CHEBI:240943

Three steps

• CHEBI:17312Reach from here →
  1. glycine N-acyltransferase (2-methylbutyryl-CoA)
  2. glycine N-acyltransferase (2-methylbutyryl-CoA)
  3. N1,N12-diacetylspermine to N1-acetylspermine conversion

  Catalysed by GLYAT, GLYATL2, GLYATL1mitochondrial matrix, cytosolOne of 2 routes

• linoleic acidReach from here →
  1. 2-Methylbutyrylglycine Transport, Extracellular
  2. Carnitine Transport by Atb0
  3. Utilized Transport

  Catalysed by SLC6A5, SLC6A14extracellular space, cytosol, endoplasmic reticulumOne of 2 routes

• sulfiteReach from here →
  1. glycine N-acyltransferase (2-methylbutyryl-CoA)
  2. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
  3. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)

  Catalysed by GLYAT, GLYATL2, GLYATL1, GSS and 1 moremitochondrial matrixOne of 6 routes

• D-aspartic acidReach from here →
  1. 2-Methylbutyrylglycine Transport, Extracellular
  2. transport of chloride (cytosol to extracellular)
  3. transport of D-aspartate (cytosol to extracellular)

  Catalysed by SLC6A5, SLC12A2, SLC12A1, SLC1A7 and 4 moreextracellular space, cytosol

• CHEBI:17380Reach from here →
  1. glycine N-acyltransferase (2-methylbutyryl-CoA)
  2. transport of glycine and tryptophan (cytosol to extracellular)
  3. Transport of 3-Hydroxy-L-Kynurenine

  Catalysed by GLYAT, GLYATL2, GLYATL1, SLC7A5mitochondrial matrix, extracellular space, cytosolOne of 2 routes

• (S)-1-pyrroline-5-carboxylateReach from here →
  1. glycine N-acyltransferase (2-methylbutyryl-CoA)
  2. transport of glycine and proline (cytosol to extracellular)
  3. L-proline:(acceptor) oxidoreductase

  Catalysed by GLYAT, GLYATL2, GLYATL1, SLC7A5 and 2 moremitochondrial matrix, extracellular space, cytosolOne of 2 routes

• agmatineReach from here →
  1. glycine N-acyltransferase (2-methylbutyryl-CoA)
  2. transport of arginine and glycine (cytosol to extracellular)
  3. L-arginine carboxy-lyase (agmatine-forming)

  Catalysed by GLYAT, GLYATL2, GLYATL1, SLC7A6mitochondrial matrix, extracellular space, cytosol

• O-hexadecanoyl-(R)-carnitineReach from here →
  1. 2-Methylbutyrylglycine Transport, Extracellular
  2. Carnitine Transport by Atb0
  3. palmitoyl-CoA:L-carnitine O-palmitoyltransferase

  Catalysed by SLC6A5, SLC6A14, CPT2, CPT1Aextracellular space, cytosol, peroxisomeOne of 10 routes

• AH2Reach from here →
  1. glycine N-acyltransferase (2-methylbutyryl-CoA)
  2. transport of alanine and glycine (cytosol to extracellular)
  3. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O

  Catalysed by GLYAT, GLYATL2, GLYATL1, SLC3A2 and 3 moremitochondrial matrix, extracellular space, cytosolOne of 6 routes

• diiodineReach from here →
  1. 2-Methylbutyrylglycine Transport, Extracellular
  2. transport of chloride and iodide (cytosol to extracellular)
  3. iodide:hydrogen-peroxide oxidoreductase

  Catalysed by SLC6A5, SLC26A4, TPOextracellular space, cytosolOne of 2 routes

• indole-3-pyruvateReach from here →
  1. glycine N-acyltransferase (2-methylbutyryl-CoA)
  2. transport of glycine and tryptophan (cytosol to extracellular)
  3. L-tryptophan + O2 + H2O = indole-3-pyruvate + H2O2 + NH4(+)

  Catalysed by GLYAT, GLYATL2, GLYATL1, SLC7A5 and 1 moremitochondrial matrix, extracellular space, cytosolOne of 3 routes

