glycine

Three steps

• Xaa-L-Pro dipeptideReach from here →
  1. transport of alanine and glycine (cytosol to extracellular)
  2. L-proline(out) + L-alanine(in) + Na(+)(out) = L-proline(in) + L-alanine(out) + Na(+)(in)
  3. Xaa-L-Pro dipeptide + H2O = an L-alpha-amino acid + L-proline

  Catalysed by SLC3A2, SLC7A5, SLC7A10, SLC1A4 and 1 moreextracellular space, cytosol, inner side of the membrane, outer side of the membrane

• 11-cis-retinyl esterReach from here →
  1. bile acid-CoA: amino acid N-acyltransferase
  2. Palmitoyl-CoA:retinol O-acyltransferase
  3. 11-cis-retinol + a fatty acyl-CoA = 11-cis-retinyl ester + CoA

  Catalysed by BAAT, DGAT1, LRAT, AWAT1 and 2 moreperoxisome, cytosolOne of 2 routes

• 13-cis-retinyl esterReach from here →
  1. a fatty acyl-CoA + glycine = an N-(fatty acyl)-glycine + CoA + H(+)
  2. a fatty acyl-CoA + glycine = an N-(fatty acyl)-glycine + CoA + H(+)
  3. 13-cis-retinol + a fatty acyl-CoA = 13-cis-retinyl ester + CoA

  Catalysed by GLYATL2, AWAT2

• 9-cis-retinyl esterReach from here →
  1. a fatty acyl-CoA + glycine = an N-(fatty acyl)-glycine + CoA + H(+)
  2. a fatty acyl-CoA + glycine = an N-(fatty acyl)-glycine + CoA + H(+)
  3. 9-cis-retinol + a fatty acyl-CoA = 9-cis-retinyl ester + CoA

  Catalysed by GLYATL2, AWAT2

• biocytinReach from here →
  1. L-Arginine:glycine amidinotransferase
  2. L-ornithine(out) + L-lysine(in) = L-ornithine(in) + L-lysine(out)
  3. biocytin + H2O = biotin + L-lysine

  Catalysed by GATM, SLC25A2, SLC25A15, BTDcytosol, inner side of the membrane, outer side of the membrane

• deoxycholate 3-sulfateReach from here →
  1. Glycodeoxycholate amidohydrolase
  2. Glycodeoxycholate amidohydrolase
  3. deoxycholate + 3'-phosphoadenylyl sulfate = deoxycholate 3-sulfate + adenosine 3',5'-bisphosphate + H(+)

  Catalysed by SULT2A1cytosol

• 3',5'-diiodo-L-thyronineReach from here →
  1. transport of alanine and glycine (cytosol to extracellular)
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
  3. 3',5'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine + AH2

  Catalysed by SLC3A2, SLC7A5, SLC7A10, MOCOS and 1 moreextracellular space, cytosol

• 1-butanoyl-2-(9Z-octadecenoyl)-glycerolReach from here →
  1. bile acid-CoA: amino acid N-acyltransferase
  2. Butanoate:CoA ligase (AMP-forming)
  3. 2-(9Z-octadecenoyl)-glycerol + butanoyl-CoA = 1-butanoyl-2-(9Z-octadecenoyl)-glycerol + CoA

  Catalysed by BAAT, ACSM4, ACSM1, ACSM2A and 5 moreperoxisome, cytosol

• 1-octanoyl-2-(9Z-octadecenoyl)-glycerolReach from here →
  1. bile acid-CoA: amino acid N-acyltransferase
  2. Octanoyl-CoA:L-carnitine O-octanoyltransferase
  3. 2-(9Z-octadecenoyl)-glycerol + octanoyl-CoA = 1-octanoyl-2-(9Z-octadecenoyl)-glycerol + CoA

  Catalysed by BAAT, CROT, MOGAT2, MOGAT1peroxisome, mitochondrial matrix

• 1-eicosanoyl-2-(9Z-octadecenoyl)-glycerolReach from here →
  1. bile acid-CoA: amino acid N-acyltransferase
  2. long-chain-fatty-acid-CoA ligase (eicosanoate)
  3. eicosanoyl-CoA + 2-(9Z-octadecenoyl)-glycerol = 1-eicosanoyl-2-(9Z-octadecenoyl)-glycerol + CoA

