Compound
leukotriene B5
An icosanoid anion that is the conjugate base of leukotriene B5, obtained by deprotonation of the carboxy group; major species at pH 7.3.
Definition from ChEBI (CHEBI:133302), read 2026-09-23. CC BY 4.0.
Structure
Loading the model…
- Class
- Organic compound, anion
- Formula
- C20H29O4
- Mass
- 333.448 g/mol
- Charge
- -1
- InChIKey
- BISQPGCQOHLHQK-HDNPQISLSA-M
- SMILES
- CC/C=CC/C=CC[C@@H](O)/C=C/C=C/C=C[C@@H](O)CCCC(=O)[O-]
- Look it up
- ChEBIPubChemBy InChIKey
Identity from ChEBI, geometry from PubChem. Not evidence.
What it touches on the way
Mechanistic reach
6 entities
6 entities reached.
0 reported hops6 assembled from the scaffold
- CYP4F2ProteinUNIPROT:P78329metabolized byInferred only36 paths18 endpoints
- CYP4F22ProteinUNIPROT:Q6NT55metabolized byInferred only34 paths17 endpoints
- CYP4F3ProteinUNIPROT:Q08477metabolized byInferred only32 paths16 endpoints
- LTA4HProteinUNIPROT:P09960substrate ofInferred only30 paths30 endpoints
- CYP4F11ProteinUNIPROT:Q9HBI6metabolized byInferred only26 paths13 endpoints
- CYP4F8ProteinUNIPROT:P98187metabolized byInferred only26 paths13 endpoints
What the reference databases state
Chemical structure
- leukotriene B5 has the functional parent leukotriene A5CompoundChEBI CHEBI:133302Inferred only
Statements
14 statements
14 statements · 2 reference databases · Subject: leukotriene B5 · Sources: Human-GEM, Rhea
- leukotriene A5 is converted to leukotriene B5CompoundRhea RHEA:85599Inferred only
- leukotriene B5 is converted to leukotriene A5CompoundHuman-GEM MAR02551Inferred only
- leukotriene A5 is converted to leukotriene B5CompoundHuman-GEM MAR02551Inferred only
- leukotriene B5 is metabolised by CYP4F11ProteinHuman-GEM MAR02553Inferred only
- leukotriene B5 is metabolised by CYP4F11ProteinHuman-GEM MAR02555Inferred only
- leukotriene B5 is metabolised by CYP4F2ProteinHuman-GEM MAR02555Inferred only
- leukotriene B5 is metabolised by CYP4F2ProteinHuman-GEM MAR02553Inferred only
- leukotriene B5 is metabolised by CYP4F22ProteinHuman-GEM MAR02555Inferred only
- leukotriene B5 is metabolised by CYP4F22ProteinHuman-GEM MAR02553Inferred only
- leukotriene B5 is metabolised by CYP4F3ProteinHuman-GEM MAR02553Inferred only
- leukotriene B5 is metabolised by CYP4F3ProteinHuman-GEM MAR02555Inferred only
- leukotriene B5 is metabolised by CYP4F8ProteinHuman-GEM MAR02555Inferred only
Show the remaining 2
- leukotriene B5 is metabolised by CYP4F8ProteinHuman-GEM MAR02553Inferred only
- leukotriene B5 is a substrate of LTA4HProteinHuman-GEM MAR02551Inferred only
Reactions
7 reactions
water+leukotriene A5leukotriene B5
Catalysed by LTA4H
Reaction pageReversibleBalancedEC 3.3.2.6cytosol
Human-GEM MAR02551CC BY 4.0Reference data
proton+leukotriene B5+NADPH(4-)+dioxygenMAM00595c+water+NADP(3-)
Catalysed by CYP4F11 or CYP4F22 or CYP4F2 or CYP4F8 or CYP4F3
Reaction pageLeft to rightBalancedEC 1.14.14.94cytosol
Human-GEM MAR02553CC BY 4.0Reference data
Reaction pageReversibleBalancedcytosol, endoplasmic reticulum
Human-GEM MAR02554CC BY 4.0Reference data
proton+leukotriene B5+NADPH(4-)+dioxygenMAM00595r+water+NADP(3-)
Catalysed by CYP4F11 or CYP4F22 or CYP4F2 or CYP4F8 or CYP4F3
Reaction pageLeft to rightBalancedEC 1.14.14.94endoplasmic reticulum
Human-GEM MAR02555CC BY 4.0Reference data
ATP+water+leukotriene B5ADP+proton+leukotriene B5+phosphate(3-)
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR10172CC BY 4.0Reference data
Reaction pageReversibleBalance undeterminableextracellular space
Human-GEM MAR10233CC BY 4.0Reference data
leukotriene A5+waterleukotriene B5
Catalysed by LTA4H
Reaction pageLeft to rightBalanced
Rhea RHEA:85599CC BY 4.0Reference data
Other names
5 names
Resolves to: leukotriene B5
- Also called
- 5,12-DiHEPE(1-)5,12-DiHEPE(1−)leukotriene B5 anionLeukotriene B5(1-)
- Systematic name
- (5S,6Z,8E,10E,12R,14Z,17Z)-5,12-dihydroxyicosa-6,8,10,14,17-pentaenoate