2-oxo-3-sulfanylpropanoate

Three steps

• 2-phenylpropan-2-olReach from here →
  1. 2-oxo-3-sulfanylpropanoate + [thioredoxin]-dithiol = [thioredoxin]-disulfide + hydrogen sulfide + pyruvate + H(+)
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. cumene hydroperoxide + 2 glutathione = 2-phenylpropan-2-ol + glutathione disulfide + H2O

  Catalysed by MPST, TSTD1, CLIC2, GPX1 and 2 more

• a hydroxy polyunsaturated fatty acidReach from here →
  1. 2-oxo-3-sulfanylpropanoate + [thioredoxin]-dithiol = [thioredoxin]-disulfide + hydrogen sulfide + pyruvate + H(+)
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. a hydroperoxy polyunsaturated fatty acid + 2 glutathione = a hydroxy polyunsaturated fatty acid + glutathione disulfide + H2O

  Catalysed by MPST, TSTD1, GPX1, GPX2 and 1 more

• tauroursodeoxycholateReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. cystine to cysteine conversion
  3. transport of GSH and tauroursodeoxycholate (cytosol to extracellular)

  Catalysed by GOT2, GOT1, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 3 routes

• glycoursodeoxycholateReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. transport of cysteine and glycine (cytosol to extracellular)
  3. glycine to glycoursodeoxycholate conversion

  Catalysed by GOT2, GOT1, SLC3A2, SLC7A5 and 1 morecytosol, extracellular spaceOne of 5 routes

• (15S)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoateReach from here →
  1. 2-oxo-3-sulfanylpropanoate + [thioredoxin]-dithiol = [thioredoxin]-disulfide + hydrogen sulfide + pyruvate + H(+)
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. (15S)-hydroperoxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + 2 glutathione = (15S)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + glutathione disulfide + H2O

  Catalysed by MPST, TSTD1, GPX1, GPX4

• a quinoneReach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. transport of fumarate and thiosulfate (cytosol to mitochondria)
  3. a quinone + succinate = fumarate + a quinol

  Catalysed by MPST, TST, SLC25A10, SDHBcytosol, mitochondrial matrixOne of 7 routes

• (11S,15S)-dihydroxy-14(R)-S-glutathionyl-(5Z,8Z,12E)-eicosatrienoateReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. cystine to cysteine conversion
  3. glutathione transferase (GSH)

  Catalysed by GOT2, GOT1, PTGES, MGST3 and 19 morecytosolOne of 5 routes

• pregnenolone sulfateReach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) (H2S2O3)
  3. Steryl-Sulfatase

  Catalysed by MPST, TST, STScytosol, Golgi apparatusOne of 2 routes

• androsterone 3alpha-sulfateReach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) (H2S2O3)
  3. steroid sulfatase (androsterone sulfate)

  Catalysed by MPST, TST, STScytosolOne of 3 routes

• prostaglandin E3Reach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. cystine to cysteine conversion
  3. transport of GSH and prostaglandin E3 (cytosol to extracellular)

  Catalysed by GOT2, GOT1, SLCO2A1cytosol, extracellular spaceOne of 6 routes

• prostaglandin A2Reach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. cystine to cysteine conversion
  3. transport of GSH and prostaglandin A2 (cytosol to extracellular)

  Catalysed by GOT2, GOT1, SLCO2A1cytosol, extracellular spaceOne of 4 routes

• prostaglandin B1Reach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. cystine to cysteine conversion
  3. transport of GSH and prostaglandin B1 (cytosol to extracellular)

  Catalysed by GOT2, GOT1, SLCO2A1cytosol, extracellular spaceOne of 2 routes

• prostaglandin J2Reach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. (S)-Lactate:NAD+ oxidoreductase
  3. Transport of Prostaglandin J2, Lactate Antiport

  Catalysed by MPST, TST, LDHB, LDHAL6Bcytosol, mitochondrial matrix, extracellular spaceOne of 2 routes

• 15-oxoprostaglandin F2alphaReach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. (S)-Lactate:NAD+ oxidoreductase
  3. Transport of 15-Keto-Prostaglandin F2A, Lactate Antiport