  Catalysed by BAAT, SLC27A2, ACSL4, ACSL3 and 7 moreperoxisome, cytosol

• O-butanoyl-(R)-carnitineReach from here →
  1. bile acid-CoA: amino acid N-acyltransferase
  2. Butanoate:CoA ligase (AMP-forming)
  3. butanoyl-CoA + (R)-carnitine = O-butanoyl-(R)-carnitine + CoA

  Catalysed by BAAT, ACSM4, ACSM1, ACSM2A and 4 moreperoxisome, cytosol

• O-[(5Z),(8Z),(11Z),(14Z)-eicosatetraenoyl]-beta-D-glucuronateReach from here →
  1. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)
  2. transport of arachidonate and GSH (cytosol to extracellular)
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + UDP-alpha-D-glucuronate = O-[(5Z),(8Z),(11Z),(14Z)-eicosatetraenoyl]-beta-D-glucuronate + UDP

  Catalysed by GSS, UGT1A9, UGT2B7, UGT1A6 and 3 morecytosol, extracellular space

• 20-O-(beta-D-glucuronosyl)-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)
  2. Resistance-Nodulation-Cell Division (Rnd) Tcdb:2.A.60.1.2
  3. 20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + UDP-alpha-D-glucuronate = 20-O-(beta-D-glucuronosyl)-(5Z,8Z,11Z,14Z)-eicosatetraenoate + UDP + H(+)

  Catalysed by GSS, SLCO2A1, UGT2B7, UGT1A1 and 1 morecytosol, extracellular space

• 15-O-(beta-D-glucuronosyl)-prostaglandin B1Reach from here →
  1. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)
  2. transport of GSH and prostaglandin B1 (cytosol to extracellular)
  3. prostaglandin B1 + UDP-alpha-D-glucuronate = 15-O-(beta-D-glucuronosyl)-prostaglandin B1 + UDP + H(+)

  Catalysed by GSS, SLCO2A1, UGT1A9, UGT2B7 and 2 morecytosol, extracellular space

• 3-iodothyronamineReach from here →
  1. transport of alanine and glycine (cytosol to extracellular)
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
  3. 3-iodothyronamine + iodide + A + H(+) = 3,5-diiodothyronamine + AH2

  Catalysed by SLC3A2, SLC7A5, SLC7A10, MOCOS and 2 moreextracellular space, cytosolOne of 2 routes

• 3-iodo-L-thyronineReach from here →
  1. transport of alanine and glycine (cytosol to extracellular)
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
  3. 3-iodo-L-thyronine + iodide + A + H(+) = 3,5-diiodo-L-thyronine + AH2

  Catalysed by SLC3A2, SLC7A5, SLC7A10, MOCOS and 2 moreextracellular space, cytosolOne of 2 routes

• 3'-iodo-L-thyronineReach from here →
  1. transport of alanine and glycine (cytosol to extracellular)
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
  3. 3'-iodo-L-thyronine + iodide + A + H(+) = 3',5'-diiodo-L-thyronine + AH2

  Catalysed by SLC3A2, SLC7A5, SLC7A10, MOCOS and 2 moreextracellular space, cytosolOne of 2 routes

• 3-oxo-(9Z)-eicosenoyl-CoAReach from here →
  1. bile acid-CoA: amino acid N-acyltransferase
  2. carnitine O-palmitoyltransferase ((7Z)-octadecenoyl-CoA)
  3. very-long-chain 3-oxoacyl-CoA synthase ((7Z)-octadecenoyl-CoA)

  Catalysed by BAAT, CPT1A, CPT1C, CPT1B and 7 moreperoxisome, cytosol

• serotonin O-sulfateReach from here →
  1. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)
  2. transport of GSH and serotonin (cytosol to extracellular)
  3. serotonin + 3'-phosphoadenylyl sulfate = serotonin O-sulfate + adenosine 3',5'-bisphosphate + H(+)

  Catalysed by GSS, SLCO1A2, SLCO1B3, SULT1A3 and 1 morecytosol, extracellular space