• 3,3'-diiodo-L-thyronine sulfateReach from here →
  1. 2-Methylbutyrylglycine Transport, Extracellular
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. Steryl-Sulfatase

  Catalysed by SLC6A5, SLC26A6, STSextracellular space, cytosol, Golgi apparatusOne of 2 routes

• (7Z,10Z,13Z)-hexadecatrienoyl-CoAReach from here →
  1. glycine N-acyltransferase (2-methylbutyryl-CoA)
  2. glycine N-acyltransferase (2-methylbutyryl-CoA)
  3. Fatty Acid Beta Oxidation (C18:3->C16:3), Mitochondrial

  Catalysed by GLYAT, GLYATL2, GLYATL1, HADHA and 2 moremitochondrial matrix

• CHEBI:17724Reach from here →
  1. glycine N-acyltransferase (2-methylbutyryl-CoA)
  2. S-Adenosyl-L-methionine:glycine N-methyltransferase
  3. dimethylglycine dehydrogenase (formaldehyde)

  Catalysed by GLYAT, GLYATL2, GLYATL1, GNMT and 2 moremitochondrial matrix, cytosolOne of 2 routes

• Ala-tRNA(Ala)Reach from here →
  1. glycine N-acyltransferase (2-methylbutyryl-CoA)
  2. transport of alanine and glycine (cytosol to extracellular)
  3. L-Alanine:tRNA(Ala) ligase (AMP-forming)

  Catalysed by GLYAT, GLYATL2, GLYATL1, SLC3A2 and 3 moremitochondrial matrix, extracellular space, cytosol

• trans-urocanateReach from here →
  1. glycine N-acyltransferase (2-methylbutyryl-CoA)
  2. transport of glycine and histidine (cytosol to extracellular)
  3. L-histidine ammonia-lyase (urocanate-forming)

  Catalysed by GLYAT, GLYATL2, GLYATL1, SLC7A6 and 1 moremitochondrial matrix, extracellular space, cytosol

• urateReach from here →
  1. glycine N-acyltransferase (2-methylbutyryl-CoA)
  2. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
  3. urate(out) + glutathione(in) = urate(in) + glutathione(out)

  Catalysed by GLYAT, GLYATL2, GLYATL1, GSS and 1 moremitochondrial matrix, inner side of the membrane, outer side of the membrane

• 5-hydroxy-L-tryptophanReach from here →
  1. glycine N-acyltransferase (2-methylbutyryl-CoA)
  2. transport of glycine and tryptophan (cytosol to extracellular)
  3. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tryptophan + O2 = 5-hydroxy-L-tryptophan + (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin

  Catalysed by GLYAT, GLYATL2, GLYATL1, SLC7A5 and 2 moremitochondrial matrix, extracellular space, cytosol

• methylarsonous acidReach from here →
  1. glycine N-acyltransferase (2-methylbutyryl-CoA)
  2. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
  3. methylarsonate + 2 glutathione + H(+) = methylarsonous acid + glutathione disulfide + H2O

  Catalysed by GLYAT, GLYATL2, GLYATL1, GSS and 2 moremitochondrial matrix

• 4-methyl-2-oxopentanoateReach from here →
  1. glycine N-acyltransferase (2-methylbutyryl-CoA)
  2. transport of glycine and leucine (cytosol to extracellular)
  3. L-Leucine:2-oxoglutarate aminotransferase

  Catalysed by GLYAT, GLYATL2, GLYATL1, SLC7A5 and 1 moremitochondrial matrix, extracellular space, cytosolOne of 5 routes

• CHEBI:17927Reach from here →
  1. glycine N-acyltransferase (2-methylbutyryl-CoA)
  2. glycine N-acyltransferase (2-methylbutyryl-CoA)
  3. N1,N8-diacetylspermidine to N1-acetylspermidine conversion

  Catalysed by GLYAT, GLYATL2, GLYATL1mitochondrial matrix, cytosolOne of 2 routes

• 3-oxopropanoic acidReach from here →
  1. 2-Methylbutyrylglycine Transport, Extracellular
  2. transport of beta-alanine and chloride (cytosol to extracellular)
  3. beta-alanine:2-oxoglutarate aminotransferase

