1-(alk-1-enyl)-2-acyl-sn-glycero-3-phosphoethanolamine

Three steps

• CHEBI:28701Reach from here →
  1. plasmenylethanolamine 2-acylhydrolase
  2. Acyl-CoA:1-alkenylglycerophosphoethanolamine O-acyltransferase
  3. Propanoyl-CoA:acetyl-CoA C-acyltransferase

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 21 morecytosol, peroxisomeOne of 7 routes

• a fatty acidReach from here →
  1. plasmenylethanolamine 2-acylhydrolase
  2. N-acylsphingosine amidohydrolase
  3. an N-acylsphinganine + H2O = sphinganine + a fatty acid

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 19 morecytosolOne of 3 routes

• acetateReach from here →
  1. phospholipase D (O-1-alk-1-enyl-2-acyl-sn-glycero-3-phosphoethanolamine)
  2. ethanolamine ammonia-lyase (acetaldehyde-forming)
  3. Acetaldehyde:NAD+ oxidoreductase

  Catalysed by PLD2, PLD1, ALDH3A1, ALDH3B1 and 2 morecytosolOne of 4 routes

• an N-acyl-(4R)-4-hydroxysphinganineReach from here →
  1. plasmenylethanolamine 2-acylhydrolase
  2. N-acylsphingosine amidohydrolase
  3. dihydroceramide,ferrocytochrome b5:oxygen oxidoreductase (C4-hydroxylating)

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 21 morecytosolOne of 2 routes

• 12-hydroxydodecanoateReach from here →
  1. plasmenylethanolamine 2-acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. alkane 1-monooxygenase (lauric acid)

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 16 morecytosol, extracellular spaceOne of 2 routes

• taurineReach from here →
  1. plasmenylethanolamine 2-acylhydrolase
  2. Acyl-CoA:1-alkenylglycerophosphoethanolamine O-acyltransferase
  3. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 19 morecytosolOne of 2 routes

• 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerolReach from here →
  1. plasmenylethanolamine 2-acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. fatty acid amide hydrolase (2-arachidonoylglycerol)

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 15 morecytosol, extracellular space

• an N-acylsphing-4-enineReach from here →
  1. plasmenylethanolamine 2-acylhydrolase
  2. N-acylsphingosine amidohydrolase
  3. delta 4-desaturase, sphingolipid (dihydroceramide pool)

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 21 morecytosolOne of 5 routes

• 1,2,3-tri-(9Z-octadecenoyl)-glycerolReach from here →
  1. plasmenylethanolamine 2-acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. 1,2-di-(9Z-octadecenoyl)-glycerol + (9Z)-octadecenoate + H(+) = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 19 morecytosol, extracellular space

• 16-hydroxyhexadecanoateReach from here →
  1. plasmenylethanolamine 2-acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. Fatty Acid Omega Oxidation (C16->W-Ohc16), Endoplasmatic Reticulum

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 16 morecytosol, extracellular space, endoplasmic reticulumOne of 2 routes

• a 1,2-diacyl-sn-glycero-3-phospho-L-serineReach from here →
  1. ethanolaminephosphotransferase (1-alkenyl-2-acylglycerol)
  2. CDP-ethanolamine + a 1,2-diacyl-sn-glycerol = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CMP + H(+)
  3. a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + L-serine = a 1,2-diacyl-sn-glycero-3-phospho-L-serine + ethanolamine

  Catalysed by SELENOI, CEPT1, PTDSS1, PTDSS2cytosol

• glycineReach from here →
  1. plasmenylethanolamine 2-acylhydrolase
  2. Acyl-CoA:1-alkenylglycerophosphoethanolamine O-acyltransferase
  3. glycine N-acyltransferase (N-arachidonoylglycine)

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 21 morecytosol, mitochondrial matrixOne of 10 routes