• (R)-noradrenaline 4'-O-sulfateReach from here →
  1. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)
  2. transport of GSH and noradrenaline (cytosol to extracellular)
  3. sulfotransferase (noradrenaline)

  Catalysed by GSS, SLCO1A2, SLCO1B3, SULT1A3cytosol, extracellular spaceOne of 2 routes

• a 2-hexadecanoyl-6-alpha-D-glucosaminy-1-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositolReach from here →
  1. hexadecanoyl-CoA + glycine = N-hexadecanoylglycine + CoA + H(+)
  2. hexadecanoyl-CoA + glycine = N-hexadecanoylglycine + CoA + H(+)
  3. a 6-(alpha-D-glucosaminyl)-1-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol + hexadecanoyl-CoA = a 2-hexadecanoyl-6-alpha-D-glucosaminy-1-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol + CoA

  Catalysed by GLYATL3, PIGW

• L-thyronineReach from here →
  1. transport of alanine and glycine (cytosol to extracellular)
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
  3. L-thyronine + iodide + A + H(+) = 3-iodo-L-thyronine + AH2

  Catalysed by SLC3A2, SLC7A5, SLC7A10, MOCOS and 1 moreextracellular space, cytosol

• thyronamineReach from here →
  1. transport of alanine and glycine (cytosol to extracellular)
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
  3. thyronamine + iodide + A + H(+) = 3-iodothyronamine + AH2

  Catalysed by SLC3A2, SLC7A5, SLC7A10, MOCOS and 1 moreextracellular space, cytosol

• 3'-iodothyronamineReach from here →
  1. transport of alanine and glycine (cytosol to extracellular)
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
  3. 3'-iodothyronamine + iodide + A + H(+) = 3',5'-diiodothyronamine + AH2

  Catalysed by SLC3A2, SLC7A5, SLC7A10, MOCOS and 2 moreextracellular space, cytosolOne of 2 routes

• 3,3'-diiodothyronamineReach from here →
  1. transport of alanine and glycine (cytosol to extracellular)
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
  3. 3,3'-diiodothyronamine + iodide + A + H(+) = 3,3',5'-triiodothyronamine + AH2

  Catalysed by SLC3A2, SLC7A5, SLC7A10, MOCOS and 2 moreextracellular space, cytosolOne of 2 routes

• 3',5'-diiodothyronamineReach from here →
  1. transport of alanine and glycine (cytosol to extracellular)
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
  3. 3',5'-diiodothyronamine + iodide + A + H(+) = 3,3',5'-triiodothyronamine + AH2

  Catalysed by SLC3A2, SLC7A5, SLC7A10, MOCOS and 1 moreextracellular space, cytosol

• 3,3',5'-triiodothyronamineReach from here →
  1. transport of alanine and glycine (cytosol to extracellular)
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
  3. 3,3',5'-triiodothyronamine + iodide + A + H(+) = 3,3',5,5'-tetraiodothyronamine + AH2

  Catalysed by SLC3A2, SLC7A5, SLC7A10, MOCOS and 1 moreextracellular space, cytosol

• L-homocysteine thiolactoneReach from here →
  1. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)
  2. Formation of Homocystine
  3. arylesterase (homocysteine-thiolactone)

  Catalysed by GSS, PON1, PON2, PON3cytosolOne of 2 routes

• L-homocysteinyl-AMPReach from here →
  1. transport of glycine and methionine (cytosol to extracellular)
  2. S-methyl-L-methionine + L-homocysteine = 2 L-methionine + H(+)
  3. L-homocysteine + ATP + H(+) = L-homocysteinyl-AMP + diphosphate

  Catalysed by SLC7A5, BHMT2, MARS1extracellular space, cytosol

• (2E,6Z,9Z,12Z)-octadecatetraenoyl-CoAReach from here →
  1. bile acid-CoA: amino acid N-acyltransferase
  2. long-chain-fatty-acid-CoA ligase (gamma-linolenate)
  3. (6Z,9Z,12Z)-octadecatrienoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E,6Z,9Z,12Z)-octadecatetraenoyl-CoA + reduced [electron-transfer flavoprotein]

