glycerol

Three steps

• (8S,15S)-dihydroperoxy-(5Z,9E,11Z,13E)-eicosatetraenoateReach from here →
  1. 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + glycerol = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + 1-octadecanoyl-sn-glycero-3-phosphocholine
  2. 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O = glycerol + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + 2 O2 = (8S,15S)-dihydroperoxy-(5Z,9E,11Z,13E)-eicosatetraenoate

  Catalysed by PLA2G4A, ABHD16A, ABHD12, MGLL and 2 more

• (14R,15S)-dihydroperoxy-(5Z,8Z,10E,12E)-eicosatetraenoateReach from here →
  1. 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + glycerol = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + 1-octadecanoyl-sn-glycero-3-phosphocholine
  2. 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O = glycerol + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + 2 O2 = (14R,15S)-dihydroperoxy-(5Z,8Z,10E,12E)-eicosatetraenoate

  Catalysed by PLA2G4A, ABHD16A, ABHD12, MGLL and 2 more

• 2,4-dinitrophenyl-S-glutathioneReach from here →
  1. 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + glycerol = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + 1-octadecanoyl-sn-glycero-3-phosphocholine
  2. 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O = glycerol + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)
  3. transport of arachidonate (cytosol to extracellular)

  Catalysed by PLA2G4A, ABHD16A, ABHD12, MGLL and 2 moreextracellular space, cytosolOne of 2 routes

• N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-phenylalanineReach from here →
  1. 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + glycerol = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + 1-octadecanoyl-sn-glycero-3-phosphocholine
  2. 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O = glycerol + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + L-phenylalanine = N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-phenylalanine + H2O

  Catalysed by PLA2G4A, ABHD16A, ABHD12, MGLL and 2 more

• 7-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + glycerol = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + 1-octadecanoyl-sn-glycero-3-phosphocholine
  2. 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O = glycerol + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)
  3. unspecific monooxygenase (arachidonate)

  Catalysed by PLA2G4A, ABHD16A, ABHD12, MGLL and 27 morecytosolOne of 2 routes

• 13-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + glycerol = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + 1-octadecanoyl-sn-glycero-3-phosphocholine
  2. 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O = glycerol + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)
  3. unspecific monooxygenase (arachidonate)

  Catalysed by PLA2G4A, ABHD16A, ABHD12, MGLL and 27 morecytosolOne of 2 routes

• 13(S)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + glycerol = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + 1-octadecanoyl-sn-glycero-3-phosphocholine
  2. 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O = glycerol + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = 13(S)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

  Catalysed by PLA2G4A, ABHD16A, ABHD12, MGLL and 2 more

• a 3-(acyloxy)acyl derivative of bacterial toxinReach from here →
  1. a monoacylglycerol + H2O = glycerol + a fatty acid + H(+)
  2. a monoacylglycerol + H2O = glycerol + a fatty acid + H(+)
  3. a 3-(acyloxy)acyl derivative of bacterial toxin + H2O = a 3-hydroxyacyl derivative of bacterial toxin + a fatty acid + H(+)

  Catalysed by LIPE, AOAH

• 16(R)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + glycerol = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + 1-octadecanoyl-sn-glycero-3-phosphocholine
  2. 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O = glycerol + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)
  3. unspecific monooxygenase (arachidonate)

  Catalysed by PLA2G4A, ABHD16A, ABHD12, MGLL and 27 morecytosol

• 1-(9Z-octadecenoyl)-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphateReach from here →
  1. glycerol + ATP = sn-glycerol 3-phosphate + ADP + H(+)
  2. sn-glycerol 3-phosphate + (9Z)-octadecenoyl-CoA = 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA
  3. (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate = 1-(9Z-octadecenoyl)-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + CoA

