-glycero-3-phosphocholineReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxohexacosanoyl-CoA)
  2. acyl-CoA pool formation and breakdown
  3. a 2-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA

  Catalysed by ACAA1, MYO5B, LPGAT1peroxisome, cytosolOne of 2 routes

• an N-acylglycineReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxohexacosanoyl-CoA)
  2. acyl-CoA pool formation and breakdown
  3. an acyl-CoA + glycine = an N-acylglycine + CoA + H(+)

  Catalysed by ACAA1, MYO5B, GLYATL3, GLYAT and 1 moreperoxisome, cytosol

• sphing-4-enineReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxohexacosanoyl-CoA)
  2. Tetracosenoyl-CoA hydrolase
  3. acyl-CoA:sphingosine N-acyltransferase

  Catalysed by ACAA1, MYO5B, BAAT, THEM4 and 4 moreperoxisome, cytosol, Golgi apparatusOne of 3 routes

• spermidineReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxohexacosanoyl-CoA)
  2. Tetracosenoyl-CoA hydrolase
  3. diamine N-acetyltransferase (N1-acetylspermidine)

  Catalysed by ACAA1, MYO5B, BAAT, THEM4 and 2 moreperoxisome, cytosolOne of 3 routes

• L-methionineReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxohexacosanoyl-CoA)
  2. Tetracosenoyl-CoA hydrolase
  3. N-acetylglutamate synthase (N-acetylmethionine)

  Catalysed by ACAA1, MYO5B, BAAT, THEM4 and 1 moreperoxisome, cytosol, mitochondrial matrix

• a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)Reach from here →
  1. acetyl-CoA C-acyltransferase (3-oxohexacosanoyl-CoA)
  2. acyl-CoA pool formation and breakdown
  3. a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA

  Catalysed by ACAA1, MYO5B, LCLAT1, MBOAT7peroxisome, cytosol

• a 1-acyl-sn-glycero-3-phosphateReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxohexacosanoyl-CoA)
  2. acyl-CoA pool formation and breakdown
  3. sn-glycerol 3-phosphate + an acyl-CoA = a 1-acyl-sn-glycero-3-phosphate + CoA

  Catalysed by ACAA1, MYO5B, GPAT3, GPAT2 and 2 moreperoxisome, cytosol

• L-alanineReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxohexacosanoyl-CoA)
  2. Tetracosenoyl-CoA hydrolase
  3. amino-acid N-acetyltransferase (N-acetyl-L-alanine)

  Catalysed by ACAA1, MYO5B, BAAT, THEM4peroxisome, cytosol, mitochondrial matrix

• L-asparagineReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxohexacosanoyl-CoA)
  2. Tetracosenoyl-CoA hydrolase
  3. N-acetylglutamate synthase (N-acetyl-L-asparagine)

  Catalysed by ACAA1, MYO5B, BAAT, THEM4 and 1 moreperoxisome, cytosol, mitochondrial matrix