  Catalysed by BAAT, SLC27A2, ACSL4, ACSL3 and 8 moreperoxisome, cytosolOne of 2 routes

• (2E,7Z,10Z)-hexadecatrienoyl-CoAReach from here →
  1. bile acid-CoA: amino acid N-acyltransferase
  2. Fatty Acid Beta Oxidation Trans (C18:2->C16:2), Mitochondrial
  3. (7Z,10Z)-hexadecadienoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E,7Z,10Z)-hexadecatrienoyl-CoA + reduced [electron-transfer flavoprotein]

  Catalysed by BAAT, HADHA, ACADVL, HADHB and 2 moreperoxisome, mitochondrial matrix

• (2E,4Z,7Z,10Z,13Z)-hexadecapentaenoyl-CoAReach from here →
  1. bile acid-CoA: amino acid N-acyltransferase
  2. Fatty Acid Beta Oxidation (C18:4->C16:4), Mitochondrial
  3. Fatty Acid Beta Oxidation (C16:4->C16:5), Mitochondrial

  Catalysed by BAAT, HADHA, ACADVL, HADHBperoxisome, mitochondrial matrixOne of 4 routes

• (2E,7Z,10Z,13Z)-hexadecatetraenoyl-CoAReach from here →
  1. bile acid-CoA: amino acid N-acyltransferase
  2. Fatty Acid Beta Oxidation (C18:3->C16:3), Mitochondrial
  3. (7Z,10Z,13Z)-hexadecatrienoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E,7Z,10Z,13Z)-hexadecatetraenoyl-CoA + reduced [electron-transfer flavoprotein]

  Catalysed by BAAT, HADHA, ACADVL, HADHB and 2 moreperoxisome, mitochondrial matrix

• (2E,4Z,7Z)-decatrienoyl-CoAReach from here →
  1. bile acid-CoA: amino acid N-acyltransferase
  2. Fatty Acid Beta Oxidation (C12:3->C10:2), Mitochondrial
  3. Fatty Acid Beta Oxidation (C10:2->C10:3), Mitochondrial

  Catalysed by BAAT, ECHS1, ACAA2, HADH and 1 moreperoxisome, mitochondrial matrixOne of 3 routes

• ursodeoxycholate 3-sulfateReach from here →
  1. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)
  2. transport of GSH and ursodeoxycholate (cytosol to extracellular)
  3. ursodeoxycholate + 3'-phosphoadenylyl sulfate = ursodeoxycholate 3-sulfate + adenosine 3',5'-bisphosphate + H(+)

  Catalysed by GSS, SLCO1A2, SLCO1B3, SULT2A1cytosol, extracellular space

• tauroursodeoxycholate 3-sulfateReach from here →
  1. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)
  2. transport of GSH and tauroursodeoxycholate (cytosol to extracellular)
  3. tauroursodeoxycholate + 3'-phosphoadenylyl sulfate = tauroursodeoxycholate 3-sulfate + adenosine 3',5'-bisphosphate + H(+)

  Catalysed by GSS, SLCO1A2, SLCO1B3, SULT2A1cytosol, extracellular space

• a long-chain alcohol wax esterReach from here →
  1. a fatty acyl-CoA + glycine = an N-(fatty acyl)-glycine + CoA + H(+)
  2. a fatty acyl-CoA + glycine = an N-(fatty acyl)-glycine + CoA + H(+)
  3. a long chain fatty alcohol + a fatty acyl-CoA = a long-chain alcohol wax ester + CoA

  Catalysed by GLYATL2, AWAT1, AWAT2

• dimethylarsinous acidReach from here →
  1. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
  2. arsenic triglutathione + 3 [thioredoxin]-dithiol + 3 S-adenosyl-L-methionine = trimethylarsine + 3 [thioredoxin]-disulfide + 3 glutathione + 3 S-adenosyl-L-homocysteine + 3 H(+)
  3. arsenic triglutathione + 2 [thioredoxin]-dithiol + 2 S-adenosyl-L-methionine + H2O = dimethylarsinous acid + 2 [thioredoxin]-disulfide + 3 glutathione + 2 S-adenosyl-L-homocysteine + 2 H(+)