• (R)-methylmalonyl-CoAReach from here →
  1. plasmenylethanolamine 2-acylhydrolase
  2. Acyl-CoA:1-alkenylglycerophosphoethanolamine O-acyltransferase
  3. aldehyde dehydrogenase (2-methyl-3-oxopropanoate)

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 19 morecytosol, mitochondrial matrixOne of 2 routes

• (S)-methylmalonyl-CoAReach from here →
  1. plasmenylethanolamine 2-acylhydrolase
  2. Acyl-CoA:1-alkenylglycerophosphoethanolamine O-acyltransferase
  3. (S)-methylmalonyl-CoA hydrolase

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 18 morecytosol, mitochondrial matrix

• 3'-dephospho-CoAReach from here →
  1. plasmenylethanolamine 2-acylhydrolase
  2. Acyl-CoA:1-alkenylglycerophosphoethanolamine O-acyltransferase
  3. acid phosphatase 2, lysosomal (CoA)

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 19 morecytosol, lysosomeOne of 2 routes

• (2E)-dodecenoyl-CoAReach from here →
  1. plasmenylethanolamine 2-acylhydrolase
  2. Acyl-CoA:1-alkenylglycerophosphoethanolamine O-acyltransferase
  3. (2E)-dodecenoyl-CoA formation

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 18 morecytosol, mitochondrial matrixOne of 3 routes

• 4,8,12-trimethyltridecanoyl-CoAReach from here →
  1. plasmenylethanolamine 2-acylhydrolase
  2. Acyl-CoA:1-alkenylglycerophosphoethanolamine O-acyltransferase
  3. propanoyl-CoA C-acyltransferase (3-ketopristanoyl-CoA)

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 20 morecytosol, peroxisomeOne of 2 routes

• (6Z,9Z,12Z)-octadecatrienoyl-CoAReach from here →
  1. plasmenylethanolamine 2-acylhydrolase
  2. Acyl-CoA:1-alkenylglycerophosphoethanolamine O-acyltransferase
  3. long-chain-fatty-acid-CoA ligase (gamma-linolenate)

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 26 morecytosolOne of 8 routes

• (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoAReach from here →
  1. plasmenylethanolamine 2-acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 25 morecytosol, extracellular space

• butanoyl-CoAReach from here →
  1. plasmenylethanolamine 2-acylhydrolase
  2. Acyl-CoA:1-alkenylglycerophosphoethanolamine O-acyltransferase
  3. Butanoate:CoA ligase (AMP-forming)

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 24 morecytosolOne of 9 routes

• dodecanoyl-CoAReach from here →
  1. plasmenylethanolamine 2-acylhydrolase
  2. Acyl-CoA:1-alkenylglycerophosphoethanolamine O-acyltransferase
  3. long-chain-fatty-acid-CoA ligase (lauric acid)

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 26 morecytosolOne of 12 routes

• glutaryl-CoAReach from here →
  1. plasmenylethanolamine 2-acylhydrolase
  2. Acyl-CoA:1-alkenylglycerophosphoethanolamine O-acyltransferase
  3. Production of Glutaryl Carnitine

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 21 morecytosolOne of 2 routes

• eicosanoyl-CoAReach from here →
  1. plasmenylethanolamine 2-acylhydrolase
  2. Acyl-CoA:1-alkenylglycerophosphoethanolamine O-acyltransferase
  3. long-chain-fatty-acid-CoA ligase (eicosanoate)

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 26 morecytosolOne of 18 routes

• itaconyl-CoAReach from here →
  1. plasmenylethanolamine 2-acylhydrolase
  2. Acyl-CoA:1-alkenylglycerophosphoethanolamine O-acyltransferase
  3. Itaconate:CoA ligase (GDP-forming)

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 21 morecytosol, mitochondrial matrixOne of 2 routes

• (9Z,12Z)-octadecadienoyl-CoAReach from here →
  1. plasmenylethanolamine 2-acylhydrolase
  2. Acyl-CoA:1-alkenylglycerophosphoethanolamine O-acyltransferase
  3. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 26 morecytosolOne of 18 routes