  Catalysed by MPST, TST, LDHB, LDHAL6Bcytosol, mitochondrial matrix, extracellular spaceOne of 2 routes

• leukotriene F4Reach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. cystine to cysteine conversion
  3. transport of GSH and leukotriene F4 (cytosol to extracellular)

  Catalysed by GOT2, GOT1cytosol, extracellular spaceOne of 2 routes

• prostaglandin A2-S-(R)-glutathioneReach from here →
  1. 2-oxo-3-sulfanylpropanoate + [thioredoxin]-dithiol = [thioredoxin]-disulfide + hydrogen sulfide + pyruvate + H(+)
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. prostaglandin A2 + glutathione = prostaglandin A2-S-(R)-glutathione

  Catalysed by MPST, TSTD1, GSTA1, GSTM1

• prostaglandin A2-S-(S)-glutathioneReach from here →
  1. 2-oxo-3-sulfanylpropanoate + [thioredoxin]-dithiol = [thioredoxin]-disulfide + hydrogen sulfide + pyruvate + H(+)
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. prostaglandin A2 + glutathione = prostaglandin A2-S-(S)-glutathione

  Catalysed by MPST, TSTD1, GSTP1, GSTM1

• prostaglandin J2-S-(R)-glutathioneReach from here →
  1. 2-oxo-3-sulfanylpropanoate + [thioredoxin]-dithiol = [thioredoxin]-disulfide + hydrogen sulfide + pyruvate + H(+)
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. prostaglandin J2 + glutathione = prostaglandin J2-S-(R)-glutathione

  Catalysed by MPST, TSTD1, GSTA1, GSTP1 and 1 more

• prostaglandin J2-S-(S)-glutathioneReach from here →
  1. 2-oxo-3-sulfanylpropanoate + [thioredoxin]-dithiol = [thioredoxin]-disulfide + hydrogen sulfide + pyruvate + H(+)
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. prostaglandin J2 + glutathione = prostaglandin J2-S-(S)-glutathione

  Catalysed by MPST, TSTD1, GSTP1, GSTM1

• 2,4-dinitrophenyl-S-glutathioneReach from here →
  1. 2-oxo-3-sulfanylpropanoate + [thioredoxin]-dithiol = [thioredoxin]-disulfide + hydrogen sulfide + pyruvate + H(+)
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. 1-chloro-2,4-dinitrobenzene + glutathione = 2,4-dinitrophenyl-S-glutathione + chloride + H(+)

  Catalysed by MPST, TSTD1, PTGES, LANCL1 and 2 more

• N-(9Z-octadecenoyl)glycineReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. transport of cysteine and glycine (cytosol to extracellular)
  3. (9Z)-octadecenoyl-CoA + glycine = N-(9Z-octadecenoyl)glycine + CoA + H(+)

  Catalysed by GOT2, GOT1, SLC3A2, SLC7A5 and 3 morecytosol, extracellular space

• N-(9Z-octadecenoyl)-L-phenylalanineReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. transport of cysteine and phenylalanine (cytosol to extracellular)
  3. L-phenylalanine + (9Z)-octadecenoate = N-(9Z-octadecenoyl)-L-phenylalanine + H2O

  Catalysed by GOT2, GOT1, SLC7A5, PM20D1cytosol, extracellular space

• N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-phenylalanineReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. transport of cysteine and phenylalanine (cytosol to extracellular)
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + L-phenylalanine = N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-phenylalanine + H2O

  Catalysed by GOT2, GOT1, SLC7A5, PM20D1cytosol, extracellular space

• N-(9Z-octadecenoyl)-L-leucineReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. transport of cysteine and leucine (cytosol to extracellular)
  3. N-(9Z-octadecenoyl)-L-leucine + H2O = L-leucine + (9Z)-octadecenoate

  Catalysed by GOT2, GOT1, SLC7A9, SLC3A1 and 1 morecytosol, extracellular space

• N-octadecanoylglycineReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. transport of cysteine and glycine (cytosol to extracellular)
  3. octadecanoyl-CoA + glycine = N-octadecanoylglycine + CoA + H(+)

