(2E)-octadecenoyl-CoA

Two steps

• cholesteryl (9Z,12Z)-octadecadienoateReach from here →
  1. fatty acyl-CoA desaturase (N-C18:1CoA -> N-C18:2CoA)
  2. Acyl-CoA:cholesterol O-acyltransferase

  Catalysed by FADS2, SOAT2, SOAT1cytosol, endoplasmic reticulumOne of 2 routes

• taurineReach from here →
  1. Carnitine O-Palmitoyltransferase
  2. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)

  Catalysed by CPT1A, CPT1C, CPT1B, BAATcytosolOne of 2 routes

• glycineReach from here →
  1. Carnitine O-Palmitoyltransferase
  2. glycine N-acyltransferase (N-arachidonoylglycine)

  Catalysed by CPT1A, CPT1C, CPT1B, GLYAT and 2 morecytosol, mitochondrial matrixOne of 10 routes

• (R)-methylmalonyl-CoAReach from here →
  1. Carnitine O-Palmitoyltransferase
  2. aldehyde dehydrogenase (2-methyl-3-oxopropanoate)

  Catalysed by CPT1A, CPT1C, CPT1B, ALDH6A1cytosol, mitochondrial matrixOne of 2 routes

• (S)-methylmalonyl-CoAReach from here →
  1. Carnitine O-Palmitoyltransferase
  2. (S)-methylmalonyl-CoA hydrolase

  Catalysed by CPT1A, CPT1C, CPT1Bcytosol, mitochondrial matrix

• 3'-dephospho-CoAReach from here →
  1. Carnitine O-Palmitoyltransferase
  2. acid phosphatase 2, lysosomal (CoA)

  Catalysed by CPT1A, CPT1C, CPT1B, ACP2cytosol, lysosomeOne of 2 routes

• (2E)-dodecenoyl-CoAReach from here →
  1. Carnitine O-Palmitoyltransferase
  2. (2E)-dodecenoyl-CoA formation

  Catalysed by CPT1A, CPT1C, CPT1Bcytosol, mitochondrial matrixOne of 3 routes

• 4,8,12-trimethyltridecanoyl-CoAReach from here →
  1. Carnitine O-Palmitoyltransferase
  2. propanoyl-CoA C-acyltransferase (3-ketopristanoyl-CoA)

  Catalysed by CPT1A, CPT1C, CPT1B, ACAA1 and 1 morecytosol, peroxisomeOne of 2 routes

• (6Z,9Z,12Z)-octadecatrienoyl-CoAReach from here →
  1. fatty acyl-CoA desaturase (N-C18:1CoA -> N-C18:2CoA)
  2. fatty acyl-CoA desaturase (N-C18:2CoA -> N-C18:3CoA)

  Catalysed by FADS2, FADS1cytosolOne of 10 routes

• butanoyl-CoAReach from here →
  1. Carnitine O-Palmitoyltransferase
  2. Butanoate:CoA ligase (AMP-forming)

  Catalysed by CPT1A, CPT1C, CPT1B, ACSM4 and 5 morecytosolOne of 9 routes

• dodecanoyl-CoAReach from here →
  1. Carnitine O-Palmitoyltransferase
  2. long-chain-fatty-acid-CoA ligase (lauric acid)

  Catalysed by CPT1A, CPT1C, CPT1B, SLC27A2 and 7 morecytosolOne of 9 routes

• glutaryl-CoAReach from here →
  1. Carnitine O-Palmitoyltransferase
  2. Production of Glutaryl Carnitine

  Catalysed by CPT1A, CPT1C, CPT1BcytosolOne of 2 routes

• eicosanoyl-CoAReach from here →
  1. Carnitine O-Palmitoyltransferase
  2. long-chain-fatty-acid-CoA ligase (eicosanoate)

  Catalysed by CPT1A, CPT1C, CPT1B, SLC27A2 and 7 morecytosolOne of 12 routes

• itaconyl-CoAReach from here →
  1. Carnitine O-Palmitoyltransferase
  2. Itaconate:CoA ligase (GDP-forming)

  Catalysed by CPT1A, CPT1C, CPT1B, SUCLG1 and 2 morecytosol, mitochondrial matrixOne of 2 routes

• tetradecanoyl-CoAReach from here →
  1. Carnitine O-Palmitoyltransferase
  2. long-chain-fatty-acid-CoA ligase (myristic acid)

  Catalysed by CPT1A, CPT1C, CPT1B, SLC27A2 and 7 morecytosolOne of 11 routes

• octanoyl-CoAReach from here →
  1. fatty acyl-CoA desaturase (N-C18:1CoA -> N-C18:2CoA)
  2. Beta Oxidation of Fatty Acid

  Catalysed by FADS2, ACADM, ACADScytosol, mitochondrial matrixOne of 22 routes

• (9Z)-octadecenoyl-CoAReach from here →
  1. octadecanoyl-CoA:NADP+ trans-2-oxidoreductase
  2. octadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O