  Catalysed by GSS, AS3MT

• docosanoateReach from here →
  1. bile acid-CoA: amino acid N-acyltransferase
  2. long-chain-fatty-acid-CoA ligase (behenic acid)
  3. Docosanoyl-CoA hydrolase

  Catalysed by BAAT, SLC27A2, ACSL4, ACSL3 and 6 moreperoxisome, cytosolOne of 4 routes

• octadecanoateReach from here →
  1. bile acid-CoA: amino acid N-acyltransferase
  2. long-chain-fatty-acid-CoA ligase (stearate)
  3. Stearoyl-CoA hydrolase

  Catalysed by BAAT, SLC27A2, ACSL4, ACSL3 and 8 moreperoxisome, cytosolOne of 4 routes

• octanoateReach from here →
  1. bile acid-CoA: amino acid N-acyltransferase
  2. Octanoyl-CoA:L-carnitine O-octanoyltransferase
  3. Octanoyl-CoA hydrolase

  Catalysed by BAAT, CROT, ACOT7peroxisome, mitochondrial matrix, cytosolOne of 2 routes

• N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamineReach from here →
  1. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)
  2. transport of arachidonate and GSH (cytosol to extracellular)
  3. fatty acylamide amidohydrolase

  Catalysed by GSS, FAAHcytosol, extracellular space

• trimethylarsineReach from here →
  1. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
  2. arsenic triglutathione + 3 [thioredoxin]-dithiol + 3 S-adenosyl-L-methionine = trimethylarsine + 3 [thioredoxin]-disulfide + 3 glutathione + 3 S-adenosyl-L-homocysteine + 3 H(+)
  3. arsenic triglutathione + 3 [thioredoxin]-dithiol + 3 S-adenosyl-L-methionine = trimethylarsine + 3 [thioredoxin]-disulfide + 3 glutathione + 3 S-adenosyl-L-homocysteine + 3 H(+)

  Catalysed by GSS, AS3MT

• imidazole-4-acetaldehydeReach from here →
  1. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)
  2. transport of GSH and histamine (cytosol to extracellular)
  3. amine oxidase copper containing (histamine)

  Catalysed by GSS, SLCO1A2, SLCO1B3, AOC2 and 2 morecytosol, extracellular spaceOne of 2 routes

• alpha-linolenic acidReach from here →
  1. bile acid-CoA: amino acid N-acyltransferase
  2. Carnitine O-Palmitoyltransferase
  3. Utilized Transport

  Catalysed by BAAT, CPT1A, CPT1C, CPT1Bperoxisome, cytosol, endoplasmic reticulumOne of 2 routes

• folic acidReach from here →
  1. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  2. 5,6,7,8-tetrahydrofolate:NAD+ oxidoreductase
  3. dihydrofolate:NAD+ oxidoreductase

  Catalysed by SHMT1, DHFR, DHFR2cytosolOne of 4 routes

• selenomethionineReach from here →
  1. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  2. histamine N-methyltransferase (SAM)
  3. Methionine Synthase

  Catalysed by SHMT1, HNMTcytosol, nucleusOne of 3 routes

• decanoateReach from here →
  1. bile acid-CoA: amino acid N-acyltransferase
  2. medium-chain acyl-CoA ligase (decanoic acid)
  3. Decanoyl-CoA hydrolase

  Catalysed by BAAT, ACSM4, ACSM1, ACSM2A and 4 moreperoxisome, cytosolOne of 2 routes

• CHEBI:27760Reach from here →
  1. transport of alanine and glycine (cytosol to extracellular)
  2. L-selenocysteine selenide-lyase (L-alanine-forming)
  3. Selenocystathionine Lysteine-lyase (deaminating)

  Catalysed by SLC3A2, SLC7A5, SLC7A10, SCLY and 1 moreextracellular space, cytosolOne of 2 routes

• 3,4-dihydroxyphenylacetaldehydeReach from here →
  1. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)
  2. transport of dopamine and GSH (cytosol to extracellular)
  3. monoamine oxidase (dopamine)

  Catalysed by GSS, SLCO1A2, SLCO1B3, AOC2 and 4 morecytosol, extracellular spaceOne of 2 routes