  Catalysed by GOT2, GOT1, SLC3A2, SLC7A5 and 2 morecytosol, extracellular space

• N-(9Z-hexadecenoyl)-glycineReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. transport of cysteine and glycine (cytosol to extracellular)
  3. (9Z)-hexadecenoyl-CoA + glycine = N-(9Z-hexadecenoyl)-glycine + CoA + H(+)

  Catalysed by GOT2, GOT1, SLC3A2, SLC7A5 and 2 morecytosol, extracellular space

• all-trans-4-hydroxyretinoateReach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. transport of pyruvate and retinoate (cytosol to extracellular)
  3. cytochrome P450 (retinoate)

  Catalysed by MPST, TST, SLC16A4, SLC16A5 and 5 morecytosol, extracellular spaceOne of 3 routes

• N-acetylcadaverineReach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. N-acetylcadaverine + H2O = cadaverine + acetate

  Catalysed by MPST, TST, SLC16A4, SLC16A5 and 4 morecytosol, extracellular space

• cholesterol sulfateReach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) (H2S2O3)
  3. Steryl-Sulfatase

  Catalysed by MPST, TST, STScytosol, Golgi apparatusOne of 2 routes

• 5alpha-dihydrotestosterone sulfateReach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) (H2S2O3)
  3. steroid sulfatase (5-alpha-dihydrotestosterone)

  Catalysed by MPST, TST, STScytosolOne of 3 routes

• (13R)-S-glutathionyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoateReach from here →
  1. 2-oxo-3-sulfanylpropanoate + [thioredoxin]-dithiol = [thioredoxin]-disulfide + hydrogen sulfide + pyruvate + H(+)
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. (13S,14S)-epoxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate + glutathione = (13R)-S-glutathionyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoate

  Catalysed by MPST, TSTD1, GSTM4, LTC4S

• all-trans-retinoyl-1-O-(beta-D-glucuronate)Reach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. transport of pyruvate and retinoate (cytosol to extracellular)
  3. glucuronosyltransferase (retinoate)

  Catalysed by MPST, TST, SLC16A4, SLC16A5 and 7 morecytosol, extracellular space, endoplasmic reticulum

• all-trans-18-hydroxyretinoateReach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. transport of pyruvate and retinoate (cytosol to extracellular)
  3. unspecific monooxygenase (retinoate)

  Catalysed by MPST, TST, SLC16A4, SLC16A5 and 29 morecytosol, extracellular spaceOne of 2 routes

• a phenyl acetateReach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. a phenyl acetate + H2O = a phenol + acetate + H(+)

  Catalysed by MPST, TST, SLC16A4, SLC16A5 and 6 morecytosol, extracellular space

• an aryl sulfateReach from here →
  1. 3-mercaptopyruvate:sulfide sulfurtransferase
  2. 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) (H2S2O3)
  3. an aryl sulfate + H2O = a phenol + sulfate + H(+)

  Catalysed by MPST, TST, ARSL, ARSF and 4 morecytosol

• 3-sulfinopyruvateReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. L-Cysteine:oxygen oxidoreductase
  3. 3-sulfino-L-alanine:2-oxoglutarate aminotransferase

  Catalysed by GOT2, GOT1, CDO1cytosolOne of 2 routes

• S-methyl glutathioneReach from here →
  1. 2-oxo-3-sulfanylpropanoate + [thioredoxin]-dithiol = [thioredoxin]-disulfide + hydrogen sulfide + pyruvate + H(+)
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. apo-[alkylcobalamin reductase] + methylcob(III)alamin + glutathione = S-methyl glutathione + cob(I)alamin-[alkylcobalamin reductase] + H(+)

  Catalysed by MPST, TSTD1, MMACHC

• N-hexadecanoylglycineReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. transport of cysteine and glycine (cytosol to extracellular)
  3. hexadecanoyl-CoA + glycine = N-hexadecanoylglycine + CoA + H(+)

  Catalysed by GOT2, GOT1, SLC3A2, SLC7A5 and 2 morecytosol, extracellular space

• N-dodecanoylglycineReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. transport of cysteine and glycine (cytosol to extracellular)
  3. dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)

  Catalysed by GOT2, GOT1, SLC3A2, SLC7A5 and 2 morecytosol, extracellular space

• N-decanoylglycineReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. transport of cysteine and glycine (cytosol to extracellular)
  3. decanoyl-CoA + glycine = N-decanoylglycine + CoA + H(+)