• tetradecanoyl-CoAReach from here →
  1. plasmenylethanolamine 2-acylhydrolase
  2. Acyl-CoA:1-alkenylglycerophosphoethanolamine O-acyltransferase
  3. long-chain-fatty-acid-CoA ligase (myristic acid)

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 26 morecytosolOne of 15 routes

• octanoyl-CoAReach from here →
  1. plasmenylethanolamine 2-acylhydrolase
  2. Acyl-CoA:1-alkenylglycerophosphoethanolamine O-acyltransferase
  3. Octanoyl-CoA:L-carnitine O-octanoyltransferase

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 19 morecytosol, mitochondrial matrixOne of 20 routes

• (9Z)-octadecenoyl-CoAReach from here →
  1. plasmenylethanolamine 2-acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. (9Z)-octadecenoate + ATP + CoA = (9Z)-octadecenoyl-CoA + AMP + diphosphate

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 22 morecytosol, extracellular space

• phytanoyl-CoAReach from here →
  1. plasmenylethanolamine 2-acylhydrolase
  2. Acyl-CoA:1-alkenylglycerophosphoethanolamine O-acyltransferase
  3. phytanate-CoA ligase

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 18 morecytosolOne of 5 routes

• octadecanoyl-CoAReach from here →
  1. plasmenylethanolamine 2-acylhydrolase
  2. Acyl-CoA:1-alkenylglycerophosphoethanolamine O-acyltransferase
  3. long-chain-fatty-acid-CoA ligase (stearate)

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 25 morecytosolOne of 21 routes

• prostaglandin H2Reach from here →
  1. plasmenylethanolamine 2-acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. prostaglandin-endoperoxide synthase (arachidonate)

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 16 morecytosol, extracellular spaceOne of 3 routes

• (12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoateReach from here →
  1. plasmenylethanolamine 2-acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 17 morecytosol, extracellular space

• (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoateReach from here →
  1. plasmenylethanolamine 2-acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 17 morecytosol, extracellular space

• (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. plasmenylethanolamine 2-acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 15 morecytosol, extracellular space

• leukotriene A4Reach from here →
  1. plasmenylethanolamine 2-acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = leukotriene A4 + H2O

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 15 morecytosol, extracellular space

• (13S)-hydroperoxy-(9Z,11E)-octadecadienoateReach from here →
  1. plasmenylethanolamine 2-acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. Linoleate:oxygen 13-oxidoreductase

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 16 morecytosol, extracellular space

• (R)-2-hydroxyoctadecanoateReach from here →
  1. plasmenylethanolamine 2-acylhydrolase
  2. (10Z)-heptadecenoic acid formation
  3. octadecanoate + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (R)-2-hydroxyoctadecanoate + 2 Fe(III)-[cytochrome b5] + H2O

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 15 morecytosol, extracellular space

• sphing-4-enineReach from here →
  1. plasmenylethanolamine 2-acylhydrolase
  2. Acyl-CoA:1-alkenylglycerophosphoethanolamine O-acyltransferase
  3. acyl-CoA:sphingosine N-acyltransferase

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 22 morecytosol, Golgi apparatusOne of 2 routes

• sphinganineReach from here →
  1. plasmenylethanolamine 2-acylhydrolase
  2. N-acylsphingosine amidohydrolase
  3. an N-acylsphinganine + H2O = sphinganine + a fatty acid

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 19 morecytosol

• spermidineReach from here →
  1. plasmenylethanolamine 2-acylhydrolase
  2. Acyl-CoA:1-alkenylglycerophosphoethanolamine O-acyltransferase
  3. diamine N-acetyltransferase (N1-acetylspermidine)

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 20 morecytosolOne of 3 routes

• L-methionineReach from here →
  1. plasmenylethanolamine 2-acylhydrolase
  2. Acyl-CoA:1-alkenylglycerophosphoethanolamine O-acyltransferase
  3. N-acetylglutamate synthase (N-acetylmethionine)