  Catalysed by SLC6A5, SLC6A6, SLC6A14, ABATextracellular space, cytosol, mitochondrial matrix

• 3-phenylpyruvateReach from here →
  1. glycine N-acyltransferase (2-methylbutyryl-CoA)
  2. transport of glycine and phenylalanine (cytosol to extracellular)
  3. Phenylalanine Transaminase, Mitochondrial

  Catalysed by GLYAT, GLYATL2, GLYATL1, SLC7A5 and 2 moremitochondrial matrix, extracellular space, cytosolOne of 6 routes

• fumaric acidReach from here →
  1. 2-Methylbutyrylglycine Transport, Extracellular
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. transport of fumarate and sulfate (cytosol to mitochondria)

  Catalysed by SLC6A5, SLC26A6, SLC25A10extracellular space, cytosol, mitochondrial matrixOne of 2 routes

• O-octanoyl-(R)-carnitineReach from here →
  1. 2-Methylbutyrylglycine Transport, Extracellular
  2. Carnitine Transport by Atb0
  3. solute carrier (L-carnitine)

  Catalysed by SLC6A5, SLC6A14, SLC25A20extracellular space, cytosol, mitochondrial matrixOne of 7 routes

• CHEBI:18132Reach from here →
  1. 2-Methylbutyrylglycine Transport, Extracellular
  2. transport of chloride and choline (cytosol to extracellular)
  3. ATP:choline phosphotransferase

  Catalysed by SLC6A5, SLC5A7, CHKA, CHKBextracellular space, cytosol

• N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamideReach from here →
  1. glycine N-acyltransferase (2-methylbutyryl-CoA)
  2. 5-Phospho-D-ribosylamine:glycine ligase (ADP-forming)
  3. 10-formyltetrahydrofolate:5'-phosphoribosylglycinamide formyltransferase

  Catalysed by GLYAT, GLYATL2, GLYATL1, GARTmitochondrial matrix, cytosol

• arsenic triglutathioneReach from here →
  1. glycine N-acyltransferase (2-methylbutyryl-CoA)
  2. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
  3. arsenic triglutathione + 3 [thioredoxin]-dithiol + 3 S-adenosyl-L-methionine = trimethylarsine + 3 [thioredoxin]-disulfide + 3 glutathione + 3 S-adenosyl-L-homocysteine + 3 H(+)

  Catalysed by GLYAT, GLYATL2, GLYATL1, GSS and 1 moremitochondrial matrixOne of 3 routes

• 2-phenylethylamineReach from here →
  1. glycine N-acyltransferase (2-methylbutyryl-CoA)
  2. transport of glycine and phenylalanine (cytosol to extracellular)
  3. L-phenylalanine carboxy-lyase (phenylethylamine-forming)

  Catalysed by GLYAT, GLYATL2, GLYATL1, SLC7A5 and 1 moremitochondrial matrix, extracellular space, cytosol

• 2-formamido-N(1)-(5-phospho-D-ribosyl)acetamidineReach from here →
  1. glycine N-acyltransferase (2-methylbutyryl-CoA)
  2. transport of glutamine and glycine (cytosol to extracellular)
  3. 5'-Phosphoribosylformylglycinamide:L-glutamine amido-ligase (ADP-forming)

  Catalysed by GLYAT, GLYATL2, GLYATL1, SLC7A5 and 1 moremitochondrial matrix, extracellular space, cytosol

• gamma-L-glutamyl-(2S)-2-aminobutanoateReach from here →
  1. glycine N-acyltransferase (2-methylbutyryl-CoA)
  2. (2S)-2-aminobutanoate + glyoxylate = 2-oxobutanoate + glycine
  3. (2S)-2-aminobutanoate + L-glutamate + ATP = gamma-L-glutamyl-(2S)-2-aminobutanoate + ADP + phosphate + H(+)

  Catalysed by GLYAT, GLYATL2, GLYATL1, AGXT2 and 1 moremitochondrial matrix

• S-methylmercury-L-cysteineReach from here →
  1. glycine N-acyltransferase (2-methylbutyryl-CoA)
  2. transport of glycine and methionine (cytosol to extracellular)
  3. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)