  Catalysed by GK, GK3, GK2, GK5 and 4 more

• 1-octadecanoyl-2-(15-hydroperoxy-5Z,8Z,11Z,13E-eicosatetraenoyl)-sn-glycero-3-phosphocholineReach from here →
  1. 1-octadecanoyl-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + glycerol = 1-(9Z,12Z,15Z-octadecatrienoyl)-glycerol + 1-octadecanoyl-sn-glycero-3-phosphocholine
  2. 1-octadecanoyl-sn-glycero-3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA
  3. 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + O2 = 1-octadecanoyl-2-(15-hydroperoxy-5Z,8Z,11Z,13E-eicosatetraenoyl)-sn-glycero-3-phosphocholine

  Catalysed by PLA2G4A, LPCAT3, ALOX15B

• 8-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoateReach from here →
  1. 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + glycerol = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + 1-octadecanoyl-sn-glycero-3-phosphocholine
  2. 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O = glycerol + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)
  3. arachidonate to 8-peroxy-(5Z,9E,11Z,14Z)-eicosatetraenoate conversion

  Catalysed by PLA2G4A, ABHD16A, ABHD12, MGLL and 1 morecytosolOne of 2 routes

• N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-serineReach from here →
  1. 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + glycerol = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + 1-octadecanoyl-sn-glycero-3-phosphocholine
  2. 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O = glycerol + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)
  3. N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-serine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + L-serine

  Catalysed by PLA2G4A, ABHD16A, ABHD12, MGLL and 3 more

• acetylcholineReach from here →
  1. 1-octadecanoyl-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + glycerol = 1-(9Z,12Z,15Z-octadecatrienoyl)-glycerol + 1-octadecanoyl-sn-glycero-3-phosphocholine
  2. 1-octadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-octadecanoyl-sn-glycero-3-phosphate + choline + H(+)
  3. Acetyl-CoA:choline O-acetyltransferase

  Catalysed by PLA2G4A, ENPP2, CHATcytosolOne of 3 routes

• arachidonoyl-CoAReach from here →
  1. 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + glycerol = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + 1-octadecanoyl-sn-glycero-3-phosphocholine
  2. 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O = glycerol + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)
  3. Arachidonate:CoA ligase (AMP-forming)

  Catalysed by PLA2G4A, ABHD16A, ABHD12, MGLL and 9 morecytosolOne of 3 routes

• 12(S)-HPETEReach from here →
  1. 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + glycerol = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + 1-octadecanoyl-sn-glycero-3-phosphocholine
  2. 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O = glycerol + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)
  3. arachidonate:oxygen 12-oxidoreductase

  Catalysed by PLA2G4A, ABHD16A, ABHD12, MGLL and 2 morecytosolOne of 4 routes

• 15(S)-HPETEReach from here →
  1. 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + glycerol = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + 1-octadecanoyl-sn-glycero-3-phosphocholine
  2. 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O = glycerol + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)
  3. arachidonate:oxygen 15-oxidoreductase

  Catalysed by PLA2G4A, ABHD16A, ABHD12, MGLL and 3 morecytosolOne of 4 routes

• 5(S)-HPETEReach from here →
  1. 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + glycerol = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + 1-octadecanoyl-sn-glycero-3-phosphocholine
  2. 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O = glycerol + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)
  3. Arachidonate:oxygen 5-oxidoreductase

  Catalysed by PLA2G4A, ABHD16A, ABHD12, MGLL and 2 morecytosol

• betaine aldehydeReach from here →
  1. 1-octadecanoyl-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + glycerol = 1-(9Z,12Z,15Z-octadecatrienoyl)-glycerol + 1-octadecanoyl-sn-glycero-3-phosphocholine
  2. 1-octadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-octadecanoyl-sn-glycero-3-phosphate + choline + H(+)
  3. choline dehydrogenase (choline)

  Catalysed by PLA2G4A, ENPP2, CHDHcytosolOne of 3 routes

• hexadecanoic acidReach from here →
  1. a monoacylglycerol + H2O = glycerol + a fatty acid + H(+)
  2. 1-acylglycerol acylhydrolase
  3. (10Z)-heptadecenoic acid formation