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 19 morecytosol, mitochondrial matrix

• a 2-acyl-sn-glycero-3-phosphocholineReach from here →
  1. ethanolaminephosphotransferase (1-alkenyl-2-acylglycerol)
  2. CDP-ethanolamine + a 1,2-diacyl-sn-glycerol = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CMP + H(+)
  3. a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + a 1,2-diacyl-sn-glycero-3-phosphocholine = an N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine + a 2-acyl-sn-glycero-3-phosphocholine + H(+)

  Catalysed by SELENOI, CEPT1, PLA2G4E, PLAAT5 and 1 morecytosol

• sphinganine 1-phosphateReach from here →
  1. plasmenylethanolamine 2-acylhydrolase
  2. Lysoplasmalogen ethanolamine phosphohydrolase
  3. Sphinganine-1-phosphate pamlmitaldehyde-lyase

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 15 morecytosol

• L-alanineReach from here →
  1. plasmenylethanolamine 2-acylhydrolase
  2. Acyl-CoA:1-alkenylglycerophosphoethanolamine O-acyltransferase
  3. amino-acid N-acetyltransferase (N-acetyl-L-alanine)

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 18 morecytosol, mitochondrial matrix

• a 1-O-alkyl-sn-glycero-3-phosphateReach from here →
  1. phospholipase D (O-1-alk-1-enyl-2-acyl-sn-glycero-3-phosphoethanolamine)
  2. a 1-O-alkyl-sn-glycero-3-phosphoethanolamine + H2O = a 1-O-alkyl-sn-glycero-3-phosphate + ethanolamine + H(+)
  3. a 1-O-alkyl-sn-glycero-3-phosphoethanolamine + H2O = a 1-O-alkyl-sn-glycero-3-phosphate + ethanolamine + H(+)

  Catalysed by PLD2, PLD1, ENPP2cytosol

• L-asparagineReach from here →
  1. plasmenylethanolamine 2-acylhydrolase
  2. Acyl-CoA:1-alkenylglycerophosphoethanolamine O-acyltransferase
  3. N-acetylglutamate synthase (N-acetyl-L-asparagine)

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 19 morecytosol, mitochondrial matrix

• L,L-cystathionineReach from here →
  1. plasmenylethanolamine 2-acylhydrolase
  2. Acyl-CoA:1-alkenylglycerophosphoethanolamine O-acyltransferase
  3. N-acetylglutamate synthase (N-acetyl-L-cystathionine)

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 19 morecytosol, mitochondrial matrix

• a 1-acyl-sn-glycero-3-phosphocholineReach from here →
  1. ethanolaminephosphotransferase (1-alkenyl-2-acylglycerol)
  2. CDP-ethanolamine + a 1,2-diacyl-sn-glycerol = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CMP + H(+)
  3. a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + a 1,2-diacyl-sn-glycero-3-phosphocholine = an N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine + a 1-acyl-sn-glycero-3-phosphocholine + H(+)

  Catalysed by SELENOI, CEPT1, PLAAT5, PLAAT2cytosol

• an acyl-CoAReach from here →
  1. plasmenylethanolamine 2-acylhydrolase
  2. Acyl-CoA:1-alkenylglycerophosphoethanolamine O-acyltransferase
  3. acyl-CoA:sphingosine N-acyltransferase

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 22 morecytosol, Golgi apparatusOne of 3 routes

• (3Z)-dodecenoyl-CoAReach from here →
  1. plasmenylethanolamine 2-acylhydrolase
  2. Acyl-CoA:1-alkenylglycerophosphoethanolamine O-acyltransferase
  3. acetyl-CoA C-acyltransferase (3-oxomyrist-5-enoyl-CoA)

  Catalysed by PLA2G10, PLA2G6, PLA2G1B, PLA2G4B and 21 morecytosol, mitochondrial matrixOne of 3 routes