  Catalysed by GLYAT, GLYATL2, GLYATL1, SLC7A5 and 1 moremitochondrial matrix, extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 6 routes

• 2-aminoisobutanoateReach from here →
  1. glycine N-acyltransferase (2-methylbutyryl-CoA)
  2. transport of alanine and glycine (cytosol to extracellular)
  3. 2-aminoisobutanoate(out) + L-alanine(in) = 2-aminoisobutanoate(in) + L-alanine(out)

  Catalysed by GLYAT, GLYATL2, GLYATL1, SLC3A2 and 2 moremitochondrial matrix, extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• 15-deoxy-Delta(12,14)-prostaglandin J2-S-(R)-glutathioneReach from here →
  1. glycine N-acyltransferase (2-methylbutyryl-CoA)
  2. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
  3. 15-deoxy-Delta(12,14)-prostaglandin J2 + glutathione = 15-deoxy-Delta(12,14)-prostaglandin J2-S-(R)-glutathione

  Catalysed by GLYAT, GLYATL2, GLYATL1, GSS and 1 moremitochondrial matrix

• (6R)-10-formyltetrahydrofolateReach from here →
  1. glycine N-acyltransferase (2-methylbutyryl-CoA)
  2. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
  3. (6S)-5,6,7,8-tetrahydrofolate + formate + ATP = (6R)-10-formyltetrahydrofolate + ADP + phosphate

  Catalysed by GLYAT, GLYATL2, GLYATL1, SHMT1 and 3 moremitochondrial matrix

• (5S)-hydroxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoateReach from here →
  1. glycine N-acyltransferase (2-methylbutyryl-CoA)
  2. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
  3. (5S)-hydroperoxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate + 2 glutathione = (5S)-hydroxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate + glutathione disulfide + H2O

  Catalysed by GLYAT, GLYATL2, GLYATL1, GSS and 2 moremitochondrial matrix

• (12S)-hydroxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoateReach from here →
  1. glycine N-acyltransferase (2-methylbutyryl-CoA)
  2. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
  3. (12S)-hydroperoxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + 2 glutathione = (12S)-hydroxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + glutathione disulfide + H2O

  Catalysed by GLYAT, GLYATL2, GLYATL1, GSS and 2 moremitochondrial matrix

• (15S)-hydroxy-(11Z,13E)-eicosadienoateReach from here →
  1. glycine N-acyltransferase (2-methylbutyryl-CoA)
  2. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
  3. (15S)-hydroperoxy-(11Z,13E)-eicosadienoate + 2 glutathione = (15S)-hydroxy-(11Z,13E)-eicosadienoate + glutathione disulfide + H2O

  Catalysed by GLYAT, GLYATL2, GLYATL1, GSS and 2 moremitochondrial matrix

• (17S)-hydroxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoateReach from here →
  1. glycine N-acyltransferase (2-methylbutyryl-CoA)
  2. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
  3. (17S)-hydroperoxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate + 2 glutathione = (17S)-hydroxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate + glutathione disulfide + H2O

  Catalysed by GLYAT, GLYATL2, GLYATL1, GSS and 2 moremitochondrial matrix

• a hydroxy-1,2-diacyl-glycero-3-phosphocholineReach from here →
  1. glycine N-acyltransferase (2-methylbutyryl-CoA)
  2. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
  3. a hydroperoxy-1,2-diacyl-glycero-3-phosphocholine + 2 glutathione = a hydroxy-1,2-diacyl-glycero-3-phosphocholine + glutathione disulfide + H2O

  Catalysed by GLYAT, GLYATL2, GLYATL1, GSS and 1 moremitochondrial matrix

• glycodeoxycholate 3-sulfateReach from here →
  1. glycine N-acyltransferase (2-methylbutyryl-CoA)
  2. Glycodeoxycholate amidohydrolase
  3. glycodeoxycholate + 3'-phosphoadenylyl sulfate = glycodeoxycholate 3-sulfate + adenosine 3',5'-bisphosphate + H(+)