  Catalysed by LIPE, ABHD12, MGLL, ABHD6cytosol, extracellular spaceOne of 12 routes

• 1-acylglycerone 3-phosphateReach from here →
  1. a monoacylglycerol + H2O = glycerol + a fatty acid + H(+)
  2. ATP:acylglycerol 3-phosphotransferase
  3. aldo-keto reductase (1-acylglycerol-3P pool)

  Catalysed by LIPE, AGK, AKR1A1cytosol

• CHEBI:15978Reach from here →
  1. glycerol + ATP = sn-glycerol 3-phosphate + ADP + H(+)
  2. CDP-glycerol + H2O = sn-glycerol 3-phosphate + CMP + 2 H(+)
  3. CDPglycerol phosphoglycerohydrolase

  Catalysed by GK, GK3, GK2, GK5 and 1 morecytosolOne of 2 routes

• dihydroxyacetoneReach from here →
  1. glycerol + ATP = sn-glycerol 3-phosphate + ADP + H(+)
  2. sn-glycerol 3-phosphate + NAD(+) = dihydroxyacetone phosphate + NADH + H(+)
  3. dihydroxyacetone + ATP = dihydroxyacetone phosphate + ADP + H(+)

  Catalysed by GK, GK3, GK2, GK5 and 3 more

• phosphatidic acidReach from here →
  1. a monoacylglycerol + H2O = glycerol + a fatty acid + H(+)
  2. ATP:acylglycerol 3-phosphotransferase
  3. acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase

  Catalysed by LIPE, AGK, AGPAT2, LCLAT1 and 7 morecytosol, mitochondrial matrixOne of 8 routes

• CHEBI:16856Reach from here →
  1. 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + glycerol = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + 1-octadecanoyl-sn-glycero-3-phosphocholine
  2. 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O = glycerol + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)
  3. transport of arachidonate and GSH (cytosol to extracellular)

  Catalysed by PLA2G4A, ABHD16A, ABHD12, MGLL and 1 moreextracellular space, cytosolOne of 2 routes

• D-erythrose 4-phosphateReach from here →
  1. glycerol + NADP(+) = D-glyceraldehyde + NADPH + H(+)
  2. D-glyceraldehyde + ATP = D-glyceraldehyde 3-phosphate + ADP + H(+)
  3. D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + beta-D-fructose 6-phosphate

  Catalysed by AKR1A1, AKR1B1, TKFC, TALDO1

• octadecanalReach from here →
  1. 1-octadecanoyl-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + glycerol = 1-(9Z,12Z,15Z-octadecatrienoyl)-glycerol + 1-octadecanoyl-sn-glycero-3-phosphocholine
  2. 1-octadecanoyl-sn-glycero-3-phosphocholine + H2O = octadecanoate + sn-glycerol 3-phosphocholine + H(+)
  3. octadecanal + NAD(+) + H2O = octadecanoate + NADH + 2 H(+)

  Catalysed by PLA2G4A, LYPLA2, ASPG, ALDH3A2

• methylglyoxalReach from here →
  1. glycerol + ATP = sn-glycerol 3-phosphate + ADP + H(+)
  2. sn-glycerol 3-phosphate + NAD(+) = dihydroxyacetone phosphate + NADH + H(+)
  3. dihydroxyacetone phosphate = methylglyoxal + phosphate

  Catalysed by GK, GK3, GK2, GK5 and 3 more

• linoleic acidReach from here →
  1. a monoacylglycerol + H2O = glycerol + a fatty acid + H(+)
  2. 1-acylglycerol acylhydrolase
  3. (10Z)-heptadecenoic acid formation

  Catalysed by LIPE, ABHD12, MGLL, ABHD6cytosol, extracellular spaceOne of 12 routes

• AH2Reach from here →
  1. 1-octadecanoyl-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + glycerol = 1-(9Z,12Z,15Z-octadecatrienoyl)-glycerol + 1-octadecanoyl-sn-glycero-3-phosphocholine
  2. 1-octadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-octadecanoyl-sn-glycero-3-phosphate + choline + H(+)
  3. choline + A = betaine aldehyde + AH2

