gamma-L-glutamyl-L-cysteine

1. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)
2. transport of GSH and sulfotaurolithocholate (cytosol to extracellular)

Catalysed by GSS, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 2 routes

1. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
2. glutathione = L-cysteinylglycine + 5-oxo-L-proline

Catalysed by GSS, CHAC2, CHAC1

1. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)
2. transport of GSH and histamine (cytosol to extracellular)

Catalysed by GSS, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 2 routes

1. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)
2. transport of GSH and thyroxine (cytosol to extracellular)

Catalysed by GSS, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 2 routes

1. gamma-glutamylcyclotransferase (gamma-glutamyl-cysteine)
2. 2 L-cysteine = S-sulfanyl-L-cysteine + L-alanine

Catalysed by GGCT, GGACT, CARS2cytosol

1. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)
2. Sulfide:glutathione,quinone oxidoreductase

Catalysed by GSS, SQORcytosol, mitochondrial matrixOne of 5 routes

1. gamma-glutamylcyclotransferase (gamma-glutamyl-cysteine)
2. (R)-4'-phosphopantothenate:L-cysteine ligase

Catalysed by GGCT, GGACT, PPCScytosolOne of 4 routes

1. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)
2. transport of dopamine and GSH (cytosol to extracellular)

Catalysed by GSS, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 2 routes

1. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)
2. transport of GSH and sulfoglycolithocholate (cytosol to extracellular)

Catalysed by GSS, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 2 routes

1. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)
2. transport of GSH and prostaglandin E2 (cytosol to extracellular)

Catalysed by GSS, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 2 routes

1. gamma-glutamylcyclotransferase (gamma-glutamyl-cysteine)
2. L-Cysteine:oxygen oxidoreductase

Catalysed by GGCT, GGACT, CDO1cytosolOne of 2 routes

1. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)
2. glutathione gamma-glutamylaminopeptidase

Catalysed by GSS, GGTLC3, GGT1, GGT5 and 3 morecytosolOne of 6 routes

1. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
2. ubiquinone-10 + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + ubiquinol-10

Catalysed by GSS, SQOR

1. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)
2. transport of GSH and noradrenaline (cytosol to extracellular)

Catalysed by GSS, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 2 routes

1. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)
2. Resistance-Nodulation-Cell Division (Rnd) Tcdb:2.A.60.1.2

Catalysed by GSS, SLCO2A1cytosol, extracellular spaceOne of 2 routes

1. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
2. (9S)-hydroperoxy-(10E,12Z)-octadecadienoate + 2 glutathione = (9S)-hydroxy-(10E,12Z)-octadecadienoate + glutathione disulfide + H2O

Catalysed by GSS, GPX1, GPX4

1. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)
2. transport of GSH and ursodeoxycholate (cytosol to extracellular)

Catalysed by GSS, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 2 routes

1. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)
2. transport of GSH and prostaglandin G2 (cytosol to extracellular)

Catalysed by GSS, SLCO2A1cytosol, extracellular spaceOne of 2 routes

1. gamma-glutamylcyclotransferase (gamma-glutamyl-cysteine)
2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O

Catalysed by GGCT, GGACT, MOCOScytosol

1. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
2. glycodeoxycholate(in) + glutathione(in) + ATP + H2O = glycodeoxycholate(out) + glutathione(out) + ADP + phosphate + H(+)

Catalysed by GSS, ABCC4inner side of the membrane, outer side of the membrane

1. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
2. (12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + 2 glutathione = (12R)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + glutathione disulfide + H2O

Catalysed by GSS, GPX1, GPX2, GPX4

1. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
2. (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + 2 glutathione = (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + glutathione disulfide + H2O

Catalysed by GSS, PTGES, MGST3, GPX1 and 3 more

1. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
2. (12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + 2 glutathione = (12S)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + glutathione disulfide + H2O

Catalysed by GSS, GPX1, GPX4

1. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)
2. transport of GSH and thromboxane B2 (cytosol to extracellular)

Catalysed by GSS, SLCO1B1cytosol, extracellular spaceOne of 2 routes

1. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
2. RX + glutathione = an S-substituted glutathione + a halide anion + H(+)

Catalysed by GSS, GSTT4, GSTA4, GSTZ1 and 20 moreOne of 2 routes

1. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
2. (13S)-hydroperoxy-(9Z,11E)-octadecadienoate + 2 glutathione = (13S)-hydroxy-(9Z,11E)-octadecadienoate + glutathione disulfide + H2O

Catalysed by GSS, GPX1, GSTA1, GPX2 and 1 more

1. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)
2. solute carrier organic anion transporter (GSH)

Catalysed by GSS, SLCO1A2, SLC7A9, SLCO1B3cytosol, extracellular spaceOne of 3 routes

1. gamma-glutamylcyclotransferase (gamma-glutamyl-cysteine)
2. transport of cysteine and tryptophan (cytosol to extracellular)
3. beta-carboline hydrolysis

Catalysed by GGCT, GGACT, SLC7A5cytosol, extracellular space

1. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)
2. transport of arachidonate and GSH (cytosol to extracellular)
3. Utilized Transport

Catalysed by GSS