  Catalysed by TECRL, TECR, SCD, SCD5cytosol

• phytanoyl-CoAReach from here →
  1. Carnitine O-Palmitoyltransferase
  2. phytanate-CoA ligase

  Catalysed by CPT1A, CPT1C, CPT1BcytosolOne of 5 routes

• sphing-4-enineReach from here →
  1. Carnitine O-Palmitoyltransferase
  2. acyl-CoA:sphingosine N-acyltransferase

  Catalysed by CPT1A, CPT1C, CPT1B, ASAH1 and 3 morecytosol, Golgi apparatusOne of 2 routes

• spermidineReach from here →
  1. Carnitine O-Palmitoyltransferase
  2. diamine N-acetyltransferase (N1-acetylspermidine)

  Catalysed by CPT1A, CPT1C, CPT1B, SAT1 and 1 morecytosolOne of 3 routes

• L-methionineReach from here →
  1. Carnitine O-Palmitoyltransferase
  2. N-acetylglutamate synthase (N-acetylmethionine)

  Catalysed by CPT1A, CPT1C, CPT1B, NAGScytosol, mitochondrial matrix

• L-alanineReach from here →
  1. Carnitine O-Palmitoyltransferase
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)

  Catalysed by CPT1A, CPT1C, CPT1Bcytosol, mitochondrial matrix

• L-asparagineReach from here →
  1. Carnitine O-Palmitoyltransferase
  2. N-acetylglutamate synthase (N-acetyl-L-asparagine)

  Catalysed by CPT1A, CPT1C, CPT1B, NAGScytosol, mitochondrial matrix

• L,L-cystathionineReach from here →
  1. Carnitine O-Palmitoyltransferase
  2. N-acetylglutamate synthase (N-acetyl-L-cystathionine)

  Catalysed by CPT1A, CPT1C, CPT1B, NAGScytosol, mitochondrial matrix

• an acyl-CoAReach from here →
  1. fatty acyl-CoA desaturase (N-C18:1CoA -> N-C18:2CoA)
  2. acyl-CoA pool formation and breakdown

  Catalysed by FADS2cytosolOne of 4 routes

• (3Z)-dodecenoyl-CoAReach from here →
  1. Carnitine O-Palmitoyltransferase
  2. acetyl-CoA C-acyltransferase (3-oxomyrist-5-enoyl-CoA)

  Catalysed by CPT1A, CPT1C, CPT1B, HADHA and 2 morecytosol, mitochondrial matrixOne of 3 routes

• (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoAReach from here →
  1. Carnitine O-Palmitoyltransferase
  2. 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate:CoA ligase (AMP-forming)

  Catalysed by CPT1A, CPT1C, CPT1B, SLC27A2 and 1 morecytosol, endoplasmic reticulumOne of 3 routes

• deoxycholoyl-CoAReach from here →
  1. Carnitine O-Palmitoyltransferase
  2. cholate-CoA ligase (3alpha,12alpha-dihydroxy-5beta-cholanate)

  Catalysed by CPT1A, CPT1C, CPT1B, SLC27A2 and 1 morecytosolOne of 4 routes

• 1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholineReach from here →
  1. fatty acyl-CoA desaturase (N-C18:1CoA -> N-C18:2CoA)
  2. (9Z,12Z)-octadecadienoyl-CoA + a 1-acyl-sn-glycero-3-phosphocholine = 1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + CoA

  Catalysed by FADS2, LPCAT3cytosol

• decanoyl-CoAReach from here →
  1. Carnitine O-Palmitoyltransferase
  2. medium-chain acyl-CoA ligase (decanoic acid)

  Catalysed by CPT1A, CPT1C, CPT1B, ACSM4 and 5 morecytosolOne of 7 routes

• (2E)-hexadecenoyl-CoAReach from here →
  1. Carnitine O-Palmitoyltransferase
  2. Carnitine O-Palmitoyltransferase

  Catalysed by CPT1A, CPT1C, CPT1BcytosolOne of 4 routes

• (9Z)-hexadecenoyl-CoAReach from here →
  1. Carnitine O-Palmitoyltransferase
  2. long-chain-fatty-acid-CoA ligase (palmitolate)

  Catalysed by CPT1A, CPT1C, CPT1B, SLC27A2 and 7 morecytosolOne of 11 routes

• 3-hydroxyisovaleryl-CoAReach from here →
  1. Carnitine O-Palmitoyltransferase
  2. (3-Hydroxyisovalerylcoa->3-Hydroxyisovalerylcarnitine)

  Catalysed by CPT1A, CPT1C, CPT1Bcytosol

• CHEBI:63544Reach from here →
  1. Carnitine O-Palmitoyltransferase
  2. long-chain-fatty-acid-CoA ligase (adrenic acid)