  Catalysed by PLA2G4A, ENPP2, CHDH

• CHEBI:18132Reach from here →
  1. 1-octadecanoyl-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + glycerol = 1-(9Z,12Z,15Z-octadecatrienoyl)-glycerol + 1-octadecanoyl-sn-glycero-3-phosphocholine
  2. 1-octadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-octadecanoyl-sn-glycero-3-phosphate + choline + H(+)
  3. ATP:choline phosphotransferase

  Catalysed by PLA2G4A, ENPP2, CHKA, CHKBcytosolOne of 2 routes

• dodecanoateReach from here →
  1. a monoacylglycerol + H2O = glycerol + a fatty acid + H(+)
  2. 1-acylglycerol acylhydrolase
  3. (10Z)-heptadecenoic acid formation

  Catalysed by LIPE, ABHD12, MGLL, ABHD6cytosol, extracellular spaceOne of 12 routes

• O-[(5Z),(8Z),(11Z),(14Z)-eicosatetraenoyl]-beta-D-glucuronateReach from here →
  1. 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + glycerol = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + 1-octadecanoyl-sn-glycero-3-phosphocholine
  2. 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O = glycerol + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + UDP-alpha-D-glucuronate = O-[(5Z),(8Z),(11Z),(14Z)-eicosatetraenoyl]-beta-D-glucuronate + UDP

  Catalysed by PLA2G4A, ABHD16A, ABHD12, MGLL and 7 more

• docosanoateReach from here →
  1. a monoacylglycerol + H2O = glycerol + a fatty acid + H(+)
  2. 1-acylglycerol acylhydrolase
  3. (10Z)-heptadecenoic acid formation

  Catalysed by LIPE, ABHD12, MGLL, ABHD6cytosol, extracellular spaceOne of 12 routes

• N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamineReach from here →
  1. 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + glycerol = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + 1-octadecanoyl-sn-glycero-3-phosphocholine
  2. 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O = glycerol + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)
  3. fatty acylamide amidohydrolase

  Catalysed by PLA2G4A, ABHD16A, ABHD12, MGLL and 2 morecytosol

• alpha-linolenic acidReach from here →
  1. a monoacylglycerol + H2O = glycerol + a fatty acid + H(+)
  2. 1-acylglycerol acylhydrolase
  3. (10Z)-heptadecenoic acid formation

  Catalysed by LIPE, ABHD12, MGLL, ABHD6cytosol, extracellular spaceOne of 12 routes

• elaidic acidReach from here →
  1. a monoacylglycerol + H2O = glycerol + a fatty acid + H(+)
  2. 1-acylglycerol acylhydrolase
  3. (10Z)-heptadecenoic acid formation

  Catalysed by LIPE, ABHD12, MGLL, ABHD6cytosol, extracellular spaceOne of 12 routes

• all-cis-docosa-4,7,10,13,16,19-hexaenoic acidReach from here →
  1. a monoacylglycerol + H2O = glycerol + a fatty acid + H(+)
  2. 1-acylglycerol acylhydrolase
  3. (10Z)-heptadecenoic acid formation

  Catalysed by LIPE, ABHD12, MGLL, ABHD6cytosol, extracellular spaceOne of 12 routes

• beta-D-fructoseReach from here →
  1. glycerol + NADP(+) = D-glyceraldehyde + NADPH + H(+)
  2. beta-D-fructose 1-phosphate = D-glyceraldehyde + dihydroxyacetone phosphate
  3. beta-D-fructose + ATP = beta-D-fructose 1-phosphate + ADP + H(+)

  Catalysed by AKR1A1, AKR1B1, ALDOB, KHK

• chlorine(.)Reach from here →
  1. 1-octadecanoyl-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + glycerol = 1-(9Z,12Z,15Z-octadecatrienoyl)-glycerol + 1-octadecanoyl-sn-glycero-3-phosphocholine
  2. 1-octadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-octadecanoyl-sn-glycero-3-phosphate + choline + H(+)
  3. transport of chloride and choline (cytosol to extracellular)

