L-histidine

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

311 compounds within 3 steps: 7 in 1, 67 in 2, 237 in 3

Two steps

D-arginineReach from here →
1. L-histidine(in) + L-ornithine(out) + H(+)(in) = L-histidine(out) + L-ornithine(in) + H(+)(out)
2. D-arginine(in) + L-ornithine(out) = D-arginine(out) + L-ornithine(in)
Catalysed by SLC25A2inner side of the membrane, outer side of the membraneOne of 2 routes
glycineReach from here →
1. L-histidine(in) + L-ornithine(out) + H(+)(in) = L-histidine(out) + L-ornithine(in) + H(+)(out)
2. L-Arginine:glycine amidinotransferase
Catalysed by SLC25A2, GATMinner side of the membrane, outer side of the membrane, cytosolOne of 13 routes
2-(N(omega)-L-arginino)succinateReach from here →
1. L-histidine(out) + L-arginine(in) + Na(+)(out) = L-histidine(in) + L-arginine(out) + Na(+)(in)
2. 2-(Nomega-L-arginino)succinate arginine-lyase (fumarate-forming)
Catalysed by SLC7A6, ASLinner side of the membrane, outer side of the membrane, cytosolOne of 2 routes
4-guanidinobutanoateReach from here →
1. L-histidine(out) + L-arginine(in) + Na(+)(out) = L-histidine(in) + L-arginine(out) + Na(+)(in)
2. 4-aminobutanoate + L-arginine = 4-guanidinobutanoate + L-ornithine
Catalysed by SLC7A6, GATMinner side of the membrane, outer side of the membrane
L-dopaReach from here →
1. L-histidine(in) + L-phenylalanine(out) = L-histidine(out) + L-phenylalanine(in)
2. L-dopa(out) + L-phenylalanine(in) = L-dopa(in) + L-phenylalanine(out)
Catalysed by SLC7A8inner side of the membrane, outer side of the membraneOne of 2 routes
3-guanidinopropanoateReach from here →
1. L-histidine(out) + L-arginine(in) + Na(+)(out) = L-histidine(in) + L-arginine(out) + Na(+)(in)
2. beta-alanine + L-arginine = 3-guanidinopropanoate + L-ornithine
Catalysed by SLC7A6, GATMinner side of the membrane, outer side of the membrane
D-ornithineReach from here →
1. L-histidine(in) + L-ornithine(out) + H(+)(in) = L-histidine(out) + L-ornithine(in) + H(+)(out)
2. D-ornithine(in) + L-ornithine(out) = D-ornithine(out) + L-ornithine(in)
Catalysed by SLC25A2inner side of the membrane, outer side of the membraneOne of 2 routes
guanidinoacetateReach from here →
1. L-histidine(out) + L-arginine(in) + Na(+)(out) = L-histidine(in) + L-arginine(out) + Na(+)(in)
2. L-Arginine:glycine amidinotransferase
Catalysed by SLC7A6, GATMinner side of the membrane, outer side of the membrane, cytosolOne of 2 routes
L-methionineReach from here →
1. L-histidine(in) + L-ornithine(out) + H(+)(in) = L-histidine(out) + L-ornithine(in) + H(+)(out)
2. transport of methionine and ornithine (cytosol to extracellular)
Catalysed by SLC25A2, SLC7A6inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 13 routes
L-tryptophanReach from here →
1. L-histidine(in) + L-ornithine(out) + H(+)(in) = L-histidine(out) + L-ornithine(in) + H(+)(out)
2. transport of ornithine and tryptophan (cytosol to extracellular)
Catalysed by SLC25A2, SLC7A6inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 10 routes
L-kynurenineReach from here →
1. L-histidine(in) + L-phenylalanine(out) = L-histidine(out) + L-phenylalanine(in)
2. Transport of L-Kynurenine
Catalysed by SLC7A8inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes
beta-alanineReach from here →
1. beta-alanine + L-histidine + ATP = carnosine + ADP + phosphate + H(+)
2. carnosine + H2O = beta-alanine + L-histidine
Catalysed by CARNS1, CNDP1
L-alanineReach from here →