  Catalysed by GLYAT, GLYATL2, GLYATL1, SULT2A1mitochondrial matrix, cytosol

• 5-(3,3-dimethylguanidino)-2-oxopentanoateReach from here →
  1. glycine N-acyltransferase (2-methylbutyryl-CoA)
  2. glycine + 2-oxoglutarate = glyoxylate + L-glutamate
  3. N(omega),N(omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + glycine

  Catalysed by GLYAT, GLYATL2, GLYATL1, AADAT and 1 moremitochondrial matrixOne of 7 routes

• 5-(3,3'-dimethylguanidino)-2-oxopentanoateReach from here →
  1. glycine N-acyltransferase (2-methylbutyryl-CoA)
  2. glycine + 2-oxoglutarate = glyoxylate + L-glutamate
  3. N(omega),N('omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + glycine

  Catalysed by GLYAT, GLYATL2, GLYATL1, AADAT and 1 moremitochondrial matrixOne of 3 routes

• 5-(3-methylguanidino)-2-oxopentanoateReach from here →
  1. glycine N-acyltransferase (2-methylbutyryl-CoA)
  2. glycine + 2-oxoglutarate = glyoxylate + L-glutamate
  3. N(omega)-methyl-L-arginine + glyoxylate = 5-(3-methylguanidino)-2-oxopentanoate + glycine

  Catalysed by GLYAT, GLYATL2, GLYATL1, AADAT and 1 moremitochondrial matrixOne of 3 routes

• (6R)-5,10-methylenetetrahydrofolic acidReach from here →
  1. glycine N-acyltransferase (2-methylbutyryl-CoA)
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase

  Catalysed by GLYAT, GLYATL2, GLYATL1, SHMT1mitochondrial matrix, cytosolOne of 7 routes

• S-disulfanyl-L-cysteineReach from here →
  1. glycine N-acyltransferase (2-methylbutyryl-CoA)
  2. transport of cysteine and glycine (cytosol to extracellular)
  3. S-sulfanyl-L-cysteine + L-cysteine = S-disulfanyl-L-cysteine + L-alanine

  Catalysed by GLYAT, GLYATL2, GLYATL1, SLC3A2 and 3 moremitochondrial matrix, extracellular space, cytosol

• (5Z)-dodecenoyl-CoAReach from here →
  1. glycine N-acyltransferase (2-methylbutyryl-CoA)
  2. glycine N-acyltransferase (2-methylbutyryl-CoA)
  3. acetyl-CoA C-acyltransferase (3-oxomyrist-7-enoyl-CoA)

  Catalysed by GLYAT, GLYATL2, GLYATL1, HADHA and 2 moremitochondrial matrixOne of 2 routes

• (11Z)-docosenoyl-CoA(4-)Reach from here →
  1. glycine N-acyltransferase (2-methylbutyryl-CoA)
  2. glycine N-acyltransferase (2-methylbutyryl-CoA)
  3. long-chain-fatty-acid-CoA ligase (cis-cetoleic acid)

  Catalysed by GLYAT, GLYATL2, GLYATL1, SLC27A2 and 7 moremitochondrial matrix, cytosolOne of 5 routes

• (7Z)-tetradecenoyl-CoAReach from here →
  1. glycine N-acyltransferase (2-methylbutyryl-CoA)
  2. glycine N-acyltransferase (2-methylbutyryl-CoA)
  3. long-chain-fatty-acid-CoA ligase ((7Z)-tetradecenoic acid)

  Catalysed by GLYAT, GLYATL2, GLYATL1, SLC27A2 and 7 moremitochondrial matrix, cytosolOne of 8 routes

• (4Z,7Z,10Z,13Z)-hexadecatetraenoyl-CoAReach from here →
  1. glycine N-acyltransferase (2-methylbutyryl-CoA)
  2. glycine N-acyltransferase (2-methylbutyryl-CoA)
  3. Fatty Acid Beta Oxidation (C18:4->C16:4), Mitochondrial

  Catalysed by GLYAT, GLYATL2, GLYATL1, HADHA and 2 moremitochondrial matrixOne of 3 routes