  Catalysed by CPT1A, CPT1C, CPT1B, SLC27A2 and 7 morecytosolOne of 7 routes

• hexacosanoyl-CoAReach from here →
  1. Carnitine O-Palmitoyltransferase
  2. long-chain-fatty-acid-CoA ligase (cerotic acid)

  Catalysed by CPT1A, CPT1C, CPT1B, SLC27A2 and 7 morecytosolOne of 5 routes

• tetracosanoyl-CoAReach from here →
  1. Carnitine O-Palmitoyltransferase
  2. long-chain-fatty-acid-CoA ligase (lignocerate)

  Catalysed by CPT1A, CPT1C, CPT1B, SLC27A2 and 7 morecytosolOne of 10 routes

• 1-octadecanoyl-2-acyl-sn-glycero-3-phospho-1D-myo-inositolReach from here →
  1. octadecanoyl-CoA:NADP+ trans-2-oxidoreductase
  2. a 2-acyl-sn-glycero-3-phospho-D-myo-inositol + octadecanoyl-CoA = 1-octadecanoyl-2-acyl-sn-glycero-3-phospho-1D-myo-inositol + CoA

  Catalysed by TECRL, TECR, LCLAT1cytosol

• docosanoyl-CoAReach from here →
  1. Carnitine O-Palmitoyltransferase
  2. long-chain-fatty-acid-CoA ligase (behenic acid)

  Catalysed by CPT1A, CPT1C, CPT1B, SLC27A2 and 7 morecytosolOne of 9 routes

• 3-oxoeicosasphinganineReach from here →
  1. octadecanoyl-CoA:NADP+ trans-2-oxidoreductase
  2. octadecanoyl-CoA + L-serine + H(+) = 3-oxoeicosasphinganine + CO2 + CoA

  Catalysed by TECRL, TECR, SPTLC1, SPTLC2 and 1 morecytosol

• 3-oxoeicosanoyl-CoAReach from here →
  1. octadecanoyl-CoA:NADP+ trans-2-oxidoreductase
  2. very-long-chain 3-oxoacyl-CoA synthase (malonyl-CoA)

  Catalysed by TECRL, TECR, ELOVL7, ELOVL1 and 5 morecytosolOne of 2 routes

• N-(octadecanoyl)-sphinganineReach from here →
  1. octadecanoyl-CoA:NADP+ trans-2-oxidoreductase
  2. sphinganine + octadecanoyl-CoA = N-(octadecanoyl)-sphinganine + CoA + H(+)

  Catalysed by TECRL, TECR, CERS1, CERS6 and 4 morecytosol

• (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoAReach from here →
  1. Carnitine O-Palmitoyltransferase
  2. long-chain-fatty-acid-CoA ligase (stearidonic acid)

  Catalysed by CPT1A, CPT1C, CPT1B, SLC27A2 and 7 morecytosolOne of 8 routes

• 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol)Reach from here →
  1. octadecanoyl-CoA:NADP+ trans-2-oxidoreductase
  2. 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + octadecanoyl-CoA = 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA

  Catalysed by TECRL, TECR, LCLAT1cytosol

• 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-(1D-myo-inositol)Reach from here →
  1. fatty acyl-CoA desaturase (N-C18:1CoA -> N-C18:2CoA)
  2. 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + (9Z,12Z)-octadecadienoyl-CoA = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA

  Catalysed by FADS2, LCLAT1cytosol

• 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)Reach from here →
  1. octadecanoyl-CoA:NADP+ trans-2-oxidoreductase
  2. 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + octadecanoyl-CoA = 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA

  Catalysed by TECRL, TECR, LCLAT1, LPGAT1cytosol

• 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-(1'-sn-glycerol)Reach from here →
  1. fatty acyl-CoA desaturase (N-C18:1CoA -> N-C18:2CoA)
  2. 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + (9Z,12Z)-octadecadienoyl-CoA = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA

  Catalysed by FADS2, LCLAT1cytosol

• 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphateReach from here →
  1. octadecanoyl-CoA:NADP+ trans-2-oxidoreductase
  2. 1-hexadecanoyl-sn-glycero-3-phosphate + octadecanoyl-CoA = 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphate + CoA

  Catalysed by TECRL, TECR, AGPAT2cytosol

• N-octadecanoylsphing-4-enineReach from here →
  1. octadecanoyl-CoA:NADP+ trans-2-oxidoreductase
  2. sphing-4-enine + octadecanoyl-CoA = N-octadecanoylsphing-4-enine + CoA + H(+)

  Catalysed by TECRL, TECR, CERS1, TLCD3B and 2 morecytosol

• 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholineReach from here →
  1. octadecanoyl-CoA:NADP+ trans-2-oxidoreductase
  2. octadecanoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + CoA

  Catalysed by TECRL, TECR, LPCAT3cytosol

• 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholineReach from here →
  1. fatty acyl-CoA desaturase (N-C18:1CoA -> N-C18:2CoA)
  2. (9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + CoA

  Catalysed by FADS2, LPCAT3, MBOAT2, LPCAT1cytosol