Proteins/UNIPROT:Q14410

GK2

ProteinUNIPROT:Q14410Glycerol kinase 2

Key enzyme in the regulation of glycerol uptake and metabolism. Essential for male fertility and sperm mitochondrial sheath formation (By similarity). Required for proper arrangement of crescent-like mitochondria to form the mitochondrial sheath during spermatogenesis (By similarity). Can induce mitochondrial clustering through interactions with PLD6 and up-regulation of phosphatidic acid synthesis in the mitochondria..

Function from UniProtKB (Q14410), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

10 statements

10 statements · 4 reference databases · Subject: GK2 · Sources: Hetionet, Reactome, Rhea, WikiPathways

Order

GK2 covaries with PRF1ProteinHetionet hetionet:covaries:2712-5551Inferred only
GK2 participates in Fatty acid beta oxidationPathwayWikiPathways WP143Inferred only
GK2 participates in MetabolismPathwayReactome R-HSA-1430728Inferred only
GK2 participates in Metabolism of lipidsPathwayReactome R-HSA-556833Inferred only
GK2 participates in Triacylglyceride synthesisPathwayWikiPathways WP325Inferred only
GK2 participates in Triglyceride biosynthesisPathwayReactome R-HSA-75109Inferred only
GK2 participates in Triglyceride metabolismPathwayReactome R-HSA-8979227Inferred only
GK2 decreases the expression of PIN1ProteinHetionet hetionet:regulates:2712-5300Inferred only
GK2 decreases the expression of RPS4Y1ProteinHetionet hetionet:regulates:2712-6192Inferred only
glycerol is a substrate of GK2CompoundRhea RHEA:21644Inferred only

Reactions

3 reactions

ATP+MAM01983mADP+proton+CHEBI:15978
Catalysed by GK5 or GK2 or GK or GK3
Reaction pageLeft to rightBalancedEC 2.7.1.30mitochondrial matrix
Human-GEM MAR00448CC BY 4.0Reference data
ATP+MAM01983cADP+proton+CHEBI:15978

Other names

6 names

Resolves to: GK2

Also called: ATP:glycerol 3-phosphotransferase 2GK 2GKP2GKTAGlycerokinase 2Glycerol kinase, testis specific 2

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