1. L-histidine(in) + L-ornithine(out) + H(+)(in) = L-histidine(out) + L-ornithine(in) + H(+)(out)
2. transport of alanine and ornithine (cytosol to extracellular)
Catalysed by SLC25A2, SLC7A6inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 12 routes
L-asparagineReach from here →
1. L-histidine(in) + L-ornithine(out) + H(+)(in) = L-histidine(out) + L-ornithine(in) + H(+)(out)
2. transport of asparagine and ornithine (cytosol to extracellular)
Catalysed by SLC25A2, SLC7A6inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 7 routes
taurocyamineReach from here →
1. L-histidine(out) + L-arginine(in) + Na(+)(out) = L-histidine(in) + L-arginine(out) + Na(+)(in)
2. taurine + L-arginine = taurocyamine + L-ornithine
Catalysed by SLC7A6, GATMinner side of the membrane, outer side of the membrane
L-glutamate 5-semialdehydeReach from here →
1. L-histidine(in) + L-ornithine(out) + H(+)(in) = L-histidine(out) + L-ornithine(in) + H(+)(out)
2. L-ornithine + 2-oxoglutarate = L-glutamate 5-semialdehyde + L-glutamate
Catalysed by SLC25A2, OATinner side of the membrane, outer side of the membrane
L-tyrosineReach from here →
1. L-histidine(in) + L-phenylalanine(out) = L-histidine(out) + L-phenylalanine(in)
2. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine
Catalysed by SLC7A8, PAHinner side of the membrane, outer side of the membrane
N(omega),N(omega)-dimethyl-L-arginineReach from here →
1. L-histidine(in) + L-ornithine(out) + H(+)(in) = L-histidine(out) + L-ornithine(in) + H(+)(out)
2. N(omega),N(omega)-dimethyl-L-arginine(in) + L-ornithine(out) = N(omega),N(omega)-dimethyl-L-arginine(out) + L-ornithine(in)
Catalysed by SLC25A2inner side of the membrane, outer side of the membraneOne of 4 routes
anserineReach from here →
1. beta-alanine + L-histidine + ATP = carnosine + ADP + phosphate + H(+)
2. carnosine + S-adenosyl-L-methionine = anserine + S-adenosyl-L-homocysteine + H(+)
Catalysed by CARNS1, CARNMT1
5-guanidino-2-oxopentanoateReach from here →
1. L-histidine(out) + L-arginine(in) + Na(+)(out) = L-histidine(in) + L-arginine(out) + Na(+)(in)
2. L-arginine + O2 + H2O = 5-guanidino-2-oxopentanoate + H2O2 + NH4(+)
Catalysed by SLC7A6, IL4I1inner side of the membrane, outer side of the membrane
N(tau)-methylhistamineReach from here →
1. L-histidine + H(+) = histamine + CO2
2. S-Adenosyl-L-methionine:histamine N-tele-methyltransferase
Catalysed by HDC, HNMTcytosolOne of 3 routes
5-amino-2-oxopentanoateReach from here →
1. L-histidine(in) + L-ornithine(out) + H(+)(in) = L-histidine(out) + L-ornithine(in) + H(+)(out)
2. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine
Catalysed by SLC25A2, AGXT2inner side of the membrane, outer side of the membraneOne of 2 routes
4-aminobutanoateReach from here →
1. 4-aminobutanoate + L-histidine + ATP = L-homocarnosine + ADP + phosphate + H(+)
2. Hydrolysis of homocarnosine
Catalysed by CARNS1, CNDP1, CNDP2cytosolOne of 2 routes
N(5)-[(Z)-amino(hydroxyimino)methyl]ornithineReach from here →
1. L-histidine(out) + L-arginine(in) + Na(+)(out) = L-histidine(in) + L-arginine(out) + Na(+)(in)
2. L-arginine,NADPH:oxygen oxidoreductase (N-(omega)-hydroxyarginine-forming)
Catalysed by SLC7A6, NOS3, NOS1, NOS2inner side of the membrane, outer side of the membrane, cytosol

Three steps

beta-carbolineReach from here →
Catalysed by SLC25A2, SLC7A6inner side of the membrane, outer side of the membrane, extracellular space, cytosol
(S)-carnitineReach from here →
Catalysed by SLC7A6