CHEBI:17380

1. 3-Hydroxy-L-kynurenine hydrolase
2. gamma-glutamyltransferase (alanine)

Catalysed by KYNU, GGT1, GGT5, GGTLC2 and 3 morecytosol, extracellular space

1. L-Kynurenine,NADPH:oxygen oxidoreductase (3-hydroxylating)
2. L-kynurenine + glyoxylate = kynurenate + glycine + H2O

Catalysed by KMO, KYAT3, AADATcytosolOne of 15 routes

1. 3-Hydroxy-L-kynurenine hydrolase
2. D-alanine(out) + L-alanine(in) = D-alanine(in) + L-alanine(out)

Catalysed by KYNU, SLC7A10cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

1. 3-Hydroxy-L-kynurenine hydrolase
2. D-threonine(out) + L-alanine(in) = D-threonine(in) + L-alanine(out)

Catalysed by KYNU, SLC7A10cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

1. L-Kynurenine,NADPH:oxygen oxidoreductase (3-hydroxylating)
2. 4-methylsulfanyl-2-oxobutanoate + L-kynurenine = kynurenate + L-methionine + H2O

Catalysed by KMO, AADATcytosolOne of 12 routes

1. 3-Hydroxy-L-kynurenine hydrolase
2. L-threonine(out) + L-alanine(in) = L-threonine(in) + L-alanine(out)

Catalysed by KYNU, SLC7A10cytosol, inner side of the membrane, outer side of the membraneOne of 4 routes

1. 3-Hydroxy-L-kynurenine hydrolase
2. beta-alanine(out) + L-alanine(in) = beta-alanine(in) + L-alanine(out)

Catalysed by KYNU, SLC7A10cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

1. 3-Hydroxy-L-kynurenine hydrolase
2. transport of alanine and asparagine (cytosol to extracellular)

Catalysed by KYNU, SLC7A5cytosol, extracellular spaceOne of 9 routes

1. L-Kynurenine,NADPH:oxygen oxidoreductase (3-hydroxylating)
2. Transport of L-Kynurenine

Catalysed by KMO, SLC7A8cytosol, extracellular spaceOne of 15 routes

1. L-Kynurenine,NADPH:oxygen oxidoreductase (3-hydroxylating)
2. L-kynurenine + NADPH + O2 + H(+) = 3-hydroxy-L-kynurenine + NADP(+) + H2O

Catalysed by KMOcytosolOne of 2 routes

1. 3-Hydroxy-L-kynurenine hydrolase
2. N(omega),N(omega)-dimethyl-L-arginine + pyruvate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-alanine

Catalysed by KYNU, AGXT2cytosol

1. 3-Hydroxy-L-kynurenine hydrolase
2. trans-4-hydroxy-L-proline(out) + L-alanine(in) + Na(+)(out) = trans-4-hydroxy-L-proline(in) + L-alanine(out) + Na(+)(in)

Catalysed by KYNU, SLC1A4cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

1. L-Kynurenine,NADPH:oxygen oxidoreductase (3-hydroxylating)
2. 2-oxopentanoate + L-kynurenine = L-2-aminopentanoate + kynurenate + H2O

Catalysed by KMO, AADATcytosol

1. L-Kynurenine,NADPH:oxygen oxidoreductase (3-hydroxylating)
2. Kynurenine-Oxoglutarate Transaminase

Catalysed by KMO, KYAT3, AADATcytosol, mitochondrial matrixOne of 13 routes

1. L-Kynurenine,NADPH:oxygen oxidoreductase (3-hydroxylating)
2. 2-oxohexanoate + L-kynurenine = L-2-aminohexanoate + kynurenate + H2O

Catalysed by KMO, AADATcytosol

1. L-Kynurenine,NADPH:oxygen oxidoreductase (3-hydroxylating)
2. N-formyl-L-kynurenine + H2O = L-kynurenine + formate + H(+)

Catalysed by KMO, AFMIDcytosolOne of 2 routes

1. L-Kynurenine,NADPH:oxygen oxidoreductase (3-hydroxylating)
2. 2-oxoadipate + L-kynurenine = L-2-aminoadipate + kynurenate + H2O

Catalysed by KMO, AADATcytosol

1. L-Kynurenine,NADPH:oxygen oxidoreductase (3-hydroxylating)
2. an L-alpha-amino acid(in) + L-kynurenine(out) = an L-alpha-amino acid(out) + L-kynurenine(in)

Catalysed by KMO, SLC7A11cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

1. 3-Hydroxy-L-kynurenine hydrolase
2. L-proline(out) + L-alanine(in) + Na(+)(out) = L-proline(in) + L-alanine(out) + Na(+)(in)

Catalysed by KYNU, SLC1A4cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

1. 3-Hydroxy-L-kynurenine hydrolase
2. gamma-glutamyltransferase (alanine)

Catalysed by KYNU, GGTLC3, GGT1, GGT5 and 3 morecytosolOne of 2 routes

1. 3-Hydroxy-L-kynurenine hydrolase
2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O

Catalysed by KYNU, MOCOScytosol

1. L-Kynurenine,NADPH:oxygen oxidoreductase (3-hydroxylating)
2. 2-oxobutanoate + L-kynurenine = (2S)-2-aminobutanoate + kynurenate + H2O

Catalysed by KMO, AADATcytosolOne of 2 routes

1. 3-Hydroxy-L-kynurenine hydrolase
2. 3-Hydroxyanthranilate:oxygen 3,4-oxidoreductase (decyclizing)

Catalysed by KYNU, HAAOcytosol

1. 3-Hydroxy-L-kynurenine hydrolase
2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
3. Carnitine O-Palmitoyltransferase

Catalysed by KYNU, CPT1A, CPT1C, CPT1Bcytosol, mitochondrial matrixOne of 245 routes

1. 3-Hydroxy-L-kynurenine hydrolase
2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
3. transport of 2-hydroxybutyrate and pyruvate (cytosol to extracellular)