  Catalysed by GOT2, GOT1, SLC3A2, SLC7A5 and 2 morecytosol, extracellular space

• N-octanoylglycineReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. transport of cysteine and glycine (cytosol to extracellular)
  3. octanoyl-CoA + glycine = N-octanoylglycine + CoA + H(+)

  Catalysed by GOT2, GOT1, SLC3A2, SLC7A5 and 2 morecytosol, extracellular space

• D-histidineReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. transport of cysteine and ornithine (cytosol to extracellular)
  3. D-histidine(in) + L-ornithine(out) + H(+)(in) = D-histidine(out) + L-ornithine(in) + H(+)(out)

  Catalysed by GOT2, GOT1, SLC7A6, SLC25A2cytosol, extracellular space, inner side of the membrane, outer side of the membraneOne of 2 routes

• L-homoarginineReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. transport of arginine and cysteine (cytosol to extracellular)
  3. L-homoarginine(in) + L-arginine(out) = L-homoarginine(out) + L-arginine(in)

  Catalysed by GOT2, GOT1, SLC7A6, SLC25A29cytosol, extracellular space, inner side of the membrane, outer side of the membraneOne of 4 routes

• L-homocarnosineReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. transport of cysteine and histidine (cytosol to extracellular)
  3. Formation of homocarnosine

  Catalysed by GOT2, GOT1, SLC7A6, CARNS1cytosol, extracellular space

• N(1)-(5-phospho-beta-D-ribosyl)glycinamideReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. transport of cysteine and glycine (cytosol to extracellular)
  3. 5-phospho-beta-D-ribosylamine + glycine + ATP = N(1)-(5-phospho-beta-D-ribosyl)glycinamide + ADP + phosphate + H(+)

  Catalysed by GOT2, GOT1, SLC3A2, SLC7A5 and 2 morecytosol, extracellular space

• 3-(methylthio)propionic acidReach from here →
  1. 2-oxo-3-sulfanylpropanoate + [thioredoxin]-dithiol = [thioredoxin]-disulfide + hydrogen sulfide + pyruvate + H(+)
  2. methanethiol + O2 + H2O = hydrogen sulfide + formaldehyde + H2O2 + H(+)
  3. leukotriene-B4 20-monooxygenase (3-(methylthio)propionic acid)

  Catalysed by MPST, SELENBP1cytosol

• L-cystine-bis-glycineReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. thioredoxin-disulfide reductase (NADPH) (cystine)
  3. L-cystine-bis-glycine + 2 H2O = L-cystine + 2 glycine

  Catalysed by GOT2, GOT1, TXNRD1, TXNRD3 and 3 morecytosolOne of 2 routes

• indoxyl sulfateReach from here →
  1. 2-oxo-3-sulfanylpropanoate + L-kynurenine = kynurenate + L-cysteine + H2O
  2. kynurenate(out) + a dicarboxylate(in) = kynurenate(in) + a dicarboxylate(out)
  3. indoxyl sulfate(out) + a dicarboxylate(in) = indoxyl sulfate(in) + a dicarboxylate(out)

  Catalysed by AADAT, SLC22A8, SLC22A6inner side of the membrane, outer side of the membraneOne of 2 routes

• glycyldehydrophenylalanineReach from here →
  1. L-Cysteine:2-oxoglutarate aminotransferase
  2. transport of cysteine and glycine (cytosol to extracellular)
  3. glycyldehydrophenylalanine + H2O = 2,3-didehydrophenylalanine + glycine

  Catalysed by GOT2, GOT1, SLC3A2, SLC7A5 and 2 morecytosol, extracellular space

• S-adenosylglutathioneReach from here →
  1. 2-oxo-3-sulfanylpropanoate + [thioredoxin]-dithiol = [thioredoxin]-disulfide + hydrogen sulfide + pyruvate + H(+)
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. apo-[alkylcobalamin reductase] + adenosylcob(III)alamin + glutathione = S-adenosylglutathione + cob(I)alamin-[alkylcobalamin reductase] + H(+)

  Catalysed by MPST, TSTD1, MMACHC