  Catalysed by PLA2G4A, ENPP2, SLC5A7extracellular space, cytosol

• phosphocholineReach from here →
  1. 1-octadecanoyl-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + glycerol = 1-(9Z,12Z,15Z-octadecatrienoyl)-glycerol + 1-octadecanoyl-sn-glycero-3-phosphocholine
  2. 1-octadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-octadecanoyl-sn-glycero-3-phosphate + choline + H(+)
  3. phosphocholine + H2O = choline + phosphate

  Catalysed by PLA2G4A, ENPP2, PHOSPHO1One of 3 routes

• acetateReach from here →
  1. 1-octadecanoyl-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + glycerol = 1-(9Z,12Z,15Z-octadecatrienoyl)-glycerol + 1-octadecanoyl-sn-glycero-3-phosphocholine
  2. 1-octadecanoyl-sn-glycero-3-phosphocholine + acetyl-CoA = 1-octadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + CoA
  3. 1-octadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-octadecanoyl-sn-glycero-3-phosphocholine + acetate + H(+)

  Catalysed by PLA2G4A, LPCAT2, ABHD3

• tetradecanoateReach from here →
  1. a monoacylglycerol + H2O = glycerol + a fatty acid + H(+)
  2. 1-acylglycerol acylhydrolase
  3. (10Z)-heptadecenoic acid formation

  Catalysed by LIPE, ABHD12, MGLL, ABHD6cytosol, extracellular spaceOne of 12 routes

• (9Z)-octadecenoateReach from here →
  1. a monoacylglycerol + H2O = glycerol + a fatty acid + H(+)
  2. 1-acylglycerol acylhydrolase
  3. (10Z)-heptadecenoic acid formation

  Catalysed by LIPE, ABHD12, MGLL, ABHD6cytosol, extracellular spaceOne of 13 routes

• (S)-dihydroorotateReach from here →
  1. glycerol + ATP = sn-glycerol 3-phosphate + ADP + H(+)
  2. a quinone + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + a quinol
  3. (S)-dihydroorotate + a quinone = orotate + a quinol

  Catalysed by GK, GK3, GK2, GK5 and 2 more

• hexacosanoateReach from here →
  1. a monoacylglycerol + H2O = glycerol + a fatty acid + H(+)
  2. 1-acylglycerol acylhydrolase
  3. (10Z)-heptadecenoic acid formation

  Catalysed by LIPE, ABHD12, MGLL, ABHD6cytosol, extracellular spaceOne of 12 routes

• tetracosanoateReach from here →
  1. a monoacylglycerol + H2O = glycerol + a fatty acid + H(+)
  2. 1-acylglycerol acylhydrolase
  3. (10Z)-heptadecenoic acid formation

  Catalysed by LIPE, ABHD12, MGLL, ABHD6cytosol, extracellular spaceOne of 12 routes

• an N-acylsphinganineReach from here →
  1. a monoacylglycerol + H2O = glycerol + a fatty acid + H(+)
  2. 1-acylglycerol acylhydrolase
  3. N-acylsphingosine amidohydrolase

  Catalysed by LIPE, ABHD12, MGLL, ABHD6 and 5 morecytosol

• eicosanoateReach from here →
  1. a monoacylglycerol + H2O = glycerol + a fatty acid + H(+)
  2. 1-acylglycerol acylhydrolase
  3. (10Z)-heptadecenoic acid formation

  Catalysed by LIPE, ABHD12, MGLL, ABHD6cytosol, extracellular spaceOne of 12 routes

• (9Z)-hexadecenoateReach from here →
  1. a monoacylglycerol + H2O = glycerol + a fatty acid + H(+)
  2. 1-acylglycerol acylhydrolase
  3. (10Z)-heptadecenoic acid formation

  Catalysed by LIPE, ABHD12, MGLL, ABHD6cytosol, extracellular spaceOne of 12 routes